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4 similar compounds to monomer 192151

Compile data set for download or QSAR
Wt: 618.1
BDBM192153
Wt: 610.1
BDBM192155
Wt: 638.1
BDBM192159
Wt: 596.1
BDBM192161

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 192153,192155,192159,192161   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM192155
PNG
(US9187441, 7E)
Show SMILES CCOC(=O)c1c(C(N(Cc2ccccc2)C(C)=O)C(=O)NC2CCCCC2)c2ccc(Cl)cc2n1C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H40ClN3O6/c1-6-42-31(40)29-27(25-18-17-23(34)19-26(25)37(29)32(41)43-33(3,4)5)28(30(39)35-24-15-11-8-12-16-24)36(21(2)38)20-22-13-9-7-10-14-22/h7,9-10,13-14,17-19,24,28H,6,8,11-12,15-16,20H2,1-5H3,(H,35,39)
PDB
MMDB

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US Patent
0.25 -12.9n/an/an/an/an/an/a20



University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...


US Patent US9187441 (2015)


BindingDB Entry DOI: 10.7270/Q2DR2T9N
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM192161
PNG
(US9187441, 7I)
Show SMILES CCOC(=O)c1c(C(N(Cc2ccccc2)C=O)C(=O)NC2CCCCC2)c2ccc(Cl)cc2n1C(=O)OC(C)(C)C
Show InChI InChI=1S/C32H38ClN3O6/c1-5-41-30(39)28-26(24-17-16-22(33)18-25(24)36(28)31(40)42-32(2,3)4)27(29(38)34-23-14-10-7-11-15-23)35(20-37)19-21-12-8-6-9-13-21/h6,8-9,12-13,16-18,20,23,27H,5,7,10-11,14-15,19H2,1-4H3,(H,34,38)
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US Patent
0.300 -12.8n/an/an/an/an/an/a20



University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...


US Patent US9187441 (2015)


BindingDB Entry DOI: 10.7270/Q2DR2T9N
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM192153
PNG
(US9187441, 7D)
Show SMILES CCOC(=O)c1c(C(N(Cc2ccccc2)C(C)=O)C(=O)NCc2ccccc2)c2ccc(Cl)cc2n1C(=O)OC(C)(C)C
Show InChI InChI=1S/C34H36ClN3O6/c1-6-43-32(41)30-28(26-18-17-25(35)19-27(26)38(30)33(42)44-34(3,4)5)29(31(40)36-20-23-13-9-7-10-14-23)37(22(2)39)21-24-15-11-8-12-16-24/h7-19,29H,6,20-21H2,1-5H3,(H,36,40)
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US Patent
1.70 -11.8n/an/an/an/an/an/a20



University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...


US Patent US9187441 (2015)


BindingDB Entry DOI: 10.7270/Q2DR2T9N
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM192159
PNG
(US9187441, 7H)
Show SMILES CCCC(=O)N(Cc1ccccc1)C(C(=O)NC1CCCCC1)c1c(C(=O)OCC)n(C(=O)OC(C)(C)C)c2cc(Cl)ccc12
Show InChI InChI=1S/C35H44ClN3O6/c1-6-14-28(40)38(22-23-15-10-8-11-16-23)30(32(41)37-25-17-12-9-13-18-25)29-26-20-19-24(36)21-27(26)39(31(29)33(42)44-7-2)34(43)45-35(3,4)5/h8,10-11,15-16,19-21,25,30H,6-7,9,12-14,17-18,22H2,1-5H3,(H,37,41)
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US Patent
2.5 -11.5n/an/an/an/an/an/a20



University of Pittsburgh—Of the Commonwealth System of Higher Education

US Patent


Assay Description
Fluorescent polarization experiments were performed as follows. Briefly, the fluorescence polarization experiments were read on an Ultra Evolution 38...


US Patent US9187441 (2015)


BindingDB Entry DOI: 10.7270/Q2DR2T9N
More data for this
Ligand-Target Pair