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27 similar compounds to monomer 26266

Wt: 404.3
BDBM22041
Purchase
Wt: 369.8
BDBM50060088
Wt: 335.4
BDBM50060114
Wt: 428.3
BDBM50060115
Wt: 461.3
BDBM50060119
Wt: 349.4
BDBM50060127
Wt: 404.3
BDBM50060131
Wt: 428.3
BDBM50060132
Wt: 349.4
BDBM50408724
Wt: 419.6
BDBM50408725
Wt: 307.3
BDBM50408726
Wt: 384.9
BDBM50408728
Wt: 454.0
BDBM50408729
Wt: 397.9
BDBM50408730
Wt: 393.4
BDBM50408731
Displayed 1 to 15 (of 27 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 22041,50060088,50060114,50060115,50060119,50060127,50060131,50060132,50408724,50408725,50408726,50408728,50408729,50408730,50408731   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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0.5 -11.8n/an/an/an/an/a7.44



Universita di Pisa



Assay Description
Assays were performed by incubating aliquots of rat kidney mitochondria suspensions with [3H]PK 11195 and a range of concentrations of the test compo...


J Med Chem 50: 404-7 (2007)


Article DOI: 10.1021/jm061137o
BindingDB Entry DOI: 10.7270/Q23J3B8X
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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0.5n/an/an/an/an/an/an/an/a



Universit£ di Salerno

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat kidney mitochondrial membranes by competitive binding assay


J Med Chem 55: 4506-10 (2012)


Article DOI: 10.1021/jm201703k
BindingDB Entry DOI: 10.7270/Q2TB1806
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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0.5n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane


J Med Chem 51: 5798-806 (2008)


Article DOI: 10.1021/jm8003224
BindingDB Entry DOI: 10.7270/Q2GF0VD5
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408728
PNG
(CHEMBL339816)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(N)cccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN4O/c1-3-11-25(12-4-2)19(27)14-18-20(15-7-9-16(22)10-8-15)24-21-17(23)6-5-13-26(18)21/h5-10,13H,3-4,11-12,14,23H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Bari"A. Moro"

Curated by ChEMBL


Assay Description
Displacement of [3H]PK11195 from TSPO in rat C6 cell membrane after 90 mins by radioligand binding assay


ACS Med Chem Lett 5: 685-9 (2014)


Article DOI: 10.1021/ml5000788
BindingDB Entry DOI: 10.7270/Q26D5VKG
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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7n/an/an/an/an/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane


J Med Chem 47: 1852-5 (2004)


Article DOI: 10.1021/jm030973k
BindingDB Entry DOI: 10.7270/Q2WQ04K6
More data for this
Ligand-Target Pair
GABA


()
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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28n/an/an/an/an/an/an/an/a



Georgetown University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 256: 1154-60 (1991)


BindingDB Entry DOI: 10.7270/Q2125R4D
More data for this
Ligand-Target Pair
GABA


()
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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500n/an/an/an/an/an/an/an/a



Georgetown University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 256: 1154-60 (1991)


BindingDB Entry DOI: 10.7270/Q2125R4D
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060127
PNG
(2-(6-Methyl-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-4-13-24(14-5-2)21(26)15-19-22(18-9-7-6-8-10-18)23-20-12-11-17(3)16-25(19)20/h6-12,16H,4-5,13-15H2,1-3H3
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n/an/a 35n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060088
PNG
(2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H24ClN3O/c1-3-12-24(13-4-2)20(26)14-18-21(16-8-6-5-7-9-16)23-19-11-10-17(22)15-25(18)19/h5-11,15H,3-4,12-14H2,1-2H3
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n/an/a 4n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060114
PNG
(2-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-N,N-diprop...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-3-13-23(14-4-2)20(25)16-18-21(17-10-6-5-7-11-17)22-19-12-8-9-15-24(18)19/h5-12,15H,3-4,13-14,16H2,1-2H3
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n/an/a 80n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060132
PNG
(2-(8-Bromo-6-methyl-2-phenyl-imidazo[1,2-a]pyridin...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Br)cc(C)cn12)-c1ccccc1
Show InChI InChI=1S/C22H26BrN3O/c1-4-11-25(12-5-2)20(27)14-19-21(17-9-7-6-8-10-17)24-22-18(23)13-16(3)15-26(19)22/h6-10,13,15H,4-5,11-12,14H2,1-3H3
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n/an/a 19n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060131
PNG
(2-(6,8-Dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-y...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-10-25(11-4-2)19(27)13-18-20(15-8-6-5-7-9-15)24-21-17(23)12-16(22)14-26(18)21/h5-9,12,14H,3-4,10-11,13H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408724
PNG
(CHEMBL338378)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cccn12)-c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-4-13-24(14-5-2)20(26)16-19-21(18-11-7-6-8-12-18)23-22-17(3)10-9-15-25(19)22/h6-12,15H,4-5,13-14,16H2,1-3H3
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n/an/a 41.7n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408725
PNG
(CHEMBL129028)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-3-5-7-13-19-29(20-14-8-6-4-2)26(31)22-24-27(23-16-10-9-11-17-23)28-25-18-12-15-21-30(24)25/h9-12,15-18,21H,3-8,13-14,19-20,22H2,1-2H3
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n/an/a 19.1n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408725
PNG
(CHEMBL129028)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-3-5-7-13-19-29(20-14-8-6-4-2)26(31)22-24-27(23-16-10-9-11-17-23)28-25-18-12-15-21-30(24)25/h9-12,15-18,21H,3-8,13-14,19-20,22H2,1-2H3
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n/an/a 13.2n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060115
PNG
(2-(6-Bromo-8-methyl-2-phenyl-imidazo[1,2-a]pyridin...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cc(Br)cn12)-c1ccccc1
Show InChI InChI=1S/C22H26BrN3O/c1-4-11-25(12-5-2)20(27)14-19-21(17-9-7-6-8-10-17)24-22-16(3)13-18(23)15-26(19)22/h6-10,13,15H,4-5,11-12,14H2,1-3H3
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n/an/a 2.63n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408726
PNG
(CHEMBL128491)
Show SMILES CCN(CC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-3-21(4-2)18(23)14-16-19(15-10-6-5-7-11-15)20-17-12-8-9-13-22(16)17/h5-13H,3-4,14H2,1-2H3
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n/an/a 525n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060114
PNG
(2-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-N,N-diprop...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-3-13-23(14-4-2)20(25)16-18-21(17-10-6-5-7-11-17)22-19-12-8-9-15-24(18)19/h5-12,15H,3-4,13-14,16H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408728
PNG
(CHEMBL339816)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(N)cccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN4O/c1-3-11-25(12-4-2)19(27)14-18-20(15-7-9-16(22)10-8-15)24-21-17(23)6-5-13-26(18)21/h5-10,13H,3-4,11-12,14,23H2,1-2H3
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n/an/a 6.31n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408729
PNG
(CHEMBL126286)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36ClN3O/c1-3-5-7-10-18-30(19-11-8-6-4-2)26(32)21-24-27(22-14-16-23(28)17-15-22)29-25-13-9-12-20-31(24)25/h9,12-17,20H,3-8,10-11,18-19,21H2,1-2H3
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n/an/a 178n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408730
PNG
(CHEMBL340752)
Show SMILES CCCCN(CCCC)C(=O)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H28ClN3O/c1-3-5-14-26(15-6-4-2)22(28)17-20-23(18-10-12-19(24)13-11-18)25-21-9-7-8-16-27(20)21/h7-13,16H,3-6,14-15,17H2,1-2H3
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n/an/a 10.5n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408731
PNG
(CHEMBL337917)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(cn12)C(=O)OC)-c1ccccc1
Show InChI InChI=1S/C23H27N3O3/c1-4-13-25(14-5-2)21(27)15-19-22(17-9-7-6-8-10-17)24-20-12-11-18(16-26(19)20)23(28)29-3/h6-12,16H,4-5,13-15H2,1-3H3
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n/an/a 16.6n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408728
PNG
(CHEMBL339816)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(N)cccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H25ClN4O/c1-3-11-25(12-4-2)19(27)14-18-20(15-7-9-16(22)10-8-15)24-21-17(23)6-5-13-26(18)21/h5-10,13H,3-4,11-12,14,23H2,1-2H3
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n/an/a 4.57n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060131
PNG
(2-(6,8-Dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-y...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-10-25(11-4-2)19(27)13-18-20(15-8-6-5-7-9-15)24-21-17(23)12-16(22)14-26(18)21/h5-9,12,14H,3-4,10-11,13H2,1-2H3
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n/an/a 4.27n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408730
PNG
(CHEMBL340752)
Show SMILES CCCCN(CCCC)C(=O)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H28ClN3O/c1-3-5-14-26(15-6-4-2)22(28)17-20-23(18-10-12-19(24)13-11-18)25-21-9-7-8-16-27(20)21/h7-13,16H,3-6,14-15,17H2,1-2H3
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n/an/a 5.89n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060115
PNG
(2-(6-Bromo-8-methyl-2-phenyl-imidazo[1,2-a]pyridin...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cc(Br)cn12)-c1ccccc1
Show InChI InChI=1S/C22H26BrN3O/c1-4-11-25(12-5-2)20(27)14-19-21(17-9-7-6-8-10-17)24-22-16(3)13-18(23)15-26(19)22/h6-10,13,15H,4-5,11-12,14H2,1-3H3
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n/an/a 1.62n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408729
PNG
(CHEMBL126286)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c(nc2ccccn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H36ClN3O/c1-3-5-7-10-18-30(19-11-8-6-4-2)26(32)21-24-27(22-14-16-23(28)17-15-22)29-25-13-9-12-20-31(24)25/h9,12-17,20H,3-8,10-11,18-19,21H2,1-2H3
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n/an/a 182n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408726
PNG
(CHEMBL128491)
Show SMILES CCN(CC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C19H21N3O/c1-3-21(4-2)18(23)14-16-19(15-10-6-5-7-11-15)20-17-12-8-9-13-22(16)17/h5-13H,3-4,14H2,1-2H3
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n/an/a 437n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060131
PNG
(2-(6,8-Dichloro-2-phenyl-imidazo[1,2-a]pyridin-3-y...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-10-25(11-4-2)19(27)13-18-20(15-8-6-5-7-9-15)24-21-17(23)12-16(22)14-26(18)21/h5-9,12,14H,3-4,10-11,13H2,1-2H3
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n/an/a 3.02n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408724
PNG
(CHEMBL338378)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cccn12)-c1ccccc1
Show InChI InChI=1S/C22H27N3O/c1-4-13-24(14-5-2)20(26)16-19-21(18-11-7-6-8-12-18)23-22-17(3)10-9-15-25(19)22/h6-12,15H,4-5,13-14,16H2,1-3H3
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n/an/a 19.9n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat cerebral cortex membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50408731
PNG
(CHEMBL337917)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(cn12)C(=O)OC)-c1ccccc1
Show InChI InChI=1S/C23H27N3O3/c1-4-13-25(14-5-2)21(27)15-19-22(17-9-7-6-8-10-17)24-20-12-11-18(16-26(19)20)23(28)29-3/h6-12,16H,4-5,13-15H2,1-3H3
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n/an/a 26.9n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060119
PNG
(2-(6-Iodo-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N,N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(I)cn12)-c1ccccc1
Show InChI InChI=1S/C21H24IN3O/c1-3-12-24(13-4-2)20(26)14-18-21(16-8-6-5-7-9-16)23-19-11-10-17(22)15-25(18)19/h5-11,15H,3-4,12-14H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060115
PNG
(2-(6-Bromo-8-methyl-2-phenyl-imidazo[1,2-a]pyridin...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2c(C)cc(Br)cn12)-c1ccccc1
Show InChI InChI=1S/C22H26BrN3O/c1-4-11-25(12-5-2)20(27)14-19-21(17-9-7-6-8-10-17)24-22-16(3)13-18(23)15-26(19)22/h6-10,13,15H,4-5,11-12,14H2,1-3H3
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n/an/a 14n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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n/an/a 7.90n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of Ro 5-4864 from peripheral (renal cell) Benzodiazepine receptor


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens-Homo sapiens (Human))
BDBM50060088
PNG
(2-(6-Chloro-2-phenyl-imidazo[1,2-a]pyridin-3-yl)-N...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccccc1
Show InChI InChI=1S/C21H24ClN3O/c1-3-12-24(13-4-2)20(26)14-18-21(16-8-6-5-7-9-16)23-19-11-10-17(22)15-25(18)19/h5-11,15H,3-4,12-14H2,1-2H3
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n/an/an/an/a 1.30E+9n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Potentiation of GABA-evoked Cl- currents in Xenopus oocytes expressing human alpha-2-beta-2-gamma-2 subunits


J Med Chem 40: 3109-18 (1997)


Article DOI: 10.1021/jm970112+
BindingDB Entry DOI: 10.7270/Q2PN9699
More data for this
Ligand-Target Pair
Bile salt export pump


(Rattus norvegicus)
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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n/an/a 2.30E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of Sprague-Dawley rat Bsep expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate up...


Drug Metab Dispos 40: 130-8 (2011)


Article DOI: 10.1124/dmd.111.040758
BindingDB Entry DOI: 10.7270/Q20Z7500
More data for this
Ligand-Target Pair
Bile salt export pump (BSEP)


(Homo sapiens (Human))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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n/an/a 9.20E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human BSEP expressed in plasma membrane vesicles of Sf21 cells assessed as inhibition of ATP-dependent [3H]taurocholate uptake


Drug Metab Dispos 40: 130-8 (2011)


Article DOI: 10.1124/dmd.111.040758
BindingDB Entry DOI: 10.7270/Q20Z7500
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM22041
PNG
(2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridi...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccc(Cl)cn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3
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n/an/a 7n/an/an/an/an/an/a



Università di Siena

Curated by ChEMBL


Assay Description
Binding affinity against peripheral benzodiazepine receptor( PBR).


J Med Chem 39: 4275-84 (1996)


Article DOI: 10.1021/jm960325j
BindingDB Entry DOI: 10.7270/Q22F7MHJ
More data for this
Ligand-Target Pair
Peripheral-Type Benzodiazepine Receptor


(Rattus norvegicus (rat))
BDBM50060114
PNG
(2-(2-Phenyl-imidazo[1,2-a]pyridin-3-yl)-N,N-diprop...)
Show SMILES CCCN(CCC)C(=O)Cc1c(nc2ccccn12)-c1ccccc1
Show InChI InChI=1S/C21H25N3O/c1-3-13-23(14-4-2)20(25)16-18-21(17-10-6-5-7-11-17)22-19-12-8-9-15-24(18)19/h5-12,15H,3-4,13-14,16H2,1-2H3
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n/an/a 95.5n/an/an/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]-PK 11195 from peripheral-type benzodiazepine receptor of rat ovary membranes


J Med Chem 42: 3934-41 (1999)


Article DOI: 10.1021/jm991035g
BindingDB Entry DOI: 10.7270/Q2JM2BTF
More data for this
Ligand-Target Pair