BindingDB logo
myBDB logout

13 similar compounds to monomer 22302

Compile data set for download or QSAR
Wt: 500.6
BDBM22303
Wt: 506.6
BDBM22304
Wt: 500.6
BDBM22307
Wt: 430.5
BDBM22308
Wt: 495.3
BDBM22309
Wt: 493.5
BDBM22310
Wt: 535.6
BDBM22311
Wt: 565.6
BDBM22312
Wt: 515.6
BDBM22313
Wt: 541.6
BDBM22314
Wt: 474.5
BDBM22315
Wt: 517.5
BDBM22316
Wt: 544.6
BDBM22317

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 22303,22304,22307,22308,22309,22310,22311,22312,22313,22314,22315,22316,22317   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22303
PNG
(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C30H32N2O3S/c1-2-3-4-10-22-16-18-24(19-17-22)36(33,34)31-20-9-13-26-25-12-6-7-14-27(25)32-30(26)29-21-23-11-5-8-15-28(23)35-29/h5-8,11-12,14-19,21,31-32H,2-4,9-10,13,20H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22304
PNG
(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Show SMILES O=S(=O)(NCCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H26N2O3S/c34-37(35,25-18-16-23(17-19-25)22-9-2-1-3-10-22)32-20-8-13-27-26-12-5-6-14-28(26)33-31(27)30-21-24-11-4-7-15-29(24)36-30/h1-7,9-12,14-19,21,32-33H,8,13,20H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22307
PNG
(N-methyl indole sulfonamide, 39 | N-{2-[2-(1-benzo...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c(-c2cc3ccccc3o2)n(C)c2ccccc12
Show InChI InChI=1S/C30H32N2O3S/c1-3-4-5-10-22-15-17-24(18-16-22)36(33,34)31-20-19-26-25-12-7-8-13-27(25)32(2)30(26)29-21-23-11-6-9-14-28(23)35-29/h6-9,11-18,21,31H,3-5,10,19-20H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 143n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22308
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C25H22N2O3S/c1-17-10-12-19(13-11-17)31(28,29)26-15-14-21-20-7-3-4-8-22(20)27-25(21)24-16-18-6-2-5-9-23(18)30-24/h2-13,16,26-27H,14-15H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22309
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES Brc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C24H19BrN2O3S/c25-17-9-11-18(12-10-17)31(28,29)26-14-13-20-19-6-2-3-7-21(19)27-24(20)23-15-16-5-1-4-8-22(16)30-23/h1-12,15,26-27H,13-14H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22310
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES O=S(=O)(NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C29H23N3O3S/c33-36(34,23-11-9-20(10-12-23)21-13-16-30-17-14-21)31-18-15-25-24-6-2-3-7-26(24)32-29(25)28-19-22-5-1-4-8-27(22)35-28/h1-14,16-17,19,31-32H,15,18H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 47n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22317
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES CN(C)CCN(C)C(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C30H32N4O4S/c1-33(2)18-19-34(3)30(35)21-12-14-23(15-13-21)39(36,37)31-17-16-25-24-9-5-6-10-26(24)32-29(25)28-20-22-8-4-7-11-27(22)38-28/h4-15,20,31-32H,16-19H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 76n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22312
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)S(=O)(=O)NCCc2c([nH]c3ccccc23)-c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C32H27N3O5S/c1-39-24-14-12-23(13-15-24)34-32(36)21-10-16-25(17-11-21)41(37,38)33-19-18-27-26-7-3-4-8-28(26)35-31(27)30-20-22-6-2-5-9-29(22)40-30/h2-17,20,33,35H,18-19H2,1H3,(H,34,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22313
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES CCCCNC(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C29H29N3O4S/c1-2-3-17-30-29(33)20-12-14-22(15-13-20)37(34,35)31-18-16-24-23-9-5-6-10-25(23)32-28(24)27-19-21-8-4-7-11-26(21)36-27/h4-15,19,31-32H,2-3,16-18H2,1H3,(H,30,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22314
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES O=C(NC1CCCCC1)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C31H31N3O4S/c35-31(33-23-9-2-1-3-10-23)21-14-16-24(17-15-21)39(36,37)32-19-18-26-25-11-5-6-12-27(25)34-30(26)29-20-22-8-4-7-13-28(22)38-29/h4-8,11-17,20,23,32,34H,1-3,9-10,18-19H2,(H,33,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22315
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES NNC(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C25H22N4O4S/c26-29-25(30)16-9-11-18(12-10-16)34(31,32)27-14-13-20-19-6-2-3-7-21(19)28-24(20)23-15-17-5-1-4-8-22(17)33-23/h1-12,15,27-28H,13-14,26H2,(H,29,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 89n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22316
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES CN(CCO)C(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C28H27N3O5S/c1-31(16-17-32)28(33)19-10-12-21(13-11-19)37(34,35)29-15-14-23-22-7-3-4-8-24(22)30-27(23)26-18-20-6-2-5-9-25(20)36-26/h2-13,18,29-30,32H,14-17H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22311
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES O=C(Nc1ccccc1)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C31H25N3O4S/c35-31(33-23-9-2-1-3-10-23)21-14-16-24(17-15-21)39(36,37)32-19-18-26-25-11-5-6-12-27(25)34-30(26)29-20-22-8-4-7-13-28(22)38-29/h1-17,20,32,34H,18-19H2,(H,33,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 15n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair