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5 similar compounds to monomer 50000109

Compile data set for download or QSAR
Wt: 105.0
BDBM23167
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Wt: 103.1
BDBM36629
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Wt: 88.0
BDBM92998
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Wt: 89.0
BDBM50000099
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Wt: 105.0
BDBM50357212
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 23167,36629,92998,50000099,50357212   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gamma-glutamyltranspeptidase 1


(Rattus norvegicus)
BDBM50357212
PNG
((L)-SERINE | Serine)
Show SMILES N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
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5.00E+4n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Rattus norvegicus Wistar (rat) rat Gamma-glutamyltranspeptidase using L-gamma-glutamyl-p-nitroanilide as substrate incubated for 15 min...


Citation and Details
More data for this
Ligand-Target Pair
Ethylene-forming enzyme (EFE)


(Malus domestica (Apple) (Pyrus malus))
BDBM36629
PNG
(Aminoisobutyric (AIB))
Show SMILES CC(C)([NH3+])C([O-])=O
Show InChI InChI=1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7)
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1.50E+5n/an/an/an/an/an/an/an/a



Duke University



Assay Description
Enzyme inhibition assay using ethylene-forming enzyme (EFE).


Chem Biol 5: 49-57 (1998)


Article DOI: 10.1124/jpet.103.064907
BindingDB Entry DOI: 10.7270/Q24J0CG6
More data for this
Ligand-Target Pair
Uncharacterized protein


(Loa loa)
BDBM50357212
PNG
((L)-SERINE | Serine)
Show SMILES N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
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4.00E+5n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of Setaria cervi Gamma-glutamyltranspeptidase using L-gamma-glutamyl-p-nitroanilide as substrate incubated for 15 min prior to substrate a...


Citation and Details
More data for this
Ligand-Target Pair
Proton-coupled amino acid transporter 1


(Homo sapiens (Human))
BDBM50000099
PNG
((2S)-2-aminopropanoic acid | (S)-2-aminopropanoic ...)
Show SMILES C[C@H](N)C(O)=O
Show InChI InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
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Article
PubMed
2.80E+6n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting


Bioorg Med Chem 19: 6409-18 (2011)

Checked by Author
Article DOI: 10.1016/j.bmc.2011.08.058
BindingDB Entry DOI: 10.7270/Q2NZ882D
More data for this
Ligand-Target Pair
Proton-coupled amino acid transporter 1


(Homo sapiens (Human))
BDBM23167
PNG
((2R)-2-amino-3-hydroxypropanoic acid | CHEMBL28512...)
Show SMILES N[C@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
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2.20E+7n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting


Bioorg Med Chem 19: 6409-18 (2011)

Checked by Author
Article DOI: 10.1016/j.bmc.2011.08.058
BindingDB Entry DOI: 10.7270/Q2NZ882D
More data for this
Ligand-Target Pair
Proton-coupled amino acid transporter 1


(Homo sapiens (Human))
BDBM36629
PNG
(Aminoisobutyric (AIB))
Show SMILES CC(C)([NH3+])C([O-])=O
Show InChI InChI=1S/C4H9NO2/c1-4(2,5)3(6)7/h5H2,1-2H3,(H,6,7)
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2.30E+7n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting


Bioorg Med Chem 19: 6409-18 (2011)

Checked by Author
Article DOI: 10.1016/j.bmc.2011.08.058
BindingDB Entry DOI: 10.7270/Q2NZ882D
More data for this
Ligand-Target Pair
Proton-coupled amino acid transporter 1


(Homo sapiens (Human))
BDBM50357212
PNG
((L)-SERINE | Serine)
Show SMILES N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
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PubMed
3.50E+7n/an/an/an/an/an/an/an/a



Martin-Luther-University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting


Bioorg Med Chem 19: 6409-18 (2011)

Checked by Author
Article DOI: 10.1016/j.bmc.2011.08.058
BindingDB Entry DOI: 10.7270/Q2NZ882D
More data for this
Ligand-Target Pair
Aspartokinase I


(Escherichia coli)
BDBM92998
PNG
(L-alanine)
Show SMILES C[C@H](N)C([O-])=O
Show InChI InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/p-1/t2-/m0/s1
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Article
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9.90E+7n/an/an/an/an/an/an/an/a



University of Akron



Assay Description
Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...


Biochemistry 31: 799-805 (1992)


Article DOI: 10.1021/bi00118a023
BindingDB Entry DOI: 10.7270/Q2GX4966
More data for this
Ligand-Target Pair
Butyrylcholinesterase (BuChE)


(Equus caballus (Horse))
BDBM50357212
PNG
((L)-SERINE | Serine)
Show SMILES N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Martin-Luther-Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of equine serum butyrylcholinesterase using butyrylthiocholineidioide as substrate preincubated for 20 mins followed by substrate addition...


Bioorg Med Chem Lett 25: 2654-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.086
BindingDB Entry DOI: 10.7270/Q2KW5HS8
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM23167
PNG
((2R)-2-amino-3-hydroxypropanoic acid | CHEMBL28512...)
Show SMILES N[C@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
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PubMed
n/an/a 670n/an/an/an/an/an/a



Institut de Recherches Servier

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound to inhibit [3H]-glycine binding to NMDA receptor


Bioorg Med Chem Lett 9: 1409-14 (1999)


Article DOI: 10.1016/s0960-894x(99)00194-8
BindingDB Entry DOI: 10.7270/Q2W0954Z
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50000099
PNG
((2S)-2-aminopropanoic acid | (S)-2-aminopropanoic ...)
Show SMILES C[C@H](N)C(O)=O
Show InChI InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
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n/an/a 1.98E+5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound required to inhibit [3H]-strychnine binding to N-methyl-D-aspartate glutamate receptor 1


J Med Chem 35: 233-41 (1992)


Article DOI: 10.1021/jm00080a006
BindingDB Entry DOI: 10.7270/Q26W9911
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50357212
PNG
((L)-SERINE | Serine)
Show SMILES N[C@@H](CO)C(O)=O
Show InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Martin-Luther-Universit£t Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrat...


Bioorg Med Chem Lett 25: 2654-6 (2015)


Article DOI: 10.1016/j.bmcl.2015.04.086
BindingDB Entry DOI: 10.7270/Q2KW5HS8
More data for this
Ligand-Target Pair