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20 similar compounds to monomer 24084

Compile data set for download or QSAR
Wt: 398.4
BDBM24085
Wt: 412.4
BDBM24086
Wt: 426.5
BDBM24087
Wt: 428.4
BDBM24088
Wt: 386.4
BDBM24089
Wt: 329.3
BDBM24053
Wt: 315.3
BDBM24067
Wt: 329.3
BDBM24068
Wt: 345.3
BDBM24069
Wt: 373.3
BDBM24070
Wt: 387.4
BDBM24071
Wt: 401.4
BDBM24072
Wt: 372.4
BDBM24073
Wt: 386.4
BDBM24074
Wt: 400.4
BDBM24075
Displayed 1 to 15 (of 20 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 24085,24086,24087,24088,24089,24053,24067,24068,24069,24070,24071,24072,24073,24074,24075   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24053
PNG
(3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-d...)
Show SMILES CN(C)C(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N3O/c1-22(2)18(24)23-17(12-6-4-3-5-7-12)11-16(21-23)14-10-13(19)8-9-15(14)20/h3-10,17H,11H2,1-2H3
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n/an/a 84n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 1775-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.030
BindingDB Entry DOI: 10.7270/Q27W69HG
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24053
PNG
(3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-d...)
Show SMILES CN(C)C(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N3O/c1-22(2)18(24)23-17(12-6-4-3-5-7-12)11-16(21-23)14-10-13(19)8-9-15(14)20/h3-10,17H,11H2,1-2H3
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n/an/a 84n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KSP


Bioorg Med Chem Lett 17: 722-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.083
BindingDB Entry DOI: 10.7270/Q2HT2Q4S
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24068
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8b | 3-(2,5-difluo...)
Show SMILES CNC(=O)N1N=C(CC1(C)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N3O/c1-18(12-6-4-3-5-7-12)11-16(22-23(18)17(24)21-2)14-10-13(19)8-9-15(14)20/h3-10H,11H2,1-2H3,(H,21,24)
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n/an/a 284n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24069
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8c | 3-(2,5-difluo...)
Show SMILES CNC(=O)N1N=C(CC1(CO)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N3O2/c1-21-17(25)23-18(11-24,12-5-3-2-4-6-12)10-16(22-23)14-9-13(19)7-8-15(14)20/h2-9,24H,10-11H2,1H3,(H,21,25)
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n/an/a 903n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24070
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8d | 3-(2,5-difluo...)
Show SMILES CCNC(=O)N1N=C(CC1(CCO)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N3O2/c1-2-23-19(27)25-20(10-11-26,14-6-4-3-5-7-14)13-18(24-25)16-12-15(21)8-9-17(16)22/h3-9,12,26H,2,10-11,13H2,1H3,(H,23,27)
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n/an/a 606n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24071
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8e | 3-(2,5-difluo...)
Show SMILES CCNC(=O)N1N=C(CC1(CCCO)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H23F2N3O2/c1-2-24-20(28)26-21(11-6-12-27,15-7-4-3-5-8-15)14-19(25-26)17-13-16(22)9-10-18(17)23/h3-5,7-10,13,27H,2,6,11-12,14H2,1H3,(H,24,28)
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n/an/a 745n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24072
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8f | 3-(2,5-difluo...)
Show SMILES CCNC(=O)N1N=C(CC1(CCCCO)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C22H25F2N3O2/c1-2-25-21(29)27-22(12-6-7-13-28,16-8-4-3-5-9-16)15-20(26-27)18-14-17(23)10-11-19(18)24/h3-5,8-11,14,28H,2,6-7,12-13,15H2,1H3,(H,25,29)
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n/an/a 697n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24073
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8g | 5-(2-aminoeth...)
Show SMILES CCNC(=O)N1N=C(CC1(CCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C20H22F2N4O/c1-2-24-19(27)26-20(10-11-23,14-6-4-3-5-7-14)13-18(25-26)16-12-15(21)8-9-17(16)22/h3-9,12H,2,10-11,13,23H2,1H3,(H,24,27)
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n/an/a 390n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24074
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8h | 5-(3-aminopro...)
Show SMILES CCNC(=O)N1N=C(CC1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-2-25-20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(26-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,2,6,11-12,14,24H2,1H3,(H,25,28)
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n/an/a 44n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24075
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8i | 5-(4-aminobut...)
Show SMILES CCNC(=O)N1N=C(CC1(CCCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C22H26F2N4O/c1-2-26-21(29)28-22(12-6-7-13-25,16-8-4-3-5-9-16)15-20(27-28)18-14-17(23)10-11-19(18)24/h3-5,8-11,14H,2,6-7,12-13,15,25H2,1H3,(H,26,29)
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n/an/a 67n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24085
PNG
(3,5-diaryl-4,5-dihydropyrazole, 10b | 3-[1-(azetid...)
Show SMILES NCCCC1(CC(=NN1C(=O)N1CCC1)c1cc(F)ccc1F)c1ccccc1
Show InChI InChI=1S/C22H24F2N4O/c23-17-8-9-19(24)18(14-17)20-15-22(10-4-11-25,16-6-2-1-3-7-16)28(26-20)21(29)27-12-5-13-27/h1-3,6-9,14H,4-5,10-13,15,25H2
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n/an/a 55n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24086
PNG
(3,5-diaryl-4,5-dihydropyrazole, 10c | 3-[3-(2,5-di...)
Show SMILES NCCCC1(CC(=NN1C(=O)N1CCCC1)c1cc(F)ccc1F)c1ccccc1
Show InChI InChI=1S/C23H26F2N4O/c24-18-9-10-20(25)19(15-18)21-16-23(11-6-12-26,17-7-2-1-3-8-17)29(27-21)22(30)28-13-4-5-14-28/h1-3,7-10,15H,4-6,11-14,16,26H2
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n/an/a 26n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24087
PNG
(3,5-diaryl-4,5-dihydropyrazole, 10d | 3-[3-(2,5-di...)
Show SMILES NCCCC1(CC(=NN1C(=O)N1CCCCC1)c1cc(F)ccc1F)c1ccccc1
Show InChI InChI=1S/C24H28F2N4O/c25-19-10-11-21(26)20(16-19)22-17-24(12-7-13-27,18-8-3-1-4-9-18)30(28-22)23(31)29-14-5-2-6-15-29/h1,3-4,8-11,16H,2,5-7,12-15,17,27H2
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n/an/a 85n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24088
PNG
(3,5-diaryl-4,5-dihydropyrazole, 10e | 3-[3-(2,5-di...)
Show SMILES NCCCC1(CC(=NN1C(=O)N1CCOCC1)c1cc(F)ccc1F)c1ccccc1
Show InChI InChI=1S/C23H26F2N4O2/c24-18-7-8-20(25)19(15-18)21-16-23(9-4-10-26,17-5-2-1-3-6-17)29(27-21)22(30)28-11-13-31-14-12-28/h1-3,5-8,15H,4,9-14,16,26H2
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n/an/a 122n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24089
PNG
((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Show SMILES CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-26(2)20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(25-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,6,11-12,14,24H2,1-2H3/t21-/m0/s1
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n/an/a 1.90n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM24089
PNG
((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Show SMILES CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-26(2)20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(25-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,6,11-12,14,24H2,1-2H3/t21-/m0/s1
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n/an/a 19.3n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The hERG IC50 values were determined by radioligand competition experiments using membrane preparations from human embryonic kidney cells that stably...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24067
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8a | 3-(2,5-difluo...)
Show SMILES CNC(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F2N3O/c1-20-17(23)22-16(11-5-3-2-4-6-11)10-15(21-22)13-9-12(18)7-8-14(13)19/h2-9,16H,10H2,1H3,(H,20,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...


Bioorg Med Chem Lett 15: 2041-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.055
BindingDB Entry DOI: 10.7270/Q2ST7PCW
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24053
PNG
(3-(2,5-difluorophenyl)-N,N-dimethyl-5-phenyl-4,5-d...)
Show SMILES CN(C)C(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C18H17F2N3O/c1-22(2)18(24)23-17(12-6-4-3-5-7-12)11-16(21-23)14-10-13(19)8-9-15(14)20/h3-10,17H,11H2,1-2H3
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n/an/a 84n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory concentration towards kinesin spindle protein activity of ATP hydrolysis in the presence of microtubules measured by ATPase assay...


Bioorg Med Chem Lett 15: 2041-5 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.055
BindingDB Entry DOI: 10.7270/Q2ST7PCW
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM24089
PNG
((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Show SMILES CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-26(2)20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(25-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,6,11-12,14,24H2,1-2H3/t21-/m0/s1
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n/an/a 1.93E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of hERG expressed in CHO cells by cell voltage clamp assay


Bioorg Med Chem Lett 17: 2697-702 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.006
BindingDB Entry DOI: 10.7270/Q26Q1WXZ
More data for this
Ligand-Target Pair
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24089
PNG
((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Show SMILES CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-26(2)20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(25-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,6,11-12,14,24H2,1-2H3/t21-/m0/s1
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n/an/a 1.90n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KSP


Bioorg Med Chem Lett 17: 2697-702 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.006
BindingDB Entry DOI: 10.7270/Q26Q1WXZ
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24089
PNG
((5S)-5-(3-aminopropyl)-3-(2,5-difluorophenyl)-N,N-...)
Show SMILES CN(C)C(=O)N1N=C(C[C@@]1(CCCN)c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N4O/c1-26(2)20(28)27-21(11-6-12-24,15-7-4-3-5-8-15)14-19(25-27)17-13-16(22)9-10-18(17)23/h3-5,7-10,13H,6,11-12,14,24H2,1-2H3/t21-/m0/s1
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n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of KSP by ATPase assay


Bioorg Med Chem Lett 17: 5390-5 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.046
BindingDB Entry DOI: 10.7270/Q2RX9BSM
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin-like protein 1


(Homo sapiens (Human))
BDBM24067
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8a | 3-(2,5-difluo...)
Show SMILES CNC(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F2N3O/c1-20-17(23)22-16(11-5-3-2-4-6-11)10-15(21-22)13-9-12(18)7-8-14(13)19/h2-9,16H,10H2,1H3,(H,20,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of KSP


Bioorg Med Chem Lett 17: 722-6 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.083
BindingDB Entry DOI: 10.7270/Q2HT2Q4S
More data for this
Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5)


(Homo sapiens (Human))
BDBM24067
PNG
(3,5-diaryl-4,5-dihydropyrazole, 8a | 3-(2,5-difluo...)
Show SMILES CNC(=O)N1N=C(CC1c1ccccc1)c1cc(F)ccc1F
Show InChI InChI=1S/C17H15F2N3O/c1-20-17(23)22-16(11-5-3-2-4-6-11)10-15(21-22)13-9-12(18)7-8-14(13)19/h2-9,16H,10H2,1H3,(H,20,23)
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n/an/a 3.14E+3n/an/an/an/a7.023



Merck Research Laboratories



Assay Description
The kinesin motor domain is incubated with microtubules, 1 mM ATP (1: 1 MgCl2 : Na-ATP), and compound at 23°C in buffer. After reaction was term...


Bioorg Med Chem Lett 16: 3175-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.040
BindingDB Entry DOI: 10.7270/Q2445JTH
More data for this
Ligand-Target Pair