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3 similar compounds to monomer 24340

Wt: 291.3
BDBM24324
Wt: 309.2
BDBM24325
Wt: 291.3
BDBM24339

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24324,24325,24339   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24339
PNG
(4-{[(3-hydroxyphenyl)methyl](4H-1,2,4-triazol-4-yl...)
Show SMILES Oc1cccc(CN(c2ccc(cc2)C#N)n2cnnc2)c1
Show InChI InChI=1S/C16H13N5O/c17-9-13-4-6-15(7-5-13)21(20-11-18-19-12-20)10-14-2-1-3-16(22)8-14/h1-8,11-12,22H,10H2
PDB
MMDB

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Article
PubMed
n/an/a 2.80n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24325
PNG
(4-{[(3-fluoro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Show SMILES Oc1ccc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1F
Show InChI InChI=1S/C16H12FN5O/c17-15-7-13(3-6-16(15)23)9-22(21-10-19-20-11-21)14-4-1-12(8-18)2-5-14/h1-7,10-11,23H,9H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


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AffyNet 
Article
PubMed
n/an/a 2.90n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24324
PNG
(4-{[(4-hydroxyphenyl)methyl](4H-1,2,4-triazol-4-yl...)
Show SMILES Oc1ccc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1
Show InChI InChI=1S/C16H13N5O/c17-9-13-1-5-15(6-2-13)21(20-11-18-19-12-20)10-14-3-7-16(22)8-4-14/h1-8,11-12,22H,10H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

AffyNet 
Article
PubMed
n/an/a 23n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair