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4 similar compounds to monomer 24332

Wt: 325.7
BDBM24326
Wt: 321.3
BDBM24329
Wt: 360.1
BDBM24333
Wt: 321.3
BDBM24343

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 24326,24329,24333,24343   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24343
PNG
(4-{[(3-hydroxy-4-methoxyphenyl)methyl](4H-1,2,4-tr...)
Show SMILES COc1ccc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1O
Show InChI InChI=1S/C17H15N5O2/c1-24-17-7-4-14(8-16(17)23)10-22(21-11-19-20-12-21)15-5-2-13(9-18)3-6-15/h2-8,11-12,23H,10H2,1H3
PDB
MMDB

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Article
PubMed
n/an/a 1.20n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24333
PNG
(4-{[(3,5-dichloro-4-hydroxyphenyl)methyl](4H-1,2,4...)
Show SMILES Oc1c(Cl)cc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1Cl
Show InChI InChI=1S/C16H11Cl2N5O/c17-14-5-12(6-15(18)16(14)24)8-23(22-9-20-21-10-22)13-3-1-11(7-19)2-4-13/h1-6,9-10,24H,8H2
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Article
PubMed
n/an/a 7.60n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24326
PNG
(4-{[(3-chloro-4-hydroxyphenyl)methyl](4H-1,2,4-tri...)
Show SMILES Oc1ccc(CN(c2ccc(cc2)C#N)n2cnnc2)cc1Cl
Show InChI InChI=1S/C16H12ClN5O/c17-15-7-13(3-6-16(15)23)9-22(21-10-19-20-11-21)14-4-1-12(8-18)2-5-14/h1-7,10-11,23H,9H2
PDB
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Article
PubMed
n/an/a 2.5n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair
Aromatase (CYP19)


(Homo sapiens (human))
BDBM24329
PNG
(4-{[(4-hydroxy-3-methoxyphenyl)methyl](4H-1,2,4-tr...)
Show SMILES COc1cc(CN(c2ccc(cc2)C#N)n2cnnc2)ccc1O
Show InChI InChI=1S/C17H15N5O2/c1-24-17-8-14(4-7-16(17)23)10-22(21-11-19-20-12-21)15-5-2-13(9-18)3-6-15/h2-8,11-12,23H,10H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

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AffyNet 
Article
PubMed
n/an/a 2.80n/an/an/an/a7.537



University of Bath



Assay Description
The extent of in vitro inhibition of aromatase activities was assessed using intact monolayers of JEG-3 cells. Aromatase activity was measured using ...


J Med Chem 50: 3540-60 (2007)

More data for this
Ligand-Target Pair