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16 similar compounds to monomer 25084

Wt: 331.3
BDBM25091
Wt: 378.3
BDBM25094
Wt: 270.2
BDBM25095
Wt: 346.3
BDBM25097
Wt: 254.2
BDBM25098
Wt: 314.3
BDBM25101
Purchase
Wt: 374.3
BDBM25102
Wt: 494.4
BDBM25103
Wt: 544.6
BDBM25104
Wt: 618.5
BDBM25105
Wt: 363.3
BDBM25106
Wt: 331.3
BDBM25110
Wt: 270.2
BDBM25100
Wt: 255.2
BDBM25111
Wt: 254.2
BDBM25082
Purchase
Displayed 1 to 15 (of 16 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 25091,25094,25095,25097,25098,25101,25102,25103,25104,25105,25106,25110,25100,25111,25082   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 50n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
Dihydrofolate reductase (DHFR)


(Toxoplasma gondii)
BDBM25101
PNG
(6,7-diphenylpteridine-2,4-diamine | CHEMBL48296 | ...)
Show SMILES Nc1nc(N)c2nc(-c3ccccc3)c(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)
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n/an/a 240n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibitory activity against Dihydrohydrofolate reductase(DHFR) of Toxoplasma gondii


J Med Chem 46: 1726-36 (2003)


Article DOI: 10.1021/jm020466n
BindingDB Entry DOI: 10.7270/Q2CR5SRW
More data for this
Ligand-Target Pair
p110α/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 165n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
p110β/p85α


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 215n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25091
PNG
(3-[4-amino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol...)
Show SMILES Nc1ncnc2nc(-c3cccc(O)c3)c(nc12)-c1cccc(O)c1
Show InChI InChI=1S/C18H13N5O2/c19-17-16-18(21-9-20-17)23-15(11-4-2-6-13(25)8-11)14(22-16)10-3-1-5-12(24)7-10/h1-9,24-25H,(H2,19,20,21,23)
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n/an/a 4.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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n/an/a 39.9n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25094
PNG
(4-[2,4-diamino-7-(3,4-dihydroxyphenyl)pteridin-6-y...)
Show SMILES Nc1nc(N)c2nc(-c3ccc(O)c(O)c3)c(nc2n1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H14N6O4/c19-16-15-17(24-18(20)23-16)22-14(8-2-4-10(26)12(28)6-8)13(21-15)7-1-3-9(25)11(27)5-7/h1-6,25-28H,(H4,19,20,22,23,24)
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n/an/a 273n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25095
PNG
(4-(2,4-diaminopteridin-6-yl)benzene-1,2-diol | dia...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H10N6O2/c13-10-9-11(18-12(14)17-10)15-4-6(16-9)5-1-2-7(19)8(20)3-5/h1-4,19-20H,(H4,13,14,15,17,18)
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n/an/a 195n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25097
PNG
(4-[2,4-diamino-7-(4-hydroxyphenyl)pteridin-6-yl]ph...)
Show SMILES Nc1nc(N)c2nc(-c3ccc(O)cc3)c(nc2n1)-c1ccc(O)cc1
Show InChI InChI=1S/C18H14N6O2/c19-16-15-17(24-18(20)23-16)22-14(10-3-7-12(26)8-4-10)13(21-15)9-1-5-11(25)6-2-9/h1-8,25-26H,(H4,19,20,22,23,24)
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n/an/a 2.70E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25098
PNG
(3-(2,4-diaminopteridin-7-yl)phenol | diaminopterid...)
Show SMILES Nc1nc(N)c2ncc(nc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)16-8(5-15-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,16,17,18)
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n/an/a 3.00E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25100
PNG
(4-(2,4-diaminopteridin-7-yl)benzene-1,2-diol | dia...)
Show SMILES Nc1nc(N)c2ncc(nc2n1)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H10N6O2/c13-10-9-11(18-12(14)17-10)16-6(4-15-9)5-1-2-7(19)8(20)3-5/h1-4,19-20H,(H4,13,14,16,17,18)
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n/an/a 5.90E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25101
PNG
(6,7-diphenylpteridine-2,4-diamine | CHEMBL48296 | ...)
Show SMILES Nc1nc(N)c2nc(-c3ccccc3)c(nc2n1)-c1ccccc1
Show InChI InChI=1S/C18H14N6/c19-16-15-17(24-18(20)23-16)22-14(12-9-5-2-6-10-12)13(21-15)11-7-3-1-4-8-11/h1-10H,(H4,19,20,22,23,24)
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n/an/a 8.50E+3n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25102
PNG
(6,7-bis(3-methoxyphenyl)pteridine-2,4-diamine | di...)
Show SMILES COc1cccc(c1)-c1nc2nc(N)nc(N)c2nc1-c1cccc(OC)c1
Show InChI InChI=1S/C20H18N6O2/c1-27-13-7-3-5-11(9-13)15-16(12-6-4-8-14(10-12)28-2)24-19-17(23-15)18(21)25-20(22)26-19/h3-10H,1-2H3,(H4,21,22,24,25,26)
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n/an/a 1.26E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25103
PNG
(3-(3-{2,4-diamino-6-[3-(2,3-dihydroxypropoxy)pheny...)
Show SMILES Nc1nc(N)c2nc(-c3cccc(OCC(O)CO)c3)c(nc2n1)-c1cccc(OCC(O)CO)c1
Show InChI InChI=1S/C24H26N6O6/c25-22-21-23(30-24(26)29-22)28-20(14-4-2-6-18(8-14)36-12-16(34)10-32)19(27-21)13-3-1-5-17(7-13)35-11-15(33)9-31/h1-8,15-16,31-34H,9-12H2,(H4,25,26,28,29,30)
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n/an/a 3.27E+4n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25104
PNG
(6,7-bis({3-[2-(diethylamino)ethoxy]phenyl})pteridi...)
Show SMILES CCN(CC)CCOc1cccc(c1)-c1nc2nc(N)nc(N)c2nc1-c1cccc(OCCN(CC)CC)c1
Show InChI InChI=1S/C30H40N8O2/c1-5-37(6-2)15-17-39-23-13-9-11-21(19-23)25-26(34-29-27(33-25)28(31)35-30(32)36-29)22-12-10-14-24(20-22)40-18-16-38(7-3)8-4/h9-14,19-20H,5-8,15-18H2,1-4H3,(H4,31,32,34,35,36)
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n/an/an/an/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25105
PNG
([3-(2,4-diamino-6-{3-[(diethoxyphosphoryl)oxy]phen...)
Show SMILES CCOP(=O)(OCC)Oc1cccc(c1)-c1nc2nc(N)nc(N)c2nc1-c1cccc(OP(=O)(OCC)OCC)c1
Show InChI InChI=1S/C26H32N6O8P2/c1-5-35-41(33,36-6-2)39-19-13-9-11-17(15-19)21-22(30-25-23(29-21)24(27)31-26(28)32-25)18-12-10-14-20(16-18)40-42(34,37-7-3)38-8-4/h9-16H,5-8H2,1-4H3,(H4,27,28,30,31,32)
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n/an/an/an/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25106
PNG
(4-[4-amino-6-(3,4-dihydroxyphenyl)pteridin-7-yl]be...)
Show SMILES Nc1ncnc2nc(-c3ccc(O)c(O)c3)c(nc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C18H13N5O4/c19-17-16-18(21-7-20-17)23-15(9-2-4-11(25)13(27)6-9)14(22-16)8-1-3-10(24)12(26)5-8/h1-7,24-27H,(H2,19,20,21,23)
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n/an/a 968n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25110
PNG
(4-[4-amino-6-(4-hydroxyphenyl)pteridin-7-yl]phenol...)
Show SMILES Nc1ncnc2nc(-c3ccc(O)cc3)c(nc12)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N5O2/c19-17-16-18(21-9-20-17)23-15(11-3-7-13(25)8-4-11)14(22-16)10-1-5-12(24)6-2-10/h1-9,24-25H,(H2,19,20,21,23)
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n/an/a 4.00E+3n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (human))
BDBM25111
PNG
(4-(4-aminopteridin-7-yl)benzene-1,2-diol | aminopt...)
Show SMILES Nc1ncnc2nc(cnc12)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C12H9N5O2/c13-11-10-12(16-5-15-11)17-7(4-14-10)6-1-2-8(18)9(19)3-6/h1-5,18-19H,(H2,13,15,16,17)
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PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


J Med Chem 50: 4279-94 (2007)


Article DOI: 10.1021/jm051056c
BindingDB Entry DOI: 10.7270/Q2D798QW
More data for this
Ligand-Target Pair
Phosphoinositide 3-Kinase (PI3K), delta


(Homo sapiens (human)-Homo sapiens (Human))
BDBM25082
PNG
(3-(2,4-diamino-pteridin-6-yl)-phenol | 3-(2,4-diam...)
Show SMILES Nc1nc(N)c2nc(cnc2n1)-c1cccc(O)c1
Show InChI InChI=1S/C12H10N6O/c13-10-9-11(18-12(14)17-10)15-5-8(16-9)6-2-1-3-7(19)4-6/h1-5,19H,(H4,13,14,15,17,18)
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PubMed
n/an/a 24n/an/an/an/a7.422



TargeGen Inc.



Assay Description
The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...


Proc Natl Acad Sci U S A 103: 19866-71 (2006)


Article DOI: 10.1073/pnas.0606956103
BindingDB Entry DOI: 10.7270/Q2J101GM
More data for this
Ligand-Target Pair