Compounds in cluster

6 similar compounds to monomer 17657

Wt: 147.1 BDBM26431 Purchase	Wt: 160.1 BDBM92992 Purchase	Wt: 146.1 BDBM93012 Purchase	Wt: 161.1 BDBM93013 Purchase	Wt: 147.1 BDBM50002371 Purchase
Wt: 145.1 BDBM50013055 Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 73 hits for monomerid = 26431,92992,93012,93013,50002371,50013055
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Metabotropic glutamate receptor (RAT)	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development, Beerse Curated by PDSP K_i Database									Mol Pharmacol 63: 1082-93 (2003) Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62
					More data for this Ligand-Target Pair
GRIK4 (Homo sapiens (Human))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	18.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Allelix Biopharmaceuticals, Inc. Curated by PDSP K_i Database									J Neurochem 62: 1-9 (1994) Article DOI: 10.1016/j.bioorg.2015.05.009 BindingDB Entry DOI: 10.7270/Q2RJ4H0P
					More data for this Ligand-Target Pair
Glutamate kainate (RABBIT)	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	31.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by PDSP K_i Database									Neuropharmacology 36: 1483-8 (1997) Article DOI: 10.1016/s0028-3908(97)00161-5 BindingDB Entry DOI: 10.7270/Q2C827T6
University of Bristol Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Neurochem 71: 2558-64 (1998) Article DOI: 10.1046/j.1471-4159.1998.71062558.x BindingDB Entry DOI: 10.7270/Q25D8QCZ
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by PDSP K_i Database									J Pharmacol Exp Ther 298: 453-60 (2001) Article DOI: 10.1016/j.bioorg.2016.02.004 BindingDB Entry DOI: 10.7270/Q2V986M2
Eli Lilly and Company Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GRIA3 (RAT)	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	118	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Institute for Bioorganic Research Curated by PDSP K_i Database									Mol Pharmacol 53: 195-201 (1998) Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 1 (RAT)	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	118	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Institute for Bioorganic Research Curated by PDSP K_i Database									Mol Pharmacol 53: 195-201 (1998) Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	131	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Suntory Institute for Bioorganic Research Curated by PDSP K_i Database									Mol Pharmacol 53: 195-201 (1998) Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Neurochem 75: 2590-601 (2000) Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 1				J Med Chem 45: 3171-83 (2002) Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Neurochem 75: 2590-601 (2000) Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	701	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Grik5 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	750	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated.				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate-Kainate 7 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	789	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic AMPA (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	868	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	940	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.11E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Binding affinity against human GluR6				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 2				J Med Chem 45: 3171-83 (2002) Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
GRIA1 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.36E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGluR4) (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Parc Club Orsay Universit£ Curated by ChEMBL					Assay Description Binding affinity at Metabotropic glutamate receptor 4				J Med Chem 45: 3171-83 (2002) Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18
Parc Club Orsay Universit£ Curated by ChEMBL					More data for this Ligand-Target Pair
Ionotropic glutamate receptor kainate 2/5 (Rattus norvegicus)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Displacement of [3H]kainate from rat GLUK6 expressed in HEK293 cells				J Med Chem 49: 2579-92 (2006) Article DOI: 10.1021/jm051086f BindingDB Entry DOI: 10.7270/Q2FQ9W76
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Ionotropic glutamate receptor kainate 2/5 (Rattus norvegicus)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.28E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Walk Curated by ChEMBL					Assay Description Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells				J Med Chem 48: 7867-81 (2005) Article DOI: 10.1021/jm050584l BindingDB Entry DOI: 10.7270/Q2V69KCT
University Walk Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Glutamate racemase (Helicobacter pylori)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Global Structural Chemistry Curated by ChEMBL					Assay Description Inhibition of Helicobacter pylori glutamate racemase				Nature 447: 817-822 (2007) Article DOI: 10.1038/nature05689 BindingDB Entry DOI: 10.7270/Q2HX1DJ3
AstraZeneca Global Structural Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
Ciba-Geigy Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ciba-Geigy Corporation Curated by PDSP K_i Database									Br J Pharmacol 95: 932-8 (1988) Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF
Ciba-Geigy Corporation Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 1 (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by PDSP K_i Database									Biochemistry 24: 2401-5 (1985) Article DOI: 10.1021/bi00331a002 BindingDB Entry DOI: 10.7270/Q2W094FK
University of Minnesota Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database									J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M
F. Hoffmann-La Roche Inc Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8) (Rattus norvegicus (Rat))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Toronto Curated by PDSP K_i Database									Neuropharmacology 40: 170-7 (2001) Article DOI: 10.1111/cbdd.12666 BindingDB Entry DOI: 10.7270/Q27P8WZ1
University of Toronto Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM50002371 (2-aminopentanedioic acidglutamic acid \| CHEMBL2763...) Show SMILES NC(CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson and Johnson Pharmaceutical Research and Development, Beerse Curated by PDSP K_i Database									Mol Pharmacol 63: 1082-93 (2003) Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62
					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Serotonin (5-HT) receptor (Rattus norvegicus (rat))	BDBM50013055 (2-aminopentanedioateglutamate \| L-Glutamate \| glut...) Show SMILES NC(CCC([O-])=O)C([O-])=O Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by PDSP K_i Database									Life Sci 19: 69-76 (1976) Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK
TBA Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Glutamate racemase (Lactobacillus fermentum)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	5.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r...				Bioorg Med Chem Lett 7: 2265-2270 (1997) Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate racemase (Lactobacillus fermentum)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition towards glutamate racemase was determined and expressed as KI				Bioorg Med Chem Lett 7: 2265-2270 (1997) Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Aspartokinase I (Escherichia coli)	BDBM92992 (L-glutamate gamma-methyl ester) Show SMILES COC(=O)CC[C@H](N)C([O-])=O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar	Purchase CHEBI PC cid PC sid UniChem Similars	Article PubMed	2.40E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Akron					Assay Description Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi...				Biochemistry 31: 799-805 (1992) Article DOI: 10.1021/bi00118a023 BindingDB Entry DOI: 10.7270/Q2GX4966
University of Akron					More data for this Ligand-Target Pair
Carbamoyl-phosphate synthase (H353N) (Escherichia coli (strain K12))	BDBM93013 (Glutamine Analogue, 5) Show SMILES COC(=O)CCC([NH3+])C([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI PC cid PC sid UniChem Similars	Article PubMed	2.50E+7	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Texas A&M University					Assay Description The rate of carbamoyl phosphate synthesis was determined by use of a coupled enzyme assay with ornithine transcarbamoylase.				Biochemistry 30: 7901-7 (1991) Article DOI: 10.1021/bi00246a005 BindingDB Entry DOI: 10.7270/Q27D2SR2
Texas A&M University					More data for this Ligand-Target Pair
Carbamoyl-phosphate synthase (H353N) (Escherichia coli (strain K12))	BDBM93012 (Glutamine Analogue, 4) Show SMILES [NH3+]C(CCC([O-])=O)C([O-])=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI KEGG PC cid PC sid UniChem Similars	Article PubMed	2.80E+7	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Texas A&M University					Assay Description The rate of carbamoyl phosphate synthesis was determined by use of a coupled enzyme assay with ornithine transcarbamoylase.				Biochemistry 30: 7901-7 (1991) Article DOI: 10.1021/bi00246a005 BindingDB Entry DOI: 10.7270/Q27D2SR2
Texas A&M University					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (mGlu7) (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
Univ. Rouen Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (mGlu8) (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.15E+4	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
Univ. Rouen Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.32E+4	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
Univ. Rouen Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a
Univ. Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGluR5 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay				Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C
Univ. Rouen Curated by ChEMBL					More data for this Ligand-Target Pair
GRIK1 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Effective concentration against GluR5 expressed in HEK293 cells				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, kainate 2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Effective concentration against human GluR6 expressed in HEK293 cells				J Med Chem 43: 1958-68 (2000) Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (RAT)	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a
The Royal Danish School of Pharmacy Curated by ChEMBL					Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5				J Med Chem 45: 4240-5 (2002) Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W
The Royal Danish School of Pharmacy Curated by ChEMBL					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (mGlu4) (Rattus norvegicus (Rat))	BDBM26431 ((2R)-2-aminopentanedioic acid \| CHEMBL76232 \| D-Gl...) Show SMILES N[C@H](CCC(O)=O)C(O)=O Show InChI	Reactome pathway UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.88E+3	n/a	n/a	n/a	n/a
INSA de Rouen and Universit£ de Rouen Curated by ChEMBL					Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured e...				Bioorg Med Chem 20: 4716-26 (2012) Article DOI: 10.1016/j.bmc.2012.06.006 BindingDB Entry DOI: 10.7270/Q2BG2Q2W
INSA de Rouen and Universit£ de Rouen Curated by ChEMBL					More data for this Ligand-Target Pair

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