Found 73 hits for monomerid = 26431,92992,93012,93013,50002371,50013055 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Metabotropic glutamate receptor
(RAT) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB
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| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development, Beerse
Curated by PDSP Ki Database
| |
Mol Pharmacol 63: 1082-93 (2003)
Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62 |
More data for this Ligand-Target Pair | |
GRIK4
(Homo sapiens (Human)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 18.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Allelix Biopharmaceuticals, Inc.
Curated by PDSP Ki Database
| |
J Neurochem 62: 1-9 (1994)
Article DOI: 10.1016/j.bioorg.2015.05.009 BindingDB Entry DOI: 10.7270/Q2RJ4H0P |
More data for this Ligand-Target Pair | |
Glutamate kainate
(RABBIT) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 31.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bristol
Curated by PDSP Ki Database
| |
Neuropharmacology 36: 1483-8 (1997)
Article DOI: 10.1016/s0028-3908(97)00161-5 BindingDB Entry DOI: 10.7270/Q2C827T6 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Neurochem 71: 2558-64 (1998)
Article DOI: 10.1046/j.1471-4159.1998.71062558.x BindingDB Entry DOI: 10.7270/Q25D8QCZ |
More data for this Ligand-Target Pair | |
GRIA3
(RAT) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 298: 453-60 (2001)
Article DOI: 10.1016/j.bioorg.2016.02.004 BindingDB Entry DOI: 10.7270/Q2V986M2 |
More data for this Ligand-Target Pair | |
GRIA3
(RAT) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 118 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Bioorganic Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 53: 195-201 (1998)
Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 1
(RAT) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 118 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Bioorganic Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 53: 195-201 (1998)
Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 131 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Suntory Institute for Bioorganic Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 53: 195-201 (1998)
Article DOI: 10.1124/mol.53.2.195 BindingDB Entry DOI: 10.7270/Q2RF5SJH |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 1
(Homo sapiens (Human)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Neurochem 75: 2590-601 (2000)
Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 1 |
J Med Chem 45: 3171-83 (2002)
Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB MMDB
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| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Neurochem 75: 2590-601 (2000)
Article DOI: 10.1046/j.1471-4159.2000.0752590.x BindingDB Entry DOI: 10.7270/Q2J67FGZ |
More data for this Ligand-Target Pair | |
GRIK1
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 701 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Binding affinity against human ionotropic glutamate receptor kainate 1 in HK293 cells using [3H]-kainate as radioligand |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Grik5
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 750 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Ability of the compound to bind to Ionotropic glutamate receptor kainate (kainate 2) was evaluated. |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate-Kainate 7
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 789 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Ability of the compound to bind to Ionotropic glutamate receptor ionotropic kainate 3 was evaluated |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic AMPA
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 868 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 4 in HEK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
GRIA2
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 2 in HK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Binding affinity against human GluR6 |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 2 |
J Med Chem 45: 3171-83 (2002)
Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
GRIA1
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Compound was tested for binding affinity against human Ionotropic glutamate receptor AMPA 1 in HEK293 cells using [3H]-AMPA as radioligand |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGluR4)
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Parc Club Orsay Universit£
Curated by ChEMBL
| Assay Description Binding affinity at Metabotropic glutamate receptor 4 |
J Med Chem 45: 3171-83 (2002)
Article DOI: 10.1021/jm010323l BindingDB Entry DOI: 10.7270/Q2B27W18 |
More data for this Ligand-Target Pair | |
Ionotropic glutamate receptor kainate 2/5
(Rattus norvegicus) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from rat GLUK6 expressed in HEK293 cells |
J Med Chem 49: 2579-92 (2006)
Article DOI: 10.1021/jm051086f BindingDB Entry DOI: 10.7270/Q2FQ9W76 |
More data for this Ligand-Target Pair |  3D Structure (docked) |
Ionotropic glutamate receptor kainate 2/5
(Rattus norvegicus) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 3.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Walk
Curated by ChEMBL
| Assay Description Displacement of [3H]kainate from rat GLUK6 receptor expressed in HEK293 cells |
J Med Chem 48: 7867-81 (2005)
Article DOI: 10.1021/jm050584l BindingDB Entry DOI: 10.7270/Q2V69KCT |
More data for this Ligand-Target Pair |  3D Structure (docked) |
Glutamate racemase
(Helicobacter pylori) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca Global Structural Chemistry
Curated by ChEMBL
| Assay Description Inhibition of Helicobacter pylori glutamate racemase |
Nature 447: 817-822 (2007)
Article DOI: 10.1038/nature05689 BindingDB Entry DOI: 10.7270/Q2HX1DJ3 |
More data for this Ligand-Target Pair |  3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 8.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Corporation
Curated by PDSP Ki Database
| |
Br J Pharmacol 95: 932-8 (1988)
Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Corporation
Curated by PDSP Ki Database
| |
Br J Pharmacol 95: 932-8 (1988)
Article DOI: 10.1111/j.1476-5381.1988.tb11723.x BindingDB Entry DOI: 10.7270/Q2Z036NF |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 1
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Minnesota
Curated by PDSP Ki Database
| |
Biochemistry 24: 2401-5 (1985)
Article DOI: 10.1021/bi00331a002 BindingDB Entry DOI: 10.7270/Q2W094FK |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 315: 711-21 (2005)
Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 315: 711-21 (2005)
Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 315: 711-21 (2005)
Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 5
(Homo sapiens (Human)) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Inc
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 315: 711-21 (2005)
Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 8 (mGlu8)
(Rattus norvegicus (Rat)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by PDSP Ki Database
| |
Neuropharmacology 40: 170-7 (2001)
Article DOI: 10.1111/cbdd.12666 BindingDB Entry DOI: 10.7270/Q27P8WZ1 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM50002371
 (2-aminopentanedioic acidglutamic acid | CHEMBL2763...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson and Johnson Pharmaceutical Research and Development, Beerse
Curated by PDSP Ki Database
| |
Mol Pharmacol 63: 1082-93 (2003)
Article DOI: 10.1124/mol.63.5.1082 BindingDB Entry DOI: 10.7270/Q2BV7F62 |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Life Sci 19: 69-76 (1976)
Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Rattus norvegicus (rat)) | BDBM50013055
 (2-aminopentanedioateglutamate | L-Glutamate | glut...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-2 | Reactome pathway KEGG
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| Article PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Life Sci 19: 69-76 (1976)
Article DOI: 10.1016/0024-3205(76)90375-1 BindingDB Entry DOI: 10.7270/Q23B5XNK |
More data for this Ligand-Target Pair | |
Glutamate racemase
(Lactobacillus fermentum) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | KEGG
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| Article
| 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for in vitro functional inhibitory potency for prevention of sarafotoxin S6c induced constriction of rat tracheal rings (ETB r... |
Bioorg Med Chem Lett 7: 2265-2270 (1997)
Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX |
More data for this Ligand-Target Pair | |
Glutamate racemase
(Lactobacillus fermentum) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | KEGG
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| Article
| 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition towards glutamate racemase was determined and expressed as KI |
Bioorg Med Chem Lett 7: 2265-2270 (1997)
Article DOI: 10.1016/S0960-894X(97)00413-7 BindingDB Entry DOI: 10.7270/Q2N58MVX |
More data for this Ligand-Target Pair | |
Aspartokinase I
(Escherichia coli) | BDBM92992
 (L-glutamate gamma-methyl ester)Show InChI InChI=1S/C6H11NO4/c1-11-5(8)3-2-4(7)6(9)10/h4H,2-3,7H2,1H3,(H,9,10)/p-1/t4-/m0/s1 | PDB
KEGG
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Similars
| Article PubMed
| 2.40E+7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Akron
| Assay Description Analogues of L-aspartic acid and beta-aspartyl phosphate were examined as inhibitors in the aspartokinase I reaction by using the coupled reaction wi... |
Biochemistry 31: 799-805 (1992)
Article DOI: 10.1021/bi00118a023 BindingDB Entry DOI: 10.7270/Q2GX4966 |
More data for this Ligand-Target Pair | |
Carbamoyl-phosphate synthase (H353N)
(Escherichia coli (strain K12)) | BDBM93013
 (Glutamine Analogue, 5)Show InChI InChI=1S/C6H11NO4/c1-11-5(8)3-2-4(7)6(9)10/h4H,2-3,7H2,1H3,(H,9,10) | PDB MMDB
KEGG
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Similars
| Article PubMed
| 2.50E+7 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Texas A&M University
| Assay Description The rate of carbamoyl phosphate synthesis was determined by use of a coupled enzyme assay with ornithine transcarbamoylase. |
Biochemistry 30: 7901-7 (1991)
Article DOI: 10.1021/bi00246a005 BindingDB Entry DOI: 10.7270/Q27D2SR2 |
More data for this Ligand-Target Pair | |
Carbamoyl-phosphate synthase (H353N)
(Escherichia coli (strain K12)) | BDBM93012
 (Glutamine Analogue, 4)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/p-1 | PDB MMDB
KEGG
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Similars
| Article PubMed
| 2.80E+7 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Texas A&M University
| Assay Description The rate of carbamoyl phosphate synthesis was determined by use of a coupled enzyme assay with ornithine transcarbamoylase. |
Biochemistry 30: 7901-7 (1991)
Article DOI: 10.1021/bi00246a005 BindingDB Entry DOI: 10.7270/Q27D2SR2 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 7 (mGlu7)
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR7 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 8 (mGlu8)
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.15E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR8 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.32E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.37E+4 | n/a | n/a | n/a | n/a |
Univ. Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGluR5 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay |
Bioorg Med Chem Lett 25: 2523-6 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C |
More data for this Ligand-Target Pair | |
GRIK1
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Effective concentration against GluR5 expressed in HEK293 cells |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, kainate 2
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by ChEMBL
| Assay Description Effective concentration against human GluR6 expressed in HEK293 cells |
J Med Chem 43: 1958-68 (2000)
Article DOI: 10.1021/jm9911682 BindingDB Entry DOI: 10.7270/Q2FX78QB |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(RAT) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 1 |
J Med Chem 45: 4240-5 (2002)
Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGlu4)
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway
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| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 4 |
J Med Chem 45: 4240-5 (2002)
Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 2 |
J Med Chem 45: 4240-5 (2002)
Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a |
The Royal Danish School of Pharmacy
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibitory activity against cloned Metabotropic glutamate receptor 5 |
J Med Chem 45: 4240-5 (2002)
Article DOI: 10.1021/jm020122x BindingDB Entry DOI: 10.7270/Q28G8K2W |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 4 (mGlu4)
(Rattus norvegicus (Rat)) | BDBM26431
 ((2R)-2-aminopentanedioic acid | CHEMBL76232 | D-Gl...)Show InChI InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1 | Reactome pathway
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| Article PubMed
| n/a | n/a | n/a | n/a | 2.88E+3 | n/a | n/a | n/a | n/a |
INSA de Rouen and Universit£ de Rouen
Curated by ChEMBL
| Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured e... |
Bioorg Med Chem 20: 4716-26 (2012)
Article DOI: 10.1016/j.bmc.2012.06.006 BindingDB Entry DOI: 10.7270/Q2BG2Q2W |
More data for this Ligand-Target Pair | |