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15 molecules are shown

Wt: 219.2
BDBM26623
Wt: 219.2
BDBM26624
Wt: 273.2
BDBM26625
Wt: 273.2
BDBM26626
Wt: 333.2
BDBM26628
Wt: 347.3
BDBM26629
Wt: 233.2
BDBM26630
Wt: 247.3
BDBM26631
Wt: 223.2
BDBM26640
Purchase
Wt: 223.2
BDBM26642
Wt: 239.6
BDBM26643
Wt: 239.6
BDBM26644
Purchase
Wt: 284.1
BDBM26645
Purchase
Wt: 284.1
BDBM26646
Purchase
Wt: 205.2
BDBM50359686

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 26623,26624,26625,26626,26628,26629,26630,26631,26640,26642,26643,26644,26645,26646,50359686   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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Article
PubMed
24n/an/an/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Competitive inhibition of PIM1 in presence of ATP


J Med Chem 55: 8199-208 (2012)


Article DOI: 10.1021/jm3009234
BindingDB Entry DOI: 10.7270/Q2930V9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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PubMed
100n/an/an/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Competitive inhibition of PIM2 in presence of ATP


J Med Chem 55: 8199-208 (2012)


Article DOI: 10.1021/jm3009234
BindingDB Entry DOI: 10.7270/Q2930V9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26625
PNG
((5Z)-5-{[4-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-6(2-4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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PubMed
n/an/a 330n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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PubMed
n/an/a 24n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26628
PNG
((5Z)-5-{[2-(methoxymethoxy)-3-(trifluoromethyl)phe...)
Show SMILES COCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C13H10F3NO4S/c1-20-6-21-10-7(3-2-4-8(10)13(14,15)16)5-9-11(18)17-12(19)22-9/h2-5H,6H2,1H3,(H,17,18,19)
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n/an/a 460n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26629
PNG
((5Z)-5-{[2-(2-methoxyethoxy)-3-(trifluoromethyl)ph...)
Show SMILES COCCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C14H12F3NO4S/c1-21-5-6-22-11-8(3-2-4-9(11)14(15,16)17)7-10-12(19)18-13(20)23-10/h2-4,7H,5-6H2,1H3,(H,18,19,20)
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n/an/a 280n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26630
PNG
((5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidi...)
Show SMILES CCc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO2S/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)
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n/an/a 600n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26631
PNG
((5Z)-5-{[4-(propan-2-yl)phenyl]methylidene}-1,3-th...)
Show SMILES CC(C)c1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C13H13NO2S/c1-8(2)10-5-3-9(4-6-10)7-11-12(15)14-13(16)17-11/h3-8H,1-2H3,(H,14,15,16)
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n/an/a 40n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26640
PNG
((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 13n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26642
PNG
((5Z)-5-[(3-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(F)c1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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PubMed
n/an/a 130n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26643
PNG
((5Z)-5-[(4-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Cl)cc1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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PubMed
n/an/a 40n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26644
PNG
((5Z)-5-[(3-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Cl)c1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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PubMed
n/an/a 600n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26645
PNG
((5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Br)cc1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 2.80E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 4.50E+4n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26623
PNG
((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C11H9NO2S/c1-7-2-4-8(5-3-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26624
PNG
((5Z)-5-[(3-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1cccc(C=C2SC(O)=NC2=O)c1
Show InChI InChI=1S/C11H9NO2S/c1-7-3-2-4-8(5-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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n/an/a 100n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26625
PNG
((5Z)-5-{[4-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-6(2-4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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n/an/a 80n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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n/an/a 100n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26628
PNG
((5Z)-5-{[2-(methoxymethoxy)-3-(trifluoromethyl)phe...)
Show SMILES COCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C13H10F3NO4S/c1-20-6-21-10-7(3-2-4-8(10)13(14,15)16)5-9-11(18)17-12(19)22-9/h2-5H,6H2,1H3,(H,17,18,19)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26629
PNG
((5Z)-5-{[2-(2-methoxyethoxy)-3-(trifluoromethyl)ph...)
Show SMILES COCCOc1c(C=C2SC(O)=NC2=O)cccc1C(F)(F)F
Show InChI InChI=1S/C14H12F3NO4S/c1-21-5-6-22-11-8(3-2-4-9(11)14(15,16)17)7-10-12(19)18-13(20)23-10/h2-4,7H,5-6H2,1H3,(H,18,19,20)
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n/an/a 4.20E+4n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26630
PNG
((5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidi...)
Show SMILES CCc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO2S/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)
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n/an/a 300n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26631
PNG
((5Z)-5-{[4-(propan-2-yl)phenyl]methylidene}-1,3-th...)
Show SMILES CC(C)c1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C13H13NO2S/c1-8(2)10-5-3-9(4-6-10)7-11-12(15)14-13(16)17-11/h3-8H,1-2H3,(H,14,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26640
PNG
((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26642
PNG
((5Z)-5-[(3-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(F)c1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 400n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26643
PNG
((5Z)-5-[(4-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Cl)cc1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 200n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26644
PNG
((5Z)-5-[(3-chlorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Cl)c1
Show InChI InChI=1S/C10H6ClNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 40n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26645
PNG
((5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Br)cc1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 90n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 100n/an/an/an/an/an/a



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
15-hydroxyprostaglandin dehydrogenase [NAD+]


(Homo sapiens (Human))
BDBM26623
PNG
((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C11H9NO2S/c1-7-2-4-8(5-3-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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n/an/a 5.82E+3n/an/an/an/a7.5n/a



Industry-Academic Cooperation Foundation, Chosun University

US Patent


Assay Description
Experimental was performed by measuring the formation of NADH at 340 nm with a fluorescence spectrophotometer. Specifically, 2 ml (in total) of the s...


US Patent US8637558 (2014)


BindingDB Entry DOI: 10.7270/Q280519F
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM26630
PNG
((5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidi...)
Show SMILES CCc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO2S/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of IR by ELISA


J Med Chem 53: 2661-5 (2010)


Article DOI: 10.1021/jm901798e
BindingDB Entry DOI: 10.7270/Q28W3DF0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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n/an/a 24n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM26630
PNG
((5Z)-5-[(4-ethylphenyl)methylidene]-1,3-thiazolidi...)
Show SMILES CCc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C12H11NO2S/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)
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n/an/a 1.11E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of IGF1R by ELISA


J Med Chem 53: 2661-5 (2010)


Article DOI: 10.1021/jm901798e
BindingDB Entry DOI: 10.7270/Q28W3DF0
More data for this
Ligand-Target Pair
CDGSH iron-sulfur domain-containing protein 1


(Homo sapiens)
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 860n/an/an/an/an/an/a



Northeast Ohio Medical University

Curated by ChEMBL


Assay Description
Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) by scintillation proximity assa...


Bioorg Med Chem Lett 21: 5498-501 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.111
BindingDB Entry DOI: 10.7270/Q2T43TFB
More data for this
Ligand-Target Pair
Acetylcholinesterase


(Electrophorus electricus (Electric eel))
BDBM50359686
PNG
(CHEMBL85105)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NO2S/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The University of Adelaide

Curated by ChEMBL


Assay Description
Inhibition of Electrophorus electricus acetylcholinesterase preincubated for 15 mins by spectrophotometry


Bioorg Med Chem 19: 7453-63 (2011)


Article DOI: 10.1016/j.bmc.2011.10.042
BindingDB Entry DOI: 10.7270/Q2WQ0468
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM26645
PNG
((5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Br)cc1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 228n/an/an/an/an/an/a



Northeast Ohio Medical University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB using kynuramine as substrate by fluorimetry


Bioorg Med Chem Lett 22: 1380-3 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.056
BindingDB Entry DOI: 10.7270/Q2J67HDW
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM26645
PNG
((5Z)-5-[(4-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(Br)cc1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 4.35E+4n/an/an/an/an/an/a



Northeast Ohio Medical University

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOA using kynuramine as substrate by fluorimetry


Bioorg Med Chem Lett 22: 1380-3 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.056
BindingDB Entry DOI: 10.7270/Q2J67HDW
More data for this
Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (TDP1)


(Homo sapiens (Human))
BDBM26640
PNG
((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1
Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a>3.33E+5n/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...


J Med Chem 55: 8671-84 (2012)


Article DOI: 10.1021/jm3008773
BindingDB Entry DOI: 10.7270/Q2MP54D1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26626
PNG
((5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)
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n/an/a 24n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


J Med Chem 55: 2641-8 (2012)


Article DOI: 10.1021/jm2014698
BindingDB Entry DOI: 10.7270/Q2Q2418B
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 6.73E+4n/an/an/an/an/an/a



Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetry


Bioorg Med Chem Lett 21: 4798-803 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.060
BindingDB Entry DOI: 10.7270/Q2GX4CKZ
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM26646
PNG
((5Z)-5-[(3-bromophenyl)methylidene]-1,3-thiazolidi...)
Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Br)c1
Show InChI InChI=1S/C10H6BrNO2S/c11-7-3-1-2-6(4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)
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n/an/a 6.07E+3n/an/an/an/an/an/a



Northeastern Ohio Universities Colleges of Medicine and Pharmacy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MAOB by amplex red assay


Bioorg Med Chem Lett 21: 4798-803 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.060
BindingDB Entry DOI: 10.7270/Q2GX4CKZ
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50359686
PNG
(CHEMBL85105)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NO2S/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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n/an/a 890n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human PIM1 using FITC-(AHX)RSRHSSYPAGT-COOH as substrate after 90 mins by mobility shift assay in presence of 50 uM ATP


Bioorg Med Chem Lett 22: 4599-604 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.098
BindingDB Entry DOI: 10.7270/Q2348MDS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50359686
PNG
(CHEMBL85105)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NO2S/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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n/an/a 4.70E+3n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human PIM2 using FITC-(AHX)RSRHSSYPAGT-COOH as substrate after 90 mins by mobility shift assay in presence of 50 uM ATP


Bioorg Med Chem Lett 22: 4599-604 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.098
BindingDB Entry DOI: 10.7270/Q2348MDS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50359686
PNG
(CHEMBL85105)
Show SMILES OC1=NC(=O)C(S1)=Cc1ccccc1
Show InChI InChI=1S/C10H7NO2S/c12-9-8(14-10(13)11-9)6-7-4-2-1-3-5-7/h1-6H,(H,11,12,13)
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n/an/a 730n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of human PIM3 using FITC-(AHX)RSRHSSYPAGT-COOH as substrate after 90 mins by mobility shift assay in presence of 50 uM ATP


Bioorg Med Chem Lett 22: 4599-604 (2012)


Article DOI: 10.1016/j.bmcl.2012.05.098
BindingDB Entry DOI: 10.7270/Q2348MDS
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26623
PNG
((5Z)-5-[(4-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1ccc(C=C2SC(O)=NC2=O)cc1
Show InChI InChI=1S/C11H9NO2S/c1-7-2-4-8(5-3-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
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PubMed
n/an/a 60n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26624
PNG
((5Z)-5-[(3-methylphenyl)methylidene]-1,3-thiazolid...)
Show SMILES Cc1cccc(C=C2SC(O)=NC2=O)c1
Show InChI InChI=1S/C11H9NO2S/c1-7-3-2-4-8(5-7)6-9-10(13)12-11(14)15-9/h2-6H,1H3,(H,12,13,14)
PDB
MMDB

KEGG

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 160n/an/an/an/a7.025



Medical University of South Carolina



Assay Description
The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...


J Med Chem 52: 74-86 (2009)


Article DOI: 10.1021/jm800937p
BindingDB Entry DOI: 10.7270/Q2S180SF
More data for this
Ligand-Target Pair