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13 molecules are shown

Compile data set for download or QSAR
Wt: 367.1
BDBM26673
Purchase
Wt: 302.3
BDBM26674
Wt: 302.3
BDBM26675
Wt: 304.2
BDBM26676
Wt: 350.7
BDBM26677
Wt: 287.3
BDBM26682
Wt: 334.7
BDBM26686
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Wt: 334.7
BDBM26687
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Wt: 330.3
BDBM26688
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Wt: 301.2
BDBM26689
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Wt: 301.2
BDBM26690
Wt: 299.3
BDBM26695
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Wt: 288.3
BDBM50209188

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 29 hits for monomerid = 26673,26674,26675,26676,26677,26682,26686,26687,26688,26689,26690,26695,50209188   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/a 50n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50209188
PNG
(6-(2-Hydroxy-phenyl)-2-oxo-4-phenyl-1,2-dihydro-py...)
Show SMILES Oc1ccccc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H12N2O2/c19-11-15-14(12-6-2-1-3-7-12)10-16(20-18(15)22)13-8-4-5-9-17(13)21/h1-10,21H,(H,20,22)
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n/an/a 50n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


J Med Chem 55: 2641-8 (2012)


Article DOI: 10.1021/jm2014698
BindingDB Entry DOI: 10.7270/Q2Q2418B
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26675
PNG
(4-(2-hydroxy-5-methylphenyl)-2-oxo-6-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)14-10-17(13-5-3-2-4-6-13)21-19(23)16(14)11-20/h2-10,22H,1H3,(H,21,23)
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n/an/a 370n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26676
PNG
(6-(2-hydroxyphenyl)-4-(4-hydroxyphenyl)-2-oxo-1,2-...)
Show SMILES Oc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1O
Show InChI InChI=1S/C18H12N2O3/c19-10-15-14(11-5-7-12(21)8-6-11)9-16(20-18(15)23)13-3-1-2-4-17(13)22/h1-9,21-22H,(H,20,23)
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n/an/a 430n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26677
PNG
(4-(3-chlorophenyl)-6-(5-ethyl-2-hydroxyphenyl)-2-o...)
Show SMILES CCc1ccc(O)c(c1)-c1cc(-c2cccc(Cl)c2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H15ClN2O2/c1-2-12-6-7-19(24)16(8-12)18-10-15(17(11-22)20(25)23-18)13-4-3-5-14(21)9-13/h3-10,24H,2H2,1H3,(H,23,25)
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n/an/a 1.03E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a 4.41E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26686
PNG
(6-(4-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
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n/an/a 920n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26687
PNG
(6-(2-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccccc1-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-15-7-3-1-5-11(15)17-13(9-21)19(23)22-18-12-6-2-4-8-16(12)24-10-14(17)18/h1-8H,10H2,(H,22,23)
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n/an/a 1.23E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26688
PNG
(6-(4-methoxyphenyl)-4-oxo-9-oxa-3-azatricyclo[8.4....)
Show SMILES COc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C20H14N2O3/c1-24-13-8-6-12(7-9-13)18-15(10-21)20(23)22-19-14-4-2-3-5-17(14)25-11-16(18)19/h2-9H,11H2,1H3,(H,22,23)
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26689
PNG
(2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)
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n/an/a 2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26690
PNG
(4-oxo-6-(pyridin-2-yl)-9-oxa-3-azatricyclo[8.4.0.0...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccccn2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-12-16(14-6-3-4-8-20-14)13-10-23-15-7-2-1-5-11(15)17(13)21-18(12)22/h1-8H,10H2,(H,21,22)
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Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26695
PNG
(4-oxo-6-(pyridin-4-yl)-3-azatricyclo[8.4.0.0^{2,7}...)
Show SMILES O=c1[nH]c-2c(CCc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C19H13N3O/c20-11-16-17(13-7-9-21-10-8-13)15-6-5-12-3-1-2-4-14(12)18(15)22-19(16)23/h1-4,7-10H,5-6H2,(H,22,23)
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n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens)
BDBM26689
PNG
(2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)
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n/an/a 1.00E+5n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2T72FSX
More data for this
Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C


(Homo sapiens)
BDBM26689
PNG
(2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...)
Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N
Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)
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n/an/a 1.00E+5n/an/an/an/a7.423



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2DV1H7P
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM26687
PNG
(6-(2-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccccc1-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-15-7-3-1-5-11(15)17-13(9-21)19(23)22-18-12-6-2-4-8-16(12)24-10-14(17)18/h1-8H,10H2,(H,22,23)
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
POsterior Segregation family member (pos-1)


(Caenorhabditis elegans)
BDBM26686
PNG
(6-(4-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
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n/an/an/an/a 3.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q28G8J4C
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM26687
PNG
(6-(2-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccccc1-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-15-7-3-1-5-11(15)17-13(9-21)19(23)22-18-12-6-2-4-8-16(12)24-10-14(17)18/h1-8H,10H2,(H,22,23)
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n/an/an/an/a 3.88E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
RecName: Full=Zinc finger protein mex-5


(Caenorhabditis elegans)
BDBM26686
PNG
(6-(4-chlorophenyl)-4-oxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES Clc1ccc(cc1)-c1c2COc3ccccc3-c2[nH]c(=O)c1C#N
Show InChI InChI=1S/C19H11ClN2O2/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
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n/an/an/an/a 5.30E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2D798VP
More data for this
Ligand-Target Pair
TPA: Essential protein of the mitochondrial intermembrane space


(Saccharomyces cerevisiae S288c)
BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...


PubChem Bioassay (2011)


BindingDB Entry DOI: 10.7270/Q2JQ0ZH4
More data for this
Ligand-Target Pair
TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)


(Saccharomyces cerevisiae S288c)
BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q25D8QFV
More data for this
Ligand-Target Pair
TPA: Essential protein of the mitochondrial intermembrane space


(Saccharomyces cerevisiae S288c)
BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2WW7G77
More data for this
Ligand-Target Pair
TPA: Essential protein of the mitochondrial intermembrane space


(Saccharomyces cerevisiae S288c)
BDBM26682
PNG
(2-amino-6-(4-hydroxyphenyl)-4-phenylpyridine-3-car...)
Show SMILES Nc1nc(cc(-c2ccccc2)c1C#N)-c1ccc(O)cc1
Show InChI InChI=1S/C18H13N3O/c19-11-16-15(12-4-2-1-3-5-12)10-17(21-18(16)20)13-6-8-14(22)9-7-13/h1-10,22H,(H2,20,21)
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n/an/a 4.52E+3n/an/an/an/an/an/a



Burnham Center for Chemical Genomics

Curated by PubChem BioAssay


Assay Description
Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...


PubChem Bioassay (2012)


BindingDB Entry DOI: 10.7270/Q2S46QHT
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209188
PNG
(6-(2-Hydroxy-phenyl)-2-oxo-4-phenyl-1,2-dihydro-py...)
Show SMILES Oc1ccccc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H12N2O2/c19-11-15-14(12-6-2-1-3-7-12)10-16(20-18(15)22)13-8-4-5-9-17(13)21/h1-10,21H,(H,20,22)
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n/an/an/a 7.50E+4n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/an/a 5.00E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.03.042
BindingDB Entry DOI: 10.7270/Q2M04534
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/a 50n/an/an/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim1 (unknown origin) assessed as [32P] incorporation preincubated for 15 mins before ATP substrate addition by coupled spectrophotomet...


Bioorg Med Chem Lett 19: 3019-22 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.061
BindingDB Entry DOI: 10.7270/Q21J99PJ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/a 50n/an/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of PIM1


Eur J Med Chem 45: 90-7 (2010)


Article DOI: 10.1016/j.ejmech.2009.09.029
BindingDB Entry DOI: 10.7270/Q20K28N2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/an/a 5.70E+3n/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of survivin


Eur J Med Chem 45: 90-7 (2010)


Article DOI: 10.1016/j.ejmech.2009.09.029
BindingDB Entry DOI: 10.7270/Q20K28N2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26673
PNG
(6-(5-bromo-2-hydroxyphenyl)-2-oxo-4-phenyl-1,2-dih...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H11BrN2O2/c19-12-6-7-17(22)14(8-12)16-9-13(11-4-2-1-3-5-11)15(10-20)18(23)21-16/h1-9,22H,(H,21,23)
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n/an/a 50n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Competitive inhibition of PIM1 in presence of ATP


J Med Chem 55: 8199-208 (2012)


Article DOI: 10.1021/jm3009234
BindingDB Entry DOI: 10.7270/Q2930V9T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26674
PNG
(6-(2-hydroxy-5-methylphenyl)-2-oxo-4-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)17-10-14(13-5-3-2-4-6-13)16(11-20)19(23)21-17/h2-10,22H,1H3,(H,21,23)
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n/an/a 340n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair