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8 similar compounds to monomer 50209195

Wt: 302.3
BDBM26674
Wt: 304.2
BDBM26676
Wt: 350.7
BDBM26677
Wt: 413.2
BDBM50209184
Wt: 425.1
BDBM50209185
Wt: 425.3
BDBM50209191
Wt: 439.3
BDBM50209197
Wt: 436.0
BDBM50209209

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 26674,26676,26677,50209184,50209185,50209191,50209197,50209209   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26674
PNG
(6-(2-hydroxy-5-methylphenyl)-2-oxo-4-phenyl-1,2-di...)
Show SMILES Cc1ccc(O)c(c1)-c1cc(-c2ccccc2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H14N2O2/c1-12-7-8-18(22)15(9-12)17-10-14(13-5-3-2-4-6-13)16(11-20)19(23)21-17/h2-10,22H,1H3,(H,21,23)
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n/an/a 340n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26676
PNG
(6-(2-hydroxyphenyl)-4-(4-hydroxyphenyl)-2-oxo-1,2-...)
Show SMILES Oc1ccc(cc1)-c1cc([nH]c(=O)c1C#N)-c1ccccc1O
Show InChI InChI=1S/C18H12N2O3/c19-10-15-14(11-5-7-12(21)8-6-11)9-16(20-18(15)23)13-3-1-2-4-17(13)22/h1-9,21-22H,(H,20,23)
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n/an/a 430n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)

More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26677
PNG
(4-(3-chlorophenyl)-6-(5-ethyl-2-hydroxyphenyl)-2-o...)
Show SMILES CCc1ccc(O)c(c1)-c1cc(-c2cccc(Cl)c2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H15ClN2O2/c1-2-12-6-7-19(24)16(8-12)18-10-15(17(11-22)20(25)23-18)13-4-3-5-14(21)9-13/h3-10,24H,2H2,1H3,(H,23,25)
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n/an/a 1.03E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209209
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,5-dichlorophenyl)...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H9BrCl2N2O2/c19-9-1-4-17(24)13(5-9)16-7-11(14(8-22)18(25)23-16)12-6-10(20)2-3-15(12)21/h1-7,24H,(H,23,25)
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n/an/an/a 800n/an/an/an/an/a



German University in Cairo

Curated by ChEMBL


Assay Description
Inhibition of survivin


Eur J Med Chem 45: 90-7 (2010)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209197
PNG
(6-(5-cyclohexyl-2-hydroxyphenyl)-4-(2,5-dichloroph...)
Show SMILES Oc1ccc(cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1)C1CCCCC1
Show InChI InChI=1S/C24H20Cl2N2O2/c25-16-7-8-21(26)18(11-16)17-12-22(28-24(30)20(17)13-27)19-10-15(6-9-23(19)29)14-4-2-1-3-5-14/h6-12,14,29H,1-5H2,(H,28,30)
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n/an/an/a 2.98E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209209
PNG
(6-(5-bromo-2-hydroxyphenyl)-4-(2,5-dichlorophenyl)...)
Show SMILES Oc1ccc(Br)cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C18H9BrCl2N2O2/c19-9-1-4-17(24)13(5-9)16-7-11(14(8-22)18(25)23-16)12-6-10(20)2-3-15(12)21/h1-7,24H,(H,23,25)
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n/an/an/a 810n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209184
PNG
(4-(2,5-dichlorophenyl)-6-(2-hydroxy-5-isobutylphen...)
Show SMILES CC(C)Cc1ccc(O)c(c1)-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H18Cl2N2O2/c1-12(2)7-13-3-6-21(27)17(8-13)20-10-15(18(11-25)22(28)26-20)16-9-14(23)4-5-19(16)24/h3-6,8-10,12,27H,7H2,1-2H3,(H,26,28)
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n/an/an/a 7.56E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209185
PNG
(6-(5-chloro-2-hydroxyphenyl)-4-(2-chloro-5-(triflu...)
Show SMILES Oc1ccc(Cl)cc1-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C19H9Cl2F3N2O2/c20-10-2-4-17(27)13(6-10)16-7-11(14(8-25)18(28)26-16)12-5-9(19(22,23)24)1-3-15(12)21/h1-7,27H,(H,26,28)
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n/an/an/a 520n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209191
PNG
(6-(5-cyclopentyl-2-hydroxyphenyl)-4-(2,5-dichlorop...)
Show SMILES Oc1ccc(cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1)C1CCCC1
Show InChI InChI=1S/C23H18Cl2N2O2/c24-15-6-7-20(25)17(10-15)16-11-21(27-23(29)19(16)12-26)18-9-14(5-8-22(18)28)13-3-1-2-4-13/h5-11,13,28H,1-4H2,(H,27,29)
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n/an/an/a 510n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair