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4 similar compounds to monomer 50209191

Wt: 350.7
BDBM26677
Wt: 413.2
BDBM50209184
Wt: 433.2
BDBM50209195
Wt: 439.3
BDBM50209197

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 26677,50209184,50209195,50209197   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM26677
PNG
(4-(3-chlorophenyl)-6-(5-ethyl-2-hydroxyphenyl)-2-o...)
Show SMILES CCc1ccc(O)c(c1)-c1cc(-c2cccc(Cl)c2)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C20H15ClN2O2/c1-2-12-6-7-19(24)16(8-12)18-10-15(17(11-22)20(25)23-18)13-4-3-5-14(21)9-13/h3-10,24H,2H2,1H3,(H,23,25)
PDB
MMDB

KEGG

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Article
PubMed
n/an/a 1.03E+3n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...


Bioorg Med Chem Lett 17: 1679-83 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209197
PNG
(6-(5-cyclohexyl-2-hydroxyphenyl)-4-(2,5-dichloroph...)
Show SMILES Oc1ccc(cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1)C1CCCCC1
Show InChI InChI=1S/C24H20Cl2N2O2/c25-16-7-8-21(26)18(11-16)17-12-22(28-24(30)20(17)13-27)19-10-15(6-9-23(19)29)14-4-2-1-3-5-14/h6-12,14,29H,1-5H2,(H,28,30)
PDB
MMDB

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KEGG

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PubMed
n/an/an/a 2.98E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209184
PNG
(4-(2,5-dichlorophenyl)-6-(2-hydroxy-5-isobutylphen...)
Show SMILES CC(C)Cc1ccc(O)c(c1)-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1
Show InChI InChI=1S/C22H18Cl2N2O2/c1-12(2)7-13-3-6-21(27)17(8-13)20-10-15(18(11-25)22(28)26-20)16-9-14(23)4-5-19(16)24/h3-6,8-10,12,27H,7H2,1-2H3,(H,26,28)
PDB
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Article
PubMed
n/an/an/a 7.56E+3n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair
Baculoviral IAP repeat-containing protein 5


(Homo sapiens)
BDBM50209195
PNG
(4-(2,5-dichloro-phenyl)-6-(4-hydroxy-biphenyl-3-yl...)
Show SMILES Oc1ccc(cc1-c1cc(-c2cc(Cl)ccc2Cl)c(C#N)c(=O)[nH]1)-c1ccccc1
Show InChI InChI=1S/C24H14Cl2N2O2/c25-16-7-8-21(26)18(11-16)17-12-22(28-24(30)20(17)13-27)19-10-15(6-9-23(19)29)14-4-2-1-3-5-14/h1-12,29H,(H,28,30)
PDB
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Article
PubMed
n/an/an/a 700n/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to human survivin expressed in Escherichia coli BL21 cells after 30 mins


Bioorg Med Chem Lett 17: 3122-9 (2007)

More data for this
Ligand-Target Pair