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42 similar compounds to monomer 50237535

Compile data set for download or QSAR
Wt: 540.6
BDBM27901
Wt: 574.6
BDBM27902
Wt: 553.6
BDBM27903
Wt: 567.6
BDBM27904
Wt: 576.6
BDBM27905
Wt: 510.5
BDBM27906
Wt: 554.6
BDBM27907
Wt: 568.6
BDBM27908
Wt: 524.6
BDBM27909
Wt: 560.5
BDBM27910
Wt: 554.6
BDBM27911
Wt: 512.6
BDBM27913
Wt: 567.6
BDBM27896
Wt: 581.7
BDBM27897
Wt: 441.4
BDBM27898
Displayed 1 to 15 (of 42 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 27901,27902,27903,27904,27905,27906,27907,27908,27909,27910,27911,27913,27896,27897,27898   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27896
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-ethoxy-2-({4-[2-(4...)
Show SMILES CCONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C32H37N7O3/c1-3-42-36-31(41)28-21-39(26-12-9-23-5-4-6-24(23)19-26)30-27(29(28)40)20-33-32(35-30)34-25-10-7-22(8-11-25)13-14-38-17-15-37(2)16-18-38/h7-12,19-21H,3-6,13-18H2,1-2H3,(H,36,41)(H,33,34,35)
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n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 3.70E+3n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27898
PNG
(2-(benzylamino)-8-(2,3-dihydro-1H-inden-5-yl)-N-me...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(NCc3ccccc3)ncc2c1=O
Show InChI InChI=1S/C25H23N5O3/c1-33-29-24(32)21-15-30(19-11-10-17-8-5-9-18(17)12-19)23-20(22(21)31)14-27-25(28-23)26-13-16-6-3-2-4-7-16/h2-4,6-7,10-12,14-15H,5,8-9,13H2,1H3,(H,29,32)(H,26,27,28)
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n/an/a 75n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27901
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCOCC4)cc3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O4/c1-39-34-29(38)26-19-36(24-10-7-21-3-2-4-22(21)17-24)28-25(27(26)37)18-31-30(33-28)32-23-8-5-20(6-9-23)11-12-35-13-15-40-16-14-35/h5-10,17-19H,2-4,11-16H2,1H3,(H,34,38)(H,31,32,33)
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n/an/a 1.30n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27902
PNG
(2-({4-[2-(4,4-difluoropiperidin-1-yl)ethyl]phenyl}...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCC(F)(F)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H32F2N6O3/c1-42-37-29(41)26-19-39(24-10-7-21-3-2-4-22(21)17-24)28-25(27(26)40)18-34-30(36-28)35-23-8-5-20(6-9-23)11-14-38-15-12-31(32,33)13-16-38/h5-10,17-19H,2-4,11-16H2,1H3,(H,37,41)(H,34,35,36)
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n/an/a 1.70n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27903
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-({...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCNC(=O)C4)cc3)ncc2c1=O
Show InChI InChI=1S/C30H31N7O4/c1-41-35-29(40)25-17-37(23-10-7-20-3-2-4-21(20)15-23)28-24(27(25)39)16-32-30(34-28)33-22-8-5-19(6-9-22)11-13-36-14-12-31-26(38)18-36/h5-10,15-17H,2-4,11-14,18H2,1H3,(H,31,38)(H,35,40)(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27904
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-({4-[2-(...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)C(=O)C4)cc3)ncc2c1=O
Show InChI InChI=1S/C31H33N7O4/c1-36-14-15-37(19-27(36)39)13-12-20-6-9-23(10-7-20)33-31-32-17-25-28(40)26(30(41)35-42-2)18-38(29(25)34-31)24-11-8-21-4-3-5-22(21)16-24/h6-11,16-18H,3-5,12-15,19H2,1-2H3,(H,35,41)(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27905
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(ethanesulf...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCS(=O)(=O)NC(C)=O)cc3)ncc2c1=O
Show InChI InChI=1S/C28H28N6O6S/c1-17(35)33-41(38,39)13-12-18-6-9-21(10-7-18)30-28-29-15-23-25(36)24(27(37)32-40-2)16-34(26(23)31-28)22-11-8-19-4-3-5-20(19)14-22/h6-11,14-16H,3-5,12-13H2,1-2H3,(H,32,37)(H,33,35)(H,29,30,31)
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n/an/a 2.40n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27906
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-5-oxo-2-{[...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCNCC3)ncc2c1=O
Show InChI InChI=1S/C29H30N6O3/c1-38-34-28(37)25-17-35(23-10-7-18-3-2-4-21(18)15-23)27-24(26(25)36)16-31-29(33-27)32-22-8-5-19(6-9-22)20-11-13-30-14-12-20/h5-10,15-17,20,30H,2-4,11-14H2,1H3,(H,34,37)(H,31,32,33)
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n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27907
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[1-(2-hydroxye...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CCO)CC3)ncc2c1=O
Show InChI InChI=1S/C31H34N6O4/c1-41-35-30(40)27-19-37(25-10-7-20-3-2-4-23(20)17-25)29-26(28(27)39)18-32-31(34-29)33-24-8-5-21(6-9-24)22-11-13-36(14-12-22)15-16-38/h5-10,17-19,22,38H,2-4,11-16H2,1H3,(H,35,40)(H,32,33,34)
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n/an/a 1.30n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a 2.20n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27910
PNG
(2-{[4-(3,3-difluoro-1-methylpiperidin-4-yl)phenyl]...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3(F)F)ncc2c1=O
Show InChI InChI=1S/C30H30F2N6O3/c1-37-13-12-25(30(31,32)17-37)19-6-9-21(10-7-19)34-29-33-15-23-26(39)24(28(40)36-41-2)16-38(27(23)35-29)22-11-8-18-4-3-5-20(18)14-22/h6-11,14-16,25H,3-5,12-13,17H2,1-2H3,(H,36,40)(H,33,34,35)
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n/an/a 0.700n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27911
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-{[3-(1-ethyl-3-hyd...)
Show SMILES CCN1CCCC(O)(C1)c1cccc(Nc2ncc3c(n2)n(cc(C(=O)NOC)c3=O)-c2ccc3CCCc3c2)c1
Show InChI InChI=1S/C31H34N6O4/c1-3-36-14-6-13-31(40,19-36)22-9-5-10-23(16-22)33-30-32-17-25-27(38)26(29(39)35-41-2)18-37(28(25)34-30)24-12-11-20-7-4-8-21(20)15-24/h5,9-12,15-18,40H,3-4,6-8,13-14,19H2,1-2H3,(H,35,39)(H,32,33,34)
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n/an/a 0.800n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27913
PNG
(8-(3-ethylphenyl)-N-methoxy-2-{[4-(1-methylpiperid...)
Show SMILES CCc1cccc(c1)-n1cc(C(=O)NOC)c(=O)c2cnc(Nc3ccc(cc3)C3CCN(C)CC3)nc12
Show InChI InChI=1S/C29H32N6O3/c1-4-19-6-5-7-23(16-19)35-18-25(28(37)33-38-3)26(36)24-17-30-29(32-27(24)35)31-22-10-8-20(9-11-22)21-12-14-34(2)15-13-21/h5-11,16-18,21H,4,12-15H2,1-3H3,(H,33,37)(H,30,31,32)
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n/an/a 0.400n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a 41n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 6n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
FLT-3 was assayed using a fluorescence polarization (FP) competition immunoassay that measured FLT-3 phosphorylation of polyGlu4Tyr. The reaction was...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a>1.00E+3n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
Axl was assayed using a fluorescence polarization (FP) competition immunoassay that measured Axl phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a>500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Tyrosine Kinase TrkA


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 500n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
TrkA was assayed using a fluorescence polarization (FP) competition immunoassay that measured TrkA phosphorylation of polyGlu4Tyr. The reaction was i...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a 13n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM27909
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-N-methoxy-2-{[4-(1-m...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(C)CC3)ncc2c1=O
Show InChI InChI=1S/C30H32N6O3/c1-35-14-12-21(13-15-35)20-6-9-23(10-7-20)32-30-31-17-25-27(37)26(29(38)34-39-2)18-36(28(25)33-30)24-11-8-19-4-3-5-22(19)16-24/h6-11,16-18,21H,3-5,12-15H2,1-2H3,(H,34,38)(H,31,32,33)
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n/an/a 6n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
KIT was assayed using a fluorescence polarization (FP) competition immunoassay that measured KIT phosphorylation of polyGlu4Tyr. The reaction was ini...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM27908
PNG
(2-[4-(4-{[8-(2,3-dihydro-1H-inden-5-yl)-6-(methoxy...)
Show SMILES CONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(cc3)C3CCN(CC(O)=O)CC3)ncc2c1=O
Show InChI InChI=1S/C31H32N6O5/c1-42-35-30(41)26-17-37(24-10-7-19-3-2-4-22(19)15-24)29-25(28(26)40)16-32-31(34-29)33-23-8-5-20(6-9-23)21-11-13-36(14-12-21)18-27(38)39/h5-10,15-17,21H,2-4,11-14,18H2,1H3,(H,35,41)(H,38,39)(H,32,33,34)
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n/an/a 9.30E+3n/an/an/an/an/a25



Johnson & Johnson Pharmaceutical



Assay Description
IRKbeta was assayed using a fluorescence polarization (FP) competition immunoassay that measured IRKbeta phosphorylation of polyGlu4Tyr. The reaction...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM27897
PNG
(8-(2,3-dihydro-1H-inden-5-yl)-2-({4-[2-(4-methylpi...)
Show SMILES CC(C)ONC(=O)c1cn(-c2ccc3CCCc3c2)c2nc(Nc3ccc(CCN4CCN(C)CC4)cc3)ncc2c1=O
Show InChI InChI=1S/C33H39N7O3/c1-22(2)43-37-32(42)29-21-40(27-12-9-24-5-4-6-25(24)19-27)31-28(30(29)41)20-34-33(36-31)35-26-10-7-23(8-11-26)13-14-39-17-15-38(3)16-18-39/h7-12,19-22H,4-6,13-18H2,1-3H3,(H,37,42)(H,34,35,36)
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n/an/a 0.5n/an/an/an/a7.522



Johnson & Johnson Pharmaceutical



Assay Description
FMS was assayed using a fluorescence polarization (FP) competition immunoassay that measured FMS phosphorylation of FMS 555-568 peptide at Y561. The ...


J Med Chem 52: 1081-99 (2009)


Article DOI: 10.1021/jm801406h
BindingDB Entry DOI: 10.7270/Q21834T7
More data for this
Ligand-Target Pair