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17 similar compounds to monomer 50323097

Compile data set for download or QSAR
Wt: 383.8
BDBM28162
Wt: 508.5
BDBM50323113
Wt: 474.9
BDBM50323115
Wt: 606.6
BDBM50323093
Wt: 593.6
BDBM50323094
Wt: 594.6
BDBM50323095
Wt: 596.1
BDBM50323096
Wt: 587.1
BDBM50323098
Wt: 587.1
BDBM50323099
Wt: 549.0
BDBM50323101
Wt: 477.9
BDBM50323123
Wt: 559.0
BDBM50323103
Wt: 573.1
BDBM50323104
Wt: 588.1
BDBM50323105
Wt: 474.9
BDBM50323107
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 46 hits for monomerid = 28162,50323113,50323115,50323093,50323094,50323095,50323096,50323098,50323099,50323101,50323123,50323103,50323104,50323105,50323107   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM28162
PNG
(5-(1H-1,3-benzodiazol-1-yl)-3-[(2-chlorophenyl)met...)
Show SMILES NC(=O)c1sc(cc1OCc1ccccc1Cl)-n1cnc2ccccc12
Show InChI InChI=1S/C19H14ClN3O2S/c20-13-6-2-1-5-12(13)10-25-16-9-17(26-18(16)19(21)24)23-11-22-14-7-3-4-8-15(14)23/h1-9,11H,10H2,(H2,21,24)
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n/an/a 12n/an/an/an/a7.222



GSK



Assay Description
The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-...


Bioorg Med Chem Lett 19: 1018-21 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.041
BindingDB Entry DOI: 10.7270/Q26T0JZX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50323115
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(pyridin-4-y...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccncc1)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-7-6-17(12-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full lungth PLK3 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323094
PNG
((R)-5-(5-(2-morpholinopyridin-4-yl)-1H-benzo[d]imi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCOCC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H26F3N5O3S/c1-18(21-4-2-3-5-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)39)38-17-36-23-14-19(6-7-24(23)38)20-8-9-35-26(15-20)37-10-12-40-13-11-37/h2-9,14-18H,10-13H2,1H3,(H2,34,39)/t18-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323095
PNG
((R)-5-(5-(2-(2-(dimethylamino)ethylamino)pyridin-4...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCN(C)C)c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2S/c1-18(21-6-4-5-7-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)40)39-17-37-23-14-19(8-9-24(23)39)20-10-11-35-26(15-20)36-12-13-38(2)3/h4-11,14-18H,12-13H2,1-3H3,(H2,34,40)(H,35,36)/t18-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323096
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-(methy...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCS(C)(=O)=O)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H26ClN5O4S2/c1-17(20-5-3-4-6-21(20)29)38-24-15-26(39-27(24)28(30)35)34-16-33-22-13-18(7-8-23(22)34)19-9-10-31-25(14-19)32-11-12-40(2,36)37/h3-10,13-17H,11-12H2,1-2H3,(H2,30,35)(H,31,32)/t17-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323098
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)c1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-17-29(41-30(27)31(33)39)38-18-35-25-15-20(7-8-26(25)38)21-9-12-34-28(16-21)36-22-10-13-37(2)14-11-22/h3-9,12,15-19,22H,10-11,13-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 4.30E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323099
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(6-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc(NC2CCN(C)CC2)nc1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-16-29(41-30(27)31(33)39)38-18-35-25-15-20(7-9-26(25)38)21-8-10-28(34-17-21)36-22-11-13-37(2)14-12-22/h3-10,15-19,22H,11-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 8.90E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323101
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H29ClN6O2S/c1-18(21-7-4-5-8-22(21)29)37-25-14-26(38-27(25)28(30)36)35-17-31-23-13-19(9-10-24(23)35)20-15-32-34(16-20)12-6-11-33(2)3/h4-5,7-10,13-18H,6,11-12H2,1-3H3,(H2,30,36)/t18-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323103
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(piperazi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCNCC1)c1ccccc1Cl
Show InChI InChI=1S/C29H27ClN6O2S/c1-18(21-4-2-3-5-22(21)30)38-25-16-27(39-28(25)29(31)37)36-17-34-23-14-19(6-7-24(23)36)20-8-9-33-26(15-20)35-12-10-32-11-13-35/h2-9,14-18,32H,10-13H2,1H3,(H2,31,37)/t18-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323104
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(4-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1Cl
Show InChI InChI=1S/C30H29ClN6O2S/c1-19(22-5-3-4-6-23(22)31)39-26-17-28(40-29(26)30(32)38)37-18-34-24-15-20(7-8-25(24)37)21-9-10-33-27(16-21)36-13-11-35(2)12-14-36/h3-10,15-19H,11-14H2,1-2H3,(H2,32,38)/t19-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323093
PNG
((R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2S/c1-19(22-5-3-4-6-23(22)31(32,33)34)42-26-17-28(43-29(26)30(35)41)40-18-37-24-15-20(7-8-25(24)40)21-9-10-36-27(16-21)39-13-11-38(2)12-14-39/h3-10,15-19H,11-14H2,1-2H3,(H2,35,41)/t19-/m1/s1
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n/an/a 400n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323094
PNG
((R)-5-(5-(2-morpholinopyridin-4-yl)-1H-benzo[d]imi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCOCC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H26F3N5O3S/c1-18(21-4-2-3-5-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)39)38-17-36-23-14-19(6-7-24(23)38)20-8-9-35-26(15-20)37-10-12-40-13-11-37/h2-9,14-18H,10-13H2,1H3,(H2,34,39)/t18-/m1/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323095
PNG
((R)-5-(5-(2-(2-(dimethylamino)ethylamino)pyridin-4...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCN(C)C)c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2S/c1-18(21-6-4-5-7-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)40)39-17-37-23-14-19(8-9-24(23)39)20-10-11-35-26(15-20)36-12-13-38(2)3/h4-11,14-18H,12-13H2,1-3H3,(H2,34,40)(H,35,36)/t18-/m1/s1
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n/an/a 800n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323098
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)c1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-17-29(41-30(27)31(33)39)38-18-35-25-15-20(7-8-26(25)38)21-9-12-34-28(16-21)36-22-10-13-37(2)14-11-22/h3-9,12,15-19,22H,10-11,13-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323099
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(6-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc(NC2CCN(C)CC2)nc1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-16-29(41-30(27)31(33)39)38-18-35-25-15-20(7-9-26(25)38)21-8-10-28(34-17-21)36-22-11-13-37(2)14-12-22/h3-10,15-19,22H,11-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 3.40E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323105
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)n1)c1ccccc1Cl
Show InChI InChI=1S/C30H30ClN7O2S/c1-18(21-5-3-4-6-22(21)31)40-26-16-27(41-28(26)29(32)39)38-17-34-24-15-19(7-8-25(24)38)23-9-12-33-30(36-23)35-20-10-13-37(2)14-11-20/h3-9,12,15-18,20H,10-11,13-14H2,1-2H3,(H2,32,39)(H,33,35,36)/t18-/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323101
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H29ClN6O2S/c1-18(21-7-4-5-8-22(21)29)37-25-14-26(38-27(25)28(30)36)35-17-31-23-13-19(9-10-24(23)35)20-15-32-34(16-20)12-6-11-33(2)3/h4-5,7-10,13-18H,6,11-12H2,1-3H3,(H2,30,36)/t18-/m1/s1
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n/an/a 900n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using diethoxyfluorescein as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323103
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(piperazi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCNCC1)c1ccccc1Cl
Show InChI InChI=1S/C29H27ClN6O2S/c1-18(21-4-2-3-5-22(21)30)38-25-16-27(39-28(25)29(31)37)36-17-34-23-14-19(6-7-24(23)36)20-8-9-33-26(15-20)35-12-10-32-11-13-35/h2-9,14-18,32H,10-13H2,1H3,(H2,31,37)/t18-/m1/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323104
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(4-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1Cl
Show InChI InChI=1S/C30H29ClN6O2S/c1-19(22-5-3-4-6-23(22)31)39-26-17-28(40-29(26)30(32)38)37-18-34-24-15-20(7-8-25(24)37)21-9-10-33-27(16-21)36-13-11-35(2)12-14-36/h3-10,15-19H,11-14H2,1-2H3,(H2,32,38)/t19-/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323093
PNG
((R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2S/c1-19(22-5-3-4-6-23(22)31(32,33)34)42-26-17-28(43-29(26)30(35)41)40-18-37-24-15-20(7-8-25(24)40)21-9-10-36-27(16-21)39-13-11-38(2)12-14-39/h3-10,15-19H,11-14H2,1-2H3,(H2,35,41)/t19-/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323094
PNG
((R)-5-(5-(2-morpholinopyridin-4-yl)-1H-benzo[d]imi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCOCC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H26F3N5O3S/c1-18(21-4-2-3-5-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)39)38-17-36-23-14-19(6-7-24(23)38)20-8-9-35-26(15-20)37-10-12-40-13-11-37/h2-9,14-18H,10-13H2,1H3,(H2,34,39)/t18-/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323095
PNG
((R)-5-(5-(2-(2-(dimethylamino)ethylamino)pyridin-4...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCN(C)C)c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2S/c1-18(21-6-4-5-7-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)40)39-17-37-23-14-19(8-9-24(23)39)20-10-11-35-26(15-20)36-12-13-38(2)3/h4-11,14-18H,12-13H2,1-3H3,(H2,34,40)(H,35,36)/t18-/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323096
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-(methy...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCS(C)(=O)=O)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H26ClN5O4S2/c1-17(20-5-3-4-6-21(20)29)38-24-15-26(39-27(24)28(30)35)34-16-33-22-13-18(7-8-23(22)34)19-9-10-31-25(14-19)32-11-12-40(2,36)37/h3-10,13-17H,11-12H2,1-2H3,(H2,30,35)(H,31,32)/t17-/m1/s1
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n/an/a 3.50E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323098
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)c1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-17-29(41-30(27)31(33)39)38-18-35-25-15-20(7-8-26(25)38)21-9-12-34-28(16-21)36-22-10-13-37(2)14-11-22/h3-9,12,15-19,22H,10-11,13-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 4.70E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323099
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(6-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc(NC2CCN(C)CC2)nc1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-16-29(41-30(27)31(33)39)38-18-35-25-15-20(7-9-26(25)38)21-8-10-28(34-17-21)36-22-11-13-37(2)14-12-22/h3-10,15-19,22H,11-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323105
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)n1)c1ccccc1Cl
Show InChI InChI=1S/C30H30ClN7O2S/c1-18(21-5-3-4-6-22(21)31)40-26-16-27(41-28(26)29(32)39)38-17-34-24-15-19(7-8-25(24)38)23-9-12-33-30(36-23)35-20-10-13-37(2)14-11-20/h3-9,12,15-18,20H,10-11,13-14H2,1-2H3,(H2,32,39)(H,33,35,36)/t18-/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 3A


(Homo sapiens (Human))
BDBM50323101
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H29ClN6O2S/c1-18(21-7-4-5-8-22(21)29)37-25-14-26(38-27(25)28(30)36)35-17-31-23-13-19(9-10-24(23)35)20-15-32-34(16-20)12-6-11-33(2)3/h4-5,7-10,13-18H,6,11-12H2,1-3H3,(H2,30,36)/t18-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP3A4 using 7-benzyloxyquinoline as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323107
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(pyridin-4-y...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-12-17(6-7-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-{3-(4-phenylpiperazin-1-ylmethyl)benzyl}resorufin as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323113
PNG
((R)-5-(5-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H19F3N4O2S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-17(6-7-21(20)33)16-8-10-31-11-9-16/h2-15H,1H3,(H2,30,34)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323107
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(pyridin-4-y...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-12-17(6-7-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323115
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(pyridin-4-y...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1ccncc1)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-7-6-17(12-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323123
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(1-methyl-1H...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1cnn(C)c1)c1ccccc1Cl
Show InChI InChI=1S/C24H20ClN5O2S/c1-14(17-5-3-4-6-18(17)25)32-21-10-22(33-23(21)24(26)31)30-13-27-19-8-7-15(9-20(19)30)16-11-28-29(2)12-16/h3-14H,1-2H3,(H2,26,31)/t14-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50323123
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(6-(1-methyl-1H...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2ccc(cc12)-c1cnn(C)c1)c1ccccc1Cl
Show InChI InChI=1S/C24H20ClN5O2S/c1-14(17-5-3-4-6-18(17)25)32-21-10-22(33-23(21)24(26)31)30-13-27-19-8-7-15(9-20(19)30)16-11-28-29(2)12-16/h3-14H,1-2H3,(H2,26,31)/t14-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full lungth PLK3 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323103
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(piperazi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCNCC1)c1ccccc1Cl
Show InChI InChI=1S/C29H27ClN6O2S/c1-18(21-4-2-3-5-22(21)30)38-25-16-27(39-28(25)29(31)37)36-17-34-23-14-19(6-7-24(23)36)20-8-9-33-26(15-20)35-12-10-32-11-13-35/h2-9,14-18,32H,10-13H2,1H3,(H2,31,37)/t18-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323104
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(4-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1Cl
Show InChI InChI=1S/C30H29ClN6O2S/c1-19(22-5-3-4-6-23(22)31)39-26-17-28(40-29(26)30(32)38)37-18-34-24-15-20(7-8-25(24)37)21-9-10-33-27(16-21)36-13-11-35(2)12-14-36/h3-10,15-19H,11-14H2,1-2H3,(H2,32,38)/t19-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323093
PNG
((R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2S/c1-19(22-5-3-4-6-23(22)31(32,33)34)42-26-17-28(43-29(26)30(35)41)40-18-37-24-15-20(7-8-25(24)40)21-9-10-36-27(16-21)39-13-11-38(2)12-14-39/h3-10,15-19H,11-14H2,1-2H3,(H2,35,41)/t19-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323094
PNG
((R)-5-(5-(2-morpholinopyridin-4-yl)-1H-benzo[d]imi...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCOCC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H26F3N5O3S/c1-18(21-4-2-3-5-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)39)38-17-36-23-14-19(6-7-24(23)38)20-8-9-35-26(15-20)37-10-12-40-13-11-37/h2-9,14-18H,10-13H2,1H3,(H2,34,39)/t18-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323095
PNG
((R)-5-(5-(2-(2-(dimethylamino)ethylamino)pyridin-4...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCN(C)C)c1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2S/c1-18(21-6-4-5-7-22(21)30(31,32)33)41-25-16-27(42-28(25)29(34)40)39-17-37-23-14-19(8-9-24(23)39)20-10-11-35-26(15-20)36-12-13-38(2)3/h4-11,14-18H,12-13H2,1-3H3,(H2,34,40)(H,35,36)/t18-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323096
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(2-(methy...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NCCS(C)(=O)=O)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H26ClN5O4S2/c1-17(20-5-3-4-6-21(20)29)38-24-15-26(39-27(24)28(30)35)34-16-33-22-13-18(7-8-23(22)34)19-9-10-31-25(14-19)32-11-12-40(2,36)37/h3-10,13-17H,11-12H2,1-2H3,(H2,30,35)(H,31,32)/t17-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323098
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)c1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-17-29(41-30(27)31(33)39)38-18-35-25-15-20(7-8-26(25)38)21-9-12-34-28(16-21)36-22-10-13-37(2)14-11-22/h3-9,12,15-19,22H,10-11,13-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323099
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(6-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccc(NC2CCN(C)CC2)nc1)c1ccccc1Cl
Show InChI InChI=1S/C31H31ClN6O2S/c1-19(23-5-3-4-6-24(23)32)40-27-16-29(41-30(27)31(33)39)38-18-35-25-15-20(7-9-26(25)38)21-8-10-28(34-17-21)36-22-11-13-37(2)14-12-22/h3-10,15-19,22H,11-14H2,1-2H3,(H2,33,39)(H,34,36)/t19-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323105
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(2-(1-methyl...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(NC2CCN(C)CC2)n1)c1ccccc1Cl
Show InChI InChI=1S/C30H30ClN7O2S/c1-18(21-5-3-4-6-22(21)31)40-26-16-27(41-28(26)29(32)39)38-17-34-24-15-19(7-8-25(24)38)23-9-12-33-30(36-23)35-20-10-13-37(2)14-11-20/h3-9,12,15-18,20H,10-11,13-14H2,1-2H3,(H2,32,39)(H,33,35,36)/t18-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50323101
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(1-(3-(dimet...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1cnn(CCCN(C)C)c1)c1ccccc1Cl
Show InChI InChI=1S/C28H29ClN6O2S/c1-18(21-7-4-5-8-22(21)29)37-25-14-26(38-27(25)28(30)36)35-17-31-23-13-19(9-10-24(23)35)20-15-32-34(16-20)12-6-11-33(2)3/h4-5,7-10,13-18H,6,11-12H2,1-3H3,(H2,30,36)/t18-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of PLK1 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50323113
PNG
((R)-5-(5-(pyridin-4-yl)-1H-benzo[d]imidazol-1-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C26H19F3N4O2S/c1-15(18-4-2-3-5-19(18)26(27,28)29)35-22-13-23(36-24(22)25(30)34)33-14-32-20-12-17(6-7-21(20)33)16-8-10-31-11-9-16/h2-15H,1H3,(H2,30,34)/t15-/m1/s1
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n/an/a 8n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full lungth PLK3 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK3


(Homo sapiens (Human))
BDBM50323107
PNG
((R)-3-(1-(2-chlorophenyl)ethoxy)-5-(5-(pyridin-4-y...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccncc1)c1ccccc1Cl
Show InChI InChI=1S/C25H19ClN4O2S/c1-15(18-4-2-3-5-19(18)26)32-22-13-23(33-24(22)25(27)31)30-14-29-20-12-17(6-7-21(20)30)16-8-10-28-11-9-16/h2-15H,1H3,(H2,27,31)/t15-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of full lungth PLK3 by SPA assay


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))
BDBM50323093
PNG
((R)-5-(5-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-...)
Show SMILES C[C@@H](Oc1cc(sc1C(N)=O)-n1cnc2cc(ccc12)-c1ccnc(c1)N1CCN(C)CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C31H29F3N6O2S/c1-19(22-5-3-4-6-23(22)31(32,33)34)42-26-17-28(43-29(26)30(35)41)40-18-37-24-15-20(7-8-25(24)40)21-9-10-36-27(16-21)39-13-11-38(2)12-14-39/h3-10,15-19H,11-14H2,1-2H3,(H2,35,41)/t19-/m1/s1
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CYP2C9 using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate by fluorescence plate reader


Bioorg Med Chem Lett 20: 4587-92 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.009
BindingDB Entry DOI: 10.7270/Q2MS3SZB
More data for this
Ligand-Target Pair