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9 molecules are shown

Wt: 338.4
BDBM28394
Purchase
Wt: 312.3
BDBM28395
Wt: 313.3
BDBM28396
Wt: 338.4
BDBM28397
Wt: 337.4
BDBM28398
Wt: 352.3
BDBM50345242
Wt: 352.3
BDBM50345243
Wt: 366.4
BDBM50345245
Wt: 395.4
BDBM50383272

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 28394,28395,28396,28397,28398,50345242,50345243,50345245,50383272   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28394
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c1-22-8-3-9-23(11-10-22)18-14-20-13-17(21-18)16-5-2-4-15(12-16)6-7-19(24)25/h2,4-7,12-14H,3,8-11H2,1H3,(H,24,25)/b7-6+
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n/an/a 57n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50383272
PNG
(CHEMBL2032375)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1cccc(C=C2SC(O)=NC2=O)c1
Show InChI InChI=1S/C20H21N5O2S/c21-14-4-6-15(7-5-14)23-18-11-22-10-16(24-18)13-3-1-2-12(8-13)9-17-19(26)25-20(27)28-17/h1-3,8-11,14-15H,4-7,21H2,(H,23,24)(H,25,26,27)/t14-,15-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


J Med Chem 55: 2641-8 (2012)


Article DOI: 10.1021/jm2014698
BindingDB Entry DOI: 10.7270/Q2Q2418B
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28396
PNG
((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Show SMILES COCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H19N3O3/c1-23-9-3-8-19-16-12-18-11-15(20-16)14-5-2-4-13(10-14)6-7-17(21)22/h2,4-7,10-12H,3,8-9H2,1H3,(H,19,20)(H,21,22)/b7-6+
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n/an/a 370n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28397
PNG
((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c20-15-5-7-16(8-6-15)22-18-12-21-11-17(23-18)14-3-1-2-13(10-14)4-9-19(24)25/h1-4,9-12,15-16H,5-8,20H2,(H,22,23)(H,24,25)/b9-4+/t15-,16-
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n/an/a 13n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28398
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Show SMILES CN1CCCN(CC1)c1cccc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C20H23N3O2/c1-22-11-4-12-23(14-13-22)19-8-3-7-18(21-19)17-6-2-5-16(15-17)9-10-20(24)25/h2-3,5-10,15H,4,11-14H2,1H3,(H,24,25)/b10-9+
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n/an/a 50n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28394
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c1-22-8-3-9-23(11-10-22)18-14-20-13-17(21-18)16-5-2-4-15(12-16)6-7-19(24)25/h2,4-7,12-14H,3,8-11H2,1H3,(H,24,25)/b7-6+
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n/an/a 40n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28395
PNG
((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+
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n/an/a 22n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28396
PNG
((2E)-3-(3-{6-[(3-methoxypropyl)amino]pyrazin-2-yl}...)
Show SMILES COCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H19N3O3/c1-23-9-3-8-19-16-12-18-11-15(20-16)14-5-2-4-13(10-14)6-7-17(21)22/h2,4-7,10-12H,3,8-9H2,1H3,(H,19,20)(H,21,22)/b7-6+
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n/an/a 480n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28397
PNG
((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c20-15-5-7-16(8-6-15)22-18-12-21-11-17(23-18)14-3-1-2-13(10-14)4-9-19(24)25/h1-4,9-12,15-16H,5-8,20H2,(H,22,23)(H,24,25)/b9-4+/t15-,16-
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n/an/a 12n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28398
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyridin-2...)
Show SMILES CN1CCCN(CC1)c1cccc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C20H23N3O2/c1-22-11-4-12-23(14-13-22)19-8-3-7-18(21-19)17-6-2-5-16(15-17)9-10-20(24)25/h2-3,5-10,15H,4,11-14H2,1H3,(H,24,25)/b10-9+
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n/an/a 46n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345242
PNG
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
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n/an/a 120n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345243
PNG
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
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n/an/a 200n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345245
PNG
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345242
PNG
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345243
PNG
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345245
PNG
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28394
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c1-22-8-3-9-23(11-10-22)18-14-20-13-17(21-18)16-5-2-4-15(12-16)6-7-19(24)25/h2,4-7,12-14H,3,8-11H2,1H3,(H,24,25)/b7-6+
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n/an/a 40n/an/an/an/an/an/a



Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Competitive inhibition of PIM2 in presence of ATP


J Med Chem 55: 8199-208 (2012)


Article DOI: 10.1021/jm3009234
BindingDB Entry DOI: 10.7270/Q2930V9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28394
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c1-22-8-3-9-23(11-10-22)18-14-20-13-17(21-18)16-5-2-4-15(12-16)6-7-19(24)25/h2,4-7,12-14H,3,8-11H2,1H3,(H,24,25)/b7-6+
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Cylene Pharmaceuticals

Curated by ChEMBL


Assay Description
Competitive inhibition of PIM1 in presence of ATP


J Med Chem 55: 8199-208 (2012)


Article DOI: 10.1021/jm3009234
BindingDB Entry DOI: 10.7270/Q2930V9T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28394
PNG
((2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2...)
Show SMILES CN1CCCN(CC1)c1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c1-22-8-3-9-23(11-10-22)18-14-20-13-17(21-18)16-5-2-4-15(12-16)6-7-19(24)25/h2,4-7,12-14H,3,8-11H2,1H3,(H,24,25)/b7-6+
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Article
PubMed
n/an/a 57n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim-1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate preincubated for 15 mins prior substrate addition measured after 45 mins by fluo...


J Med Chem 55: 2641-8 (2012)


Article DOI: 10.1021/jm2014698
BindingDB Entry DOI: 10.7270/Q2Q2418B
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Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28395
PNG
((2E)-3-(3-{6-[(4-aminobutyl)amino]pyrazin-2-yl}phe...)
Show SMILES NCCCCNc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C17H20N4O2/c18-8-1-2-9-20-16-12-19-11-15(21-16)14-5-3-4-13(10-14)6-7-17(22)23/h3-7,10-12H,1-2,8-9,18H2,(H,20,21)(H,22,23)/b7-6+
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n/an/a 33n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair