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13 molecules are shown

Wt: 338.4
BDBM28397
Wt: 239.2
BDBM50345235
Wt: 240.2
BDBM50345236
Wt: 242.2
BDBM50345237
Wt: 352.3
BDBM50345238
Wt: 311.3
BDBM50345239
Wt: 326.3
BDBM50345240
Wt: 326.3
BDBM50345241
Wt: 352.3
BDBM50345242
Wt: 352.3
BDBM50345243
Wt: 338.3
BDBM50345244
Wt: 366.4
BDBM50345245
Wt: 310.3
BDBM50345246

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 28397,50345235,50345236,50345237,50345238,50345239,50345240,50345241,50345242,50345243,50345244,50345245,50345246   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM28397
PNG
((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c20-15-5-7-16(8-6-15)22-18-12-21-11-17(23-18)14-3-1-2-13(10-14)4-9-19(24)25/h1-4,9-12,15-16H,5-8,20H2,(H,22,23)(H,24,25)/b9-4+/t15-,16-
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n/an/a 13n/an/an/an/a7.522



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345246
PNG
(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CNC2)n1
Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22)
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n/an/a 100n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345235
PNG
(5-(pyridin-3-yl)benzofuran-2-carboxylic acid | CHE...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cccnc1
Show InChI InChI=1S/C14H9NO3/c16-14(17)13-7-11-6-9(3-4-12(11)18-13)10-2-1-5-15-8-10/h1-8H,(H,16,17)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345236
PNG
(5-(pyrazin-2-yl)benzofuran-2-carboxylic acid | CHE...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnccn1
Show InChI InChI=1S/C13H8N2O3/c16-13(17)12-6-9-5-8(1-2-11(9)18-12)10-7-14-3-4-15-10/h1-7H,(H,16,17)
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n/an/a 7.40E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345237
PNG
(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)
Show SMILES Cn1cc(cn1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345238
PNG
(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NCC2CCNCC2)n1
Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25)
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n/an/a 380n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345239
PNG
(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22)
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n/an/a 6.00E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345240
PNG
(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)
Show SMILES NCCCCNc1ccnc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345241
PNG
(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)
Show SMILES NCCCCNc1nccc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
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n/an/a 460n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345242
PNG
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
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n/an/a 120n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345243
PNG
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
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n/an/a 200n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345244
PNG
(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CCNCC2)n1
Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24)
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n/an/a 210n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345245
PNG
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
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n/an/a 53n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM50345246
PNG
(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CNC2)n1
Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22)
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n/an/a 450n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345235
PNG
(5-(pyridin-3-yl)benzofuran-2-carboxylic acid | CHE...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cccnc1
Show InChI InChI=1S/C14H9NO3/c16-14(17)13-7-11-6-9(3-4-12(11)18-13)10-2-1-5-15-8-10/h1-8H,(H,16,17)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345236
PNG
(5-(pyrazin-2-yl)benzofuran-2-carboxylic acid | CHE...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnccn1
Show InChI InChI=1S/C13H8N2O3/c16-13(17)12-6-9-5-8(1-2-11(9)18-12)10-7-14-3-4-15-10/h1-7H,(H,16,17)
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n/an/a 1.19E+4n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345237
PNG
(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)
Show SMILES Cn1cc(cn1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345238
PNG
(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NCC2CCNCC2)n1
Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25)
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n/an/a 160n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345239
PNG
(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345240
PNG
(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)
Show SMILES NCCCCNc1ccnc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345241
PNG
(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)
Show SMILES NCCCCNc1nccc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345242
PNG
(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345243
PNG
(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345244
PNG
(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CCNCC2)n1
Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24)
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM50345245
PNG
(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
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Genzyme Corp.

Curated by ChEMBL


Assay Description
Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift method


Bioorg Med Chem Lett 21: 3050-6 (2011)


Article DOI: 10.1016/j.bmcl.2011.03.030
BindingDB Entry DOI: 10.7270/Q2ZP46GG
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM28397
PNG
((2E)-3-(3-{6-[(4-aminocyclohexyl)amino]pyrazin-2-y...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1cccc(\C=C\C(O)=O)c1
Show InChI InChI=1S/C19H22N4O2/c20-15-5-7-16(8-6-15)22-18-12-21-11-17(23-18)14-3-1-2-13(10-14)4-9-19(24)25/h1-4,9-12,15-16H,5-8,20H2,(H,22,23)(H,24,25)/b9-4+/t15-,16-
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Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The activity of Pim kinase was measured in a homogeneous luciferase assay using GST-Pim, biotinylated peptide substrate and a luciferin-luciferase de...


J Med Chem 52: 1814-27 (2009)


Article DOI: 10.1021/jm801242y
BindingDB Entry DOI: 10.7270/Q25T3HS3
More data for this
Ligand-Target Pair