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14 similar compounds to monomer 29921

Wt: 484.3
BDBM29898
Wt: 525.4
BDBM29902
Wt: 471.3
BDBM29913
Wt: 485.3
BDBM29914
Wt: 499.3
BDBM29915
Wt: 539.4
BDBM29916
Wt: 553.4
BDBM29917
Purchase
Wt: 539.4
BDBM29919
Wt: 567.4
BDBM29920
Wt: 525.4
BDBM29922
Wt: 539.4
BDBM29923
Purchase
Wt: 553.4
BDBM29924
Wt: 553.4
BDBM29925
Wt: 565.4
BDBM29926

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 29898,29902,29913,29914,29915,29916,29917,29919,29920,29922,29923,29924,29925,29926   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29898
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 9)
Show SMILES CC(C)(C)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C23H20Cl2FN7/c1-23(2,3)33-12-16(31-32-33)11-28-15-6-17-21(30-14-4-5-20(26)18(24)7-14)13(9-27)10-29-22(17)19(25)8-15/h4-8,10,12,28H,11H2,1-3H3,(H,29,30)
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n/an/a 170n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29902
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 13)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCC5CCCN5)nn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C25H23Cl2FN8/c26-21-9-17(3-4-23(21)28)33-24-15(11-29)12-32-25-20(24)8-18(10-22(25)27)31-13-19-14-36(35-34-19)7-5-16-2-1-6-30-16/h3-4,8-10,12,14,16,30-31H,1-2,5-7,13H2,(H,32,33)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29913
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 24)
Show SMILES NCCn1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C21H17Cl2FN8/c22-17-6-13(1-2-19(17)24)29-20-12(8-26)9-28-21-16(20)5-14(7-18(21)23)27-10-15-11-32(4-3-25)31-30-15/h1-2,5-7,9,11,27H,3-4,10,25H2,(H,28,29)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29914
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 25)
Show SMILES NCCCn1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C22H19Cl2FN8/c23-18-7-14(2-3-20(18)25)30-21-13(9-27)10-29-22-17(21)6-15(8-19(22)24)28-11-16-12-33(32-31-16)5-1-4-26/h2-3,6-8,10,12,28H,1,4-5,11,26H2,(H,29,30)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29915
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 26)
Show SMILES CN(C)CCn1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C23H21Cl2FN8/c1-33(2)5-6-34-13-17(31-32-34)12-28-16-7-18-22(30-15-3-4-21(26)19(24)8-15)14(10-27)11-29-23(18)20(25)9-16/h3-4,7-9,11,13,28H,5-6,12H2,1-2H3,(H,29,30)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29916
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 27)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCC5)nn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C26H25Cl2FN8/c27-22-11-18(4-5-24(22)29)33-25-17(13-30)14-32-26-21(25)10-19(12-23(26)28)31-15-20-16-37(35-34-20)9-8-36-6-2-1-3-7-36/h4-5,10-12,14,16,31H,1-3,6-9,15H2,(H,32,33)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29926
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 37)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(nn4)C4CCN(CC4)C4CCC4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C28H27Cl2FN8/c29-24-11-18(4-5-26(24)31)35-27-17(13-32)14-34-28-23(27)10-19(12-25(28)30)33-15-20-16-39(37-36-20)22-6-8-38(9-7-22)21-2-1-3-21/h4-5,10-12,14,16,21-22,33H,1-3,6-9,15H2,(H,34,35)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29919
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 30)
Show SMILES CN1CCCC1CCn1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C26H25Cl2FN8/c1-36-7-2-3-20(36)6-8-37-15-19(34-35-37)14-31-18-9-21-25(33-17-4-5-24(29)22(27)10-17)16(12-30)13-32-26(21)23(28)11-18/h4-5,9-11,13,15,20,31H,2-3,6-8,14H2,1H3,(H,32,33)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29920
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 31)
Show SMILES CCN1CCC(CCn2cc(CNc3cc(Cl)c4ncc(C#N)c(Nc5ccc(F)c(Cl)c5)c4c3)nn2)CC1
Show InChI InChI=1S/C28H29Cl2FN8/c1-2-38-8-5-18(6-9-38)7-10-39-17-22(36-37-39)16-33-21-11-23-27(35-20-3-4-26(31)24(29)12-20)19(14-32)15-34-28(23)25(30)13-21/h3-4,11-13,15,17-18,33H,2,5-10,16H2,1H3,(H,34,35)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29922
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 33)
Show SMILES CN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C25H23Cl2FN8/c1-35-6-4-19(5-7-35)36-14-18(33-34-36)13-30-17-8-20-24(32-16-2-3-23(28)21(26)9-16)15(11-29)12-31-25(20)22(27)10-17/h2-3,8-10,12,14,19,30H,4-7,13H2,1H3,(H,31,32)
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n/an/a 2.20n/an/an/an/an/an/a



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29923
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 34)
Show SMILES CCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C26H25Cl2FN8/c1-2-36-7-5-20(6-8-36)37-15-19(34-35-37)14-31-18-9-21-25(33-17-3-4-24(29)22(27)10-17)16(12-30)13-32-26(21)23(28)11-18/h3-4,9-11,13,15,20,31H,2,5-8,14H2,1H3,(H,32,33)
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n/an/a 1.60n/an/an/an/an/an/a



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29924
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 35)
Show SMILES CCCN1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C27H27Cl2FN8/c1-2-7-37-8-5-21(6-9-37)38-16-20(35-36-38)15-32-19-10-22-26(34-18-3-4-25(30)23(28)11-18)17(13-31)14-33-27(22)24(29)12-19/h3-4,10-12,14,16,21,32H,2,5-9,15H2,1H3,(H,33,34)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29925
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 36)
Show SMILES CC(C)N1CCC(CC1)n1cc(CNc2cc(Cl)c3ncc(C#N)c(Nc4ccc(F)c(Cl)c4)c3c2)nn1
Show InChI InChI=1S/C27H27Cl2FN8/c1-16(2)37-7-5-21(6-8-37)38-15-20(35-36-38)14-32-19-9-22-26(34-18-3-4-25(30)23(28)10-18)17(12-31)13-33-27(22)24(29)11-19/h3-4,9-11,13,15-16,21,32H,5-8,14H2,1-2H3,(H,33,34)
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Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29917
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 28)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(CCN5CCCCCC5)nn4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C27H27Cl2FN8/c28-23-12-19(5-6-25(23)30)34-26-18(14-31)15-33-27-22(26)11-20(13-24(27)29)32-16-21-17-38(36-35-21)10-9-37-7-3-1-2-4-8-37/h5-6,11-13,15,17,32H,1-4,7-10,16H2,(H,33,34)
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n/an/a 28n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair