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2 similar compounds to monomer 29911

Wt: 504.3
BDBM29899
Wt: 505.3
BDBM29912

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 29899,29912   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29899
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 10)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(nn4)-c4ccccc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C25H16Cl2FN7/c26-21-9-16(6-7-23(21)28)32-24-15(11-29)12-31-25-20(24)8-17(10-22(25)27)30-13-18-14-35(34-33-18)19-4-2-1-3-5-19/h1-10,12,14,30H,13H2,(H,31,32)
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 120n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 8


(Homo sapiens (human))
BDBM29912
PNG
(substituted 6-aminoquinoline-3-carbonitrile, 23)
Show SMILES Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cn(nn4)-c4ccncc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C24H15Cl2FN8/c25-20-8-15(1-2-22(20)27)32-23-14(10-28)11-31-24-19(23)7-16(9-21(24)26)30-12-17-13-35(34-33-17)18-3-5-29-6-4-18/h1-9,11,13,30H,12H2,(H,31,32)
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

AffyNet 
Article
PubMed
n/an/a 3n/an/an/an/a7.230



Wyeth Research



Assay Description
Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...


Bioorg Med Chem Lett 19: 3485-8 (2009)

More data for this
Ligand-Target Pair