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65 similar compounds to monomer 31056

Compile data set for download or QSAR
Wt: 412.4
BDBM30019
Purchase
Wt: 452.5
BDBM30021
Wt: 382.4
BDBM30050
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Wt: 382.4
BDBM30051
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Wt: 412.4
BDBM30052
Wt: 412.4
BDBM30055
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Wt: 412.4
BDBM30056
Wt: 396.4
BDBM30058
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Wt: 352.4
BDBM30060
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Wt: 352.4
BDBM30061
Wt: 352.4
BDBM30062
Wt: 382.4
BDBM30063
Wt: 382.4
BDBM30065
Wt: 382.4
BDBM30066
Wt: 382.4
BDBM30067
Displayed 1 to 15 (of 63 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 30019,30021,30050,30051,30052,30055,30056,30058,30060,30061,30062,30063,30065,30066,30067   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30019
PNG
(BMCL181297 Compound 5F | triazolothiadiazine, 5)
Show SMILES COc1ccc(OC)c(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
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Article
PubMed
n/an/a 6.70n/an/an/an/a7.222



National Human Genome Research Institute



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 19: 3686-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.057
BindingDB Entry DOI: 10.7270/Q2W37TNT
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30067
PNG
(triazolothiadiazine, 6H)
Show SMILES COc1cc(OC)cc(c1)-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C19H18N4O3S/c1-24-13-8-12(9-14(10-13)25-2)18-20-21-19-23(18)22-16(11-27-19)15-6-4-5-7-17(15)26-3/h4-10H,11H2,1-3H3
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PubMed
n/an/a 1.34E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30050
PNG
(triazolothiadiazine, 5B)
Show SMILES COc1cccc(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H18N4O3S/c1-24-14-6-4-5-13(9-14)18-20-21-19-23(18)22-15(11-27-19)12-7-8-16(25-2)17(10-12)26-3/h4-10H,11H2,1-3H3
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PubMed
n/an/a 126n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30051
PNG
(triazolothiadiazine, 5C)
Show SMILES COc1ccc(cc1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C19H18N4O3S/c1-24-14-7-4-12(5-8-14)18-20-21-19-23(18)22-15(11-27-19)13-6-9-16(25-2)17(10-13)26-3/h4-10H,11H2,1-3H3
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PubMed
n/an/a 88.9n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30052
PNG
(triazolothiadiazine, 5D)
Show SMILES COc1ccc(cc1OC)C1=Nn2c(SC1)nnc2-c1cccc(OC)c1OC
Show InChI InChI=1S/C20H20N4O4S/c1-25-15-9-8-12(10-17(15)27-3)14-11-29-20-22-21-19(24(20)23-14)13-6-5-7-16(26-2)18(13)28-4/h5-10H,11H2,1-4H3
PDB
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PubMed
n/an/a 112n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30019
PNG
(BMCL181297 Compound 5F | triazolothiadiazine, 5)
Show SMILES COc1ccc(OC)c(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
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PubMed
n/an/a 10n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30055
PNG
(triazolothiadiazine, 5G)
Show SMILES COc1ccc(cc1OC)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H20N4O4S/c1-25-15-7-5-12(9-17(15)27-3)14-11-29-20-22-21-19(24(20)23-14)13-6-8-16(26-2)18(10-13)28-4/h5-10H,11H2,1-4H3
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PubMed
n/an/a 177n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30056
PNG
(triazolothiadiazine, 5H)
Show SMILES COc1cc(OC)cc(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H20N4O4S/c1-25-14-7-13(8-15(10-14)26-2)19-21-22-20-24(19)23-16(11-29-20)12-5-6-17(27-3)18(9-12)28-4/h5-10H,11H2,1-4H3
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PubMed
n/an/a 50n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30058
PNG
(triazolothiadiazine, 5J)
Show SMILES CCOc1ccccc1-c1nnc2SCC(=Nn12)c1ccc(OC)c(OC)c1
Show InChI InChI=1S/C20H20N4O3S/c1-4-27-16-8-6-5-7-14(16)19-21-22-20-24(19)23-15(12-28-20)13-9-10-17(25-2)18(11-13)26-3/h5-11H,4,12H2,1-3H3
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PubMed
n/an/a 50n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30060
PNG
(triazolothiadiazine, 6A)
Show SMILES COc1ccccc1-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C18H16N4O2S/c1-23-15-9-5-3-7-12(15)14-11-25-18-20-19-17(22(18)21-14)13-8-4-6-10-16(13)24-2/h3-10H,11H2,1-2H3
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PubMed
n/an/a 2.00E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30061
PNG
(triazolothiadiazine, 6B)
Show SMILES COc1cccc(c1)-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C18H16N4O2S/c1-23-13-7-5-6-12(10-13)17-19-20-18-22(17)21-15(11-25-18)14-8-3-4-9-16(14)24-2/h3-10H,11H2,1-2H3
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n/an/a 1.34E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30062
PNG
(triazolothiadiazine, 6C)
Show SMILES COc1ccc(cc1)-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C18H16N4O2S/c1-23-13-9-7-12(8-10-13)17-19-20-18-22(17)21-15(11-25-18)14-5-3-4-6-16(14)24-2/h3-10H,11H2,1-2H3
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PubMed
n/an/a 1.41E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30063
PNG
(triazolothiadiazine, 6D)
Show SMILES COc1cccc(-c2nnc3SCC(=Nn23)c2ccccc2OC)c1OC
Show InChI InChI=1S/C19H18N4O3S/c1-24-15-9-5-4-7-12(15)14-11-27-19-21-20-18(23(19)22-14)13-8-6-10-16(25-2)17(13)26-3/h4-10H,11H2,1-3H3
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PubMed
n/an/a>2.00E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30065
PNG
(triazolothiadiazine, 6F)
Show SMILES COc1ccc(OC)c(c1)-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C19H18N4O3S/c1-24-12-8-9-17(26-3)14(10-12)18-20-21-19-23(18)22-15(11-27-19)13-6-4-5-7-16(13)25-2/h4-10H,11H2,1-3H3
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PubMed
n/an/a 1.96E+4n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30066
PNG
(triazolothiadiazine, 6G)
Show SMILES COc1ccc(cc1OC)-c1nnc2SCC(=Nn12)c1ccccc1OC
Show InChI InChI=1S/C19H18N4O3S/c1-24-15-7-5-4-6-13(15)14-11-27-19-21-20-18(23(19)22-14)12-8-9-16(25-2)17(10-12)26-3/h4-10H,11H2,1-3H3
PDB
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PubMed
n/an/a 8.90E+3n/an/an/an/a7.222



NIH



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 18: 1297-303 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.028
BindingDB Entry DOI: 10.7270/Q2RB72ZX
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A


(Homo sapiens (Human))
BDBM30021
PNG
(triazolothiadiazine, 7)
Show SMILES COc1ccc(OC)c(c1)-c1nnc2SCC(=Nn12)c1ccc(OC)c(OCC2CC2)c1
Show InChI InChI=1S/C23H24N4O4S/c1-28-16-7-9-19(29-2)17(11-16)22-24-25-23-27(22)26-18(13-32-23)15-6-8-20(30-3)21(10-15)31-12-14-4-5-14/h6-11,14H,4-5,12-13H2,1-3H3
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n/an/a 6.10n/an/an/an/a7.222



National Human Genome Research Institute



Assay Description
Inhibition of PDE4A was performed using IMAP technology (Molecular Devices, CA). PDE4A1A mixture was dispensed into 1536-well black/solid bottom assa...


Bioorg Med Chem Lett 19: 3686-92 (2009)


Article DOI: 10.1016/j.bmcl.2009.01.057
BindingDB Entry DOI: 10.7270/Q2W37TNT
More data for this
Ligand-Target Pair