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2 similar compounds to monomer 50298223

Wt: 302.3
BDBM3006
Wt: 260.6
BDBM3005

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 3006,3005   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3005
PNG
(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
PDB
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 160n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM3006
PNG
(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Show SMILES N(c1[nH]nc2ncnc(Nc3ccccc3)c12)c1ccccc1
Show InChI InChI=1S/C17H14N6/c1-3-7-12(8-4-1)20-15-14-16(19-11-18-15)22-23-17(14)21-13-9-5-2-6-10-13/h1-11H,(H3,18,19,20,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


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Article
PubMed
n/an/a 58n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Tyrosine-protein kinase V-ABL


(Abelson murine leukemia virus)
BDBM3005
PNG
(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 410n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3006
PNG
(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Show SMILES N(c1[nH]nc2ncnc(Nc3ccccc3)c12)c1ccccc1
Show InChI InChI=1S/C17H14N6/c1-3-7-12(8-4-1)20-15-14-16(19-11-18-15)22-23-17(14)21-13-9-5-2-6-10-13/h1-11H,(H3,18,19,20,21,22,23)
PDB
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Article
PubMed
n/an/a 6.90E+3n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3005
PNG
(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3006
PNG
(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Show SMILES N(c1[nH]nc2ncnc(Nc3ccccc3)c12)c1ccccc1
Show InChI InChI=1S/C17H14N6/c1-3-7-12(8-4-1)20-15-14-16(19-11-18-15)22-23-17(14)21-13-9-5-2-6-10-13/h1-11H,(H3,18,19,20,21,22,23)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 7.50E+4n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM3005
PNG
(3-((3-Chlorophenyl)amino)-4-amino-1H-pyrazolo[3,4-...)
Show SMILES Nc1ncnc2n[nH]c(Nc3cccc(Cl)c3)c12
Show InChI InChI=1S/C11H9ClN6/c12-6-2-1-3-7(4-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
PDB
MMDB

Reactome pathway
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PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 2.40E+4n/an/an/an/a7.5n/a



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair
Tyrosine-protein kinase V-ABL


(Abelson murine leukemia virus)
BDBM3006
PNG
(3,4-Di-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidine ...)
Show SMILES N(c1[nH]nc2ncnc(Nc3ccccc3)c12)c1ccccc1
Show InChI InChI=1S/C17H14N6/c1-3-7-12(8-4-1)20-15-14-16(19-11-18-15)22-23-17(14)21-13-9-5-2-6-10-13/h1-11H,(H3,18,19,20,21,22,23)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 1.96E+3n/an/an/an/a7.520



Novartis Pharmaceuticals



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 40: 3601-16 (1997)


Article DOI: 10.1021/jm970124v
BindingDB Entry DOI: 10.7270/Q2H70D0N
More data for this
Ligand-Target Pair