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53 similar compounds to monomer 98036

Wt: 382.3
BDBM30632
Wt: 392.4
BDBM30650
Wt: 378.3
BDBM30645
Wt: 390.4
BDBM31312
Wt: 362.3
BDBM30652
Wt: 475.5
BDBM136222
Wt: 418.4
BDBM136218
Wt: 476.5
BDBM136146
Wt: 390.4
BDBM136150
Wt: 432.4
BDBM136217
Wt: 418.4
BDBM136256
Wt: 468.5
BDBM136154
Wt: 496.5
BDBM136155
Wt: 432.4
BDBM136157
Wt: 460.5
BDBM136158
Displayed 1 to 15 (of 53 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 30632,30650,30645,31312,30652,136222,136218,136146,136150,136217,136256,136154,136155,136157,136158   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM30632
PNG
(US8853193, 32-17)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCC(F)F)c12)C(N)=O
Show InChI InChI=1S/C17H14N2O2/c1-19-15-10-6-5-9-13(15)16(20)14(17(19)21)11-18-12-7-3-2-4-8-12/h2-11,18H,1H3/b14-11+
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US Patent
n/an/a 16n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136222
PNG
(US8853193, 32-1 | US8853193, 62)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN(C)C)c2c1C
Show InChI InChI=1S/C22H26FN5O4S/c1-12-17-19(25-11-26-21(17)33-18(12)22(30)31-5)27-15-7-6-14(23)10-16(15)32-13(2)20(29)24-8-9-28(3)4/h6-7,10-11,13H,8-9H2,1-5H3,(H,24,29)(H,25,26,27)
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n/an/a 267n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM30650
PNG
(US8853193, 32-30)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OC(CO)CO)c12)C(N)=O
Show InChI InChI=1S/C18H13N3O2.ClH/c1-12-7-8-14(23-12)10-13(11-19)18(22)21-17-6-2-5-16-15(17)4-3-9-20-16;/h2-10H,1H3,(H,21,22);1H/b13-10+;
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n/an/a 56n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM30652
PNG
(US8853193, 32-32)
Show SMILES Cc1c(sc2ncnc(Nc3ccc(F)cc3OCCO)c12)C(N)=O
Show InChI InChI=1S/C17H17NO2.ClH.H2O/c1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;/h2-6,13,19-20H,7-9H2,1H3;1H;1H2/t13-;;/m1../s1
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n/an/a 27n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM31312
PNG
(US8853193, 32-37)
Show SMILES COCC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C18H19FN4O3S/c1-9(7-25-3)26-13-6-11(19)4-5-12(13)23-17-14-10(2)15(16(20)24)27-18(14)22-8-21-17/h4-6,8-9H,7H2,1-3H3,(H2,20,24)(H,21,22,23)
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n/an/a 8n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136146
PNG
(US8853193, 1-2)
Show SMILES CC(CNC(=O)OC(C)(C)C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C22H25FN4O5S/c1-11(9-24-21(30)32-22(3,4)5)31-15-8-13(23)6-7-14(15)27-18-16-12(2)17(20(28)29)33-19(16)26-10-25-18/h6-8,10-11H,9H2,1-5H3,(H,24,30)(H,28,29)(H,25,26,27)
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n/an/a 52n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136150
PNG
(US8853193, 2-1)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CN)c2c1C
Show InChI InChI=1S/C18H19FN4O3S/c1-9(7-20)26-13-6-11(19)4-5-12(13)23-16-14-10(2)15(18(24)25-3)27-17(14)22-8-21-16/h4-6,8-9H,7,20H2,1-3H3,(H,21,22,23)
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n/an/a 70n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136154
PNG
(US8853193, 3-1)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(C)(=O)=O)c2c1C
Show InChI InChI=1S/C19H21FN4O5S2/c1-10(8-23-31(4,26)27)29-14-7-12(20)5-6-13(14)24-17-15-11(2)16(19(25)28-3)30-18(15)22-9-21-17/h5-7,9-10,23H,8H2,1-4H3,(H,21,22,24)
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n/an/a 41n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136155
PNG
(US8853193, 3-2)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNS(=O)(=O)C(C)C)c2c1C
Show InChI InChI=1S/C21H25FN4O5S2/c1-11(2)33(28,29)25-9-12(3)31-16-8-14(22)6-7-15(16)26-19-17-13(4)18(21(27)30-5)32-20(17)24-10-23-19/h6-8,10-12,25H,9H2,1-5H3,(H,23,24,26)
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n/an/a 204n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136157
PNG
(US8853193, 3-4)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(C)=O)c2c1C
Show InChI InChI=1S/C20H21FN4O4S/c1-10(8-22-12(3)26)29-15-7-13(21)5-6-14(15)25-18-16-11(2)17(20(27)28-4)30-19(16)24-9-23-18/h5-7,9-10H,8H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 261n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136158
PNG
(US8853193, 3-5)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)CNC(=O)C(C)C)c2c1C
Show InChI InChI=1S/C22H25FN4O4S/c1-11(2)20(28)24-9-12(3)31-16-8-14(23)6-7-15(16)27-19-17-13(4)18(22(29)30-5)32-21(17)26-10-25-19/h6-8,10-12H,9H2,1-5H3,(H,24,28)(H,25,26,27)
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n/an/a 443n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136217
PNG
(US8853193, 31-3 | US8853193, 61)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12
Show InChI InChI=1S/C20H21FN4O4S/c1-5-22-18(26)11(3)29-14-8-12(21)6-7-13(14)25-17-15-10(2)16(20(27)28-4)30-19(15)24-9-23-17/h6-9,11H,5H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 77n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136218
PNG
(US8853193, 31-4 | US8853193, 39)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C19H19FN4O4S/c1-4-21-17(25)10(3)28-13-7-11(20)5-6-12(13)24-16-14-9(2)15(19(26)27)29-18(14)23-8-22-16/h5-8,10H,4H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,24)
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n/an/a 19n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136222
PNG
(US8853193, 32-1 | US8853193, 62)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C(=O)NCCN(C)C)c2c1C
Show InChI InChI=1S/C22H26FN5O4S/c1-12-17-19(25-11-26-21(17)33-18(12)22(30)31-5)27-15-7-6-14(23)10-16(15)32-13(2)20(29)24-8-9-28(3)4/h6-7,10-11,13H,8-9H2,1-5H3,(H,24,29)(H,25,26,27)
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n/an/a 267n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136218
PNG
(US8853193, 31-4 | US8853193, 39)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12
Show InChI InChI=1S/C19H19FN4O4S/c1-4-21-17(25)10(3)28-13-7-11(20)5-6-12(13)24-16-14-9(2)15(19(26)27)29-18(14)23-8-22-16/h5-8,10H,4H2,1-3H3,(H,21,25)(H,26,27)(H,22,23,24)
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n/an/a 19n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136256
PNG
(US8853193, 47)
Show SMILES COC(=O)c1sc2ncnc(Nc3ccc(cc3OC(CF)CF)C#N)c2c1C
Show InChI InChI=1S/C19H16F2N4O3S/c1-10-15-17(23-9-24-18(15)29-16(10)19(26)27-2)25-13-4-3-11(8-22)5-14(13)28-12(6-20)7-21/h3-5,9,12H,6-7H2,1-2H3,(H,23,24,25)
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n/an/a 125n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM136217
PNG
(US8853193, 31-3 | US8853193, 61)
Show SMILES CCNC(=O)C(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(=O)OC)c(C)c12
Show InChI InChI=1S/C20H21FN4O4S/c1-5-22-18(26)11(3)29-14-8-12(21)6-7-13(14)25-17-15-10(2)16(20(27)28-4)30-19(15)24-9-23-17/h6-9,11H,5H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 77n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2


(Homo sapiens (Human))
BDBM30645
PNG
(US8853193, 32-28)
Show SMILES CC(CF)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12
Show InChI InChI=1S/C16H10ClN3O2S3/c17-13-7-8-14(23-13)25(21,22)20-11-5-3-10(4-6-11)15-19-12-2-1-9-18-16(12)24-15/h1-9,20H
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n/an/a 3n/an/an/an/a7.430



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...


US Patent US8853193 (2014)


BindingDB Entry DOI: 10.7270/Q2GX4983
More data for this
Ligand-Target Pair