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143 similar compounds to monomer 50041074

Compile data set for download or QSAR
Wt: 492.4
BDBM31199
Wt: 577.5
BDBM31202
Wt: 577.5
BDBM31203
Wt: 575.5
BDBM31204
Wt: 562.5
BDBM119727
Purchase
Wt: 596.4
BDBM112742
Wt: 562.4
BDBM112743
Wt: 562.4
BDBM112744
Wt: 477.3
BDBM112746
Wt: 477.3
BDBM112747
Wt: 575.5
BDBM112748
Wt: 491.3
BDBM112749
Wt: 491.3
BDBM112750
Wt: 519.3
BDBM112751
Wt: 519.3
BDBM112752
Displayed 1 to 15 (of 143 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 31199,31202,31203,31204,119727,112742,112743,112744,112746,112747,112748,112749,112750,112751,112752   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31202
PNG
(JMC493432 Compound 8 | MI-63)
Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m1/s1
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Article
PubMed
1.70n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assay


J Med Chem 52: 7970-3 (2009)


Article DOI: 10.1021/jm901400z
BindingDB Entry DOI: 10.7270/Q2N29X17
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112748
PNG
(US8629141, 15)
Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1
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1.70n/an/an/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...


J Med Chem 57: 10486-98 (2014)


Article DOI: 10.1021/jm501541j
BindingDB Entry DOI: 10.7270/Q2HH6MQK
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31202
PNG
(JMC493432 Compound 8 | MI-63)
Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m1/s1
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3 -11.5n/an/an/an/an/a7.523



University of Michigan



Assay Description
The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...


J Med Chem 49: 3432-5 (2006)


Article DOI: 10.1021/jm051122a
BindingDB Entry DOI: 10.7270/Q24F1P3B
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31199
PNG
(spiro-oxindole, 5)
Show SMILES CN(C)C(=O)[C@@H]1N[C@H](CC(C)(C)C)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C25H28Cl2FN3O2/c1-24(2,3)12-18-25(15-10-9-13(26)11-17(15)29-23(25)33)19(21(30-18)22(32)31(4)5)14-7-6-8-16(27)20(14)28/h6-11,18-19,21,30H,12H2,1-5H3,(H,29,33)/t18-,19+,21-,25+/m1/s1
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38 -10.0n/an/an/an/an/a7.523



University of Michigan



Assay Description
The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...


J Med Chem 49: 3432-5 (2006)


Article DOI: 10.1021/jm051122a
BindingDB Entry DOI: 10.7270/Q24F1P3B
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31204
PNG
(spiro-oxindole, 10)
Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCCCC1
Show InChI InChI=1S/C30H37Cl2FN4O2/c1-29(2,3)17-23-30(20-11-10-18(31)16-22(20)35-28(30)39)24(19-8-7-9-21(32)25(19)33)26(36-23)27(38)34-12-15-37-13-5-4-6-14-37/h7-11,16,23-24,26,36H,4-6,12-15,17H2,1-3H3,(H,34,38)(H,35,39)/t23-,24+,26-,30+/m1/s1
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39 -10.0n/an/an/an/an/a7.523



University of Michigan



Assay Description
The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...


J Med Chem 49: 3432-5 (2006)


Article DOI: 10.1021/jm051122a
BindingDB Entry DOI: 10.7270/Q24F1P3B
More data for this
Ligand-Target Pair
MDM2-MDMX


(Homo sapiens (Human))
BDBM112752
PNG
(US8629141, 19)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25+/m0/s1
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525n/an/an/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-3-beta-3-gamma-2


J Med Chem 60: 2819-2839 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31203
PNG
(spiro-oxindole, 9)
Show SMILES CC(C)(C)C[C@@H]1N[C@@H]([C@@H](c2cccc(Cl)c2F)[C@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m0/s1
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PubMed
4.00E+3 -7.31n/an/an/an/an/a7.523



University of Michigan



Assay Description
The dose-dependent binding experiments were carried out with serial dilutions of the tested compounds in DMSO. A 5 ul sample of the tested samples an...


J Med Chem 49: 3432-5 (2006)


Article DOI: 10.1021/jm051122a
BindingDB Entry DOI: 10.7270/Q24F1P3B
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112752
PNG
(US8629141, 19)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112744
PNG
(US8629141, 11)
Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCOCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C28H30Cl2FN3O4/c29-15-4-9-19-21(14-15)33-26(37)28(19)22(18-2-1-3-20(30)23(18)31)24(34-27(28)10-12-38-13-11-27)25(36)32-16-5-7-17(35)8-6-16/h1-4,9,14,16-17,22,24,34-35H,5-8,10-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28+/m0/s1
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n/an/a<5.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112746
PNG
(US8629141, 13)
Show SMILES CNC(=O)[C@@H]1NC2(CCNCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C23H23Cl2FN4O2/c1-27-20(31)19-17(13-3-2-4-15(25)18(13)26)23(22(30-19)7-9-28-10-8-22)14-6-5-12(24)11-16(14)29-21(23)32/h2-6,11,17,19,28,30H,7-10H2,1H3,(H,27,31)(H,29,32)/t17-,19+,23-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112748
PNG
(US8629141, 15)
Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1
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n/an/a 21n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human His-tagged MDM2 (1 to 118 residues) using FAM tagged p53-based peptide by fluorescence prolarization based protein binding ...


J Med Chem 57: 10486-98 (2014)


Article DOI: 10.1021/jm501541j
BindingDB Entry DOI: 10.7270/Q2HH6MQK
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM31202
PNG
(JMC493432 Compound 8 | MI-63)
Show SMILES CC(C)(C)C[C@H]1N[C@H]([C@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m1/s1
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n/an/a 28.3n/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of his-tagged human recombinant MDM2 binding to p53-based peptide PMDM6-F by fluorescence polarization assay


J Med Chem 52: 7970-3 (2009)


Article DOI: 10.1021/jm901400z
BindingDB Entry DOI: 10.7270/Q2N29X17
More data for this
Ligand-Target Pair
MDM2-MDMX


(Homo sapiens (Human))
BDBM112747
PNG
(US8629141, 14)
Show SMILES CNC(=O)[C@@H]1NC2(CCNCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C23H23Cl2FN4O2/c1-27-20(31)19-17(13-3-2-4-15(25)18(13)26)23(22(30-19)7-9-28-10-8-22)14-6-5-12(24)11-16(14)29-21(23)32/h2-6,11,17,19,28,30H,7-10H2,1H3,(H,27,31)(H,29,32)/t17-,19+,23+/m0/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2


J Med Chem 60: 2819-2839 (2017)

More data for this
Ligand-Target Pair
MDM2-MDMX


(Homo sapiens (Human))
BDBM112752
PNG
(US8629141, 19)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25+/m0/s1
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n/an/a 2.11E+3n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Ro- 15-1788 binding to human GABA-A receptor alpha-5-beta-3-gamma-2 subunits


J Med Chem 60: 2819-2839 (2017)

More data for this
Ligand-Target Pair
MDM2-MDMX


(Homo sapiens (Human))
BDBM112750
PNG
(US8629141, 17)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(C)CC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C24H25Cl2FN4O2/c1-28-21(32)20-18(14-4-3-5-16(26)19(14)27)24(23(30-20)8-10-31(2)11-9-23)15-7-6-13(25)12-17(15)29-22(24)33/h3-7,12,18,20,30H,8-11H2,1-2H3,(H,28,32)(H,29,33)/t18-,20+,24+/m0/s1
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n/an/a>2.00E+3n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of [3H]-Ro- 15-1788 binding to recombinant human gamma-aminobutyric-acid A receptor alpha-1-beta-3-gamma-2


J Med Chem 60: 2819-2839 (2017)

More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112750
PNG
(US8629141, 17)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(C)CC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C24H25Cl2FN4O2/c1-28-21(32)20-18(14-4-3-5-16(26)19(14)27)24(23(30-20)8-10-31(2)11-9-23)15-7-6-13(25)12-17(15)29-22(24)33/h3-7,12,18,20,30H,8-11H2,1-2H3,(H,28,32)(H,29,33)/t18-,20+,24+/m0/s1
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US Patent
n/an/a>5.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112749
PNG
(US8629141, 16)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(C)CC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C24H25Cl2FN4O2/c1-28-21(32)20-18(14-4-3-5-16(26)19(14)27)24(23(30-20)8-10-31(2)11-9-23)15-7-6-13(25)12-17(15)29-22(24)33/h3-7,12,18,20,30H,8-11H2,1-2H3,(H,28,32)(H,29,33)/t18-,20+,24-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112748
PNG
(US8629141, 15)
Show SMILES Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C29H33Cl2FN4O3/c30-18-7-8-20-22(17-18)34-27(38)29(20)23(19-5-4-6-21(31)24(19)32)25(35-28(29)9-2-1-3-10-28)26(37)33-11-12-36-13-15-39-16-14-36/h4-8,17,23,25,35H,1-3,9-16H2,(H,33,37)(H,34,38)/t23-,25+,29+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112747
PNG
(US8629141, 14)
Show SMILES CNC(=O)[C@@H]1NC2(CCNCC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C23H23Cl2FN4O2/c1-27-20(31)19-17(13-3-2-4-15(25)18(13)26)23(22(30-19)7-9-28-10-8-22)14-6-5-12(24)11-16(14)29-21(23)32/h2-6,11,17,19,28,30H,7-10H2,1H3,(H,27,31)(H,29,32)/t17-,19+,23+/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112743
PNG
(US8629141, 10)
Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCOCC2)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C28H30Cl2FN3O4/c29-15-4-9-19-21(14-15)33-26(37)28(19)22(18-2-1-3-20(30)23(18)31)24(34-27(28)10-12-38-13-11-27)25(36)32-16-5-7-17(35)8-6-16/h1-4,9,14,16-17,22,24,34-35H,5-8,10-13H2,(H,32,36)(H,33,37)/t16?,17-,22-,24+,28-/m0/s1
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n/an/a<5.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112742
PNG
(US8629141, 9)
Show SMILES O[C@H]1CCC(CC1)NC(=O)[C@@H]1NC2(CCC(F)(F)CC2)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C29H30Cl2F3N3O3/c30-15-4-9-19-21(14-15)36-26(40)29(19)22(18-2-1-3-20(31)23(18)32)24(25(39)35-16-5-7-17(38)8-6-16)37-27(29)10-12-28(33,34)13-11-27/h1-4,9,14,16-17,22,24,37-38H,5-8,10-13H2,(H,35,39)(H,36,40)/t16?,17-,22-,24+,29+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM112751
PNG
(US8629141, 18)
Show SMILES CNC(=O)[C@@H]1NC2(CCN(CC2)C(C)=O)[C@@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21
Show InChI InChI=1S/C25H25Cl2FN4O3/c1-13(33)32-10-8-24(9-11-32)25(16-7-6-14(26)12-18(16)30-23(25)35)19(21(31-24)22(34)29-2)15-4-3-5-17(27)20(15)28/h3-7,12,19,21,31H,8-11H2,1-2H3,(H,29,34)(H,30,35)/t19-,21+,25-/m0/s1
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n/an/a>5.00E+3n/an/an/an/an/an/a



The Regents of the University of Michigan; Sanofi

US Patent


Assay Description
The binding affinity of the MDM2 inhibitors disclosed herein was determined using a fluorescence polarization-based (FP-based) binding assay using a ...


US Patent US8629141 (2014)


BindingDB Entry DOI: 10.7270/Q2W094KC
More data for this
Ligand-Target Pair