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5 similar compounds to monomer 31074

Compile data set for download or QSAR
Wt: 314.3
BDBM32143
Wt: 357.4
BDBM50372505
Wt: 343.4
BDBM50372506
Wt: 342.4
BDBM50372508
Wt: 414.4
BDBM50429090
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 32143,50372505,50372506,50372508,50429090   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heat shock protein HSP 90-alpha


(Homo sapiens (Human))
BDBM32143
PNG
(4-methyl-N-(6-oxidanylquinolin-8-yl)benzenesulfona...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cc(O)cc2cccnc12
Show InChI InChI=1S/C16H14N2O3S/c1-11-4-6-14(7-5-11)22(20,21)18-15-10-13(19)9-12-3-2-8-17-16(12)15/h2-10,18-19H,1H3
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n/an/a 5.00E+4n/an/an/an/a7.423



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2Q23XM6
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372505
PNG
(CHEMBL401505)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2N)c2nc(C)ccc2c1
Show InChI InChI=1S/C18H19N3O3S/c1-11-4-7-17(15(19)8-11)25(22,23)21-16-10-14(24-3)9-13-6-5-12(2)20-18(13)16/h4-10,21H,19H2,1-3H3
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PubMed
n/an/an/an/a 9.40E+3n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372506
PNG
(CHEMBL256061)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2N)c2ncccc2c1
Show InChI InChI=1S/C17H17N3O3S/c1-11-5-6-16(14(18)8-11)24(21,22)20-15-10-13(23-2)9-12-4-3-7-19-17(12)15/h3-10,20H,18H2,1-2H3
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n/an/an/an/a 4.00E+3n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372508
PNG
(CHEMBL256244)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2nc(C)ccc2c1
Show InChI InChI=1S/C18H18N2O3S/c1-12-4-8-16(9-5-12)24(21,22)20-17-11-15(23-3)10-14-7-6-13(2)19-18(14)17/h4-11,20H,1-3H3
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n/an/an/an/a 2.00E+4n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assay


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
LDL-associated phospholipase A2


(Homo sapiens (Human))
BDBM50429090
PNG
(CHEMBL2335743 | Zinquin-E)
Show SMILES CCOC(=O)COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2nc(C)ccc2c1
Show InChI InChI=1S/C21H22N2O5S/c1-4-27-20(24)13-28-17-11-16-8-7-15(3)22-21(16)19(12-17)23-29(25,26)18-9-5-14(2)6-10-18/h5-12,23H,4,13H2,1-3H3
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



ActivX Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human plasma Lp-PLA2 using 2- thio-PAF as substrate incubated for 20 mins prior to substrate addition measured after 1 hr


Bioorg Med Chem Lett 23: 1553-6 (2013)


Article DOI: 10.1016/j.bmcl.2012.11.048
BindingDB Entry DOI: 10.7270/Q2571DCV
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM50372508
PNG
(CHEMBL256244)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2nc(C)ccc2c1
Show InChI InChI=1S/C18H18N2O3S/c1-12-4-8-16(9-5-12)24(21,22)20-17-11-15(23-3)10-14-7-6-13(2)19-18(14)17/h4-11,20H,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372505
PNG
(CHEMBL401505)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2N)c2nc(C)ccc2c1
Show InChI InChI=1S/C18H19N3O3S/c1-11-4-7-17(15(19)8-11)25(22,23)21-16-10-14(24-3)9-13-6-5-12(2)20-18(13)16/h4-10,21H,19H2,1-3H3
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n/an/an/an/a 3.00E+3n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372506
PNG
(CHEMBL256061)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2N)c2ncccc2c1
Show InChI InChI=1S/C17H17N3O3S/c1-11-5-6-16(14(18)8-11)24(21,22)20-15-10-13(23-2)9-12-4-3-7-19-17(12)15/h3-10,20H,18H2,1-2H3
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n/an/an/an/a 4.00E+3n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
I-kappa-B-alpha


(Homo sapiens (Human))
BDBM50372508
PNG
(CHEMBL256244)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2)c2nc(C)ccc2c1
Show InChI InChI=1S/C18H18N2O3S/c1-12-4-8-16(9-5-12)24(21,22)20-17-11-15(23-3)10-14-7-6-13(2)19-18(14)17/h4-11,20H,1-3H3
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n/an/an/an/a 2.00E+4n/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair
Nuclear factor NF-kappa-B


(Homo sapiens (Human))
BDBM50372506
PNG
(CHEMBL256061)
Show SMILES COc1cc(NS(=O)(=O)c2ccc(C)cc2N)c2ncccc2c1
Show InChI InChI=1S/C17H17N3O3S/c1-11-5-6-16(14(18)8-11)24(21,22)20-15-10-13(23-2)9-12-4-3-7-19-17(12)15/h3-10,20H,18H2,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



Columbia University

Curated by ChEMBL


Assay Description
Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVEC


Bioorg Med Chem Lett 18: 329-35 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.100
BindingDB Entry DOI: 10.7270/Q2348M63
More data for this
Ligand-Target Pair