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14 molecules are shown

Wt: 377.4
BDBM35047
Wt: 333.8
BDBM34985
Wt: 334.8
BDBM34986
Wt: 335.8
BDBM34987
Wt: 335.8
BDBM34988
Wt: 335.8
BDBM34989
Wt: 349.8
BDBM34990
Wt: 349.8
BDBM34991
Wt: 279.7
BDBM34992
Wt: 321.8
BDBM34994
Wt: 341.8
BDBM34995
Wt: 357.8
BDBM34998
Wt: 385.8
BDBM35003
Wt: 259.3
BDBM35006

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 35047,34985,34986,34987,34988,34989,34990,34991,34992,34994,34995,34998,35003,35006   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35047
PNG
(benzothienopyrimidinone deriv., 20b)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1
Show InChI InChI=1S/C21H19N3O2S/c25-15-8-9-24(11-15)12-18-22-19-16-10-14(13-4-2-1-3-5-13)6-7-17(16)27-20(19)21(26)23-18/h1-7,10,15,25H,8-9,11-12H2,(H,22,23,26)/t15-/m0/s1
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3 -11.6n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34988
PNG
(benzothienopyrimidinone deriv., 6e)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14ClN3O2S/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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5 -11.2n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34989
PNG
(benzothienopyrimidinone deriv., 6f)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14ClN3O2S/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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9 -10.9n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM35047
PNG
(benzothienopyrimidinone deriv., 20b)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(ccc4sc3c(=O)[nH]2)-c2ccccc2)C1
Show InChI InChI=1S/C21H19N3O2S/c25-15-8-9-24(11-15)12-18-22-19-16-10-14(13-4-2-1-3-5-13)6-7-17(16)27-20(19)21(26)23-18/h1-7,10,15,25H,8-9,11-12H2,(H,22,23,26)/t15-/m0/s1
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10 -10.9n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34986
PNG
(benzothienopyrimidinone deriv., 6c)
Show SMILES Clc1ccc2sc3c(nc(CN4CCCNC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H15ClN4OS/c16-9-2-3-11-10(6-9)13-14(22-11)15(21)19-12(18-13)7-20-5-1-4-17-8-20/h2-3,6,17H,1,4-5,7-8H2,(H,18,19,21)
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11 -10.8n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34994
PNG
(benzothienopyrimidinone deriv., 6k)
Show SMILES CN(C)CCCc1nc2c3cc(Cl)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C15H16ClN3OS/c1-19(2)7-3-4-12-17-13-10-8-9(16)5-6-11(10)21-14(13)15(20)18-12/h5-6,8H,3-4,7H2,1-2H3,(H,17,18,20)
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11 -10.8n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34985
PNG
(benzothienopyrimidinone deriv., 6b)
Show SMILES Clc1ccc2sc3c(nc(CN4CCCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C16H16ClN3OS/c17-10-4-5-12-11(8-10)14-15(22-12)16(21)19-13(18-14)9-20-6-2-1-3-7-20/h4-5,8H,1-3,6-7,9H2,(H,18,19,21)
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12 -10.7n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34988
PNG
(benzothienopyrimidinone deriv., 6e)
Show SMILES O[C@H]1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14ClN3O2S/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m0/s1
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29 -10.3n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34990
PNG
(benzothienopyrimidinone deriv., 6g)
Show SMILES OC1CCCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C16H16ClN3O2S/c17-9-3-4-12-11(6-9)14-15(23-12)16(22)19-13(18-14)8-20-5-1-2-10(21)7-20/h3-4,6,10,21H,1-2,5,7-8H2,(H,18,19,22)
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33 -10.1n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM35003
PNG
(benzothienopyrimidinone deriv., 6t)
Show SMILES Oc1cccc(CCNCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)c1
Show InChI InChI=1S/C19H16ClN3O2S/c20-12-4-5-15-14(9-12)17-18(26-15)19(25)23-16(22-17)10-21-7-6-11-2-1-3-13(24)8-11/h1-5,8-9,21,24H,6-7,10H2,(H,22,23,25)
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40 -10.1n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34991
PNG
(benzothienopyrimidinone deriv., 6h)
Show SMILES OC1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H16ClN3O2S/c17-9-1-2-12-11(7-9)14-15(23-12)16(22)19-13(18-14)8-20-5-3-10(21)4-6-20/h1-2,7,10,21H,3-6,8H2,(H,18,19,22)
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42 -9.99n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34995
PNG
(benzothienopyrimidinone deriv., 6l)
Show SMILES Clc1ccc2sc3c(nc(CNc4ccccc4)[nH]c3=O)c2c1
Show InChI InChI=1S/C17H12ClN3OS/c18-10-6-7-13-12(8-10)15-16(23-13)17(22)21-14(20-15)9-19-11-4-2-1-3-5-11/h1-8,19H,9H2,(H,20,21,22)
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44 -9.96n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35003
PNG
(benzothienopyrimidinone deriv., 6t)
Show SMILES Oc1cccc(CCNCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)c1
Show InChI InChI=1S/C19H16ClN3O2S/c20-12-4-5-15-14(9-12)17-18(26-15)19(25)23-16(22-17)10-21-7-6-11-2-1-3-13(24)8-11/h1-5,8-9,21,24H,6-7,10H2,(H,22,23,25)
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49 -9.90n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34992
PNG
(benzothienopyrimidinone deriv., 6i)
Show SMILES CNCc1nc2c3cc(Cl)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C12H10ClN3OS/c1-14-5-9-15-10-7-4-6(13)2-3-8(7)18-11(10)12(17)16-9/h2-4,14H,5H2,1H3,(H,15,16,17)
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71 -9.68n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34989
PNG
(benzothienopyrimidinone deriv., 6f)
Show SMILES O[C@@H]1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C15H14ClN3O2S/c16-8-1-2-11-10(5-8)13-14(22-11)15(21)18-12(17-13)7-19-4-3-9(20)6-19/h1-2,5,9,20H,3-4,6-7H2,(H,17,18,21)/t9-/m1/s1
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84 -9.65n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34998
PNG
(benzothienopyrimidinone deriv., 6o)
Show SMILES Oc1ccc(NCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-9-1-6-13-12(7-9)15-16(24-13)17(23)21-14(20-15)8-19-10-2-4-11(22)5-3-10/h1-7,19,22H,8H2,(H,20,21,23)
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107 -9.44n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34986
PNG
(benzothienopyrimidinone deriv., 6c)
Show SMILES Clc1ccc2sc3c(nc(CN4CCCNC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H15ClN4OS/c16-9-2-3-11-10(6-9)13-14(22-11)15(21)19-12(18-13)7-20-5-1-4-17-8-20/h2-3,6,17H,1,4-5,7-8H2,(H,18,19,21)
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138 -9.35n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34985
PNG
(benzothienopyrimidinone deriv., 6b)
Show SMILES Clc1ccc2sc3c(nc(CN4CCCCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C16H16ClN3OS/c17-10-4-5-12-11(8-10)14-15(22-12)16(21)19-13(18-14)9-20-6-2-1-3-7-20/h4-5,8H,1-3,6-7,9H2,(H,18,19,21)
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149 -9.31n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34992
PNG
(benzothienopyrimidinone deriv., 6i)
Show SMILES CNCc1nc2c3cc(Cl)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C12H10ClN3OS/c1-14-5-9-15-10-7-4-6(13)2-3-8(7)18-11(10)12(17)16-9/h2-4,14H,5H2,1H3,(H,15,16,17)
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153 -9.29n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34991
PNG
(benzothienopyrimidinone deriv., 6h)
Show SMILES OC1CCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)CC1
Show InChI InChI=1S/C16H16ClN3O2S/c17-9-1-2-12-11(7-9)14-15(23-12)16(22)19-13(18-14)8-20-5-3-10(21)4-6-20/h1-2,7,10,21H,3-6,8H2,(H,18,19,22)
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206 -9.11n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34994
PNG
(benzothienopyrimidinone deriv., 6k)
Show SMILES CN(C)CCCc1nc2c3cc(Cl)ccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C15H16ClN3OS/c1-19(2)7-3-4-12-17-13-10-8-9(16)5-6-11(10)21-14(13)15(20)18-12/h5-6,8H,3-4,7H2,1-2H3,(H,17,18,20)
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211 -9.10n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM35006
PNG
(benzothienopyrimidinone deriv., 9)
Show SMILES CN(C)Cc1nc2c3ccccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C13H13N3OS/c1-16(2)7-10-14-11-8-5-3-4-6-9(8)18-12(11)13(17)15-10/h3-6H,7H2,1-2H3,(H,14,15,17)
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238 -9.03n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM35006
PNG
(benzothienopyrimidinone deriv., 9)
Show SMILES CN(C)Cc1nc2c3ccccc3sc2c(=O)[nH]1
Show InChI InChI=1S/C13H13N3OS/c1-16(2)7-10-14-11-8-5-3-4-6-9(8)18-12(11)13(17)15-10/h3-6H,7H2,1-2H3,(H,14,15,17)
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296 -8.84n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PIM


(Homo sapiens (Human))
BDBM34987
PNG
(benzothienopyrimidinone deriv., 6d)
Show SMILES Clc1ccc2sc3c(nc(CN4CCOCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14ClN3O2S/c16-9-1-2-11-10(7-9)13-14(22-11)15(20)18-12(17-13)8-19-3-5-21-6-4-19/h1-2,7H,3-6,8H2,(H,17,18,20)
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332 -8.77n/an/an/an/an/a7.523



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34987
PNG
(benzothienopyrimidinone deriv., 6d)
Show SMILES Clc1ccc2sc3c(nc(CN4CCOCC4)[nH]c3=O)c2c1
Show InChI InChI=1S/C15H14ClN3O2S/c16-9-1-2-11-10(7-9)13-14(22-11)15(20)18-12(17-13)8-19-3-5-21-6-4-19/h1-2,7H,3-6,8H2,(H,17,18,20)
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1.25E+3 -8.05n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34995
PNG
(benzothienopyrimidinone deriv., 6l)
Show SMILES Clc1ccc2sc3c(nc(CNc4ccccc4)[nH]c3=O)c2c1
Show InChI InChI=1S/C17H12ClN3OS/c18-10-6-7-13-12(8-10)15-16(23-13)17(22)21-14(20-15)9-19-11-4-2-1-3-5-11/h1-8,19H,9H2,(H,20,21,22)
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>1.42E+3>-7.97n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34990
PNG
(benzothienopyrimidinone deriv., 6g)
Show SMILES OC1CCCN(Cc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)C1
Show InChI InChI=1S/C16H16ClN3O2S/c17-9-3-4-12-11(6-9)14-15(23-12)16(22)19-13(18-14)8-20-5-1-2-10(21)7-20/h3-4,6,10,21H,1-2,5,7-8H2,(H,18,19,22)
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>1.42E+3>-7.97n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (human))
BDBM34998
PNG
(benzothienopyrimidinone deriv., 6o)
Show SMILES Oc1ccc(NCc2nc3c4cc(Cl)ccc4sc3c(=O)[nH]2)cc1
Show InChI InChI=1S/C17H12ClN3O2S/c18-9-1-6-13-12(7-9)15-16(24-13)17(23)21-14(20-15)8-19-10-2-4-11(22)5-3-10/h1-7,19,22H,8H2,(H,20,21,23)
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>1.42E+3>-7.97n/an/an/an/an/an/a25



Abbott Laboratories



Assay Description
In 384-well v-bottom polypropylene plates, compound (2% DMSO) was mixed with Pim kinase and peptide substrate, followed by immediate initiation with ...


J Med Chem 52: 6621-36 (2009)


Article DOI: 10.1021/jm900943h
BindingDB Entry DOI: 10.7270/Q27P8WQW
More data for this
Ligand-Target Pair