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6 similar compounds to monomer 35094

Compile data set for download or QSAR
Wt: 485.4
BDBM35088
Wt: 471.4
BDBM35090
Wt: 471.4
BDBM35091
Wt: 437.4
BDBM35093
Wt: 437.4
BDBM35095
Wt: 409.4
BDBM35096

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 35088,35090,35091,35093,35095,35096   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35096
PNG
(biarylether alcohol quinoline, 5g)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2ccc(CO)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(6-3-7-21(23)24(25,26)27)22(15)17-4-2-5-19(12-17)30-18-10-8-16(14-29)9-11-18/h2-13,29H,14H2,1H3
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n/an/a 31n/a 1.37E+3n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35088
PNG
(biarylether alcohol quinoline, 5a)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(Cc3ccccc3)cnc3c(cccc23)C(F)(F)F)c1
Show InChI InChI=1S/C30H22F3NO2/c31-30(32,33)27-14-6-13-26-28(23(18-34-29(26)27)15-20-7-2-1-3-8-20)22-10-5-12-25(17-22)36-24-11-4-9-21(16-24)19-35/h1-14,16-18,35H,15,19H2
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n/an/a 75n/an/an/an/an/an/a



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35090
PNG
(biarylether alcohol quinoline, 5c)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)c1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-14-6-13-24-27(25(17-33-28(24)26)20-8-2-1-3-9-20)21-10-5-12-23(16-21)35-22-11-4-7-19(15-22)18-34/h1-17,34H,18H2
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n/an/a 47n/an/an/an/an/an/a



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35091
PNG
(biarylether alcohol quinoline, 5d)
Show SMILES OCc1ccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)cc1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-11-5-10-24-27(25(17-33-28(24)26)20-6-2-1-3-7-20)21-8-4-9-23(16-21)35-22-14-12-19(18-34)13-15-22/h1-17,34H,18H2
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Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35093
PNG
(3-methyl quinoline, 8b)
Show SMILES COC(=O)c1cccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)c1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(10-5-11-21(23)25(26,27)28)22(15)16-6-3-8-18(12-16)32-19-9-4-7-17(13-19)24(30)31-2/h3-14H,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35095
PNG
(3-methyl quinoline, 8c)
Show SMILES COC(=O)c1ccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(7-4-8-21(23)25(26,27)28)22(15)17-5-3-6-19(13-17)32-18-11-9-16(10-12-18)24(30)31-2/h3-14H,1-2H3
PDB
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Article
PubMed
n/an/a>1.00E+3n/an/an/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35096
PNG
(biarylether alcohol quinoline, 5g)
Show SMILES Cc1cnc2c(cccc2c1-c1cccc(Oc2ccc(CO)cc2)c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3NO2/c1-15-13-28-23-20(6-3-7-21(23)24(25,26)27)22(15)17-4-2-5-19(12-17)30-18-10-8-16(14-29)9-11-18/h2-13,29H,14H2,1H3
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n/an/a 131n/an/an/an/an/an/a



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35088
PNG
(biarylether alcohol quinoline, 5a)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(Cc3ccccc3)cnc3c(cccc23)C(F)(F)F)c1
Show InChI InChI=1S/C30H22F3NO2/c31-30(32,33)27-14-6-13-26-28(23(18-34-29(26)27)15-20-7-2-1-3-8-20)22-10-5-12-25(17-22)36-24-11-4-9-21(16-24)19-35/h1-14,16-18,35H,15,19H2
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n/an/a 11.7n/a 1.03E+3n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35090
PNG
(biarylether alcohol quinoline, 5c)
Show SMILES OCc1cccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)c1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-14-6-13-24-27(25(17-33-28(24)26)20-8-2-1-3-9-20)21-10-5-12-23(16-21)35-22-11-4-7-19(15-22)18-34/h1-17,34H,18H2
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n/an/a 14n/a 210n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35091
PNG
(biarylether alcohol quinoline, 5d)
Show SMILES OCc1ccc(Oc2cccc(c2)-c2c(cnc3c(cccc23)C(F)(F)F)-c2ccccc2)cc1
Show InChI InChI=1S/C29H20F3NO2/c30-29(31,32)26-11-5-10-24-27(25(17-33-28(24)26)20-6-2-1-3-7-20)21-8-4-9-23(16-21)35-22-14-12-19(18-34)13-15-22/h1-17,34H,18H2
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n/an/a 10n/a 646n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor beta (LXR-beta)


(Homo sapiens (Human))
BDBM35093
PNG
(3-methyl quinoline, 8b)
Show SMILES COC(=O)c1cccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)c1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(10-5-11-21(23)25(26,27)28)22(15)16-6-3-8-18(12-16)32-19-9-4-7-17(13-19)24(30)31-2/h3-14H,1-2H3
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n/an/a 435n/a 3.40E+3n/an/a7.44



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair
Liver X Receptor alpha (LXR-alpha)


(Homo sapiens (Human))
BDBM35095
PNG
(3-methyl quinoline, 8c)
Show SMILES COC(=O)c1ccc(Oc2cccc(c2)-c2c(C)cnc3c(cccc23)C(F)(F)F)cc1
Show InChI InChI=1S/C25H18F3NO3/c1-15-14-29-23-20(7-4-8-21(23)25(26,27)28)22(15)17-5-3-6-19(13-17)32-18-11-9-16(10-12-18)24(30)31-2/h3-14H,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Wyeth Research



Assay Description
Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRalpha coated flash plates. Each concentration of...


Bioorg Med Chem 17: 8086-92 (2009)


Article DOI: 10.1016/j.bmc.2009.10.001
BindingDB Entry DOI: 10.7270/Q2VH5M54
More data for this
Ligand-Target Pair