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17 similar compounds to monomer 21

Compile data set for download or QSAR
Wt: 504.3
BDBM4658
Wt: 487.3
BDBM4664
Wt: 430.9
BDBM4668
Wt: 410.4
BDBM4669
Wt: 426.4
BDBM4671
Wt: 493.3
BDBM4673
Wt: 461.3
BDBM4675
Purchase
Wt: 396.4
BDBM4676
Wt: 479.3
BDBM4678
Wt: 489.3
BDBM4680
Wt: 475.3
BDBM4681
Wt: 475.3
BDBM4683
Wt: 475.3
BDBM4684
Wt: 463.3
BDBM50380450
Wt: 463.3
BDBM50380471
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 4658,4664,4668,4669,4671,4673,4675,4676,4678,4680,4681,4683,4684,50380450,50380471   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4658
PNG
(4-Anilinoquinazoline 5 | N-(4-bromo-2-fluorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C23H27BrFN5O2/c1-29-7-9-30(10-8-29)6-3-11-32-22-14-20-17(13-21(22)31-2)23(27-15-26-20)28-19-5-4-16(24)12-18(19)25/h4-5,12-15H,3,6-11H2,1-2H3,(H,26,27,28)
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n/an/a 550n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM50380471
PNG
(CHEMBL2018766)
Show SMILES CCN(CC)CCOc1cc2ncnc(Nc3ccc(Br)cc3F)c2cc1OC
Show InChI InChI=1S/C21H24BrFN4O2/c1-4-27(5-2)8-9-29-20-12-18-15(11-19(20)28-3)21(25-13-24-18)26-17-7-6-14(22)10-16(17)23/h6-7,10-13H,4-5,8-9H2,1-3H3,(H,24,25,26)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Univ. Lille Nord de France

Curated by ChEMBL


Assay Description
Inhibition of recombinant human VEGFR-2 using poly(Glu4/Tyr) and [gamma32P]ATP as substrate after 1 hr by scintillation counting


J Med Chem 55: 1189-204 (2012)


Article DOI: 10.1021/jm2013453
BindingDB Entry DOI: 10.7270/Q2086695
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4668
PNG
(4-Anilinoquinazoline 15 | N-(4-chloro-2-fluorophen...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 2.00E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4669
PNG
(4-Anilinoquinazoline 16 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O2/c1-15-4-5-19(18(24)10-15)27-23-17-11-21(29-3)22(12-20(17)25-14-26-23)30-13-16-6-8-28(2)9-7-16/h4-5,10-12,14,16H,6-9,13H2,1-3H3,(H,25,26,27)
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n/an/a 500n/an/an/an/a7.422



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4671
PNG
(4-Anilinoquinazoline 18 | 4-fluoro-5-({6-methoxy-7...)
Show SMILES COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O3/c1-14-8-17(24)19(10-20(14)29)27-23-16-9-21(30-3)22(11-18(16)25-13-26-23)31-12-15-4-6-28(2)7-5-15/h8-11,13,15,29H,4-7,12H2,1-3H3,(H,25,26,27)
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n/an/a 25n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4673
PNG
(4-Anilinoquinazoline 20 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-29-5-3-13(4-6-29)11-31-20-10-18-15(9-19(20)30-2)22(27-12-26-18)28-21-16(24)7-14(23)8-17(21)25/h7-10,12-13H,3-6,11H2,1-2H3,(H,26,27,28)
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n/an/a 500n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4675
PNG
(4-Anilinoquinazoline 22 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H22BrFN4O2/c1-28-19-9-15-18(10-20(19)29-11-13-4-6-24-7-5-13)25-12-26-21(15)27-17-3-2-14(22)8-16(17)23/h2-3,8-10,12-13,24H,4-7,11H2,1H3,(H,25,26,27)
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n/an/a 900n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4676
PNG
(4-Anilinoquinazoline 23 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C22H25FN4O2/c1-14-3-4-18(17(23)9-14)27-22-16-10-20(28-2)21(11-19(16)25-13-26-22)29-12-15-5-7-24-8-6-15/h3-4,9-11,13,15,24H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 700n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4678
PNG
(4-Anilinoquinazoline 25 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H21BrF2N4O2/c1-29-18-8-14-17(9-19(18)30-10-12-2-4-25-5-3-12)26-11-27-21(14)28-20-15(23)6-13(22)7-16(20)24/h6-9,11-12,25H,2-5,10H2,1H3,(H,26,27,28)
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n/an/a 800n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4680
PNG
(4-Anilinoquinazoline 27 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCN(C)CC1
Show InChI InChI=1S/C23H26BrFN4O2/c1-29-8-5-15(6-9-29)7-10-31-22-13-20-17(12-21(22)30-2)23(27-14-26-20)28-19-4-3-16(24)11-18(19)25/h3-4,11-15H,5-10H2,1-2H3,(H,26,27,28)
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n/an/a 150n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4681
PNG
(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCNCC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-29-20-11-16-19(12-21(20)30-9-6-14-4-7-25-8-5-14)26-13-27-22(16)28-18-3-2-15(23)10-17(18)24/h2-3,10-14,25H,4-9H2,1H3,(H,26,27,28)
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n/an/a 200n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4683
PNG
(4-Anilinoquinazoline 30 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m1/s1
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n/an/a 500n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor


(Homo sapiens (human))
BDBM4684
PNG
(4-Anilinoquinazoline 31 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m0/s1
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n/an/a 500n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4658
PNG
(4-Anilinoquinazoline 5 | N-(4-bromo-2-fluorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C23H27BrFN5O2/c1-29-7-9-30(10-8-29)6-3-11-32-22-14-20-17(13-21(22)31-2)23(27-15-26-20)28-19-5-4-16(24)12-18(19)25/h4-5,12-15H,3,6-11H2,1-2H3,(H,26,27,28)
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n/an/a 9n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4664
PNG
(4-Anilinoquinazoline 11 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC\C=C\CN1CCCC1
Show InChI InChI=1S/C23H24BrFN4O2/c1-30-21-13-17-20(14-22(21)31-11-5-4-10-29-8-2-3-9-29)26-15-27-23(17)28-19-7-6-16(24)12-18(19)25/h4-7,12-15H,2-3,8-11H2,1H3,(H,26,27,28)/b5-4+
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n/an/a 8n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4668
PNG
(4-Anilinoquinazoline 15 | N-(4-chloro-2-fluorophen...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 15n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4669
PNG
(4-Anilinoquinazoline 16 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O2/c1-15-4-5-19(18(24)10-15)27-23-17-11-21(29-3)22(12-20(17)25-14-26-23)30-13-16-6-8-28(2)9-7-16/h4-5,10-12,14,16H,6-9,13H2,1-3H3,(H,25,26,27)
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n/an/a 25n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4671
PNG
(4-Anilinoquinazoline 18 | 4-fluoro-5-({6-methoxy-7...)
Show SMILES COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O3/c1-14-8-17(24)19(10-20(14)29)27-23-16-9-21(30-3)22(11-18(16)25-13-26-23)31-12-15-4-6-28(2)7-5-15/h8-11,13,15,29H,4-7,12H2,1-3H3,(H,25,26,27)
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AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4673
PNG
(4-Anilinoquinazoline 20 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-29-5-3-13(4-6-29)11-31-20-10-18-15(9-19(20)30-2)22(27-12-26-18)28-21-16(24)7-14(23)8-17(21)25/h7-10,12-13H,3-6,11H2,1-2H3,(H,26,27,28)
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n/an/a 10n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4675
PNG
(4-Anilinoquinazoline 22 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H22BrFN4O2/c1-28-19-9-15-18(10-20(19)29-11-13-4-6-24-7-5-13)25-12-26-21(15)27-17-3-2-14(22)8-16(17)23/h2-3,8-10,12-13,24H,4-7,11H2,1H3,(H,25,26,27)
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n/an/a 70n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4676
PNG
(4-Anilinoquinazoline 23 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C22H25FN4O2/c1-14-3-4-18(17(23)9-14)27-22-16-10-20(28-2)21(11-19(16)25-13-26-22)29-12-15-5-7-24-8-6-15/h3-4,9-11,13,15,24H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 30n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4678
PNG
(4-Anilinoquinazoline 25 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H21BrF2N4O2/c1-29-18-8-14-17(9-19(18)30-10-12-2-4-25-5-3-12)26-11-27-21(14)28-20-15(23)6-13(22)7-16(20)24/h6-9,11-12,25H,2-5,10H2,1H3,(H,26,27,28)
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n/an/a 15n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4680
PNG
(4-Anilinoquinazoline 27 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCN(C)CC1
Show InChI InChI=1S/C23H26BrFN4O2/c1-29-8-5-15(6-9-29)7-10-31-22-13-20-17(12-21(22)30-2)23(27-14-26-20)28-19-4-3-16(24)11-18(19)25/h3-4,11-15H,5-10H2,1-2H3,(H,26,27,28)
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n/an/a 6n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4681
PNG
(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCNCC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-29-20-11-16-19(12-21(20)30-9-6-14-4-7-25-8-5-14)26-13-27-22(16)28-18-3-2-15(23)10-17(18)24/h2-3,10-14,25H,4-9H2,1H3,(H,26,27,28)
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n/an/a 40n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4683
PNG
(4-Anilinoquinazoline 30 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m1/s1
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n/an/a 1n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM4684
PNG
(4-Anilinoquinazoline 31 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m0/s1
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n/an/a 10n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4658
PNG
(4-Anilinoquinazoline 5 | N-(4-bromo-2-fluorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C23H27BrFN5O2/c1-29-7-9-30(10-8-29)6-3-11-32-22-14-20-17(13-21(22)31-2)23(27-15-26-20)28-19-5-4-16(24)12-18(19)25/h4-5,12-15H,3,6-11H2,1-2H3,(H,26,27,28)
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n/an/a 2.00E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4664
PNG
(4-Anilinoquinazoline 11 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC\C=C\CN1CCCC1
Show InChI InChI=1S/C23H24BrFN4O2/c1-30-21-13-17-20(14-22(21)31-11-5-4-10-29-8-2-3-9-29)26-15-27-23(17)28-19-7-6-16(24)12-18(19)25/h4-7,12-15H,2-3,8-11H2,1H3,(H,26,27,28)/b5-4+
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n/an/a 2.10E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4668
PNG
(4-Anilinoquinazoline 15 | N-(4-chloro-2-fluorophen...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 4.30E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4669
PNG
(4-Anilinoquinazoline 16 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O2/c1-15-4-5-19(18(24)10-15)27-23-17-11-21(29-3)22(12-20(17)25-14-26-23)30-13-16-6-8-28(2)9-7-16/h4-5,10-12,14,16H,6-9,13H2,1-3H3,(H,25,26,27)
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n/an/a 1.35E+4n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4671
PNG
(4-Anilinoquinazoline 18 | 4-fluoro-5-({6-methoxy-7...)
Show SMILES COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O3/c1-14-8-17(24)19(10-20(14)29)27-23-16-9-21(30-3)22(11-18(16)25-13-26-23)31-12-15-4-6-28(2)7-5-15/h8-11,13,15,29H,4-7,12H2,1-3H3,(H,25,26,27)
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n/an/a 1.50E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4673
PNG
(4-Anilinoquinazoline 20 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-29-5-3-13(4-6-29)11-31-20-10-18-15(9-19(20)30-2)22(27-12-26-18)28-21-16(24)7-14(23)8-17(21)25/h7-10,12-13H,3-6,11H2,1-2H3,(H,26,27,28)
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n/an/a 1.50E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4675
PNG
(4-Anilinoquinazoline 22 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H22BrFN4O2/c1-28-19-9-15-18(10-20(19)29-11-13-4-6-24-7-5-13)25-12-26-21(15)27-17-3-2-14(22)8-16(17)23/h2-3,8-10,12-13,24H,4-7,11H2,1H3,(H,25,26,27)
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n/an/a 6.00E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4676
PNG
(4-Anilinoquinazoline 23 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C22H25FN4O2/c1-14-3-4-18(17(23)9-14)27-22-16-10-20(28-2)21(11-19(16)25-13-26-22)29-12-15-5-7-24-8-6-15/h3-4,9-11,13,15,24H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 1.23E+4n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4678
PNG
(4-Anilinoquinazoline 25 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H21BrF2N4O2/c1-29-18-8-14-17(9-19(18)30-10-12-2-4-25-5-3-12)26-11-27-21(14)28-20-15(23)6-13(22)7-16(20)24/h6-9,11-12,25H,2-5,10H2,1H3,(H,26,27,28)
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n/an/a 1.90E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4680
PNG
(4-Anilinoquinazoline 27 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCN(C)CC1
Show InChI InChI=1S/C23H26BrFN4O2/c1-29-8-5-15(6-9-29)7-10-31-22-13-20-17(12-21(22)30-2)23(27-14-26-20)28-19-4-3-16(24)11-18(19)25/h3-4,11-15H,5-10H2,1-2H3,(H,26,27,28)
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n/an/a 2.10E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4681
PNG
(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCNCC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-29-20-11-16-19(12-21(20)30-9-6-14-4-7-25-8-5-14)26-13-27-22(16)28-18-3-2-15(23)10-17(18)24/h2-3,10-14,25H,4-9H2,1H3,(H,26,27,28)
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n/an/a 2.70E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4683
PNG
(4-Anilinoquinazoline 30 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM4684
PNG
(4-Anilinoquinazoline 31 | N-(4-bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@H]1CCCN(C)C1
Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-3-4-14(11-28)12-30-21-10-19-16(9-20(21)29-2)22(26-13-25-19)27-18-6-5-15(23)8-17(18)24/h5-6,8-10,13-14H,3-4,7,11-12H2,1-2H3,(H,25,26,27)/t14-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit FGFR-1 TK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4658
PNG
(4-Anilinoquinazoline 5 | N-(4-bromo-2-fluorophenyl...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C23H27BrFN5O2/c1-29-7-9-30(10-8-29)6-3-11-32-22-14-20-17(13-21(22)31-2)23(27-15-26-20)28-19-5-4-16(24)12-18(19)25/h4-5,12-15H,3,6-11H2,1-2H3,(H,26,27,28)
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n/an/a 100n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4664
PNG
(4-Anilinoquinazoline 11 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC\C=C\CN1CCCC1
Show InChI InChI=1S/C23H24BrFN4O2/c1-30-21-13-17-20(14-22(21)31-11-5-4-10-29-8-2-3-9-29)26-15-27-23(17)28-19-7-6-16(24)12-18(19)25/h4-7,12-15H,2-3,8-11H2,1H3,(H,26,27,28)/b5-4+
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n/an/a 100n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4668
PNG
(4-Anilinoquinazoline 15 | N-(4-chloro-2-fluorophen...)
Show SMILES COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H24ClFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 300n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4669
PNG
(4-Anilinoquinazoline 16 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O2/c1-15-4-5-19(18(24)10-15)27-23-17-11-21(29-3)22(12-20(17)25-14-26-23)30-13-16-6-8-28(2)9-7-16/h4-5,10-12,14,16H,6-9,13H2,1-3H3,(H,25,26,27)
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n/an/a 1.00E+3n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4671
PNG
(4-Anilinoquinazoline 18 | 4-fluoro-5-({6-methoxy-7...)
Show SMILES COc1cc2c(Nc3cc(O)c(C)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C23H27FN4O3/c1-14-8-17(24)19(10-20(14)29)27-23-16-9-21(30-3)22(11-18(16)25-13-26-23)31-12-15-4-6-28(2)7-5-15/h8-11,13,15,29H,4-7,12H2,1-3H3,(H,25,26,27)
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n/an/a 300n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4673
PNG
(4-Anilinoquinazoline 20 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C22H23BrF2N4O2/c1-29-5-3-13(4-6-29)11-31-20-10-18-15(9-19(20)30-2)22(27-12-26-18)28-21-16(24)7-14(23)8-17(21)25/h7-10,12-13H,3-6,11H2,1-2H3,(H,26,27,28)
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n/an/a 300n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4675
PNG
(4-Anilinoquinazoline 22 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H22BrFN4O2/c1-28-19-9-15-18(10-20(19)29-11-13-4-6-24-7-5-13)25-12-26-21(15)27-17-3-2-14(22)8-16(17)23/h2-3,8-10,12-13,24H,4-7,11H2,1H3,(H,25,26,27)
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n/an/a 200n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4676
PNG
(4-Anilinoquinazoline 23 | N-(2-fluoro-4-methylphen...)
Show SMILES COc1cc2c(Nc3ccc(C)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C22H25FN4O2/c1-14-3-4-18(17(23)9-14)27-22-16-10-20(28-2)21(11-19(16)25-13-26-22)29-12-15-5-7-24-8-6-15/h3-4,9-11,13,15,24H,5-8,12H2,1-2H3,(H,25,26,27)
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n/an/a 500n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4678
PNG
(4-Anilinoquinazoline 25 | N-(4-bromo-2,6-difluorop...)
Show SMILES COc1cc2c(Nc3c(F)cc(Br)cc3F)ncnc2cc1OCC1CCNCC1
Show InChI InChI=1S/C21H21BrF2N4O2/c1-29-18-8-14-17(9-19(18)30-10-12-2-4-25-5-3-12)26-11-27-21(14)28-20-15(23)6-13(22)7-16(20)24/h6-9,11-12,25H,2-5,10H2,1H3,(H,26,27,28)
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n/an/a 450n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4680
PNG
(4-Anilinoquinazoline 27 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCN(C)CC1
Show InChI InChI=1S/C23H26BrFN4O2/c1-29-8-5-15(6-9-29)7-10-31-22-13-20-17(12-21(22)30-2)23(27-14-26-20)28-19-4-3-16(24)11-18(19)25/h3-4,11-15H,5-10H2,1-2H3,(H,26,27,28)
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n/an/a 200n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (human))
BDBM4681
PNG
(4-Anilinoquinazoline 28 | N-(4-Bromo-2-fluoropheny...)
Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCC1CCNCC1
Show InChI InChI=1S/C22H24BrFN4O2/c1-29-20-11-16-19(12-21(20)30-9-6-14-4-7-25-8-5-14)26-13-27-22(16)28-18-3-2-15(23)10-17(18)24/h2-3,10-14,25H,4-9H2,1H3,(H,26,27,28)
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n/an/a 200n/an/an/an/an/a25



AstraZeneca



Assay Description
An ELISA assay was used to determine the ability of inhibitor to inhibit EGF-R RTK activity. The compounds were incubated with enzyme 20 min at room ...


J Med Chem 45: 1300-12 (2002)


Article DOI: 10.1021/jm011022e
BindingDB Entry DOI: 10.7270/Q29C6VMW
More data for this
Ligand-Target Pair
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