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73 similar compounds to monomer 145314

Compile data set for download or QSAR
Wt: 417.8
BDBM145347
Wt: 415.9
BDBM145366
Wt: 377.8
BDBM145263
Wt: 423.8
BDBM145521
Wt: 403.7
BDBM145302
Wt: 440.9
BDBM145410
Wt: 415.9
BDBM145519
Wt: 472.8
BDBM145312
Wt: 403.8
BDBM145316
Wt: 399.8
BDBM145320
Wt: 433.8
BDBM145530
Wt: 429.8
BDBM145532
Wt: 389.7
BDBM145324
Wt: 450.3
BDBM145325
Wt: 349.8
BDBM145326
Displayed 1 to 15 (of 73 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 145347,145366,145263,145521,145302,145410,145519,145312,145316,145320,145530,145532,145324,145325,145326   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145263
PNG
(US8952169, 114 | US8952169, 42)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F
Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-8-13(17)15(9-14(12)18)23-10-11-6-4-2-3-5-7-11/h8-9,11H,2-7,10H2,1H3,(H,19,20)
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US Patent
n/an/a 44n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 3.60n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145312
PNG
(US8952169, 91)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2C[C@@H]3CC[C@H](C2)N3CC(F)(F)F)cc1F
Show InChI InChI=1S/C18H21ClF4N2O4S/c1-30(27,28)24-17(26)13-6-14(19)16(7-15(13)20)29-8-10-4-11-2-3-12(5-10)25(11)9-18(21,22)23/h6-7,10-12H,2-5,8-9H2,1H3,(H,24,26)/t10-,11-,12+
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n/an/a 1.21E+3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145316
PNG
(US8952169, 95)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC3(CCC3)CC2)cc1F
Show InChI InChI=1S/C18H23ClFNO4S/c1-26(23,24)21-17(22)13-9-14(19)16(10-15(13)20)25-11-12-3-7-18(8-4-12)5-2-6-18/h9-10,12H,2-8,11H2,1H3,(H,21,22)
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n/an/a 17n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145320
PNG
(US8952169, 99)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC(F)(F)CC2)cc1F
Show InChI InChI=1S/C15H17ClF3NO4S/c1-25(22,23)20-14(21)10-6-11(16)13(7-12(10)17)24-8-9-2-4-15(18,19)5-3-9/h6-7,9H,2-5,8H2,1H3,(H,20,21)
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n/an/a 558n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145324
PNG
(US8952169, 103)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C13H12ClF4NO4S/c1-24(21,22)19-11(20)7-4-8(14)10(5-9(7)15)23-6-12(2-3-12)13(16,17)18/h4-5H,2-3,6H2,1H3,(H,19,20)
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n/an/a 603n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145325
PNG
(US8952169, 104)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(Cl)(C4)C2)C3)cc1F
Show InChI InChI=1S/C19H22Cl2FNO4S/c1-28(25,26)23-17(24)13-3-14(20)16(4-15(13)22)27-10-18-5-11-2-12(6-18)8-19(21,7-11)9-18/h3-4,11-12H,2,5-10H2,1H3,(H,23,24)
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n/an/a 53n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145326
PNG
(US8952169, 105)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCC2)cc1F
Show InChI InChI=1S/C14H17ClFNO4S/c1-22(19,20)17-14(18)10-6-11(15)13(7-12(10)16)21-8-9-4-2-3-5-9/h6-7,9H,2-5,8H2,1H3,(H,17,18)
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n/an/a 264n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145263
PNG
(US8952169, 114 | US8952169, 42)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F
Show InChI InChI=1S/C16H21ClFNO4S/c1-24(21,22)19-16(20)12-8-13(17)15(9-14(12)18)23-10-11-6-4-2-3-5-7-11/h8-9,11H,2-7,10H2,1H3,(H,19,20)
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n/an/a 44n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145347
PNG
(US8952169, 126 | US8952169, 128 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)
PDB

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US Patent
n/an/a 392n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145347
PNG
(US8952169, 126 | US8952169, 128 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)
PDB

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n/an/a 291n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 9n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145410
PNG
(US8952169, 189)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(C#N)C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H22ClFN2O4S/c1-29(26,27)24-19(25)15-7-16(21)18(8-17(15)22)28-10-20(9-23)13-3-11-2-12(5-13)6-14(20)4-11/h7-8,11-14H,2-6,10H2,1H3,(H,24,25)
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n/an/a 310n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145519
PNG
(US8952169, 315)
Show SMILES Fc1cc(OCC2CCC3(CC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H23ClFNO4S/c20-15-9-14(18(23)22-27(24,25)13-1-2-13)16(21)10-17(15)26-11-12-3-5-19(6-4-12)7-8-19/h9-10,12-13H,1-8,11H2,(H,22,23)
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n/an/a 19n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145521
PNG
(US8952169, 317 | US8952169, 322)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C17H17ClF3NO4S/c18-13-5-10(16(23)22-27(24,25)9-1-2-9)14(19)6-15(13)26-7-8-3-11-12(4-8)17(11,20)21/h5-6,8-9,11-12H,1-4,7H2,(H,22,23)
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n/an/a 80n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145521
PNG
(US8952169, 317 | US8952169, 322)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C17H17ClF3NO4S/c18-13-5-10(16(23)22-27(24,25)9-1-2-9)14(19)6-15(13)26-7-8-3-11-12(4-8)17(11,20)21/h5-6,8-9,11-12H,1-4,7H2,(H,22,23)
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n/an/a 81n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145530
PNG
(US8952169, 326)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)c(F)c1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-18(24)13-5-14(20)17(16(22)15(13)21)27-9-19-6-10-2-11(7-19)4-12(3-10)8-19/h5,10-12H,2-4,6-9H2,1H3,(H,23,24)
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n/an/a 190n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145532
PNG
(US8952169, 328)
Show SMILES Fc1cc(OCC2(CCC2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C16H16ClF4NO4S/c17-11-6-10(14(23)22-27(24,25)9-2-3-9)12(18)7-13(11)26-8-15(4-1-5-15)16(19,20)21/h6-7,9H,1-5,8H2,(H,22,23)
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n/an/a 24n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 9.30n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 743n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 743n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145347
PNG
(US8952169, 126 | US8952169, 128 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)
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n/an/a 30.3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 3.60n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145519
PNG
(US8952169, 315)
Show SMILES Fc1cc(OCC2CCC3(CC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C19H23ClFNO4S/c20-15-9-14(18(23)22-27(24,25)13-1-2-13)16(21)10-17(15)26-11-12-3-5-19(6-4-12)7-8-19/h9-10,12-13H,1-8,11H2,(H,22,23)
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n/an/a 19n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145521
PNG
(US8952169, 317 | US8952169, 322)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C17H17ClF3NO4S/c18-13-5-10(16(23)22-27(24,25)9-1-2-9)14(19)6-15(13)26-7-8-3-11-12(4-8)17(11,20)21/h5-6,8-9,11-12H,1-4,7H2,(H,22,23)
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n/an/a 180n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145521
PNG
(US8952169, 317 | US8952169, 322)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C17H17ClF3NO4S/c18-13-5-10(16(23)22-27(24,25)9-1-2-9)14(19)6-15(13)26-7-8-3-11-12(4-8)17(11,20)21/h5-6,8-9,11-12H,1-4,7H2,(H,22,23)
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n/an/a 200n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145530
PNG
(US8952169, 326)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(C4)C2)C3)c(F)c1F
Show InChI InChI=1S/C19H22ClF2NO4S/c1-28(25,26)23-18(24)13-5-14(20)17(16(22)15(13)21)27-9-19-6-10-2-11(7-19)4-12(3-10)8-19/h5,10-12H,2-4,6-9H2,1H3,(H,23,24)
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n/an/a 1.50E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145532
PNG
(US8952169, 328)
Show SMILES Fc1cc(OCC2(CCC2)C(F)(F)F)c(Cl)cc1C(=O)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C16H16ClF4NO4S/c17-11-6-10(14(23)22-27(24,25)9-2-3-9)12(18)7-13(11)26-8-15(4-1-5-15)16(19,20)21/h6-7,9H,1-5,8H2,(H,22,23)
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n/an/a 70n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145366
PNG
(US8952169, 145 | US8952169, 445 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3C4CCC(C4)C3C2)cc1F
Show InChI InChI=1S/C19H23ClFNO4S/c1-27(24,25)22-19(23)15-7-16(20)18(8-17(15)21)26-9-10-4-13-11-2-3-12(6-11)14(13)5-10/h7-8,10-14H,2-6,9H2,1H3,(H,22,23)
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n/an/a 3.60n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145347
PNG
(US8952169, 126 | US8952169, 128 | US9771376, Examp...)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OC2CCC(CC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H16ClF4NO4S/c1-26(23,24)21-14(22)10-6-11(16)13(7-12(10)17)25-9-4-2-8(3-5-9)15(18,19)20/h6-9H,2-5H2,1H3,(H,21,22)
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n/an/a 30.3n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145302
PNG
(US8952169, 81)
Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C14H14ClF4NO4S/c1-25(22,23)20-12(21)8-5-9(15)11(6-10(8)16)24-7-13(3-2-4-13)14(17,18)19/h5-6H,2-4,7H2,1H3,(H,20,21)
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n/an/a 122n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair