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91 similar compounds to monomer 145281

Compile data set for download or QSAR
Wt: 405.4
BDBM145604
Wt: 431.4
BDBM145637
Wt: 421.5
BDBM145411
Wt: 465.5
BDBM145413
Wt: 399.4
BDBM145414
Wt: 417.4
BDBM145514
Wt: 409.5
BDBM145616
Wt: 419.4
BDBM145618
Wt: 403.5
BDBM145307
Wt: 479.6
BDBM145417
Wt: 479.6
BDBM145418
Wt: 475.4
BDBM145419
Wt: 491.6
BDBM145420
Wt: 451.4
BDBM145622
Wt: 477.5
BDBM145623
Displayed 1 to 15 (of 91 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 145604,145637,145411,145413,145414,145514,145616,145618,145307,145417,145418,145419,145420,145622,145623   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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US Patent
n/an/a 3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 1.31n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145413
PNG
(US8952169, 192)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-24(27)20-11-19(16-2-3-16)23(12-22(20)25)31-13-21-17-7-14-6-15(9-17)10-18(21)8-14/h11-12,14-18,21H,2-10,13H2,1H3,(H,26,27)
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n/an/a 5n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145414
PNG
(US8952169, 193)
Show SMILES OCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C19H26FNO5S/c20-17-11-18(26-12-13-4-2-1-3-5-13)15(14-6-7-14)10-16(17)19(23)21-27(24,25)9-8-22/h10-11,13-14,22H,1-9,12H2,(H,21,23)
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n/an/a 66n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145417
PNG
(US8952169, 196)
Show SMILES CCOCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H34FNO5S/c1-2-31-5-6-33(29,30)27-24(28)21-10-20(19-3-4-19)23(11-22(21)26)32-15-25-12-16-7-17(13-25)9-18(8-16)14-25/h10-11,16-19H,2-9,12-15H2,1H3,(H,27,28)
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US Patent
n/an/a 12n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145418
PNG
(US8952169, 197)
Show SMILES COCCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H34FNO5S/c1-31-5-2-6-33(29,30)27-24(28)21-10-20(19-3-4-19)23(11-22(21)26)32-15-25-12-16-7-17(13-25)9-18(8-16)14-25/h10-11,16-19H,2-9,12-15H2,1H3,(H,27,28)
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n/an/a 22n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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US Patent
n/an/a 14n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145420
PNG
(US8952169, 199)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CCOCC1)C1CC1
Show InChI InChI=1S/C26H34FNO5S/c27-23-11-24(33-15-26-12-16-7-17(13-26)9-18(8-16)14-26)21(19-1-2-19)10-22(23)25(29)28-34(30,31)20-3-5-32-6-4-20/h10-11,16-20H,1-9,12-15H2,(H,28,29)
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n/an/a 15n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145514
PNG
(US8952169, 310)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C19H22F3NO4S/c1-28(25,26)23-17(24)13-8-12(11-5-6-11)15(9-14(13)20)27-10-18-7-3-2-4-16(18)19(18,21)22/h8-9,11,16H,2-7,10H2,1H3,(H,23,24)
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n/an/a 84n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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US Patent
n/an/a 22n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 27n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145616
PNG
(US8952169, 419)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC2(CC2)CC1
Show InChI InChI=1S/C21H28FNO4S/c1-20(5-7-21(8-6-20)9-10-21)13-27-18-12-17(22)16(11-15(18)14-3-4-14)19(24)23-28(2,25)26/h11-12,14H,3-10,13H2,1-2H3,(H,23,24)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145618
PNG
(US8952169, 421)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CCCCC2)C(F)F)cc1F
Show InChI InChI=1S/C19H24F3NO4S/c1-28(25,26)23-17(24)14-9-13(12-5-6-12)16(10-15(14)20)27-11-19(18(21)22)7-3-2-4-8-19/h9-10,12,18H,2-8,11H2,1H3,(H,23,24)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145622
PNG
(US8952169, 425)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C20H25F4NO4S/c1-19(7-5-13(6-8-19)20(22,23)24)11-29-17-10-16(21)15(9-14(17)12-3-4-12)18(26)25-30(2,27)28/h9-10,12-13H,3-8,11H2,1-2H3,(H,25,26)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145623
PNG
(US8952169, 426)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H27F4NO4S/c1-21(8-6-14(7-9-21)22(24,25)26)12-31-19-11-18(23)17(10-16(19)13-2-3-13)20(28)27-32(29,30)15-4-5-15/h10-11,13-15H,2-9,12H2,1H3,(H,27,28)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145637
PNG
(US8952169, 442 | US8952169, 443)
Show SMILES Fc1cc(OCC2CCCC(F)(F)C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C20H24F3NO4S/c21-17-9-18(28-11-12-2-1-7-20(22,23)10-12)15(13-3-4-13)8-16(17)19(25)24-29(26,27)14-5-6-14/h8-9,12-14H,1-7,10-11H2,(H,24,25)
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n/an/a 6n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145637
PNG
(US8952169, 442 | US8952169, 443)
Show SMILES Fc1cc(OCC2CCCC(F)(F)C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C20H24F3NO4S/c21-17-9-18(28-11-12-2-1-7-20(22,23)10-12)15(13-3-4-13)8-16(17)19(25)24-29(26,27)14-5-6-14/h8-9,12-14H,1-7,10-11H2,(H,24,25)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145637
PNG
(US8952169, 442 | US8952169, 443)
Show SMILES Fc1cc(OCC2CCCC(F)(F)C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C20H24F3NO4S/c21-17-9-18(28-11-12-2-1-7-20(22,23)10-12)15(13-3-4-13)8-16(17)19(25)24-29(26,27)14-5-6-14/h8-9,12-14H,1-7,10-11H2,(H,24,25)
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n/an/a 6n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145637
PNG
(US8952169, 442 | US8952169, 443)
Show SMILES Fc1cc(OCC2CCCC(F)(F)C2)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C20H24F3NO4S/c21-17-9-18(28-11-12-2-1-7-20(22,23)10-12)15(13-3-4-13)8-16(17)19(25)24-29(26,27)14-5-6-14/h8-9,12-14H,1-7,10-11H2,(H,24,25)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 700n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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n/an/a 3.50E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145307
PNG
(US8952169, 86 | US9771376, Example 86)
Show SMILES CS(=O)(=O)NC(=O)c1ccc(OCC23CC4CC(CC(C4)C2)C3)c(c1)C1CC1
Show InChI InChI=1S/C22H29NO4S/c1-28(25,26)23-21(24)18-4-5-20(19(9-18)17-2-3-17)27-13-22-10-14-6-15(11-22)8-16(7-14)12-22/h4-5,9,14-17H,2-3,6-8,10-13H2,1H3,(H,23,24)
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n/an/a 1.31n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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n/an/a 20n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145514
PNG
(US8952169, 310)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C19H22F3NO4S/c1-28(25,26)23-17(24)13-8-12(11-5-6-11)15(9-14(13)20)27-10-18-7-3-2-4-16(18)19(18,21)22/h8-9,11,16H,2-7,10H2,1H3,(H,23,24)
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n/an/a 10n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 300n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 420n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145616
PNG
(US8952169, 419)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC2(CC2)CC1
Show InChI InChI=1S/C21H28FNO4S/c1-20(5-7-21(8-6-20)9-10-21)13-27-18-12-17(22)16(11-15(18)14-3-4-14)19(24)23-28(2,25)26/h11-12,14H,3-10,13H2,1-2H3,(H,23,24)
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n/an/a 58n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145618
PNG
(US8952169, 421)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CCCCC2)C(F)F)cc1F
Show InChI InChI=1S/C19H24F3NO4S/c1-28(25,26)23-17(24)14-9-13(12-5-6-12)16(10-15(14)20)27-11-19(18(21)22)7-3-2-4-8-19/h9-10,12,18H,2-8,11H2,1H3,(H,23,24)
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n/an/a 32n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145622
PNG
(US8952169, 425)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C20H25F4NO4S/c1-19(7-5-13(6-8-19)20(22,23)24)11-29-17-10-16(21)15(9-14(17)12-3-4-12)18(26)25-30(2,27)28/h9-10,12-13H,3-8,11H2,1-2H3,(H,25,26)
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n/an/a 59n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145623
PNG
(US8952169, 426)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H27F4NO4S/c1-21(8-6-14(7-9-21)22(24,25)26)12-31-19-11-18(23)17(10-16(19)13-2-3-13)20(28)27-32(29,30)15-4-5-15/h10-11,13-15H,2-9,12H2,1H3,(H,27,28)
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n/an/a 51n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145411
PNG
(US8952169, 190)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-22(25)18-9-17(14-2-3-14)21(10-20(18)23)28-11-19-15-5-12-4-13(7-15)8-16(19)6-12/h9-10,12-16,19H,2-8,11H2,1H3,(H,24,25)
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n/an/a 3.10n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair