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81 similar compounds to monomer 145417

Compile data set for download or QSAR
Wt: 405.4
BDBM145604
Wt: 421.5
BDBM145411
Wt: 465.5
BDBM145413
Wt: 399.4
BDBM145414
Wt: 417.4
BDBM145514
Wt: 461.4
BDBM145515
Wt: 409.5
BDBM145616
Wt: 419.4
BDBM145618
Wt: 479.6
BDBM145418
Wt: 475.4
BDBM145419
Wt: 491.6
BDBM145420
Wt: 451.4
BDBM145622
Wt: 477.5
BDBM145623
Wt: 463.4
BDBM145625
Wt: 477.5
BDBM145421
Displayed 1 to 15 (of 81 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 145604,145411,145413,145414,145514,145515,145616,145618,145418,145419,145420,145622,145623,145625,145421   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145411
PNG
(US8952169, 190)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-22(25)18-9-17(14-2-3-14)21(10-20(18)23)28-11-19-15-5-12-4-13(7-15)8-16(19)6-12/h9-10,12-16,19H,2-8,11H2,1H3,(H,24,25)
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US Patent
n/an/a 3.10n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145625
PNG
(US8952169, 428)
Show SMILES Fc1cc(OCC2CCC(CC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-18-10-19(30-11-12-1-5-14(6-2-12)21(23,24)25)16(13-3-4-13)9-17(18)20(27)26-31(28,29)15-7-8-15/h9-10,12-15H,1-8,11H2,(H,26,27)
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n/an/a 12n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145414
PNG
(US8952169, 193)
Show SMILES OCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCCC2)cc1F
Show InChI InChI=1S/C19H26FNO5S/c20-17-11-18(26-12-13-4-2-1-3-5-13)15(14-6-7-14)10-16(17)19(23)21-27(24,25)9-8-22/h10-11,13-14,22H,1-9,12H2,(H,21,23)
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US Patent
n/an/a 66n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145418
PNG
(US8952169, 197)
Show SMILES COCCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F
Show InChI InChI=1S/C25H34FNO5S/c1-31-5-2-6-33(29,30)27-24(28)21-10-20(19-3-4-19)23(11-22(21)26)32-15-25-12-16-7-17(13-25)9-18(8-16)14-25/h10-11,16-19H,2-9,12-15H2,1H3,(H,27,28)
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US Patent
n/an/a 22n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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US Patent
n/an/a 14n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145420
PNG
(US8952169, 199)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CCOCC1)C1CC1
Show InChI InChI=1S/C26H34FNO5S/c27-23-11-24(33-15-26-12-16-7-17(13-26)9-18(8-16)14-26)21(19-1-2-19)10-22(23)25(29)28-34(30,31)20-3-5-32-6-4-20/h10-11,16-20H,1-9,12-15H2,(H,28,29)
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n/an/a 15n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145421
PNG
(US8952169, 200)
Show SMILES Fc1cc(OCC23CC4CC(CC(C4)C2)C3)c(cc1C(=O)NS(=O)(=O)C1CCOC1)C1CC1
Show InChI InChI=1S/C25H32FNO5S/c26-22-9-23(32-14-25-10-15-5-16(11-25)7-17(6-15)12-25)20(18-1-2-18)8-21(22)24(28)27-33(29,30)19-3-4-31-13-19/h8-9,15-19H,1-7,10-14H2,(H,27,28)
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n/an/a 5n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145514
PNG
(US8952169, 310)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C19H22F3NO4S/c1-28(25,26)23-17(24)13-8-12(11-5-6-11)15(9-14(13)20)27-10-18-7-3-2-4-16(18)19(18,21)22/h8-9,11,16H,2-7,10H2,1H3,(H,23,24)
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n/an/a 84n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145515
PNG
(US8952169, 311)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C21H26F3NO5S/c1-29-8-9-31(27,28)25-19(26)15-10-14(13-5-6-13)17(11-16(15)22)30-12-20-7-3-2-4-18(20)21(20,23)24/h10-11,13,18H,2-9,12H2,1H3,(H,25,26)
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US Patent
n/an/a 30n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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US Patent
n/an/a 22n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 27n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145616
PNG
(US8952169, 419)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC2(CC2)CC1
Show InChI InChI=1S/C21H28FNO4S/c1-20(5-7-21(8-6-20)9-10-21)13-27-18-12-17(22)16(11-15(18)14-3-4-14)19(24)23-28(2,25)26/h11-12,14H,3-10,13H2,1-2H3,(H,23,24)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145618
PNG
(US8952169, 421)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CCCCC2)C(F)F)cc1F
Show InChI InChI=1S/C19H24F3NO4S/c1-28(25,26)23-17(24)14-9-13(12-5-6-12)16(10-15(14)20)27-11-19(18(21)22)7-3-2-4-8-19/h9-10,12,18H,2-8,11H2,1H3,(H,23,24)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145622
PNG
(US8952169, 425)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C20H25F4NO4S/c1-19(7-5-13(6-8-19)20(22,23)24)11-29-17-10-16(21)15(9-14(17)12-3-4-12)18(26)25-30(2,27)28/h9-10,12-13H,3-8,11H2,1-2H3,(H,25,26)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145623
PNG
(US8952169, 426)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H27F4NO4S/c1-21(8-6-14(7-9-21)22(24,25)26)12-31-19-11-18(23)17(10-16(19)13-2-3-13)20(28)27-32(29,30)15-4-5-15/h10-11,13-15H,2-9,12H2,1H3,(H,27,28)
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n/an/a 2n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145625
PNG
(US8952169, 428)
Show SMILES Fc1cc(OCC2CCC(CC2)C(F)(F)F)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1
Show InChI InChI=1S/C21H25F4NO4S/c22-18-10-19(30-11-12-1-5-14(6-2-12)21(23,24)25)16(13-3-4-13)9-17(18)20(27)26-31(28,29)15-7-8-15/h9-10,12-15H,1-8,11H2,(H,26,27)
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n/an/a 4n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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n/an/a 3.50E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145419
PNG
(US8952169, 198)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4(F)CC(F)(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C22H25F4NO4S/c1-32(29,30)27-18(28)15-4-14(13-2-3-13)17(5-16(15)23)31-12-19-6-20(24)9-21(25,7-19)11-22(26,8-19)10-20/h4-5,13H,2-3,6-12H2,1H3,(H,27,28)
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n/an/a 20n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145514
PNG
(US8952169, 310)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C19H22F3NO4S/c1-28(25,26)23-17(24)13-8-12(11-5-6-11)15(9-14(13)20)27-10-18-7-3-2-4-16(18)19(18,21)22/h8-9,11,16H,2-7,10H2,1H3,(H,23,24)
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n/an/a 10n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145515
PNG
(US8952169, 311)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CCCCC2C3(F)F)cc1F
Show InChI InChI=1S/C21H26F3NO5S/c1-29-8-9-31(27,28)25-19(26)15-10-14(13-5-6-13)17(11-16(15)22)30-12-20-7-3-2-4-18(20)21(20,23)24/h10-11,13,18H,2-9,12H2,1H3,(H,25,26)
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n/an/a 53n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 300n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145604
PNG
(US8952169, 402 | US8952169, 406)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCCC(F)(F)C2)cc1F
Show InChI InChI=1S/C18H22F3NO4S/c1-27(24,25)22-17(23)14-7-13(12-4-5-12)16(8-15(14)19)26-10-11-3-2-6-18(20,21)9-11/h7-8,11-12H,2-6,9-10H2,1H3,(H,22,23)
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n/an/a 420n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145616
PNG
(US8952169, 419)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC2(CC2)CC1
Show InChI InChI=1S/C21H28FNO4S/c1-20(5-7-21(8-6-20)9-10-21)13-27-18-12-17(22)16(11-15(18)14-3-4-14)19(24)23-28(2,25)26/h11-12,14H,3-10,13H2,1-2H3,(H,23,24)
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n/an/a 58n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145618
PNG
(US8952169, 421)
Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2(CCCCC2)C(F)F)cc1F
Show InChI InChI=1S/C19H24F3NO4S/c1-28(25,26)23-17(24)14-9-13(12-5-6-12)16(10-15(14)20)27-11-19(18(21)22)7-3-2-4-8-19/h9-10,12,18H,2-8,11H2,1H3,(H,23,24)
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n/an/a 32n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145622
PNG
(US8952169, 425)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C20H25F4NO4S/c1-19(7-5-13(6-8-19)20(22,23)24)11-29-17-10-16(21)15(9-14(17)12-3-4-12)18(26)25-30(2,27)28/h9-10,12-13H,3-8,11H2,1-2H3,(H,25,26)
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n/an/a 59n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145623
PNG
(US8952169, 426)
Show SMILES CC1(COc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)C2CC2)CCC(CC1)C(F)(F)F
Show InChI InChI=1S/C22H27F4NO4S/c1-21(8-6-14(7-9-21)22(24,25)26)12-31-19-11-18(23)17(10-16(19)13-2-3-13)20(28)27-32(29,30)15-4-5-15/h10-11,13-15H,2-9,12H2,1H3,(H,27,28)
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n/an/a 51n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145413
PNG
(US8952169, 192)
Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-24(27)20-11-19(16-2-3-16)23(12-22(20)25)31-13-21-17-7-14-6-15(9-17)10-18(21)8-14/h11-12,14-18,21H,2-10,13H2,1H3,(H,26,27)
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n/an/a 5n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair