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58 similar compounds to monomer 145254

Compile data set for download or QSAR
Wt: 438.8
BDBM145520
Wt: 432.8
BDBM145303
Wt: 455.9
BDBM145409
Wt: 444.9
BDBM145518
Wt: 472.9
BDBM145620
Wt: 432.9
BDBM145308
Wt: 418.9
BDBM145309
Wt: 462.9
BDBM145310
Wt: 480.9
BDBM145313
Wt: 404.8
BDBM145315
Wt: 432.9
BDBM145317
Wt: 444.9
BDBM145318
Wt: 404.8
BDBM145319
Wt: 474.9
BDBM145527
Wt: 406.9
BDBM145321
Displayed 1 to 15 (of 58 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 145520,145303,145409,145518,145620,145308,145309,145310,145313,145315,145317,145318,145319,145527,145321   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145303
PNG
(US8952169, 82 | US9771376, Example 82)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H17ClF4N2O4S/c1-22(2)27(24,25)21-13(23)9-6-10(16)12(7-11(9)17)26-8-14(4-3-5-14)15(18,19)20/h6-7H,3-5,8H2,1-2H3,(H,21,23)
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US Patent
n/an/a 294n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145318
PNG
(US8952169, 97 | US9771376, Example 97)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)
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n/an/a 7.30n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145309
PNG
(US8952169, 88)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC3(CC3)CC2)cc1F
Show InChI InChI=1S/C18H24ClFN2O4S/c1-22(2)27(24,25)21-17(23)13-9-14(19)16(10-15(13)20)26-11-12-3-5-18(6-4-12)7-8-18/h9-10,12H,3-8,11H2,1-2H3,(H,21,23)
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US Patent
n/an/a 121n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145310
PNG
(US8952169, 89)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F
Show InChI InChI=1S/C20H25ClF2N2O4S/c1-25(2)30(27,28)24-18(26)14-4-15(21)17(5-16(14)22)29-11-19-6-12-3-13(7-19)9-20(23,8-12)10-19/h4-5,12-13H,3,6-11H2,1-2H3,(H,24,26)
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n/an/a 234n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145313
PNG
(US8952169, 92)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C20H24ClF3N2O4S/c1-26(2)31(28,29)25-18(27)14-5-15(21)17(6-16(14)22)30-10-19-7-11-3-12(8-19)20(23,24)13(4-11)9-19/h5-6,11-13H,3-4,7-10H2,1-2H3,(H,25,27)
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n/an/a 221n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145315
PNG
(US8952169, 94)
Show SMILES CC1(C)[C@@H]2C[C@H]1[C@@H](COc1cc(F)c(cc1Cl)C(=O)NS(N)(=O)=O)CC2
Show InChI InChI=1S/C17H22ClFN2O4S/c1-17(2)10-4-3-9(12(17)5-10)8-25-15-7-14(19)11(6-13(15)18)16(22)21-26(20,23)24/h6-7,9-10,12H,3-5,8H2,1-2H3,(H,21,22)(H2,20,23,24)/t9-,10+,12+/m1/s1
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n/an/a 224n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145317
PNG
(US8952169, 96)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F
Show InChI InChI=1S/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12-,14-/m0/s1
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n/an/a 164n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145318
PNG
(US8952169, 97 | US9771376, Example 97)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)
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n/an/a 51n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145319
PNG
(US8952169, 98)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CC3CCC2C3)cc1F
Show InChI InChI=1S/C17H22ClFN2O4S/c1-21(2)26(23,24)20-17(22)13-7-14(18)16(8-15(13)19)25-9-12-6-10-3-4-11(12)5-10/h7-8,10-12H,3-6,9H2,1-2H3,(H,20,22)
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n/an/a 382n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145321
PNG
(US8952169, 100)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCCCCC2)cc1F
Show InChI InChI=1S/C17H24ClFN2O4S/c1-21(2)26(23,24)20-17(22)13-9-14(18)16(10-15(13)19)25-11-12-7-5-3-4-6-8-12/h9-10,12H,3-8,11H2,1-2H3,(H,20,22)
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n/an/a 299n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145409
PNG
(US8952169, 188)
Show SMILES CNS(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(C#N)C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H23ClFN3O4S/c1-24-30(27,28)25-19(26)15-7-16(21)18(8-17(15)22)29-10-20(9-23)13-3-11-2-12(5-13)6-14(20)4-11/h7-8,11-14,24H,2-6,10H2,1H3,(H,25,26)
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n/an/a 880n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145518
PNG
(US8952169, 314)
Show SMILES Fc1cc(OCC2CCC3(CCC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C20H26ClFN2O4S/c21-16-11-15(19(25)23-29(26,27)24-9-2-10-24)17(22)12-18(16)28-13-14-3-7-20(8-4-14)5-1-6-20/h11-12,14H,1-10,13H2,(H,23,25)
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n/an/a 25n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145520
PNG
(US8952169, 316 | US8952169, 321)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H18ClF3N2O4S/c18-13-6-10(16(24)22-28(25,26)23-2-1-3-23)14(19)7-15(13)27-8-9-4-11-12(5-9)17(11,20)21/h6-7,9,11-12H,1-5,8H2,(H,22,24)
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n/an/a 260n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145520
PNG
(US8952169, 316 | US8952169, 321)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H18ClF3N2O4S/c18-13-6-10(16(24)22-28(25,26)23-2-1-3-23)14(19)7-15(13)27-8-9-4-11-12(5-9)17(11,20)21/h6-7,9,11-12H,1-5,8H2,(H,22,24)
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n/an/a 200n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145527
PNG
(US8952169, 323)
Show SMILES Fc1c(F)c(cc(Cl)c1OCC12CC3CC(CC(C3)C1)C2)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C21H25ClF2N2O4S/c22-16-7-15(20(27)25-31(28,29)26-2-1-3-26)17(23)18(24)19(16)30-11-21-8-12-4-13(9-21)6-14(5-12)10-21/h7,12-14H,1-6,8-11H2,(H,25,27)
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n/an/a 370n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145620
PNG
(US8952169, 423)
Show SMILES CO[C@@]12CC3CC(C1)[C@H](Oc1cc(F)c(cc1Cl)C(=O)NS(=O)(=O)N1CCC1)C(C3)C2
Show InChI InChI=1S/C21H26ClFN2O5S/c1-29-21-9-12-5-13(10-21)19(14(6-12)11-21)30-18-8-17(23)15(7-16(18)22)20(26)24-31(27,28)25-3-2-4-25/h7-8,12-14,19H,2-6,9-11H2,1H3,(H,24,26)/t12?,13?,14?,19-,21-
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n/an/a 1.40E+3n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 5 subunit alpha


(Homo sapiens (Human))
BDBM145313
PNG
(US8952169, 92)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C20H24ClF3N2O4S/c1-26(2)31(28,29)25-18(27)14-5-15(21)17(6-16(14)22)30-10-19-7-11-3-12(8-19)20(23,24)13(4-11)9-19/h5-6,11-13H,3-4,7-10H2,1-2H3,(H,25,27)
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n/an/a 3.76E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145303
PNG
(US8952169, 82 | US9771376, Example 82)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H17ClF4N2O4S/c1-22(2)27(24,25)21-13(23)9-6-10(16)12(7-11(9)17)26-8-14(4-3-5-14)15(18,19)20/h6-7H,3-5,8H2,1-2H3,(H,21,23)
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n/an/a 41.6n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145313
PNG
(US8952169, 92)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC23CC4CC(C2)C(F)(F)C(C4)C3)cc1F
Show InChI InChI=1S/C20H24ClF3N2O4S/c1-26(2)31(28,29)25-18(27)14-5-15(21)17(6-16(14)22)30-10-19-7-11-3-12(8-19)20(23,24)13(4-11)9-19/h5-6,11-13H,3-4,7-10H2,1-2H3,(H,25,27)
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n/an/a 53.1n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145318
PNG
(US8952169, 97 | US9771376, Example 97)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2C3CC4CC(C3)CC2C4)cc1F
Show InChI InChI=1S/C20H26ClFN2O4S/c1-24(2)29(26,27)23-20(25)15-8-17(21)19(9-18(15)22)28-10-16-13-4-11-3-12(6-13)7-14(16)5-11/h8-9,11-14,16H,3-7,10H2,1-2H3,(H,23,25)
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n/an/a 7.30n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145518
PNG
(US8952169, 314)
Show SMILES Fc1cc(OCC2CCC3(CCC3)CC2)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C20H26ClFN2O4S/c21-16-11-15(19(25)23-29(26,27)24-9-2-10-24)17(22)12-18(16)28-13-14-3-7-20(8-4-14)5-1-6-20/h11-12,14H,1-10,13H2,(H,23,25)
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n/an/a 77n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145520
PNG
(US8952169, 316 | US8952169, 321)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H18ClF3N2O4S/c18-13-6-10(16(24)22-28(25,26)23-2-1-3-23)14(19)7-15(13)27-8-9-4-11-12(5-9)17(11,20)21/h6-7,9,11-12H,1-5,8H2,(H,22,24)
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n/an/a 300n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145520
PNG
(US8952169, 316 | US8952169, 321)
Show SMILES Fc1cc(OCC2CC3C(C2)C3(F)F)c(Cl)cc1C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C17H18ClF3N2O4S/c18-13-6-10(16(24)22-28(25,26)23-2-1-3-23)14(19)7-15(13)27-8-9-4-11-12(5-9)17(11,20)21/h6-7,9,11-12H,1-5,8H2,(H,22,24)
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n/an/a 260n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145527
PNG
(US8952169, 323)
Show SMILES Fc1c(F)c(cc(Cl)c1OCC12CC3CC(CC(C3)C1)C2)C(=O)NS(=O)(=O)N1CCC1
Show InChI InChI=1S/C21H25ClF2N2O4S/c22-16-7-15(20(27)25-31(28,29)26-2-1-3-26)17(23)18(24)19(16)30-11-21-8-12-4-13(9-21)6-14(5-12)10-21/h7,12-14H,1-6,8-11H2,(H,25,27)
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n/an/a 2.30E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145620
PNG
(US8952169, 423)
Show SMILES CO[C@@]12CC3CC(C1)[C@H](Oc1cc(F)c(cc1Cl)C(=O)NS(=O)(=O)N1CCC1)C(C3)C2
Show InChI InChI=1S/C21H26ClFN2O5S/c1-29-21-9-12-5-13(10-21)19(14(6-12)11-21)30-18-8-17(23)15(7-16(18)22)20(26)24-31(27,28)25-3-2-4-25/h7-8,12-14,19H,2-6,9-11H2,1H3,(H,24,26)/t12?,13?,14?,19-,21-
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n/an/a 3.60E+3n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145303
PNG
(US8952169, 82 | US9771376, Example 82)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2(CCC2)C(F)(F)F)cc1F
Show InChI InChI=1S/C15H17ClF4N2O4S/c1-22(2)27(24,25)21-13(23)9-6-10(16)12(7-11(9)17)26-8-14(4-3-5-14)15(18,19)20/h6-7H,3-5,8H2,1-2H3,(H,21,23)
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n/an/a 41.6n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent


Assay Description
The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...


US Patent US9771376 (2017)

More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145308
PNG
(US8952169, 87)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OCC2CCC3(CCC3)CC2)cc1F
Show InChI InChI=1S/C19H26ClFN2O4S/c1-23(2)28(25,26)22-18(24)14-10-15(20)17(11-16(14)21)27-12-13-4-8-19(9-5-13)6-3-7-19/h10-11,13H,3-9,12H2,1-2H3,(H,22,24)
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n/an/a 81n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair