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39 similar compounds to monomer 146688

Compile data set for download or QSAR
Wt: 413.4
BDBM119841
Wt: 431.4
BDBM119842
Wt: 431.4
BDBM119847
Wt: 399.4
BDBM119849
Wt: 381.4
BDBM119851
Wt: 371.4
BDBM146887
Wt: 357.3
BDBM146673
Wt: 386.8
BDBM146687
Wt: 400.4
BDBM146691
Wt: 370.4
BDBM146697
Wt: 390.8
BDBM146698
Wt: 374.3
BDBM146699
Wt: 407.2
BDBM146700
Wt: 366.4
BDBM146701
Wt: 386.8
BDBM146702
Displayed 1 to 15 (of 39 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 119841,119842,119847,119849,119851,146887,146673,146687,146691,146697,146698,146699,146700,146701,146702   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119841
PNG
(US8691986, 7)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)
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n/an/a 4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 2n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119847
PNG
(US8691986, 13)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.70n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.30n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 2.60n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119841
PNG
(US8691986, 7)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H20FN5O/c1-26-24(31)18-8-6-16(12-19(18)25)22-23(28-11-10-27-22)17-13-30(14-17)21-9-7-15-4-2-3-5-20(15)29-21/h2-12,17H,13-14H2,1H3,(H,26,31)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119842
PNG
(US8691986, 8)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119847
PNG
(US8691986, 13)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2cc(F)ccc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-5-2-15(11-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-3-14-10-17(25)4-6-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.00E+4n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cGMP-dependent 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 3.30E+3n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146673
PNG
(US8957073, 4.7 | US9718803, 4.7)
Show SMILES Fc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.0123n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21 | US9718803, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00230n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25 | US9718803, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00620n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31 | US9718803, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00510n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32 | US9718803, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00410n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146699
PNG
(US8957073, 4.33 | US9718803, 4.33)
Show SMILES Fc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00990n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146700
PNG
(US8957073, 4.34 | US9718803, 4.34)
Show SMILES Clc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16Cl2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00840n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35 | US9718803, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00550n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36 | US9718803, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00670n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146887
PNG
(US8957073, 23.8 | US9718803, 23.8)
Show SMILES Nc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H18FN5/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13,24H2
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n/an/a 4.37n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.30n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119849
PNG
(US8691986, 16 | US9718803, 30.4)
Show SMILES NC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H18FN5O/c24-18-11-15(5-7-17(18)23(25)30)21-22(27-10-9-26-21)16-12-29(13-16)20-8-6-14-3-1-2-4-19(14)28-20/h1-11,16H,12-13H2,(H2,25,30)
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n/an/a 2n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146673
PNG
(US8957073, 4.7 | US9718803, 4.7)
Show SMILES Fc1cncc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C21H16FN5/c22-17-9-15(10-23-11-17)20-21(25-8-7-24-20)16-12-27(13-16)19-6-5-14-3-1-2-4-18(14)26-19/h1-11,16H,12-13H2
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n/an/a 0.0120n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146687
PNG
(US8957073, 4.21 | US9718803, 4.21)
Show SMILES Cc1cc(ccc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-12-17(6-8-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-7-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00200n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146691
PNG
(US8957073, 4.25 | US9718803, 4.25)
Show SMILES CCOc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H21FN4O/c1-2-30-21-9-7-17(13-19(21)25)23-24(27-12-11-26-23)18-14-29(15-18)22-10-8-16-5-3-4-6-20(16)28-22/h3-13,18H,2,14-15H2,1H3
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n/an/a 0.00600n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146697
PNG
(US8957073, 4.31 | US9718803, 4.31)
Show SMILES Cc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19FN4/c1-15-10-17(12-19(24)11-15)22-23(26-9-8-25-22)18-13-28(14-18)21-7-6-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00500n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146698
PNG
(US8957073, 4.32 | US9718803, 4.32)
Show SMILES Fc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16ClFN4/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00400n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146699
PNG
(US8957073, 4.33 | US9718803, 4.33)
Show SMILES Fc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16F2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.0100n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146700
PNG
(US8957073, 4.34 | US9718803, 4.34)
Show SMILES Clc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H16Cl2N4/c23-17-7-5-15(11-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13H2
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n/an/a 0.00800n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146701
PNG
(US8957073, 4.35 | US9718803, 4.35)
Show SMILES Cc1ccc(cc1C)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H22N4/c1-16-7-8-19(13-17(16)2)23-24(26-12-11-25-23)20-14-28(15-20)22-10-9-18-5-3-4-6-21(18)27-22/h3-13,20H,14-15H2,1-2H3
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n/an/a 0.00500n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146702
PNG
(US8957073, 4.36 | US9718803, 4.36)
Show SMILES Cc1ccc(cc1Cl)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19ClN4/c1-15-6-7-17(12-19(15)24)22-23(26-11-10-25-22)18-13-28(14-18)21-9-8-16-4-2-3-5-20(16)27-21/h2-12,18H,13-14H2,1H3
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n/an/a 0.00700n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146887
PNG
(US8957073, 23.8 | US9718803, 23.8)
Show SMILES Nc1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C22H18FN5/c23-17-11-15(5-7-18(17)24)21-22(26-10-9-25-21)16-12-28(13-16)20-8-6-14-3-1-2-4-19(14)27-20/h1-11,16H,12-13,24H2
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n/an/a 4.37n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119851
PNG
(US8691986, 15 | US9718803, 30.2)
Show SMILES NC(=O)c1ccc(cc1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C23H19N5O/c24-23(29)17-7-5-16(6-8-17)21-22(26-12-11-25-21)18-13-28(14-18)20-10-9-15-3-1-2-4-19(15)27-20/h1-12,18H,13-14H2,(H2,24,29)
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n/an/a 1.30n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM119842
PNG
(US8691986, 8)
Show SMILES CNC(=O)c1ccc(cc1F)-c1nccnc1C1CN(C1)c1ccc2ccc(F)cc2n1
Show InChI InChI=1S/C24H19F2N5O/c1-27-24(32)18-6-3-15(10-19(18)26)22-23(29-9-8-28-22)16-12-31(13-16)21-7-4-14-2-5-17(25)11-20(14)30-21/h2-11,16H,12-13H2,1H3,(H,27,32)
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n/an/a 0.5n/an/an/an/a7.225



Amgen Inc.

US Patent


Assay Description
IMAP TR-FRET progressive binding system, FAM-cAMP substrate were from Molecular Devices (Sunnyvale, Calif.). The PDE IMAP assay was conducted in a 3...


US Patent US8691986 (2014)


BindingDB Entry DOI: 10.7270/Q26T0K9T
More data for this
Ligand-Target Pair