BindingDB logo
myBDB logout

49 similar compounds to monomer 50116105

Compile data set for download or QSAR
Wt: 308.3
BDBM48546
Purchase
Wt: 320.4
BDBM49017
Purchase
Wt: 322.4
BDBM50071231
Wt: 356.8
BDBM50071233
Wt: 356.8
BDBM50071237
Wt: 352.4
BDBM50149653
Wt: 366.4
BDBM50149660
Wt: 408.5
BDBM50149662
Wt: 366.5
BDBM50149666
Wt: 380.5
BDBM50149672
Wt: 337.4
BDBM50149681
Wt: 370.9
BDBM50148884
Wt: 351.4
BDBM50148896
Wt: 356.8
BDBM50148898
Purchase
Wt: 352.4
BDBM50148902
Displayed 1 to 15 (of 49 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 48546,49017,50071231,50071233,50071237,50149653,50149660,50149662,50149666,50149672,50149681,50148884,50148896,50148898,50148902   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148898
PNG
(CHEMBL333903 | [3-(4-Chloro-phenyl)-2,5-dimethyl-3...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H25ClN4/c1-5-11-24(12-6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-7-9-17(21)10-8-16/h7-10,13H,5-6,11-12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148902
PNG
(CHEMBL263492 | [3-(4-Methoxy-phenyl)-2,5-dimethyl-...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1
Show InChI InChI=1S/C21H28N4O/c1-6-12-24(13-7-2)19-14-15(3)22-21-20(16(4)23-25(19)21)17-8-10-18(26-5)11-9-17/h8-11,14H,6-7,12-13H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.60n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149672
PNG
(CHEMBL184850 | [3-(5-Dimethylamino-3-methyl-pyridi...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)19-13-16(4)24-22-20(17(5)25-28(19)22)21-15(3)12-18(14-23-21)26(6)7/h12-14H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149672
PNG
(CHEMBL184850 | [3-(5-Dimethylamino-3-methyl-pyridi...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)19-13-16(4)24-22-20(17(5)25-28(19)22)21-15(3)12-18(14-23-21)26(6)7/h12-14H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149662
PNG
(CHEMBL185055 | [3-(5-Diethylamino-3-methyl-pyridin...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(CC)CC
Show InChI InChI=1S/C24H36N6/c1-8-12-29(13-9-2)21-15-18(6)26-24-22(19(7)27-30(21)24)23-17(5)14-20(16-25-23)28(10-3)11-4/h14-16H,8-13H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071233
PNG
(Butyl-[3-(2-chloro-phenyl)-2,5-dimethyl-pyrazolo[1...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccccc1Cl
Show InChI InChI=1S/C20H25ClN4/c1-5-7-12-24(6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-10-8-9-11-17(16)21/h8-11,13H,5-7,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149666
PNG
(CHEMBL181812 | [2,5-Dimethyl-3-(3-methyl-5-methyla...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(NC)cc1C
Show InChI InChI=1S/C21H30N6/c1-7-9-26(10-8-2)18-12-15(4)24-21-19(16(5)25-27(18)21)20-14(3)11-17(22-6)13-23-20/h11-13,22H,7-10H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071237
PNG
(Butyl-[3-(4-chloro-phenyl)-2,5-dimethyl-pyrazolo[1...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H25ClN4/c1-5-7-12-24(6-2)18-13-14(3)22-20-19(15(4)23-25(18)20)16-8-10-17(21)11-9-16/h8-11,13H,5-7,12H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
77n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149653
PNG
(CHEMBL182595 | [3-(5-Amino-3-methyl-pyridin-2-yl)-...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(N)cc1C
Show InChI InChI=1S/C20H28N6/c1-6-8-25(9-7-2)17-11-14(4)23-20-18(15(5)24-26(17)20)19-13(3)10-16(21)12-22-19/h10-12H,6-9,21H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
85n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149653
PNG
(CHEMBL182595 | [3-(5-Amino-3-methyl-pyridin-2-yl)-...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(N)cc1C
Show InChI InChI=1S/C20H28N6/c1-6-8-25(9-7-2)17-11-14(4)23-20-18(15(5)24-26(17)20)19-13(3)10-16(21)12-22-19/h10-12H,6-9,21H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
85n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148884
PNG
(CHEMBL121116 | [3-(4-Chloro-phenyl)-5-ethyl-2-meth...)
Show SMILES CCCN(CCC)c1cc(CC)nc2c(c(C)nn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H27ClN4/c1-5-12-25(13-6-2)19-14-18(7-3)23-21-20(15(4)24-26(19)21)16-8-10-17(22)11-9-16/h8-11,14H,5-7,12-13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
100n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149660
PNG
(CHEMBL181684 | [2,5-Dimethyl-3-(3-methyl-5-nitroso...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N=O
Show InChI InChI=1S/C20H26N6O/c1-6-8-25(9-7-2)17-11-14(4)22-20-18(15(5)23-26(17)20)19-13(3)10-16(24-27)12-21-19/h10-12H,6-9H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
100n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149681
PNG
(CHEMBL362437 | [2,5-Dimethyl-3-(3-methyl-pyridin-2...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncccc1C
Show InChI InChI=1S/C20H27N5/c1-6-11-24(12-7-2)17-13-15(4)22-20-18(16(5)23-25(17)20)19-14(3)9-8-10-21-19/h8-10,13H,6-7,11-12H2,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity for recombinant human CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50071231
PNG
(Butyl-(2,5-dimethyl-3-phenyl-pyrazolo[1,5-a]pyrimi...)
Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1ccccc1
Show InChI InChI=1S/C20H26N4/c1-5-7-13-23(6-2)18-14-15(3)21-20-19(16(4)22-24(18)20)17-11-9-8-10-12-17/h8-12,14H,5-7,13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
511n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Displacement of [125I]-0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells


Bioorg Med Chem Lett 8: 2067-70 (1999)


Article DOI: 10.1016/s0960-894x(98)00372-2
BindingDB Entry DOI: 10.7270/Q2125RTC
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50148896
PNG
(CHEMBL122988 | [3-(4-Aminomethyl-phenyl)-2,5-dimet...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(CN)cc1
Show InChI InChI=1S/C21H29N5/c1-5-11-25(12-6-2)19-13-15(3)23-21-20(16(4)24-26(19)21)18-9-7-17(14-22)8-10-18/h7-10,13H,5-6,11-12,14,22H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Binding affinity to the cloned human corticotropin releasing factor receptor 1


Bioorg Med Chem Lett 14: 3669-73 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.019
BindingDB Entry DOI: 10.7270/Q2T72GWP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149672
PNG
(CHEMBL184850 | [3-(5-Dimethylamino-3-methyl-pyridi...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)19-13-16(4)24-22-20(17(5)25-28(19)22)21-15(3)12-18(14-23-21)26(6)7/h12-14H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CRF-stimulated cAMP production in cells expressing CRF1 receptor


Bioorg Med Chem Lett 14: 3943-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.056
BindingDB Entry DOI: 10.7270/Q2KK9B7F
More data for this
Ligand-Target Pair
eukaryotic translation initiation factor 4 gamma, 1 isoform 4


(Homo sapiens (Human))
BDBM48546
PNG
(4-(2,5-dimethyl-3-phenyl-7-pyrazolo[1,5-a]pyrimidi...)
Show SMILES Cc1nn2c(cc(C)nc2c1-c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C18H20N4O/c1-13-12-16(21-8-10-23-11-9-21)22-18(19-13)17(14(2)20-22)15-6-4-3-5-7-15/h3-7,12H,8-11H2,1-2H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/a 6.40E+4n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...


PubChem Bioassay (2009)


BindingDB Entry DOI: 10.7270/Q2RN3686
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50149672
PNG
(CHEMBL184850 | [3-(5-Dimethylamino-3-methyl-pyridi...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)19-13-16(4)24-22-20(17(5)25-28(19)22)21-15(3)12-18(14-23-21)26(6)7/h12-14H,8-11H2,1-7H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor


J Med Chem 47: 4787-98 (2004)


Article DOI: 10.1021/jm040058e
BindingDB Entry DOI: 10.7270/Q2N29WDR
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM49017
PNG
(2-methyl-3-phenyl-5-propan-2-yl-7-(1-pyrrolidinyl)...)
Show SMILES CC(C)c1cc(N2CCCC2)n2nc(C)c(-c3ccccc3)c2n1
Show InChI InChI=1S/C20H24N4/c1-14(2)17-13-18(23-11-7-8-12-23)24-20(21-17)19(15(3)22-24)16-9-5-4-6-10-16/h4-6,9-10,13-14H,7-8,11-12H2,1-3H3
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

PCBioAssay
n/an/an/an/a 0.00967n/an/an/an/a



Vanderbilt Screening Center for GPCRs, Ion Channels and Transporters

Curated by PubChem BioAssay


Assay Description
Assay Provider: Val Watts Assay Provider Affiliation: Purdue University Grant Title: Allosteric Modulators of D1 Receptors Grant Number: 1 X01 MH0776...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q2H41PVH
More data for this
Ligand-Target Pair