BindingDB logo
myBDB logout

12 molecules are shown

Wt: 258.0
BDBM50001266
Purchase
Wt: 349.5
BDBM50005034
Wt: 203.1
BDBM50004950
Purchase
Wt: 230.0
BDBM50004960
Purchase
Wt: 259.0
BDBM50052625
Wt: 225.6
BDBM50280272
Wt: 330.1
BDBM50280805
Wt: 247.2
BDBM50280806
Wt: 316.0
BDBM50280807
Wt: 238.6
BDBM50280277
Wt: 301.6
BDBM50283029
Wt: 315.6
BDBM50283030

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 50001266,50005034,50004950,50004960,50052625,50280272,50280805,50280806,50280807,50280277,50283029,50283030   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]glycine from glycine site on the NMDA receptor.


J Med Chem 35: 3319-24 (1992)


Article DOI: 10.1021/jm00096a002
BindingDB Entry DOI: 10.7270/Q2WM1F13
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
40n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM


Bioorg Med Chem Lett 3: 81-84 (1993)


Article DOI: 10.1016/S0960-894X(00)80096-7
BindingDB Entry DOI: 10.7270/Q2MK6CTN
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
40n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Ability to displace strychnine-insensitive [3H]-glycine binding to rat cortical membranes.


J Med Chem 35: 3423-5 (1992)


Article DOI: 10.1021/jm00096a019
BindingDB Entry DOI: 10.7270/Q2RR1X68
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
90n/an/an/an/an/an/an/an/a



Universita'degli Studi di Firenze

Curated by ChEMBL


Assay Description
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]-Gly as radioligan...


J Med Chem 47: 262-72 (2003)


Article DOI: 10.1021/jm030906q
BindingDB Entry DOI: 10.7270/Q2668CM6
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50280807
PNG
(3-Carboxymethyl-5,7-dichloro-4-oxo-1,4-dihydro-qui...)
Show SMILES OC(=O)Cc1c(O)c2c(Cl)cc(Cl)cc2nc1C(O)=O
Show InChI InChI=1S/C12H7Cl2NO5/c13-4-1-6(14)9-7(2-4)15-10(12(19)20)5(11(9)18)3-8(16)17/h1-2H,3H2,(H,15,18)(H,16,17)(H,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
650n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM


Bioorg Med Chem Lett 3: 81-84 (1993)


Article DOI: 10.1016/S0960-894X(00)80096-7
BindingDB Entry DOI: 10.7270/Q2MK6CTN
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004960
PNG
(4,6-Dichloro-1H-indole-2-carboxylic acid | CHEMBL3...)
Show SMILES OC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1
Show InChI InChI=1S/C9H5Cl2NO2/c10-4-1-6(11)5-3-8(9(13)14)12-7(5)2-4/h1-3,12H,(H,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
980n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM


Bioorg Med Chem Lett 3: 81-84 (1993)


Article DOI: 10.1016/S0960-894X(00)80096-7
BindingDB Entry DOI: 10.7270/Q2MK6CTN
More data for this
Ligand-Target Pair
NMDA


()
BDBM50004960
PNG
(4,6-Dichloro-1H-indole-2-carboxylic acid | CHEMBL3...)
Show SMILES OC(=O)c1cc2c(Cl)cc(Cl)cc2[nH]1
Show InChI InChI=1S/C9H5Cl2NO2/c10-4-1-6(11)5-3-8(9(13)14)12-7(5)2-4/h1-3,12H,(H,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
2.90E+3n/an/an/an/an/an/an/an/a



Johannes Gutenberg-Universität

Curated by ChEMBL


Assay Description
Tested for the affinity for the glycine binding site of the N-methyl-D-aspartate glutamate receptor using pig brain membranes in binding assay with [...


J Med Chem 46: 64-73 (2002)


Article DOI: 10.1021/jm020955n
BindingDB Entry DOI: 10.7270/Q2NZ8703
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50280805
PNG
(3-(2-Carboxy-ethyl)-5,7-dichloro-4-oxo-1,4-dihydro...)
Show SMILES OC(=O)CCc1c(O)c2c(Cl)cc(Cl)cc2nc1C(O)=O
Show InChI InChI=1S/C13H9Cl2NO5/c14-5-3-7(15)10-8(4-5)16-11(13(20)21)6(12(10)19)1-2-9(17)18/h3-4H,1-2H2,(H,16,19)(H,17,18)(H,20,21)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
7.04E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM


Bioorg Med Chem Lett 3: 81-84 (1993)


Article DOI: 10.1016/S0960-894X(00)80096-7
BindingDB Entry DOI: 10.7270/Q2MK6CTN
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50280806
PNG
(3-Carboxymethyl-4-oxo-1,4-dihydro-quinoline-2-carb...)
Show SMILES OC(=O)Cc1c(O)c2ccccc2nc1C(O)=O
Show InChI InChI=1S/C12H9NO5/c14-9(15)5-7-10(12(17)18)13-8-4-2-1-3-6(8)11(7)16/h1-4H,5H2,(H,13,16)(H,14,15)(H,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
1.48E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the ability to displace [3H]-glycine, by greater than 50%, from NMDA receptor of rat cortical membranes at a dose of 10 microM


Bioorg Med Chem Lett 3: 81-84 (1993)


Article DOI: 10.1016/S0960-894X(00)80096-7
BindingDB Entry DOI: 10.7270/Q2MK6CTN
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



Università di Messina

Curated by ChEMBL


Assay Description
Inhibition of specific binding of [3H]-glycine to NMDA receptors, in rat cortical membranes at 32 uM conc.


Bioorg Med Chem Lett 13: 443-6 (2003)


Article DOI: 10.1016/s0960-894x(02)00955-1
BindingDB Entry DOI: 10.7270/Q2K073MV
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50005034
PNG
(7-Chloro-5-iodo-4-oxo-1,4-dihydro-quinoline-2-carb...)
Show SMILES OC(=O)c1cc(O)c2c(I)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5ClINO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50004950
PNG
(4-Methoxy-quinoline-2-carboxylic acid | CHEMBL5177...)
Show SMILES COc1cc(nc2ccccc12)C(O)=O
Show InChI InChI=1S/C11H9NO3/c1-15-10-6-9(11(13)14)12-8-5-3-2-4-7(8)10/h2-6H,1H3,(H,13,14)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Marion Merrell Dow Research Institute

Curated by ChEMBL


Assay Description
The compound was evaluated for the ability to compete with [3H]-glycine for strychnine-insensitive binding sites on rat cortical and hippocampal memb...


J Med Chem 35: 1791-9 (1992)


Article DOI: 10.1021/jm00088a014
BindingDB Entry DOI: 10.7270/Q22R3QMQ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/a 330n/an/an/an/a



Universita' di Firenze

Curated by ChEMBL


Assay Description
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstrated by the ability to inhibit the binding of thechannel-blocking ...


J Med Chem 42: 2478-84 (1999)


Article DOI: 10.1021/jm981102r
BindingDB Entry DOI: 10.7270/Q20K27R0
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50005034
PNG
(7-Chloro-5-iodo-4-oxo-1,4-dihydro-quinoline-2-carb...)
Show SMILES OC(=O)c1cc(O)c2c(I)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5ClINO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 32n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50052625
PNG
(5,7-Dichloro-1H-quinoline-2,3,4-trione 3-oxime | C...)
Show SMILES Oc1c(N=O)c(=O)[nH]c2cc(Cl)cc(Cl)c12
Show InChI InChI=1S/C9H4Cl2N2O3/c10-3-1-4(11)6-5(2-3)12-9(15)7(13-16)8(6)14/h1-2H,(H2,12,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 33n/an/an/an/an/an/a



CoCensys Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- DCKA binding to NMDA receptor of rat brain membranes


J Med Chem 39: 3248-55 (1996)


Article DOI: 10.1021/jm960214k
BindingDB Entry DOI: 10.7270/Q2QC02KC
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50280272
PNG
(6-Chloro-3-hydroxymethyl-1H-indole-2-carboxylic ac...)
Show SMILES OCc1c([nH]c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C10H8ClNO3/c11-5-1-2-6-7(4-13)9(10(14)15)12-8(6)3-5/h1-3,12-13H,4H2,(H,14,15)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
n/an/a 9.00E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes


Bioorg Med Chem Lett 2: 1627-1630 (1992)


Article DOI: 10.1016/S0960-894X(00)80444-8
BindingDB Entry DOI: 10.7270/Q22V2G1V
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50280277
PNG
(3-Carbamoyl-6-chloro-1H-indole-2-carboxylic acid |...)
Show SMILES NC(=O)c1c([nH]c2cc(Cl)ccc12)C(O)=O
Show InChI InChI=1S/C10H7ClN2O3/c11-4-1-2-5-6(3-4)13-8(10(15)16)7(5)9(12)14/h1-3,13H,(H2,12,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 810n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-L-689,560 binding to Glycine site of NMDA receptor of rat cortical membranes


Bioorg Med Chem Lett 2: 1627-1630 (1992)


Article DOI: 10.1016/S0960-894X(00)80444-8
BindingDB Entry DOI: 10.7270/Q22V2G1V
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50283030
PNG
(7-Chloro-4-(2-phosphono-ethyl)-quinoline-2-carboxy...)
Show SMILES OC(=O)c1cc(CCP(O)(O)=O)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C12H11ClNO5P/c13-8-1-2-9-7(3-4-20(17,18)19)5-11(12(15)16)14-10(9)6-8/h1-2,5-6H,3-4H2,(H,15,16)(H2,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a>1.00E+6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at glycine co-agonist site of rat NMDA receptor


Bioorg Med Chem Lett 4: 2035-2040 (1994)


Article DOI: 10.1016/S0960-894X(01)80558-8
BindingDB Entry DOI: 10.7270/Q2TB17CQ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50283029
PNG
(7-Chloro-4-phosphonomethyl-quinoline-2-carboxylic ...)
Show SMILES OC(=O)c1cc(CP(O)(O)=O)c2ccc(Cl)cc2n1
Show InChI InChI=1S/C11H9ClNO5P/c12-7-1-2-8-6(5-19(16,17)18)3-10(11(14)15)13-9(8)4-7/h1-4H,5H2,(H,14,15)(H2,16,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
n/an/a 6.90E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at glycine co-agonist site of rat NMDA receptor


Bioorg Med Chem Lett 4: 2035-2040 (1994)


Article DOI: 10.1016/S0960-894X(01)80558-8
BindingDB Entry DOI: 10.7270/Q2TB17CQ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
n/an/a 860n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MK-801 binding to a N-methyl-D-aspartic acid(NMDA) receptor in glycine-sensitive rat cortical membranes.


J Med Chem 35: 3423-5 (1992)


Article DOI: 10.1021/jm00096a019
BindingDB Entry DOI: 10.7270/Q2RR1X68
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50001266
PNG
(5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID ...)
Show SMILES OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1
Show InChI InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability of compound to compete with [3H]-glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus


Bioorg Med Chem Lett 1: 455-460 (1991)


Article DOI: 10.1016/S0960-894X(01)81105-7
BindingDB Entry DOI: 10.7270/Q26T0MJC
More data for this
Ligand-Target Pair