BindingDB logo
myBDB logout

9 similar compounds to monomer 50001874

Compile data set for download or QSAR
Wt: 436.6
BDBM50001856
Wt: 408.5
BDBM50001858
Wt: 380.5
BDBM50001864
Wt: 394.5
BDBM50001866
Wt: 377.4
BDBM50001868
Wt: 400.9
BDBM50001875
Wt: 394.5
BDBM50001878
Wt: 422.6
BDBM50001879
Wt: 366.4
BDBM50001882

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50001856,50001858,50001864,50001866,50001868,50001875,50001878,50001879,50001882   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001858
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1
Show InChI InChI=1S/C25H36N4O/c1-20(2)23-8-4-5-9-24(23)28-16-14-27(15-17-28)18-21-11-12-22(26(21)3)19-29-13-7-6-10-25(29)30/h4-5,8-9,11-12,20H,6-7,10,13-19H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
1.40n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001879
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C26H38N4O/c1-21(2)24-9-6-7-10-25(24)29-17-15-28(16-18-29)19-22-12-13-23(27(22)3)20-30-14-8-4-5-11-26(30)31/h6-7,9-10,12-13,21H,4-5,8,11,14-20H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.30n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001856
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C27H40N4O/c1-22(2)25-10-7-8-11-26(25)30-18-16-29(17-19-30)20-23-13-14-24(28(23)3)21-31-15-9-5-4-6-12-27(31)32/h7-8,10-11,13-14,22H,4-6,9,12,15-21H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
3.30n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001866
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-19(2)22-7-4-5-8-23(22)27-15-13-26(14-16-27)17-20-10-11-21(25(20)3)18-28-12-6-9-24(28)29/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.60n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001878
PNG
(1-{1-Methyl-5-[4-(2-propyl-phenyl)-piperazin-1-ylm...)
Show SMILES CCCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-3-7-20-8-4-5-9-23(20)27-16-14-26(15-17-27)18-21-11-12-22(25(21)2)19-28-13-6-10-24(28)29/h4-5,8-9,11-12H,3,6-7,10,13-19H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001866
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-19(2)22-7-4-5-8-23(22)27-15-13-26(14-16-27)17-20-10-11-21(25(20)3)18-28-12-6-9-24(28)29/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
20n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001864
PNG
(1-{5-[4-(2-Ethyl-phenyl)-piperazin-1-ylmethyl]-1-m...)
Show SMILES CCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C23H32N4O/c1-3-19-7-4-5-8-22(19)26-15-13-25(14-16-26)17-20-10-11-21(24(20)2)18-27-12-6-9-23(27)28/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
23n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001878
PNG
(1-{1-Methyl-5-[4-(2-propyl-phenyl)-piperazin-1-ylm...)
Show SMILES CCCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-3-7-20-8-4-5-9-23(20)27-16-14-26(15-17-27)18-21-11-12-22(25(21)2)19-28-13-6-10-24(28)29/h4-5,8-9,11-12H,3,6-7,10,13-19H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
27n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001875
PNG
(1-{5-[4-(3-Chloro-phenyl)-piperazin-1-ylmethyl]-1-...)
Show SMILES Cn1c(CN2CCN(CC2)c2cccc(Cl)c2)ccc1CN1CCCCC1=O
Show InChI InChI=1S/C22H29ClN4O/c1-24-20(8-9-21(24)17-27-10-3-2-7-22(27)28)16-25-11-13-26(14-12-25)19-6-4-5-18(23)15-19/h4-6,8-9,15H,2-3,7,10-14,16-17H2,1H3
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
34n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor by displacing [3H]WB-4101 from rat hippocampus


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001875
PNG
(1-{5-[4-(3-Chloro-phenyl)-piperazin-1-ylmethyl]-1-...)
Show SMILES Cn1c(CN2CCN(CC2)c2cccc(Cl)c2)ccc1CN1CCCCC1=O
Show InChI InChI=1S/C22H29ClN4O/c1-24-20(8-9-21(24)17-27-10-3-2-7-22(27)28)16-25-11-13-26(14-12-25)19-6-4-5-18(23)15-19/h4-6,8-9,15H,2-3,7,10-14,16-17H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
35n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001856
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C27H40N4O/c1-22(2)25-10-7-8-11-26(25)30-18-16-29(17-19-30)20-23-13-14-24(28(23)3)21-31-15-9-5-4-6-12-27(31)32/h7-8,10-11,13-14,22H,4-6,9,12,15-21H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
36n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001864
PNG
(1-{5-[4-(2-Ethyl-phenyl)-piperazin-1-ylmethyl]-1-m...)
Show SMILES CCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C23H32N4O/c1-3-19-7-4-5-8-22(19)26-15-13-25(14-16-26)17-20-10-11-21(24(20)2)18-27-12-6-9-23(27)28/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001858
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1
Show InChI InChI=1S/C25H36N4O/c1-20(2)23-8-4-5-9-24(23)28-16-14-27(15-17-28)18-21-11-12-22(26(21)3)19-29-13-7-6-10-25(29)30/h4-5,8-9,11-12,20H,6-7,10,13-19H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
41n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001856
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C27H40N4O/c1-22(2)25-10-7-8-11-26(25)30-18-16-29(17-19-30)20-23-13-14-24(28(23)3)21-31-15-9-5-4-6-12-27(31)32/h7-8,10-11,13-14,22H,4-6,9,12,15-21H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
50n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001879
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C26H38N4O/c1-21(2)24-9-6-7-10-25(24)29-17-15-28(16-18-29)19-22-12-13-23(27(22)3)20-30-14-8-4-5-11-26(30)31/h6-7,9-10,12-13,21H,4-5,8,11,14-20H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
54n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001868
PNG
(2-{4-[1-Methyl-5-(2-oxo-pyrrolidin-1-ylmethyl)-1H-...)
Show SMILES Cn1c(CN2CCCC2=O)ccc1CN1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H27N5O/c1-24-19(8-9-20(24)17-27-10-4-7-22(27)28)16-25-11-13-26(14-12-25)21-6-3-2-5-18(21)15-23/h2-3,5-6,8-9H,4,7,10-14,16-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
64n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001866
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-19(2)22-7-4-5-8-23(22)27-15-13-26(14-16-27)17-20-10-11-21(25(20)3)18-28-12-6-9-24(28)29/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
76n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001879
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C26H38N4O/c1-21(2)24-9-6-7-10-25(24)29-17-15-28(16-18-29)19-22-12-13-23(27(22)3)20-30-14-8-4-5-11-26(30)31/h6-7,9-10,12-13,21H,4-5,8,11,14-20H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
82n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50001875
PNG
(1-{5-[4-(3-Chloro-phenyl)-piperazin-1-ylmethyl]-1-...)
Show SMILES Cn1c(CN2CCN(CC2)c2cccc(Cl)c2)ccc1CN1CCCCC1=O
Show InChI InChI=1S/C22H29ClN4O/c1-24-20(8-9-21(24)17-27-10-3-2-7-22(27)28)16-25-11-13-26(14-12-25)19-6-4-5-18(23)15-19/h4-6,8-9,15H,2-3,7,10-14,16-17H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
95n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1B receptor by displacing [3H]serotonin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001879
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C26H38N4O/c1-21(2)24-9-6-7-10-25(24)29-17-15-28(16-18-29)19-22-12-13-23(27(22)3)20-30-14-8-4-5-11-26(30)31/h6-7,9-10,12-13,21H,4-5,8,11,14-20H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001882
PNG
(1-[1-Methyl-5-(4-o-tolyl-piperazin-1-ylmethyl)-1H-...)
Show SMILES Cc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C22H30N4O/c1-18-6-3-4-7-21(18)25-14-12-24(13-15-25)16-19-9-10-20(23(19)2)17-26-11-5-8-22(26)27/h3-4,6-7,9-10H,5,8,11-17H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
136n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards Alpha-1 adrenergic receptor by displacing [3H]WB-4101 radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001858
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCC3=O)n2C)CC1
Show InChI InChI=1S/C25H36N4O/c1-20(2)23-8-4-5-9-24(23)28-16-14-27(15-17-28)18-21-11-12-22(26(21)3)19-29-13-7-6-10-25(29)30/h4-5,8-9,11-12,20H,6-7,10,13-19H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
137n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001868
PNG
(2-{4-[1-Methyl-5-(2-oxo-pyrrolidin-1-ylmethyl)-1H-...)
Show SMILES Cn1c(CN2CCCC2=O)ccc1CN1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H27N5O/c1-24-19(8-9-20(24)17-27-10-4-7-22(27)28)16-25-11-13-26(14-12-25)21-6-3-2-5-18(21)15-23/h2-3,5-6,8-9H,4,7,10-14,16-17H2,1H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
140n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001882
PNG
(1-[1-Methyl-5-(4-o-tolyl-piperazin-1-ylmethyl)-1H-...)
Show SMILES Cc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C22H30N4O/c1-18-6-3-4-7-21(18)25-14-12-24(13-15-25)16-19-9-10-20(23(19)2)17-26-11-5-8-22(26)27/h3-4,6-7,9-10H,5,8,11-17H2,1-2H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
167n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001856
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCCCCC3=O)n2C)CC1
Show InChI InChI=1S/C27H40N4O/c1-22(2)25-10-7-8-11-26(25)30-18-16-29(17-19-30)20-23-13-14-24(28(23)3)21-31-15-9-5-4-6-12-27(31)32/h7-8,10-11,13-14,22H,4-6,9,12,15-21H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
196n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001864
PNG
(1-{5-[4-(2-Ethyl-phenyl)-piperazin-1-ylmethyl]-1-m...)
Show SMILES CCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C23H32N4O/c1-3-19-7-4-5-8-22(19)26-15-13-25(14-16-26)17-20-10-11-21(24(20)2)18-27-12-6-9-23(27)28/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
227n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001878
PNG
(1-{1-Methyl-5-[4-(2-propyl-phenyl)-piperazin-1-ylm...)
Show SMILES CCCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-3-7-20-8-4-5-9-23(20)27-16-14-26(15-17-27)18-21-11-12-22(25(21)2)19-28-13-6-10-24(28)29/h4-5,8-9,11-12H,3,6-7,10,13-19H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
283n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001864
PNG
(1-{5-[4-(2-Ethyl-phenyl)-piperazin-1-ylmethyl]-1-m...)
Show SMILES CCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C23H32N4O/c1-3-19-7-4-5-8-22(19)26-15-13-25(14-16-26)17-20-10-11-21(24(20)2)18-27-12-6-9-23(27)28/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
304n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001878
PNG
(1-{1-Methyl-5-[4-(2-propyl-phenyl)-piperazin-1-ylm...)
Show SMILES CCCc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-3-7-20-8-4-5-9-23(20)27-16-14-26(15-17-27)18-21-11-12-22(25(21)2)19-28-13-6-10-24(28)29/h4-5,8-9,11-12H,3,6-7,10,13-19H2,1-2H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
317n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001866
PNG
(1-{5-[4-(2-Isopropyl-phenyl)-piperazin-1-ylmethyl]...)
Show SMILES CC(C)c1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C24H34N4O/c1-19(2)22-7-4-5-8-23(22)27-15-13-26(14-16-27)17-20-10-11-21(25(20)3)18-28-12-6-9-24(28)29/h4-5,7-8,10-11,19H,6,9,12-18H2,1-3H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
409n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 2 receptor by displacing [3H]ketanserin radioligand in rat cerebral cort...


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001882
PNG
(1-[1-Methyl-5-(4-o-tolyl-piperazin-1-ylmethyl)-1H-...)
Show SMILES Cc1ccccc1N1CCN(Cc2ccc(CN3CCCC3=O)n2C)CC1
Show InChI InChI=1S/C22H30N4O/c1-18-6-3-4-7-21(18)25-14-12-24(13-15-25)16-19-9-10-20(23(19)2)17-26-11-5-8-22(26)27/h3-4,6-7,9-10H,5,8,11-17H2,1-2H3
PDB
MMDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
The compound was tested for its binding affinity towards 5-hydroxytryptamine 1 receptor by displacing [3H]5-HT radioligand in rat cerebral cortex


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001868
PNG
(2-{4-[1-Methyl-5-(2-oxo-pyrrolidin-1-ylmethyl)-1H-...)
Show SMILES Cn1c(CN2CCCC2=O)ccc1CN1CCN(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H27N5O/c1-24-19(8-9-20(24)17-27-10-4-7-22(27)28)16-25-11-13-26(14-12-25)21-6-3-2-5-18(21)15-23/h2-3,5-6,8-9H,4,7,10-14,16-17H2,1H3
Reactome pathway
KEGG

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.00E+3n/an/an/an/an/an/an/an/a



R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Binding affinity towards dopamine receptor D2 by displacing [3H]spiperone radioligand in rat striatum


J Med Chem 35: 552-8 (1992)


Article DOI: 10.1021/jm00081a018
BindingDB Entry DOI: 10.7270/Q2PR7WMW
More data for this
Ligand-Target Pair