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7 similar compounds to monomer 50061567

Wt: 192.3
BDBM50452168
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Wt: 162.2
BDBM50001898
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Wt: 204.3
BDBM50007402
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Wt: 212.2
BDBM50007411
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Wt: 191.2
BDBM50106345
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Wt: 226.3
BDBM50397286
Wt: 164.2
BDBM50404731
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50452168,50001898,50007402,50007411,50106345,50397286,50404731   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50007411
PNG
(1-Naphthalen-2-yl-piperazine | CHEMBL278509)
Show SMILES C1CN(CCN1)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2/c1-2-4-13-11-14(6-5-12(13)3-1)16-9-7-15-8-10-16/h1-6,11,15H,7-10H2
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32n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells


J Med Chem 39: 4017-26 (1996)

More data for this
Ligand-Target Pair
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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PubMed
63.3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]-5-HT displacement.


J Med Chem 32: 1052-6 (1989)

More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007402
PNG
(1-Phenyl-4-propyl-piperazine | 1-Phenyl-4-propylpi...)
Show SMILES CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C13H20N2/c1-2-8-14-9-11-15(12-10-14)13-6-4-3-5-7-13/h3-7H,2,8-12H2,1H3
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74n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


J Med Chem 34: 3360-5 (1992)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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149n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]-WB-4101 displacement.


J Med Chem 32: 1052-6 (1989)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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380n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain


J Med Chem 31: 1968-71 (1988)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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380n/an/an/an/an/an/an/an/a



Universidad Complutense

Curated by ChEMBL


Assay Description
Binding affinity towards rat 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT radioligand.


J Med Chem 39: 4439-50 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(RAT)
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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430n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by PDSP Ki Database




Eur J Pharmacol 168: 387-92 (1989)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50007402
PNG
(1-Phenyl-4-propyl-piperazine | 1-Phenyl-4-propylpi...)
Show SMILES CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C13H20N2/c1-2-8-14-9-11-15(12-10-14)13-6-4-3-5-7-13/h3-7H,2,8-12H2,1H3
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470n/an/an/an/an/an/an/an/a



NeuroSearch Sweden AB

Curated by ChEMBL


Assay Description
Displacement of [3H]7-OH-DPAT from human D2S receptor high affinity site expressed in HEK293 cells


Eur J Med Chem 62: 241-55 (2013)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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500n/an/an/an/an/an/an/an/a



Solvay Duphar Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]-2-(di-N-propylamino)-8-hydroxytetralin from central 5-hydroxytryptamine 1A receptor recognition sites in rat frontal cortex homo...


J Med Chem 38: 1942-54 (1995)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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500n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
Binding affinity was evaluated by determining in vitro displacement of [3H]-8-OH-DPAT from the central 5-hydroxytryptamine 1A receptor recognition si...


J Med Chem 40: 300-12 (1997)

More data for this
Ligand-Target Pair
Serotonin 3 (5-HT3) receptor


(Homo sapiens (Human))
BDBM50397286
PNG
(CHEMBL2169968)
Show SMILES CN1CCN(CC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C15H18N2/c1-16-8-10-17(11-9-16)15-7-6-13-4-2-3-5-14(13)12-15/h2-7,12H,8-11H2,1H3
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537n/an/an/an/an/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Displacement of [3H]granisetron from 5HT3A receptor expressed in HEK293 cells after 24 hrs by scintillation counting in presence of quipazine


J Med Chem 55: 8603-14 (2012)

More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50007411
PNG
(1-Naphthalen-2-yl-piperazine | CHEMBL278509)
Show SMILES C1CN(CCN1)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2/c1-2-4-13-11-14(6-5-12(13)3-1)16-9-7-15-8-10-16/h1-6,11,15H,7-10H2
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550n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


J Med Chem 34: 3360-5 (1992)

More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity against rat Dopamine receptor D2.


J Med Chem 32: 1052-6 (1989)

More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat Dopamine receptor D1 by [3H]-SCH-23,390 displacement.


J Med Chem 32: 1052-6 (1989)

More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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1.51E+3n/an/an/an/an/an/an/an/a



Gedeon Richter Plc., Gyömroiút 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Displacement of [3H]-UK14304 from recombinant human alpha2c adrenergic receptor expressed in CHOK1 cell membranes after 30 mins by scintillation coun...


Bioorg Med Chem 23: 3991-9 (2015)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50007411
PNG
(1-Naphthalen-2-yl-piperazine | CHEMBL278509)
Show SMILES C1CN(CCN1)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2/c1-2-4-13-11-14(6-5-12(13)3-1)16-9-7-15-8-10-16/h1-6,11,15H,7-10H2
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2.10E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity for rodent 5-hydroxytryptamine 5A receptor


J Med Chem 46: 2795-812 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007411
PNG
(1-Naphthalen-2-yl-piperazine | CHEMBL278509)
Show SMILES C1CN(CCN1)c1ccc2ccccc2c1
Show InChI InChI=1S/C14H16N2/c1-2-4-13-11-14(6-5-12(13)3-1)16-9-7-15-8-10-16/h1-6,11,15H,7-10H2
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2.90E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brain


J Med Chem 31: 1968-71 (1988)

More data for this
Ligand-Target Pair
Serotonin 3a (5-HT3a)/3b (5-HT3b)/3c (5-HT3c)/3d (5-HT3d)/3e (5-HT3e) receptor


(Homo sapiens (Human))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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3.00E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cells


J Med Chem 39: 4017-26 (1996)

More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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6.80E+3n/an/an/an/an/an/an/an/a



Solvay Pharma

Curated by ChEMBL


Assay Description
In vitro displacement of [3H]-spiperone from Dopamine receptor D2 binding site in rat striatum.


J Med Chem 40: 300-12 (1997)

More data for this
Ligand-Target Pair
Sigma


(HUMAN)
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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1.14E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligand


J Med Chem 34: 3360-5 (1992)

More data for this
Ligand-Target Pair
Monoamine oxidase


(Rattus norvegicus (rat))
BDBM50007402
PNG
(1-Phenyl-4-propyl-piperazine | 1-Phenyl-4-propylpi...)
Show SMILES CCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C13H20N2/c1-2-8-14-9-11-15(12-10-14)13-6-4-3-5-7-13/h3-7H,2,8-12H2,1H3
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4.68E+4n/an/an/an/an/an/an/an/a



NeuroSearch Sweden AB

Curated by ChEMBL


Assay Description
Displacement of [3H]-Ro 41-1049 from MAO-A receptor in rat cerebral cortex


J Med Chem 55: 3242-9 (2012)

More data for this
Ligand-Target Pair
glutathione S-transferase


(Homo sapiens)
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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PCBioAssay
n/an/an/an/a 3.73E+4n/an/an/an/a



NMMLSC

Curated by PubChem BioAssay


Assay Description
University of New Mexico Assay Overview: Assay Support: NIH 1X01 MH079850-01 HTS to identify small molecule regulators of Bcl-2 family protein int...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (human))
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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n/an/a 2.75E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2007)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404731
PNG
(CHEMBL138614)
Show SMILES CN(C)CCNc1ccccc1
Show InChI InChI=1S/C10H16N2/c1-12(2)9-8-11-10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3
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n/an/an/a 955n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
The binding affinity to 5-hydroxytryptamine 2B receptor of rat fundus


J Med Chem 25: 68-70 (1982)

More data for this
Ligand-Target Pair
PTK2B protein tyrosine kinase 2 beta (PTK2B)


(Homo sapiens (Human))
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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n/an/a 2.83E+3n/an/an/an/an/an/a



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...


PubChem Bioassay (2009)

More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50404731
PNG
(CHEMBL138614)
Show SMILES CN(C)CCNc1ccccc1
Show InChI InChI=1S/C10H16N2/c1-12(2)9-8-11-10-6-4-3-5-7-10/h3-7,11H,8-9H2,1-2H3
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n/an/an/a 955n/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes


Citation and Details
More data for this
Ligand-Target Pair
Serotonin receptor 2a and 2b (5HT2A and 5HT2B)


(RAT)
BDBM50452168
PNG
(CHEMBL138604)
Show SMILES CCN(CCN(C)C)c1ccccc1
Show InChI InChI=1S/C12H20N2/c1-4-14(11-10-13(2)3)12-8-6-5-7-9-12/h5-9H,4,10-11H2,1-3H3
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n/an/an/a 537n/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]5-HT binding to serotonin receptor of rat fundus membranes


Citation and Details
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
PDB
MMDB

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n/an/a>1.00E+5n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...


J Med Chem 35: 743-50 (1992)

More data for this
Ligand-Target Pair
Alpha-2C adrenergic receptor


(Homo sapiens (Human))
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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Article
PubMed
n/an/an/an/a<5.01E+5n/an/an/an/a



Gedeon Richter Plc., Gyömroiút 19-21, Budapest H-1103, Hungary.

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human alpha2c adrenergic receptor expressed in CHOK1 cells co-expressing Gqi5 assessed as induction of cytoplasmic ca...


Bioorg Med Chem 23: 3991-9 (2015)

More data for this
Ligand-Target Pair
Estrogen receptor


(Homo sapiens (human))
BDBM50106345
PNG
(4-(4-Methyl-piperazin-1-yl)-phenylamine | CHEMBL34...)
Show SMILES CN1CCN(CC1)c1ccc(N)cc1
Show InChI InChI=1S/C11H17N3/c1-13-6-8-14(9-7-13)11-4-2-10(12)3-5-11/h2-5H,6-9,12H2,1H3
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n/an/a 7.13E+3n/an/an/an/an/an/a



Emory University Molecular Libraries Screening Center

Curated by PubChem BioAssay


Assay Description
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...


PubChem Bioassay (2008)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (human))
BDBM50001898
PNG
(1-Phenyl-piperazine | CHEMBL9434 | PHENYLPIPERAZIN...)
Show SMILES C1CN(CCN1)c1ccccc1
Show InChI InChI=1S/C10H14N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h1-5,11H,6-9H2
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n/an/a 1.90E+4n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...


J Med Chem 35: 743-50 (1992)

More data for this
Ligand-Target Pair