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15 similar compounds to monomer 50011977

Wt: 414.9
BDBM50003266
Wt: 491.0
BDBM50003269
Wt: 428.9
BDBM50003271
Wt: 428.9
BDBM50003288
Wt: 424.5
BDBM50011970
Wt: 396.5
BDBM50011971
Wt: 425.5
BDBM50011974
Wt: 458.9
BDBM50011975
Wt: 425.5
BDBM50011976
Wt: 410.5
BDBM50011978
Wt: 380.5
BDBM50048069
Wt: 493.4
BDBM50048076
Wt: 458.9
BDBM50048078
Wt: 474.5
BDBM50282362
Wt: 493.4
BDBM50282363

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50003266,50003269,50003271,50003288,50011970,50011971,50011974,50011975,50011976,50011978,50048069,50048076,50048078,50282362,50282363   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50282362
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c2ccccc12
Show InChI InChI=1S/C27H26N2O4S/c1-2-3-10-25-28-16-20(14-19(26(30)31)15-21-7-6-13-34-21)29(25)17-18-11-12-24(27(32)33)23-9-5-4-8-22(18)23/h4-9,11-14,16H,2-3,10,15,17H2,1H3,(H,30,31)(H,32,33)/b19-14+
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n/an/a 1.20n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for Angiotensin II receptor, type 1 affinity in the absence of BSA


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011970
PNG
(2-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O4S/c1-2-3-10-21-24-14-18(12-17(22(26)27)13-19-8-6-11-30-19)25(21)15-16-7-4-5-9-20(16)23(28)29/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)(H,28,29)/b17-12+
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n/an/a 6.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50003269
PNG
(3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2...)
Show SMILES CCCCc1ncc(\C=C(/C(c2cccs2)c2ccccc2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C28H27ClN2O2S/c1-2-3-15-26-30-18-22(31(26)19-21-12-7-8-13-24(21)29)17-23(28(32)33)27(25-14-9-16-34-25)20-10-5-4-6-11-20/h4-14,16-18,27H,2-3,15,19H2,1H3,(H,32,33)/b23-17+
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n/an/a 2.40E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Angiotensin II receptor specific binding to rat mesenteric arteries


J Med Chem 35: 3858-72 (1992)


Article DOI: 10.1021/jm00099a013
BindingDB Entry DOI: 10.7270/Q23T9G4T
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50003271
PNG
(3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2...)
Show SMILES CCCCc1ncc(\C=C(/Cc2sccc2C)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O2S/c1-3-4-9-22-25-14-19(26(22)15-17-7-5-6-8-20(17)24)12-18(23(27)28)13-21-16(2)10-11-29-21/h5-8,10-12,14H,3-4,9,13,15H2,1-2H3,(H,27,28)/b18-12+
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n/an/a 730n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Angiotensin II receptor specific binding to rat mesenteric arteries


J Med Chem 35: 3858-72 (1992)


Article DOI: 10.1021/jm00099a013
BindingDB Entry DOI: 10.7270/Q23T9G4T
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50003288
PNG
(3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-yl]-2...)
Show SMILES CCCCc1ncc(\C=C(/Cc2ccc(C)s2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C23H25ClN2O2S/c1-3-4-9-22-25-14-19(26(22)15-17-7-5-6-8-21(17)24)12-18(23(27)28)13-20-11-10-16(2)29-20/h5-8,10-12,14H,3-4,9,13,15H2,1-2H3,(H,27,28)/b18-12+
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n/an/a 700n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Angiotensin II receptor specific binding to rat mesenteric arteries


J Med Chem 35: 3858-72 (1992)


Article DOI: 10.1021/jm00099a013
BindingDB Entry DOI: 10.7270/Q23T9G4T
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011970
PNG
(2-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1C(O)=O
Show InChI InChI=1S/C23H24N2O4S/c1-2-3-10-21-24-14-18(12-17(22(26)27)13-19-8-6-11-30-19)25(21)15-16-7-4-5-9-20(16)23(28)29/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)(H,28,29)/b17-12+
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n/an/a 6.00E+3n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011971
PNG
(3-[2-Butyl-3-(2-hydroxy-benzyl)-3H-imidazol-4-yl]-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1O
Show InChI InChI=1S/C22H24N2O3S/c1-2-3-10-21-23-14-18(24(21)15-16-7-4-5-9-20(16)25)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14,25H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 90n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011974
PNG
(3-[2-Butyl-3-(2-nitro-benzyl)-3H-imidazol-4-yl]-2-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H23N3O4S/c1-2-3-10-21-23-14-18(12-17(22(26)27)13-19-8-6-11-30-19)24(21)15-16-7-4-5-9-20(16)25(28)29/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 31n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011975
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1Cl)C(O)=O
Show InChI InChI=1S/C23H23ClN2O4S/c1-2-3-6-21-25-13-18(10-17(23(29)30)11-19-5-4-9-31-19)26(21)14-16-8-7-15(22(27)28)12-20(16)24/h4-5,7-10,12-13H,2-3,6,11,14H2,1H3,(H,27,28)(H,29,30)/b17-10+
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n/an/a 1.5n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50003266
PNG
((E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-y...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O2S/c1-2-3-10-21-24-14-18(25(21)15-16-7-4-5-9-20(16)23)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 440n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011976
PNG
(3-[2-Butyl-3-(4-nitro-benzyl)-3H-imidazol-4-yl]-2-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H23N3O4S/c1-2-3-6-21-23-14-19(12-17(22(26)27)13-20-5-4-11-30-20)24(21)15-16-7-9-18(10-8-16)25(28)29/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 620n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II AT2


(RAT)
BDBM50011978
PNG
(3-[2-Butyl-3-(4-hydroxy-3-methyl-benzyl)-3H-imidaz...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(O)c(C)c1
Show InChI InChI=1S/C23H26N2O3S/c1-3-4-7-22-24-14-19(12-18(23(27)28)13-20-6-5-10-29-20)25(22)15-17-8-9-21(26)16(2)11-17/h5-6,8-12,14,26H,3-4,7,13,15H2,1-2H3,(H,27,28)/b18-12+
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n/an/a 21n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
In vitro inhibition of [125I]-AII specific binding towards Angiotensin II receptor in rat mesenteric membranes.


J Med Chem 34: 1514-7 (1991)


Article DOI: 10.1021/jm00108a043
BindingDB Entry DOI: 10.7270/Q2TD9WBV
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50282362
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c2ccccc12
Show InChI InChI=1S/C27H26N2O4S/c1-2-3-10-25-28-16-20(14-19(26(30)31)15-21-7-6-13-34-21)29(25)17-18-11-12-24(27(32)33)23-9-5-4-8-22(18)23/h4-9,11-14,16H,2-3,10,15,17H2,1H3,(H,30,31)(H,32,33)/b19-14+
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n/an/a 31n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSA


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50011975
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1Cl)C(O)=O
Show InChI InChI=1S/C23H23ClN2O4S/c1-2-3-6-21-25-13-18(10-17(23(29)30)11-19-5-4-9-31-19)26(21)14-16-8-7-15(22(27)28)12-20(16)24/h4-5,7-10,12-13H,2-3,6,11,14H2,1H3,(H,27,28)(H,29,30)/b17-10+
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50048069
PNG
((E)-3-(3-Benzyl-2-butyl-3H-imidazol-4-yl)-2-thioph...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1
Show InChI InChI=1S/C22H24N2O2S/c1-2-3-11-21-23-15-19(24(21)16-17-8-5-4-6-9-17)13-18(22(25)26)14-20-10-7-12-27-20/h4-10,12-13,15H,2-3,11,14,16H2,1H3,(H,25,26)/b18-13+
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TBA

Curated by ChEMBL


Assay Description
Tested for binding affinity to Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50048076
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1cc(Cl)c(cc1Cl)C(O)=O
Show InChI InChI=1S/C23H22Cl2N2O4S/c1-2-3-6-21-26-12-16(8-14(22(28)29)9-17-5-4-7-32-17)27(21)13-15-10-20(25)18(23(30)31)11-19(15)24/h4-5,7-8,10-12H,2-3,6,9,13H2,1H3,(H,28,29)(H,30,31)/b14-8+
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TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50282363
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c(Cl)c1Cl
Show InChI InChI=1S/C23H22Cl2N2O4S/c1-2-3-6-19-26-12-16(10-15(22(28)29)11-17-5-4-9-32-17)27(19)13-14-7-8-18(23(30)31)21(25)20(14)24/h4-5,7-10,12H,2-3,6,11,13H2,1H3,(H,28,29)(H,30,31)/b15-10+
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n/an/a 0.160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50282362
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c2ccccc12
Show InChI InChI=1S/C27H26N2O4S/c1-2-3-10-25-28-16-20(14-19(26(30)31)15-21-7-6-13-34-21)29(25)17-18-11-12-24(27(32)33)23-9-5-4-8-22(18)23/h4-9,11-14,16H,2-3,10,15,17H2,1H3,(H,30,31)(H,32,33)/b19-14+
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TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50048078
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c(Cl)c1
Show InChI InChI=1S/C23H23ClN2O4S/c1-2-3-6-21-25-13-17(11-16(22(27)28)12-18-5-4-9-31-18)26(21)14-15-7-8-19(23(29)30)20(24)10-15/h4-5,7-11,13H,2-3,6,12,14H2,1H3,(H,27,28)(H,29,30)/b16-11+
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50003266
PNG
((E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-y...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O2S/c1-2-3-10-21-24-14-18(25(21)15-16-7-4-5-9-20(16)23)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 4.53E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for binding affinity to Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 23-28 (1994)


Article DOI: 10.1016/S0960-894X(01)81116-1
BindingDB Entry DOI: 10.7270/Q29G5MRF
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50048069
PNG
((E)-3-(3-Benzyl-2-butyl-3H-imidazol-4-yl)-2-thioph...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1
Show InChI InChI=1S/C22H24N2O2S/c1-2-3-11-21-23-15-19(24(21)16-17-8-5-4-6-9-17)13-18(22(25)26)14-20-10-7-12-27-20/h4-10,12-13,15H,2-3,11,14,16H2,1H3,(H,25,26)/b18-13+
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n/an/a 4.53E+3n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50048076
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1cc(Cl)c(cc1Cl)C(O)=O
Show InChI InChI=1S/C23H22Cl2N2O4S/c1-2-3-6-21-26-12-16(8-14(22(28)29)9-17-5-4-7-32-17)27(21)13-15-10-20(25)18(23(30)31)11-19(15)24/h4-5,7-8,10-12H,2-3,6,9,13H2,1H3,(H,28,29)(H,30,31)/b14-8+
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n/an/a 35n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50048078
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(C(O)=O)c(Cl)c1
Show InChI InChI=1S/C23H23ClN2O4S/c1-2-3-6-21-25-13-17(11-16(22(27)28)12-18-5-4-9-31-18)26(21)14-15-7-8-19(23(29)30)20(24)10-15/h4-5,7-11,13H,2-3,6,12,14H2,1H3,(H,27,28)(H,29,30)/b16-11+
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50003266
PNG
((E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-y...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O2S/c1-2-3-10-21-24-14-18(25(21)15-16-7-4-5-9-20(16)23)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 440n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011974
PNG
(3-[2-Butyl-3-(2-nitro-benzyl)-3H-imidazol-4-yl]-2-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H23N3O4S/c1-2-3-10-21-23-14-18(12-17(22(26)27)13-19-8-6-11-30-19)24(21)15-16-7-4-5-9-20(16)25(28)29/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 31n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011978
PNG
(3-[2-Butyl-3-(4-hydroxy-3-methyl-benzyl)-3H-imidaz...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(O)c(C)c1
Show InChI InChI=1S/C23H26N2O3S/c1-3-4-7-22-24-14-19(12-18(23(27)28)13-20-6-5-10-29-20)25(22)15-17-8-9-21(26)16(2)11-17/h5-6,8-12,14,26H,3-4,7,13,15H2,1-2H3,(H,27,28)/b18-12+
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n/an/a 21n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011971
PNG
(3-[2-Butyl-3-(2-hydroxy-benzyl)-3H-imidazol-4-yl]-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1O
Show InChI InChI=1S/C22H24N2O3S/c1-2-3-10-21-23-14-18(24(21)15-16-7-4-5-9-20(16)25)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14,25H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 34n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011975
PNG
(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1Cl)C(O)=O
Show InChI InChI=1S/C23H23ClN2O4S/c1-2-3-6-21-25-13-18(10-17(23(29)30)11-19-5-4-9-31-19)26(21)14-16-8-7-15(22(27)28)12-20(16)24/h4-5,7-10,12-13H,2-3,6,11,14H2,1H3,(H,27,28)(H,29,30)/b17-10+
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II receptor


(RAT)
BDBM50011976
PNG
(3-[2-Butyl-3-(4-nitro-benzyl)-3H-imidazol-4-yl]-2-...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C22H23N3O4S/c1-2-3-6-21-23-14-19(12-17(22(26)27)13-20-5-4-11-30-20)24(21)15-16-7-9-18(10-8-16)25(28)29/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 620n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of [125I]AII binding to Angiotensin II receptor, type 1 of rat mesenteric arteries


Citation and Details

Article DOI: 10.1021/jm00065a011
More data for this
Ligand-Target Pair
Angiotensin II AT1B


(RAT)
BDBM50003266
PNG
((E)-3-[2-Butyl-3-(2-chloro-benzyl)-3H-imidazol-4-y...)
Show SMILES CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc1ccccc1Cl
Show InChI InChI=1S/C22H23ClN2O2S/c1-2-3-10-21-24-14-18(25(21)15-16-7-4-5-9-20(16)23)12-17(22(26)27)13-19-8-6-11-28-19/h4-9,11-12,14H,2-3,10,13,15H2,1H3,(H,26,27)/b17-12+
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n/an/a 440n/an/an/an/an/an/a



SmithKline Beecham Pharmaceuticals

Curated by ChEMBL


Assay Description
Inhibition of [125I]-Angiotensin II receptor specific binding to rat mesenteric arteries


J Med Chem 35: 3858-72 (1992)


Article DOI: 10.1021/jm00099a013
BindingDB Entry DOI: 10.7270/Q23T9G4T
More data for this
Ligand-Target Pair