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19 similar compounds to monomer 50267614

Compile data set for download or QSAR
Wt: 522.5
BDBM50003626
Wt: 526.4
BDBM50003635
Wt: 494.4
BDBM50003633
Wt: 544.4
BDBM50003623
Wt: 526.4
BDBM50003625
Wt: 533.4
BDBM50003630
Wt: 587.3
BDBM50003631
Wt: 526.4
BDBM50003629
Wt: 542.9
BDBM50003637
Wt: 587.3
BDBM50003622
Wt: 522.5
BDBM50003641
Wt: 453.5
BDBM50267727
Wt: 507.4
BDBM50267765
Wt: 488.6
BDBM50267811
Wt: 456.6
BDBM50267812
Displayed 1 to 15 (of 19 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50003626,50003635,50003633,50003623,50003625,50003630,50003631,50003629,50003637,50003622,50003641,50267727,50267765,50267811,50267812   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003631
PNG
(CHEMBL523957)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccc(Br)cc3)(CC1)CC2
Show InChI InChI=1S/C29H33BrNO2.BrH/c30-27-13-11-24(12-14-27)23-33-22-21-31-18-15-28(16-19-31,17-20-31)29(32,25-7-3-1-4-8-25)26-9-5-2-6-10-26;/h1-14,32H,15-23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50267812
PNG
(4-{Hydroxy[bis(4-methylphenyl)]methyl}-1-{2-[(phen...)
Show SMILES Cc1ccc(cc1)C(O)(c1ccc(C)cc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2
Show InChI InChI=1S/C31H38NO2/c1-25-8-12-28(13-9-25)31(33,29-14-10-26(2)11-15-29)30-16-19-32(20-17-30,21-18-30)22-23-34-24-27-6-4-3-5-7-27/h3-15,33H,16-24H2,1-2H3/q+1
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n/an/a 1.20E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003629
PNG
(CHEMBL489212)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3cccc(F)c3)(CC1)CC2
Show InChI InChI=1S/C29H33FNO2.BrH/c30-27-13-7-8-24(22-27)23-33-21-20-31-17-14-28(15-18-31,16-19-31)29(32,25-9-3-1-4-10-25)26-11-5-2-6-12-26;/h1-13,22,32H,14-21,23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003637
PNG
(CHEMBL523474)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccc(Cl)cc3)(CC1)CC2
Show InChI InChI=1S/C29H33ClNO2.BrH/c30-27-13-11-24(12-14-27)23-33-22-21-31-18-15-28(16-19-31,17-20-31)29(32,25-7-3-1-4-8-25)26-9-5-2-6-10-26;/h1-14,32H,15-23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003635
PNG
(CHEMBL521781)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccc(F)cc3)(CC1)CC2
Show InChI InChI=1S/C29H33FNO2.BrH/c30-27-13-11-24(12-14-27)23-33-22-21-31-18-15-28(16-19-31,17-20-31)29(32,25-7-3-1-4-8-25)26-9-5-2-6-10-26;/h1-14,32H,15-23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003626
PNG
(CHEMBL489211)
Show SMILES Cc1ccc(COCC[N+]23CCC(CC2)(CC3)C(O)(c2ccccc2)c2ccccc2)cc1
Show InChI InChI=1S/C30H36NO2.BrH/c1-25-12-14-26(15-13-25)24-33-23-22-31-19-16-29(17-20-31,18-21-31)30(32,27-8-4-2-5-9-27)28-10-6-3-7-11-28;/h2-15,32H,16-24H2,1H3;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003630
PNG
(CHEMBL523598)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccc(cc3)C#N)(CC1)CC2
Show InChI InChI=1S/C30H33N2O2.BrH/c31-23-25-11-13-26(14-12-25)24-34-22-21-32-18-15-29(16-19-32,17-20-32)30(33,27-7-3-1-4-8-27)28-9-5-2-6-10-28;/h1-14,33H,15-22,24H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003641
PNG
(CHEMBL476434)
Show SMILES Cc1cccc(COCC[N+]23CCC(CC2)(CC3)C(O)(c2ccccc2)c2ccccc2)c1
Show InChI InChI=1S/C30H36NO2.BrH/c1-25-9-8-10-26(23-25)24-33-22-21-31-18-15-29(16-19-31,17-20-31)30(32,27-11-4-2-5-12-27)28-13-6-3-7-14-28;/h2-14,23,32H,15-22,24H2,1H3;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003633
PNG
(CHEMBL490243)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3)(CC1)C2
Show InChI InChI=1S/C28H32NO2.BrH/c30-28(25-12-6-2-7-13-25,26-14-8-3-9-15-26)27-16-18-29(23-27,19-17-27)20-21-31-22-24-10-4-1-5-11-24;/h1-15,30H,16-23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003623
PNG
(CHEMBL522081)
Show SMILES OC(c1ccc(F)cc1)(c1ccc(F)cc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2
Show InChI InChI=1S/C29H32F2NO2.BrH/c30-26-10-6-24(7-11-26)29(33,25-8-12-27(31)13-9-25)28-14-17-32(18-15-28,19-16-28)20-21-34-22-23-4-2-1-3-5-23;/h1-13,33H,14-22H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003625
PNG
(CHEMBL490237)
Show SMILES [Br-].OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3F)(CC1)CC2
Show InChI InChI=1S/C29H33FNO2.BrH/c30-27-14-8-7-9-24(27)23-33-22-21-31-18-15-28(16-19-31,17-20-31)29(32,25-10-3-1-4-11-25)26-12-5-2-6-13-26;/h1-14,32H,15-23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50267727
PNG
(1-(2-{[(2-Cyanophenyl)methyl]oxy}ethyl)-4-[hydroxy...)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3C#N)(CC1)CC2
Show InChI InChI=1S/C30H33N2O2/c31-23-25-9-7-8-10-26(25)24-34-22-21-32-18-15-29(16-19-32,17-20-32)30(33,27-11-3-1-4-12-27)28-13-5-2-6-14-28/h1-14,33H,15-22,24H2/q+1
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n/an/a 5.40E+6n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50267765
PNG
(1-(2-{[(2-Bromophenyl)methyl]oxy}ethyl)-4-[hydroxy...)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3ccccc3Br)(CC1)CC2
Show InChI InChI=1S/C29H33BrNO2/c30-27-14-8-7-9-24(27)23-33-22-21-31-18-15-28(16-19-31,17-20-31)29(32,25-10-3-1-4-11-25)26-12-5-2-6-13-26/h1-14,32H,15-23H2/q+1
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n/an/a 2.20E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50267811
PNG
(4-(Hydroxy{bis[4-(methyloxy)phenyl]}methyl)-1-{2-[...)
Show SMILES COc1ccc(cc1)C(O)(c1ccc(OC)cc1)C12CC[N+](CCOCc3ccccc3)(CC1)CC2
Show InChI InChI=1S/C31H38NO4/c1-34-28-12-8-26(9-13-28)31(33,27-10-14-29(35-2)15-11-27)30-16-19-32(20-17-30,21-18-30)22-23-36-24-25-6-4-3-5-7-25/h3-15,33H,16-24H2,1-2H3/q+1
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n/an/a 3.60E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair
Muscarinic acetylcholine receptor M3


(Homo sapiens (Human))
BDBM50003622
PNG
(CHEMBL524119)
Show SMILES OC(c1ccccc1)(c1ccccc1)C12CC[N+](CCOCc3cccc(Br)c3)(CC1)CC2
Show InChI InChI=1S/C29H33BrNO2.BrH/c30-27-13-7-8-24(22-27)23-33-21-20-31-17-14-28(15-18-31,16-19-31)29(32,25-9-3-1-4-10-25)26-11-5-2-6-12-26;/h1-13,22,32H,14-21,23H2;1H/q+1;/p-1
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n/an/a<1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilizatio...


J Med Chem 52: 2493-505 (2009)


Article DOI: 10.1021/jm801601v
BindingDB Entry DOI: 10.7270/Q2H131X8
More data for this
Ligand-Target Pair