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21 similar compounds to monomer 50306442

Compile data set for download or QSAR
Wt: 313.8
BDBM50004823
Wt: 313.8
BDBM50010711
Wt: 313.8
BDBM50010712
Wt: 313.8
BDBM50010715
Wt: 313.8
BDBM50017815
Wt: 329.8
BDBM50306435
Wt: 356.8
BDBM50306437
Wt: 407.9
BDBM50306443
Wt: 414.9
BDBM50306444
Wt: 434.9
BDBM50306445
Wt: 473.9
BDBM50306446
Wt: 425.8
BDBM50306447
Wt: 419.9
BDBM50306448
Wt: 432.9
BDBM50306449
Wt: 419.9
BDBM50306450
Displayed 1 to 15 (of 21 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 61 hits for monomerid = 50004823,50010711,50010712,50010715,50017815,50306435,50306437,50306443,50306444,50306445,50306446,50306447,50306448,50306449,50306450   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306443
PNG
((6aS,13bS)-11-chloro-4-(3-fluorophenyl)-7-methyl-6...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(F)c1
Show InChI InChI=1S/C25H23ClFNO/c1-28-11-10-16-13-22(26)24(29)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)28)15-4-2-5-17(27)12-15/h2-7,12-14,23,25,29H,8-11H2,1H3/t23-,25+/m0/s1
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0.400n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306445
PNG
((6aS,13bS)-11-chloro-7-methyl-4-(3-nitrophenyl)-6,...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C25H23ClN2O3/c1-27-11-10-16-13-22(26)24(29)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)27)15-4-2-5-17(12-15)28(30)31/h2-7,12-14,23,25,29H,8-11H2,1H3/t23-,25+/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306435
PNG
((6aS,13bS)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(O)cccc21
Show InChI InChI=1S/C19H20ClNO2/c1-21-8-7-11-9-15(20)18(23)10-14(11)19-13-3-2-4-17(22)12(13)5-6-16(19)21/h2-4,9-10,16,19,22-23H,5-8H2,1H3/t16-,19+/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306444
PNG
(3-((6aS,13bS)-11-chloro-12-hydroxy-7-methyl-6,6a,7...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)C#N
Show InChI InChI=1S/C26H23ClN2O/c1-29-11-10-18-13-23(27)25(30)14-22(18)26-21-7-3-6-19(20(21)8-9-24(26)29)17-5-2-4-16(12-17)15-28/h2-7,12-14,24,26,30H,8-11H2,1H3/t24-,26+/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306449
PNG
((6aS,13bS)-11-chloro-4-(4-(dimethylamino)phenyl)-7...)
Show SMILES CN(C)c1ccc(cc1)-c1cccc2[C@H]3[C@H](CCc12)N(C)CCc1cc(Cl)c(O)cc31
Show InChI InChI=1S/C27H29ClN2O/c1-29(2)19-9-7-17(8-10-19)20-5-4-6-22-21(20)11-12-25-27(22)23-16-26(31)24(28)15-18(23)13-14-30(25)3/h4-10,15-16,25,27,31H,11-14H2,1-3H3/t25-,27+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306450
PNG
((6aS,13bS)-11-chloro-4-(4-(hydroxymethyl)phenyl)-7...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1ccc(CO)cc1
Show InChI InChI=1S/C26H26ClNO2/c1-28-12-11-18-13-23(27)25(30)14-22(18)26-21-4-2-3-19(20(21)9-10-24(26)28)17-7-5-16(15-29)6-8-17/h2-8,13-14,24,26,29-30H,9-12,15H2,1H3/t24-,26+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306448
PNG
((6aS,13bS)-11-chloro-4-(4-methoxyphenyl)-7-methyl-...)
Show SMILES COc1ccc(cc1)-c1cccc2[C@H]3[C@H](CCc12)N(C)CCc1cc(Cl)c(O)cc31
Show InChI InChI=1S/C26H26ClNO2/c1-28-13-12-17-14-23(27)25(29)15-22(17)26-21-5-3-4-19(20(21)10-11-24(26)28)16-6-8-18(30-2)9-7-16/h3-9,14-15,24,26,29H,10-13H2,1-2H3/t24-,26+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306447
PNG
((6aS,13bS)-11-chloro-4-(3,5-difluorophenyl)-7-meth...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H22ClF2NO/c1-29-8-7-14-11-22(26)24(30)13-21(14)25-20-4-2-3-18(19(20)5-6-23(25)29)15-9-16(27)12-17(28)10-15/h2-4,9-13,23,25,30H,5-8H2,1H3/t23-,25+/m0/s1
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0.900n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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1.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D1 receptor


Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50306435
PNG
((6aS,13bS)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(O)cccc21
Show InChI InChI=1S/C19H20ClNO2/c1-21-8-7-11-9-15(20)18(23)10-14(11)19-13-3-2-4-17(22)12(13)5-6-16(19)21/h2-4,9-10,16,19,22-23H,5-8H2,1H3/t16-,19+/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306437
PNG
(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(CN=O)cccc21
Show InChI InChI=1S/C20H21ClN2O2/c1-23-8-7-12-9-17(21)19(24)10-16(12)20-15-4-2-3-13(11-22-25)14(15)5-6-18(20)23/h2-4,9-10,18,20,24H,5-8,11H2,1H3/t18-,20+/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH-23,390 binding to rat striatal homogenate dopamine receptor D1


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1


J Med Chem 33: 2197-204 (1990)


Article DOI: 10.1021/jm00170a025
BindingDB Entry DOI: 10.7270/Q2TD9XZB
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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1.90n/an/an/an/an/an/an/an/a



University of Lund

Curated by ChEMBL


Assay Description
Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1


J Med Chem 35: 502-7 (1992)


Article DOI: 10.1021/jm00081a010
BindingDB Entry DOI: 10.7270/Q2TH8N95
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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2n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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2n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D5 receptor


Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50306446
PNG
((6aR,13bS)-11-chloro-7-methyl-4-(3-(trifluorometho...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@H]1CCc1c2cccc1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H23ClF3NO2/c1-31-11-10-16-13-22(27)24(32)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)31)15-4-2-5-17(12-15)33-26(28,29)30/h2-7,12-14,23,25,32H,8-11H2,1H3/t23-,25-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50017815
PNG
(11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahydro-6H-7-a...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C2C1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3
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3.30n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH-23,390 binding to rat striatal homogenate dopamine receptor D1


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50306437
PNG
(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(CN=O)cccc21
Show InChI InChI=1S/C20H21ClN2O2/c1-23-8-7-12-9-17(21)19(24)10-16(12)20-15-4-2-3-13(11-22-25)14(15)5-6-18(20)23/h2-4,9-10,18,20,24H,5-8,11H2,1H3/t18-,20+/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50306444
PNG
(3-((6aS,13bS)-11-chloro-12-hydroxy-7-methyl-6,6a,7...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)C#N
Show InChI InChI=1S/C26H23ClN2O/c1-29-11-10-18-13-23(27)25(30)14-22(18)26-21-7-3-6-19(20(21)8-9-24(26)29)17-5-2-4-16(12-17)15-28/h2-7,12-14,24,26,30H,8-11H2,1H3/t24-,26+/m0/s1
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3.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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3.60n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 247: 1093-102 (1988)


BindingDB Entry DOI: 10.7270/Q2NK3CHS
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50306445
PNG
((6aS,13bS)-11-chloro-7-methyl-4-(3-nitrophenyl)-6,...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C25H23ClN2O3/c1-27-11-10-16-13-22(26)24(29)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)27)15-4-2-5-17(12-15)28(30)31/h2-7,12-14,23,25,29H,8-11H2,1H3/t23-,25+/m0/s1
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4.70n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50306448
PNG
((6aS,13bS)-11-chloro-4-(4-methoxyphenyl)-7-methyl-...)
Show SMILES COc1ccc(cc1)-c1cccc2[C@H]3[C@H](CCc12)N(C)CCc1cc(Cl)c(O)cc31
Show InChI InChI=1S/C26H26ClNO2/c1-28-13-12-17-14-23(27)25(29)15-22(17)26-21-5-3-4-19(20(21)10-11-24(26)28)16-6-8-18(30-2)9-7-16/h3-9,14-15,24,26,29H,10-13H2,1-2H3/t24-,26+/m0/s1
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6.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306449
PNG
((6aS,13bS)-11-chloro-4-(4-(dimethylamino)phenyl)-7...)
Show SMILES CN(C)c1ccc(cc1)-c1cccc2[C@H]3[C@H](CCc12)N(C)CCc1cc(Cl)c(O)cc31
Show InChI InChI=1S/C27H29ClN2O/c1-29(2)19-9-7-17(8-10-19)20-5-4-6-22-21(20)11-12-25-27(22)23-16-26(31)24(28)15-18(23)13-14-30(25)3/h4-10,15-16,25,27,31H,11-14H2,1-3H3/t25-,27+/m0/s1
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12n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306450
PNG
((6aS,13bS)-11-chloro-4-(4-(hydroxymethyl)phenyl)-7...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1ccc(CO)cc1
Show InChI InChI=1S/C26H26ClNO2/c1-28-12-11-18-13-23(27)25(30)14-22(18)26-21-4-2-3-19(20(21)9-10-24(26)28)17-7-5-16(15-29)6-8-17/h2-8,13-14,24,26,29-30H,9-12,15H2,1H3/t24-,26+/m0/s1
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89n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306443
PNG
((6aS,13bS)-11-chloro-4-(3-fluorophenyl)-7-methyl-6...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(F)c1
Show InChI InChI=1S/C25H23ClFNO/c1-28-11-10-16-13-22(26)24(29)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)28)15-4-2-5-17(27)12-15/h2-7,12-14,23,25,29H,8-11H2,1H3/t23-,25+/m0/s1
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223n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306447
PNG
((6aS,13bS)-11-chloro-4-(3,5-difluorophenyl)-7-meth...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cc(F)cc(F)c1
Show InChI InChI=1S/C25H22ClF2NO/c1-29-8-7-14-11-22(26)24(30)13-21(14)25-20-4-2-3-18(19(20)5-6-23(25)29)15-9-16(27)12-17(28)10-15/h2-4,9-13,23,25,30H,5-8H2,1H3/t23-,25+/m0/s1
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312n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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321n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 247: 1093-102 (1988)


BindingDB Entry DOI: 10.7270/Q2NK3CHS
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306435
PNG
((6aS,13bS)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(O)cccc21
Show InChI InChI=1S/C19H20ClNO2/c1-21-8-7-11-9-15(20)18(23)10-14(11)19-13-3-2-4-17(22)12(13)5-6-16(19)21/h2-4,9-10,16,19,22-23H,5-8H2,1H3/t16-,19+/m0/s1
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440n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010711
PNG
((6aR,13bS )11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m0/s1
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474n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH-23,390 binding to rat striatal homogenate dopamine receptor D1


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
Dopamine receptors; D1 & D2


(RAT)
BDBM50010711
PNG
((6aR,13bS )11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m0/s1
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513n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from rat striatal homogenate dopamine receptor D2


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010715
PNG
((6aS,13bS)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m1/s1
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513n/an/an/an/an/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1


J Med Chem 33: 2197-204 (1990)


Article DOI: 10.1021/jm00170a025
BindingDB Entry DOI: 10.7270/Q2TD9XZB
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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514n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from rat striatal homogenate dopamine receptor D2


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010715
PNG
((6aS,13bS)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m1/s1
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531n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH-23,390 binding to rat striatal homogenate dopamine receptor D1


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010711
PNG
((6aR,13bS )11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m0/s1
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531n/an/an/an/an/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1


J Med Chem 33: 2197-204 (1990)


Article DOI: 10.1021/jm00170a025
BindingDB Entry DOI: 10.7270/Q2TD9XZB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306448
PNG
((6aS,13bS)-11-chloro-4-(4-methoxyphenyl)-7-methyl-...)
Show SMILES COc1ccc(cc1)-c1cccc2[C@H]3[C@H](CCc12)N(C)CCc1cc(Cl)c(O)cc31
Show InChI InChI=1S/C26H26ClNO2/c1-28-13-12-17-14-23(27)25(29)15-22(17)26-21-5-3-4-19(20(21)10-11-24(26)28)16-6-8-18(30-2)9-7-16/h3-9,14-15,24,26,29H,10-13H2,1-2H3/t24-,26+/m0/s1
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550n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306444
PNG
(3-((6aS,13bS)-11-chloro-12-hydroxy-7-methyl-6,6a,7...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)C#N
Show InChI InChI=1S/C26H23ClN2O/c1-29-11-10-18-13-23(27)25(30)14-22(18)26-21-7-3-6-19(20(21)8-9-24(26)29)17-5-2-4-16(12-17)15-28/h2-7,12-14,24,26,30H,8-11H2,1H3/t24-,26+/m0/s1
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584n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306445
PNG
((6aS,13bS)-11-chloro-7-methyl-4-(3-nitrophenyl)-6,...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C25H23ClN2O3/c1-27-11-10-16-13-22(26)24(29)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)27)15-4-2-5-17(12-15)28(30)31/h2-7,12-14,23,25,29H,8-11H2,1H3/t23-,25+/m0/s1
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618n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306437
PNG
(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(CN=O)cccc21
Show InChI InChI=1S/C20H21ClN2O2/c1-23-8-7-12-9-17(21)19(24)10-16(12)20-15-4-2-3-13(11-22-25)14(15)5-6-18(20)23/h2-4,9-10,18,20,24H,5-8,11H2,1H3/t18-,20+/m0/s1
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882n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50010712
PNG
((6aR,13bR)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m1/s1
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898n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-SCH-23,390 binding to rat striatal homogenate dopamine receptor D1


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))
BDBM50010712
PNG
((6aR,13bR)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m1/s1
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898n/an/an/an/an/an/an/an/a



Royal Danish School of Pharmacy

Curated by ChEMBL


Assay Description
Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1


J Med Chem 33: 2197-204 (1990)


Article DOI: 10.1021/jm00170a025
BindingDB Entry DOI: 10.7270/Q2TD9XZB
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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980n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D2 receptor


Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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980n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50306446
PNG
((6aR,13bS)-11-chloro-7-methyl-4-(3-(trifluorometho...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@H]1CCc1c2cccc1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C26H23ClF3NO2/c1-31-11-10-16-13-22(27)24(32)14-21(16)25-20-7-3-6-18(19(20)8-9-23(25)31)15-4-2-5-17(12-15)33-26(28,29)30/h2-7,12-14,23,25,32H,8-11H2,1H3/t23-,25-/m1/s1
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1.61E+3n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [3H]methylspiperon from dopamine D2 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010715
PNG
((6aS,13bS)11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahy...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m1/s1
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3.05E+3n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from rat striatal homogenate dopamine receptor D2


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50010711
PNG
((6aR,13bS )11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19-/m0/s1
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3.48E+3n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from rat striatal homogenate dopamine receptor D2


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50306435
PNG
((6aS,13bS)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(O)cccc21
Show InChI InChI=1S/C19H20ClNO2/c1-21-8-7-11-9-15(20)18(23)10-14(11)19-13-3-2-4-17(22)12(13)5-6-16(19)21/h2-4,9-10,16,19,22-23H,5-8H2,1H3/t16-,19+/m0/s1
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3.99E+3n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D4 receptor expressed in mouse LTK cells by scintillation counting


Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50017815
PNG
(11-Chloro-7-methyl-5,6a,7,8,9,13b-hexahydro-6H-7-a...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C2C1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3
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4.12E+3n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]-spiperone from rat striatal homogenate dopamine receptor D2


J Med Chem 32: 1913-21 (1989)


Article DOI: 10.1021/jm00128a038
BindingDB Entry DOI: 10.7270/Q2VQ31P4
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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4.27E+3n/an/an/an/an/an/an/an/a



Schering-Plough Corporation

Curated by PDSP Ki Database




J Pharmacol Exp Ther 247: 1093-102 (1988)


BindingDB Entry DOI: 10.7270/Q2NK3CHS
More data for this
Ligand-Target Pair
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