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22 similar compounds to monomer 50005039

Compile data set for download or QSAR
Wt: 393.2
BDBM50005036
Wt: 385.2
BDBM50005040
Wt: 391.2
BDBM50005043
Wt: 407.2
BDBM50005045
Wt: 365.2
BDBM50005049
Wt: 391.2
BDBM50005050
Wt: 331.1
BDBM50005077
Wt: 379.2
BDBM50005053
Wt: 329.1
BDBM50005056
Wt: 371.2
BDBM50005058
Wt: 393.2
BDBM50005065
Wt: 413.6
BDBM50005066
Wt: 395.2
BDBM50005067
Wt: 366.1
BDBM50005071
Wt: 365.2
BDBM50005073
Displayed 1 to 15 (of 22 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50005036,50005040,50005043,50005045,50005049,50005050,50005077,50005053,50005056,50005058,50005065,50005066,50005067,50005071,50005073   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005036
PNG
(5,7-Dichloro-4-(2-p-tolyl-acetylamino)-1,2,3,4-tet...)
Show SMILES Cc1ccc(CC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C19H18Cl2N2O3/c1-10-2-4-11(5-3-10)6-17(24)23-15-9-16(19(25)26)22-14-8-12(20)7-13(21)18(14)15/h2-5,7-8,15-16,22H,6,9H2,1H3,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005043
PNG
(5,7-Dichloro-4-(3-oxo-3,4-dihydro-1H-isoquinolin-2...)
Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3CC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H16Cl2N2O3/c20-12-6-13(21)18-14(7-12)22-15(19(25)26)8-16(18)23-9-11-4-2-1-3-10(11)5-17(23)24/h1-4,6-7,15-16,22H,5,8-9H2,(H,25,26)/t15-,16+/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005045
PNG
(5,7-Dichloro-4-(4-phenyl-butyrylamino)-1,2,3,4-tet...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C20H20Cl2N2O3/c21-13-9-14(22)19-15(10-13)23-17(20(26)27)11-16(19)24-18(25)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-10,16-17,23H,4,7-8,11H2,(H,24,25)(H,26,27)/t16-,17+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005049
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005050
PNG
(5,7-Dichloro-4-(1,3-dioxo-1,3-dihydro-isoindol-2-y...)
Show SMILES OC(=O)[C@H]1C[C@H](N2C(=O)c3ccccc3C2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H12Cl2N2O4/c19-8-5-11(20)15-12(6-8)21-13(18(25)26)7-14(15)22-16(23)9-3-1-2-4-10(9)17(22)24/h1-6,13-14,21H,7H2,(H,25,26)/t13-,14+/m1/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005056
PNG
(5,7-Dichloro-4-(2-oxo-pyrrolidin-1-yl)-1,2,3,4-tet...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCCC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C14H14Cl2N2O3/c15-7-4-8(16)13-9(5-7)17-10(14(20)21)6-11(13)18-3-1-2-12(18)19/h4-5,10-11,17H,1-3,6H2,(H,20,21)/t10-,11+/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005058
PNG
(5,7-Dichloro-4-(cyclohexanecarbonyl-amino)-1,2,3,4...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)C2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H20Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h6-7,9,13-14,20H,1-5,8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005065
PNG
(5,7-Dichloro-4-(3-phenyl-propionylamino)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H18Cl2N2O3/c20-12-8-13(21)18-14(9-12)22-16(19(25)26)10-15(18)23-17(24)7-6-11-4-2-1-3-5-11/h1-5,8-9,15-16,22H,6-7,10H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005066
PNG
(5,7-Dichloro-4-[2-(4-chloro-phenyl)-acetylamino]-1...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccc(Cl)cc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H15Cl3N2O3/c19-10-3-1-9(2-4-10)5-16(24)23-14-8-15(18(25)26)22-13-7-11(20)6-12(21)17(13)14/h1-4,6-7,14-15,22H,5,8H2,(H,23,24)(H,25,26)/t14-,15+/m0/s1
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n/an/a 52n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005067
PNG
(5,7-Dichloro-4-[2-(4-hydroxy-phenyl)-acetylamino]-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccc(O)cc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O4/c19-10-6-12(20)17-13(7-10)21-15(18(25)26)8-14(17)22-16(24)5-9-1-3-11(23)4-2-9/h1-4,6-7,14-15,21,23H,5,8H2,(H,22,24)(H,25,26)/t14-,15+/m0/s1
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n/an/a 30n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005071
PNG
(5,7-Dichloro-4-[(pyridine-4-carbonyl)-amino]-1,2,3...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccncc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C16H13Cl2N3O3/c17-9-5-10(18)14-11(6-9)20-13(16(23)24)7-12(14)21-15(22)8-1-3-19-4-2-8/h1-6,12-13,20H,7H2,(H,21,22)(H,23,24)/t12-,13+/m0/s1
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n/an/a 630n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005073
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14-/m1/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005077
PNG
(4-Butyrylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES CCCC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C14H16Cl2N2O3/c1-2-3-12(19)18-10-6-11(14(20)21)17-9-5-7(15)4-8(16)13(9)10/h4-5,10-11,17H,2-3,6H2,1H3,(H,18,19)(H,20,21)/t10-,11+/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005053
PNG
((-) 5,7-Dichloro-4-phenylacetylamino-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Cc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H16Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h1-5,7-8,14-15,21H,6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 5.90E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005040
PNG
(5,7-Dichloro-4-(2-cyclohexyl-acetylamino)-1,2,3,4-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CC2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H22Cl2N2O3/c19-11-7-12(20)17-13(8-11)21-15(18(24)25)9-14(17)22-16(23)6-10-4-2-1-3-5-10/h7-8,10,14-15,21H,1-6,9H2,(H,22,23)(H,24,25)/t14-,15+/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair