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17 similar compounds to monomer 50005064

Compile data set for download or QSAR
Wt: 394.2
BDBM50005038
Wt: 406.2
BDBM50005044
Wt: 407.2
BDBM50005045
Wt: 406.2
BDBM50005048
Wt: 365.2
BDBM50005049
Wt: 331.1
BDBM50005077
Wt: 456.3
BDBM50005054
Wt: 394.2
BDBM50005059
Wt: 392.2
BDBM50005061
Wt: 393.2
BDBM50005065
Wt: 394.2
BDBM50005072
Wt: 365.2
BDBM50005073
Wt: 386.2
BDBM50005074
Wt: 380.2
BDBM50005075
Purchase
Wt: 430.2
BDBM50005081
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50005038,50005044,50005045,50005048,50005049,50005077,50005054,50005059,50005061,50005065,50005072,50005073,50005074,50005075,50005081   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005038
PNG
(5,7-Dichloro-4-(3-m-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1cccc(NC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)c1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-3-2-4-11(5-9)21-18(26)23-14-8-15(17(24)25)22-13-7-10(19)6-12(20)16(13)14/h2-7,14-15,22H,8H2,1H3,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005044
PNG
((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCN(C2=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-8-13(21)17-14(9-11)22-15(18(25)26)10-16(17)24-7-6-23(19(24)27)12-4-2-1-3-5-12/h1-5,8-9,15-16,22H,6-7,10H2,(H,25,26)/t15-,16+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005045
PNG
(5,7-Dichloro-4-(4-phenyl-butyrylamino)-1,2,3,4-tet...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C20H20Cl2N2O3/c21-13-9-14(22)19-15(10-13)23-17(20(26)27)11-16(19)24-18(25)8-4-7-12-5-2-1-3-6-12/h1-3,5-6,9-10,16-17,23H,4,7-8,11H2,(H,24,25)(H,26,27)/t16-,17+/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005048
PNG
(5,7-Dichloro-4-[(2,3-dihydro-indole-1-carbonyl)-am...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)N2CCc3ccccc23)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-7-12(21)17-13(8-11)22-15(18(25)26)9-14(17)23-19(27)24-6-5-10-3-1-2-4-16(10)24/h1-4,7-8,14-15,22H,5-6,9H2,(H,23,27)(H,25,26)/t14-,15+/m0/s1
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n/an/a 220n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005049
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14+/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005054
PNG
(5,7-Dichloro-4-(3,3-diphenyl-ureido)-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)N(c2ccccc2)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C23H19Cl2N3O3/c24-14-11-17(25)21-18(12-14)26-20(22(29)30)13-19(21)27-23(31)28(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h1-12,19-20,26H,13H2,(H,27,31)(H,29,30)/t19-,20+/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005059
PNG
(5,7-Dichloro-4-(3-methyl-3-phenyl-ureido)-1,2,3,4-...)
Show SMILES CN(C(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O)c1ccccc1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-23(11-5-3-2-4-6-11)18(26)22-14-9-15(17(24)25)21-13-8-10(19)7-12(20)16(13)14/h2-8,14-15,21H,9H2,1H3,(H,22,26)(H,24,25)/t14-,15+/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005061
PNG
(5,7-Dichloro-4-(2-oxo-1,4-dihydro-2H-quinazolin-3-...)
Show SMILES OC(=O)[C@H]1C[C@H](N2Cc3ccccc3NC2=O)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C18H15Cl2N3O3/c19-10-5-11(20)16-13(6-10)21-14(17(24)25)7-15(16)23-8-9-3-1-2-4-12(9)22-18(23)26/h1-6,14-15,21H,7-8H2,(H,22,26)(H,24,25)/t14-,15+/m1/s1
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n/an/a 510n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005072
PNG
(5,7-Dichloro-4-(3-p-tolyl-ureido)-1,2,3,4-tetrahyd...)
Show SMILES Cc1ccc(NC(=O)N[C@H]2C[C@@H](Nc3cc(Cl)cc(Cl)c23)C(O)=O)cc1
Show InChI InChI=1S/C18H17Cl2N3O3/c1-9-2-4-11(5-3-9)21-18(26)23-14-8-15(17(24)25)22-13-7-10(19)6-12(20)16(13)14/h2-7,14-15,22H,8H2,1H3,(H,24,25)(H2,21,23,26)/t14-,15+/m0/s1
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n/an/a 5n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005065
PNG
(5,7-Dichloro-4-(3-phenyl-propionylamino)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)CCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H18Cl2N2O3/c20-12-8-13(21)18-14(9-12)22-16(19(25)26)10-15(18)23-17(24)7-6-11-4-2-1-3-5-11/h1-5,8-9,15-16,22H,6-7,10H2,(H,23,24)(H,25,26)/t15-,16+/m0/s1
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n/an/a 76n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005073
PNG
(4-Benzoylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES OC(=O)[C@H]1C[C@@H](NC(=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-10-6-11(19)15-12(7-10)20-14(17(23)24)8-13(15)21-16(22)9-4-2-1-3-5-9/h1-7,13-14,20H,8H2,(H,21,22)(H,23,24)/t13-,14-/m1/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005074
PNG
(5,7-Dichloro-4-(3-cyclohexyl-ureido)-1,2,3,4-tetra...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)NC2CCCCC2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H21Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h6-7,10,13-14,21H,1-5,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 7.40n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005077
PNG
(4-Butyrylamino-5,7-dichloro-1,2,3,4-tetrahydro-qui...)
Show SMILES CCCC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C14H16Cl2N2O3/c1-2-3-12(19)18-10-6-11(14(20)21)17-9-5-7(15)4-8(16)13(9)10/h4-5,10-11,17H,2-3,6H2,1H3,(H,18,19)(H,20,21)/t10-,11+/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005081
PNG
(5,7-Dichloro-4-(3-naphthalen-1-yl-ureido)-1,2,3,4-...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2cccc3ccccc23)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C21H17Cl2N3O3/c22-12-8-14(23)19-16(9-12)24-18(20(27)28)10-17(19)26-21(29)25-15-7-3-5-11-4-1-2-6-13(11)15/h1-9,17-18,24H,10H2,(H,27,28)(H2,25,26,29)/t17-,18+/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to N-methyl-D-aspartate glutamate receptor from rat cortical membranes


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the binding of [3H]-L-689,560 ([3H]-4) to the strychnine-insensitive glycine site on rat brain membranes


J Med Chem 37: 1402-5 (1994)


Article DOI: 10.1021/jm00036a002
BindingDB Entry DOI: 10.7270/Q2DF6Q8C
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005075
PNG
((2R,4S)-5,7-Dichloro-4-(3-phenyl-ureido)-1,2,3,4-t...)
Show SMILES OC(=O)[C@H]1C[C@H](NC(=O)Nc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H15Cl2N3O3/c18-9-6-11(19)15-12(7-9)21-14(16(23)24)8-13(15)22-17(25)20-10-4-2-1-3-5-10/h1-7,13-14,21H,8H2,(H,23,24)(H2,20,22,25)/t13-,14+/m0/s1
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n/an/a 7.80n/an/an/an/an/an/a



Università degli Studi di Urbino

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]-glycine to N-methyl-D-aspartate glutamate receptor 1 from crude synaptic membranes prepared from adult rat cerebral cor...


J Med Chem 41: 808-20 (1998)


Article DOI: 10.1021/jm970416w
BindingDB Entry DOI: 10.7270/Q2QZ293M
More data for this
Ligand-Target Pair
Ionotropic glutamate receptor NMDA 1/2D


(RAT)
BDBM50005044
PNG
((2R,4S)-5,7-Dichloro-4-(2-oxo-3-phenyl-imidazolidi...)
Show SMILES OC(=O)[C@H]1C[C@H](N2CCN(C2=O)c2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C19H17Cl2N3O3/c20-11-8-13(21)17-14(9-11)22-15(18(25)26)10-16(17)24-7-6-23(19(24)27)12-4-2-1-3-5-12/h1-5,8-9,15-16,22H,6-7,10H2,(H,25,26)/t15-,16+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair