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4 similar compounds to monomer 50005076

Compile data set for download or QSAR
Wt: 261.1
BDBM50005082
Wt: 246.0
BDBM50005085
Wt: 303.1
BDBM50005052
Wt: 351.2
BDBM50005088

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50005082,50005085,50005052,50005088   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glutamate-NMDA


(RAT)
BDBM50005052
PNG
(4-Acetylamino-5,7-dichloro-1,2,3,4-tetrahydro-quin...)
Show SMILES CC(=O)N[C@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C12H12Cl2N2O3/c1-5(17)15-9-4-10(12(18)19)16-8-3-6(13)2-7(14)11(8)9/h2-3,9-10,16H,4H2,1H3,(H,15,17)(H,18,19)/t9-,10+/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 900n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50005085
PNG
(5,7-Dichloro-1,2,3,4-tetrahydro-quinoline-2-carbox...)
Show SMILES OC(=O)[C@H]1CCc2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C10H9Cl2NO2/c11-5-3-7(12)6-1-2-8(10(14)15)13-9(6)4-5/h3-4,8,13H,1-2H2,(H,14,15)/t8-/m1/s1
PDB

UniProtKB/SwissProt

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AffyNet 
CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 6.40E+3n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50005088
PNG
(4-Benzylamino-5,7-dichloro-1,2,3,4-tetrahydro-quin...)
Show SMILES OC(=O)[C@H]1C[C@H](NCc2ccccc2)c2c(Cl)cc(Cl)cc2N1
Show InChI InChI=1S/C17H16Cl2N2O2/c18-11-6-12(19)16-13(20-9-10-4-2-1-3-5-10)8-15(17(22)23)21-14(16)7-11/h1-7,13,15,20-21H,8-9H2,(H,22,23)/t13-,15+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.07E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair
Glutamate-NMDA


(RAT)
BDBM50005082
PNG
(4-Amino-5,7-dichloro-1,2,3,4-tetrahydro-quinoline-...)
Show SMILES N[C@@H]1C[C@@H](Nc2cc(Cl)cc(Cl)c12)C(O)=O
Show InChI InChI=1S/C10H10Cl2N2O2/c11-4-1-5(12)9-6(13)3-8(10(15)16)14-7(9)2-4/h1-2,6,8,14H,3,13H2,(H,15,16)/t6-,8-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.41E+4n/an/an/an/an/an/a



Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]- glycine binding to NMDA receptor from rat cortical membranes.


J Med Chem 35: 1954-68 (1992)


Article DOI: 10.1021/jm00089a004
BindingDB Entry DOI: 10.7270/Q2T72GCZ
More data for this
Ligand-Target Pair