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39 similar compounds to monomer 50005459

Wt: 481.4
BDBM50008163
Wt: 420.9
BDBM50008165
Wt: 410.9
BDBM50008166
Wt: 396.9
BDBM50008168
Wt: 459.4
BDBM50008170
Wt: 434.9
BDBM50008176
Wt: 382.8
BDBM50008181
Wt: 403.3
BDBM50008182
Wt: 368.8
BDBM50008184
Wt: 394.8
BDBM50008186
Wt: 368.8
BDBM50008188
Wt: 354.8
BDBM50008189
Wt: 446.9
BDBM50008190
Wt: 403.3
BDBM50008191
Wt: 389.2
BDBM50008195
Displayed 1 to 15 (of 39 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50008163,50008165,50008166,50008168,50008170,50008176,50008181,50008182,50008184,50008186,50008188,50008189,50008190,50008191,50008195   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cholecystokinin receptor


(RAT)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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PubMed
129n/an/an/an/an/an/an/an/a



Universitá di Siena

Curated by ChEMBL


Assay Description
Binding affinity against Cholecystokinin type A receptor using [125I]-(BH)-CCK-8 as radioligand in rat pancreas.


J Med Chem 39: 860-72 (1996)

More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [125I]-CCK-OP radioligand from Cholecystokinin type A receptor in rat pancreatic acinar membrane binding assay


Bioorg Med Chem Lett 2: 1251-1256 (1992)

More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008165
PNG
(4-(3-Chloro-benzoylamino)-4-(decahydro-naphthalen-...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1
Show InChI InChI=1S/C22H29ClN2O4/c23-17-7-3-6-16(12-17)21(28)25-19(10-11-20(26)27)22(29)24-18-9-8-14-4-1-2-5-15(14)13-18/h3,6-7,12,14-15,18-19H,1-2,4-5,8-11,13H2,(H,24,29)(H,25,28)(H,26,27)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50008163
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3,5-dichlor...)
Show SMILES OC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H30Cl2N2O4/c25-18-8-17(9-19(26)10-18)22(31)28-20(1-2-21(29)30)23(32)27-4-3-24-11-14-5-15(12-24)7-16(6-14)13-24/h8-10,14-16,20H,1-7,11-13H2,(H,27,32)(H,28,31)(H,29,30)
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n/an/a 8.10E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008166
PNG
(4-(3-Chloro-benzoylamino)-4-(3,3-diethyl-pentylcar...)
Show SMILES CCC(CC)(CC)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H31ClN2O4/c1-4-21(5-2,6-3)12-13-23-20(28)17(10-11-18(25)26)24-19(27)15-8-7-9-16(22)14-15/h7-9,14,17H,4-6,10-13H2,1-3H3,(H,23,28)(H,24,27)(H,25,26)
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n/an/a 900n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008168
PNG
(4-(3-Chloro-benzoylamino)-4-(2-ethyl-hexylcarbamoy...)
Show SMILES CCCCC(CC)CNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H29ClN2O4/c1-3-5-7-14(4-2)13-22-20(27)17(10-11-18(24)25)23-19(26)15-8-6-9-16(21)12-15/h6,8-9,12,14,17H,3-5,7,10-11,13H2,1-2H3,(H,22,27)(H,23,26)(H,24,25)
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n/an/a 6.80E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to cholecystokinin type B receptor in rabbit gastric gland


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008176
PNG
(4-(3-Chloro-benzoylamino)-4-(spiro[5.5]undec-3-ylc...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1
Show InChI InChI=1S/C23H31ClN2O4/c24-17-6-4-5-16(15-17)21(29)26-19(7-8-20(27)28)22(30)25-18-9-13-23(14-10-18)11-2-1-3-12-23/h4-6,15,18-19H,1-3,7-14H2,(H,25,30)(H,26,29)(H,27,28)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 50n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008181
PNG
(4-(3-Chloro-benzoylamino)-4-(4,4-dimethyl-pentylca...)
Show SMILES CC(C)(C)CCCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H27ClN2O4/c1-19(2,3)10-5-11-21-18(26)15(8-9-16(23)24)22-17(25)13-6-4-7-14(20)12-13/h4,6-7,12,15H,5,8-11H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 3.20E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008182
PNG
(4-(2,3-Dichloro-benzoylamino)-4-(3,3-dimethyl-buty...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H24Cl2N2O4/c1-18(2,3)9-10-21-17(26)13(7-8-14(23)24)22-16(25)11-5-4-6-12(19)15(11)20/h4-6,13H,7-10H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008186
PNG
(4-(3-Chloro-benzoylamino)-4-(4,4-dimethyl-cyclohex...)
Show SMILES CC1(C)CCC(CC1)NC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H27ClN2O4/c1-20(2)10-8-15(9-11-20)22-19(27)16(6-7-17(24)25)23-18(26)13-4-3-5-14(21)12-13/h3-5,12,15-16H,6-11H2,1-2H3,(H,22,27)(H,23,26)(H,24,25)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008188
PNG
(4-(3-Chloro-benzoylamino)-4-hexylcarbamoyl-butyric...)
Show SMILES CCCCCCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H25ClN2O4/c1-2-3-4-5-11-20-18(25)15(9-10-16(22)23)21-17(24)13-7-6-8-14(19)12-13/h6-8,12,15H,2-5,9-11H2,1H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 2.15E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008189
PNG
(4-(3-Chloro-benzoylamino)-4-(3-methyl-butylcarbamo...)
Show SMILES CC(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H23ClN2O4/c1-11(2)8-9-19-17(24)14(6-7-15(21)22)20-16(23)12-4-3-5-13(18)10-12/h3-5,10-11,14H,6-9H2,1-2H3,(H,19,24)(H,20,23)(H,21,22)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of [125I](BH)-CCK-8 binding to cholecystokinin type A receptor in rat pancreatic acini; Inactive


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008191
PNG
(4-(3,4-Dichloro-benzoylamino)-4-(3,3-dimethyl-buty...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O4/c1-18(2,3)8-9-21-17(26)14(6-7-15(23)24)22-16(25)11-4-5-12(19)13(20)10-11/h4-5,10,14H,6-9H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 1.88E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008195
PNG
(4-(3,4-Dichloro-benzoylamino)-4-pentylcarbamoyl-bu...)
Show SMILES CCCCCNC(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N2O4/c1-2-3-4-9-20-17(25)14(7-8-15(22)23)21-16(24)11-5-6-12(18)13(19)10-11/h5-6,10,14H,2-4,7-9H2,1H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% the specific binding of [125I](BH)-CCK-8 to CCK-B(B2) in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008166
PNG
(4-(3-Chloro-benzoylamino)-4-(3,3-diethyl-pentylcar...)
Show SMILES CCC(CC)(CC)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H31ClN2O4/c1-4-21(5-2,6-3)12-13-23-20(28)17(10-11-18(25)26)24-19(27)15-8-7-9-16(22)14-15/h7-9,14,17H,4-6,10-13H2,1-3H3,(H,23,28)(H,24,27)(H,25,26)
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n/an/a 8.00E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008190
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-be...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H31ClN2O4/c25-19-3-1-2-18(11-19)22(30)27-20(4-5-21(28)29)23(31)26-7-6-24-12-15-8-16(13-24)10-17(9-15)14-24/h1-3,11,15-17,20H,4-10,12-14H2,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 400n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]gastrin to Cholecystokinin type B receptor from guinea pig gastric glands


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008163
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3,5-dichlor...)
Show SMILES OC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H30Cl2N2O4/c25-18-8-17(9-19(26)10-18)22(31)28-20(1-2-21(29)30)23(32)27-4-3-24-11-14-5-15(12-24)7-16(6-14)13-24/h8-10,14-16,20H,1-7,11-13H2,(H,27,32)(H,28,31)(H,29,30)
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n/an/a 3.28E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008191
PNG
(4-(3,4-Dichloro-benzoylamino)-4-(3,3-dimethyl-buty...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H24Cl2N2O4/c1-18(2,3)8-9-21-17(26)14(6-7-15(23)24)22-16(25)11-4-5-12(19)13(20)10-11/h4-5,10,14H,6-9H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008182
PNG
(4-(2,3-Dichloro-benzoylamino)-4-(3,3-dimethyl-buty...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H24Cl2N2O4/c1-18(2,3)9-10-21-17(26)13(7-8-14(23)24)22-16(25)11-5-4-6-12(19)15(11)20/h4-6,13H,7-10H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of [125I](BH)-CCK-8 binding to cholecystokinin type A receptor in rat pancreatic acini; Inactive


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008168
PNG
(4-(3-Chloro-benzoylamino)-4-(2-ethyl-hexylcarbamoy...)
Show SMILES CCCCC(CC)CNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H29ClN2O4/c1-3-5-7-14(4-2)13-22-20(27)17(10-11-18(24)25)23-19(26)15-8-6-9-16(21)12-15/h6,8-9,12,14,17H,3-5,7,10-11,13H2,1-2H3,(H,22,27)(H,23,26)(H,24,25)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008195
PNG
(4-(3,4-Dichloro-benzoylamino)-4-pentylcarbamoyl-bu...)
Show SMILES CCCCCNC(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H22Cl2N2O4/c1-2-3-4-9-20-17(25)14(7-8-15(22)23)21-16(24)11-5-6-12(18)13(19)10-11/h5-6,10,14H,2-4,7-9H2,1H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 8.60E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50008184
PNG
(4-(3-Chloro-benzoylamino)-4-(3,3-dimethyl-butylcar...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H25ClN2O4/c1-18(2,3)9-10-20-17(25)14(7-8-15(22)23)21-16(24)12-5-4-6-13(19)11-12/h4-6,11,14H,7-10H2,1-3H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008184
PNG
(4-(3-Chloro-benzoylamino)-4-(3,3-dimethyl-butylcar...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H25ClN2O4/c1-18(2,3)9-10-20-17(25)14(7-8-15(22)23)21-16(24)12-5-4-6-13(19)11-12/h4-6,11,14H,7-10H2,1-3H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008163
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3,5-dichlor...)
Show SMILES OC(=O)CCC(NC(=O)c1cc(Cl)cc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H30Cl2N2O4/c25-18-8-17(9-19(26)10-18)22(31)28-20(1-2-21(29)30)23(32)27-4-3-24-11-14-5-15(12-24)7-16(6-14)13-24/h8-10,14-16,20H,1-7,11-13H2,(H,27,32)(H,28,31)(H,29,30)
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n/an/a 300n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008165
PNG
(4-(3-Chloro-benzoylamino)-4-(decahydro-naphthalen-...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2CCCCC2C1
Show InChI InChI=1S/C22H29ClN2O4/c23-17-7-3-6-16(12-17)21(28)25-19(10-11-20(26)27)22(29)24-18-9-8-14-4-1-2-5-15(14)13-18/h3,6-7,12,14-15,18-19H,1-2,4-5,8-11,13H2,(H,24,29)(H,25,28)(H,26,27)
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n/an/a 2.30E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(Homo sapiens (human))
BDBM50008190
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-be...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H31ClN2O4/c25-19-3-1-2-18(11-19)22(30)27-20(4-5-21(28)29)23(31)26-7-6-24-12-15-8-16(13-24)10-17(9-15)14-24/h1-3,11,15-17,20H,4-10,12-14H2,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 8.30E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% the specific binding of [3H]pentagastrin to Cholecystokinin type B receptor in rabbit gastric gland


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008190
PNG
(4-(2-Adamantan-1-yl-ethylcarbamoyl)-4-(3-chloro-be...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NCCC12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C24H31ClN2O4/c25-19-3-1-2-18(11-19)22(30)27-20(4-5-21(28)29)23(31)26-7-6-24-12-15-8-16(13-24)10-17(9-15)14-24/h1-3,11,15-17,20H,4-10,12-14H2,(H,26,31)(H,27,30)(H,28,29)
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n/an/a 3.33E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008189
PNG
(4-(3-Chloro-benzoylamino)-4-(3-methyl-butylcarbamo...)
Show SMILES CC(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C17H23ClN2O4/c1-11(2)8-9-19-17(24)14(6-7-15(21)22)20-16(23)12-4-3-5-13(18)10-12/h3-5,10-11,14H,6-9H2,1-2H3,(H,19,24)(H,20,23)(H,21,22)
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n/an/a 3.53E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008188
PNG
(4-(3-Chloro-benzoylamino)-4-hexylcarbamoyl-butyric...)
Show SMILES CCCCCCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H25ClN2O4/c1-2-3-4-5-11-20-18(25)15(9-10-16(22)23)21-17(24)13-7-6-8-14(19)12-13/h6-8,12,15H,2-5,9-11H2,1H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 8.00E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008184
PNG
(4-(3-Chloro-benzoylamino)-4-(3,3-dimethyl-butylcar...)
Show SMILES CC(C)(C)CCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C18H25ClN2O4/c1-18(2,3)9-10-20-17(25)14(7-8-15(22)23)21-16(24)12-5-4-6-13(19)11-12/h4-6,11,14H,7-10H2,1-3H3,(H,20,25)(H,21,24)(H,22,23)
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n/an/a 9.05E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008176
PNG
(4-(3-Chloro-benzoylamino)-4-(spiro[5.5]undec-3-ylc...)
Show SMILES OC(=O)CCC(NC(=O)c1cccc(Cl)c1)C(=O)NC1CCC2(CCCCC2)CC1
Show InChI InChI=1S/C23H31ClN2O4/c24-17-6-4-5-16(15-17)21(29)26-19(7-8-20(27)28)22(30)25-18-9-13-23(14-10-18)11-2-1-3-12-23/h4-6,15,18-19H,1-3,7-14H2,(H,25,30)(H,26,29)(H,27,28)
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n/an/a 3.50E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008181
PNG
(4-(3-Chloro-benzoylamino)-4-(4,4-dimethyl-pentylca...)
Show SMILES CC(C)(C)CCCNC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H27ClN2O4/c1-19(2,3)10-5-11-21-18(26)15(8-9-16(23)24)22-17(25)13-6-4-7-14(20)12-13/h4,6-7,12,15H,5,8-11H2,1-3H3,(H,21,26)(H,22,25)(H,23,24)
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n/an/a 2.79E+4n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Concentration required to inhibit by 50% specific binding of [125I](BH)-CCK-8 to cholecystokinin type A receptor in rat pancreatic acini


Citation and Details
More data for this
Ligand-Target Pair
CCKBR


(RAT)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of the specific binding of [125I](BH)-CCK-8 to Cholecystokinin type B receptor in rat brain cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
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n/an/a 18n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]- CCK-33 to rat pancreas


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin A receptor


(Cavia porcellus)
BDBM50008170
PNG
(4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-...)
Show SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C22H32Cl2N2O4/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28)
MMDB

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n/an/a 2.20E+3n/an/an/an/an/an/a



Merck Sharp& Dohme Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of binding of [125I]- CCK-33 to guinea pig cortex


Citation and Details
More data for this
Ligand-Target Pair
Cholecystokinin receptor


(RAT)
BDBM50008186
PNG
(4-(3-Chloro-benzoylamino)-4-(4,4-dimethyl-cyclohex...)
Show SMILES CC1(C)CCC(CC1)NC(=O)C(CCC(O)=O)NC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H27ClN2O4/c1-20(2)10-8-15(9-11-20)22-19(27)16(6-7-17(24)25)23-18(26)13-4-3-5-14(21)12-13/h3-5,12,15-16H,6-11H2,1-2H3,(H,22,27)(H,23,26)(H,24,25)
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Rotta Research Laboratorium

Curated by ChEMBL


Assay Description
Inhibition of [125I](BH)-CCK-8 binding to cholecystokinin type A receptor in rat pancreatic acini; Inactive


Citation and Details
More data for this
Ligand-Target Pair