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6 similar compounds to monomer 50006956

Compile data set for download or QSAR
Wt: 272.3
BDBM50006961
Wt: 389.4
BDBM50006950
Wt: 300.3
BDBM50006960
Wt: 313.3
BDBM50006962
Wt: 314.3
BDBM50006963
Wt: 312.3
BDBM50006964

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50006961,50006950,50006960,50006962,50006963,50006964   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006950
PNG
(2-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-4,9-dihydro-...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H23N5O2/c28-21-20-19(17-8-4-5-9-18(17)23-20)24-22(29)27(21)15-12-25-10-13-26(14-11-25)16-6-2-1-3-7-16/h1-9,23H,10-15H2,(H,24,29)
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Article
PubMed
1.80n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity for Alpha-1 adrenergic receptor measured by displacing [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor and beta-3 adrenergic receptor


(Homo sapiens (Human))
BDBM50006950
PNG
(2-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-4,9-dihydro-...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H23N5O2/c28-21-20-19(17-8-4-5-9-18(17)23-20)24-22(29)27(21)15-12-25-10-13-26(14-11-25)16-6-2-1-3-7-16/h1-9,23H,10-15H2,(H,24,29)
PDB
MMDB

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Article
PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity towards Beta-2 adrenergic receptor in human periipheral mononuclear leukocyte membranes using [125I]-pindolol


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006963
PNG
(2-(2-Morpholin-4-yl-ethyl)-4,9-dihydro-2,4,9-triaz...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCOCC1
Show InChI InChI=1S/C16H18N4O3/c21-15-14-13(11-3-1-2-4-12(11)17-14)18-16(22)20(15)6-5-19-7-9-23-10-8-19/h1-4,17H,5-10H2,(H,18,22)
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006961
PNG
(2-(2-Dimethylamino-ethyl)-4,9-dihydro-2,4,9-triaza...)
Show SMILES CN(C)CCn1c(=O)[nH]c2c3ccccc3[nH]c2c1=O
Show InChI InChI=1S/C14H16N4O2/c1-17(2)7-8-18-13(19)12-11(16-14(18)20)9-5-3-4-6-10(9)15-12/h3-6,15H,7-8H2,1-2H3,(H,16,20)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006962
PNG
(2-(2-Piperazin-1-yl-ethyl)-4,9-dihydro-2,4,9-triaz...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCNCC1
Show InChI InChI=1S/C16H19N5O2/c22-15-14-13(11-3-1-2-4-12(11)18-14)19-16(23)21(15)10-9-20-7-5-17-6-8-20/h1-4,17-18H,5-10H2,(H,19,23)
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity for Alpha-1 adrenergic receptor measured by displacing [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006964
PNG
(2-(2-Piperidin-1-yl-ethyl)-4,9-dihydro-2,4,9-triaz...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCCCC1
Show InChI InChI=1S/C17H20N4O2/c22-16-15-14(12-6-2-3-7-13(12)18-15)19-17(23)21(16)11-10-20-8-4-1-5-9-20/h2-3,6-7,18H,1,4-5,8-11H2,(H,19,23)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50006950
PNG
(2-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-4,9-dihydro-...)
Show SMILES O=c1[nH]c2c3ccccc3[nH]c2c(=O)n1CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H23N5O2/c28-21-20-19(17-8-4-5-9-18(17)23-20)24-22(29)27(21)15-12-25-10-13-26(14-11-25)16-6-2-1-3-7-16/h1-9,23H,10-15H2,(H,24,29)
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>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity for 5-hydroxytryptamine 1A receptor measured by displacing [3H]-8-OH-DPAT from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50006960
PNG
(2-(2-Diethylamino-ethyl)-4,9-dihydro-2,4,9-triaza-...)
Show SMILES CCN(CC)CCn1c(=O)[nH]c2c3ccccc3[nH]c2c1=O
Show InChI InChI=1S/C16H20N4O2/c1-3-19(4-2)9-10-20-15(21)14-13(18-16(20)22)11-7-5-6-8-12(11)17-14/h5-8,17H,3-4,9-10H2,1-2H3,(H,18,22)
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PubMed
>1.00E+5n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair