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17 similar compounds to monomer 82517

Wt: 423.5
BDBM50007177
Wt: 407.5
BDBM50018456
Wt: 351.4
BDBM50062274
Wt: 419.5
BDBM50083042
Wt: 379.4
BDBM50132020
Wt: 443.5
BDBM50132066
Wt: 391.4
BDBM50155686
Wt: 391.4
BDBM50155688
Wt: 441.5
BDBM50155689
Wt: 419.5
BDBM50155690
Wt: 379.4
BDBM50216047
Wt: 365.4
BDBM50289019
Purchase
Wt: 436.5
BDBM50300488
Wt: 450.5
BDBM50300489
Wt: 395.5
BDBM50328457
Displayed 1 to 15 (of 17 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50007177,50018456,50062274,50083042,50132020,50132066,50155686,50155688,50155689,50155690,50216047,50289019,50300488,50300489,50328457   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50300488
PNG
(5-(Dimethylamino)-2-[4-[4-(2-methoxyphenyl)-1-pipe...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3ccc(cc3C2=O)N(C)C)CC1
Show InChI InChI=1S/C25H32N4O3/c1-26(2)19-10-11-20-21(18-19)25(31)29(24(20)30)13-7-6-12-27-14-16-28(17-15-27)22-8-4-5-9-23(22)32-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3
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0.5n/an/an/an/an/an/an/an/a



Universita degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells after 120 mins


J Med Chem 52: 7892-6 (2009)

More data for this
Ligand-Target Pair
Dopamine receptors; D3 & D4


(Homo sapiens (Human))
BDBM50328457
PNG
(CHEMBL1258494 | N-[4-[4-(2-Methoxyphenyl)piperazin...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19-10-11-20(2)21(18-19)24(28)25-12-6-7-13-26-14-16-27(17-15-26)22-8-4-5-9-23(22)29-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3,(H,25,28)
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4.70n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human dopamine D3 receptor expressed in CHO cells


J Med Chem 53: 7219-28 (2010)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155686
PNG
(2-{(E)-4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES COc1ccccc1N1CCN(C\C=C\CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H25N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-11H,12-17H2,1H3/b7-6+
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5n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50018456
PNG
(2-{5-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-pentyl}...)
Show SMILES COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C24H29N3O3/c1-30-22-12-6-5-11-21(22)26-17-15-25(16-18-26)13-7-2-8-14-27-23(28)19-9-3-4-10-20(19)24(27)29/h3-6,9-12H,2,7-8,13-18H2,1H3
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5n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity of compound towards 5-HT 1A receptor by measuring ability to displace [3H]-OH-DPAT from 5-hydroxytryptamine 1A receptor in rat stria...


J Med Chem 32: 1921-6 (1989)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50300489
PNG
(5-(Dimethylamino)-2-[5-[4-(2-methoxyphenyl)-1-pipe...)
Show SMILES COc1ccccc1N1CCN(CCCCCN2C(=O)c3ccc(cc3C2=O)N(C)C)CC1
Show InChI InChI=1S/C26H34N4O3/c1-27(2)20-11-12-21-22(19-20)26(32)30(25(21)31)14-8-4-7-13-28-15-17-29(18-16-28)23-9-5-6-10-24(23)33-3/h5-6,9-12,19H,4,7-8,13-18H2,1-3H3
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7.80n/an/an/an/an/an/an/an/a



Universita degli Studi di Bari

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells after 120 mins


J Med Chem 52: 7892-6 (2009)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50083042
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohe...)
Show SMILES COc1ccccc1N1CCN(CC1)C1CCC(CC1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C25H29N3O3/c1-31-23-9-5-4-8-22(23)27-16-14-26(15-17-27)18-10-12-19(13-11-18)28-24(29)20-6-2-3-7-21(20)25(28)30/h2-9,18-19H,10-17H2,1H3
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8n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
Ability of the compound to displace [3H]-8-OH-DPAT from 5-hydroxytryptamine 1A receptor


J Med Chem 42: 4952-60 (2000)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155690
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohe...)
Show SMILES COc1ccccc1N1CCN(CC1)[C@H]1CC[C@@H](CC1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C25H29N3O3/c1-31-23-9-5-4-8-22(23)27-16-14-26(15-17-27)18-10-12-19(13-11-18)28-24(29)20-6-2-3-7-21(20)25(28)30/h2-9,18-19H,10-17H2,1H3/t18-,19-
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8n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50062274
PNG
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H25N3O2/c1-26-20-9-5-4-8-19(20)23-13-10-22(11-14-23)12-15-24-16-17-6-2-3-7-18(17)21(24)25/h2-9H,10-16H2,1H3
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14.9n/an/an/an/an/an/an/an/a



University of Pennsylvania

Curated by ChEMBL


Assay Description
In vitro binding affinity for 5-hydroxytryptamine 1A receptor in rat hippocampal membranes by [125I]-labeled agonist displacement.


J Med Chem 41: 157-66 (1998)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328457
PNG
(CHEMBL1258494 | N-[4-[4-(2-Methoxyphenyl)piperazin...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19-10-11-20(2)21(18-19)24(28)25-12-6-7-13-26-14-16-27(17-15-26)22-8-4-5-9-23(22)29-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3,(H,25,28)
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17n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells


J Med Chem 53: 7219-28 (2010)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50132020
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-28-20-10-5-4-9-19(20)24-15-13-23(14-16-24)11-6-12-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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20n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]-8-OH-DPAT displacement.


Bioorg Med Chem Lett 6: 689-694 (1996)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50007177
PNG
(2-{4-[4-(2,5-Dimethoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES COc1ccc(OC)c(c1)N1CCN(CCCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C24H29N3O4/c1-30-18-9-10-22(31-2)21(17-18)26-15-13-25(14-16-26)11-5-6-12-27-23(28)19-7-3-4-8-20(19)24(27)29/h3-4,7-10,17H,5-6,11-16H2,1-2H3
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22n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 1A receptor of rat hippocampus using [3H]-8-hydroxy-2-(di-n-propylamine) tetralin (8-OH-DPAT) as a radio...


J Med Chem 34: 2633-8 (1991)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50328457
PNG
(CHEMBL1258494 | N-[4-[4-(2-Methoxyphenyl)piperazin...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19-10-11-20(2)21(18-19)24(28)25-12-6-7-13-26-14-16-27(17-15-26)22-8-4-5-9-23(22)29-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3,(H,25,28)
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22n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human dopamine D2 long receptor expressed in CHO cells


J Med Chem 53: 7219-28 (2010)

More data for this
Ligand-Target Pair
Dopamine receptors; D3 & D4


(Homo sapiens (Human))
BDBM50132066
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3cc4ccccc4cc3C2=O)CC1
Show InChI InChI=1S/C27H29N3O3/c1-33-25-11-5-4-10-24(25)29-16-14-28(15-17-29)12-6-7-13-30-26(31)22-18-20-8-2-3-9-21(20)19-23(22)27(30)32/h2-5,8-11,18-19H,6-7,12-17H2,1H3
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23.3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Binding affinity for human dopamine receptor D3 by displacing [125I]-iodosulpiride expressed in CHO cells


J Med Chem 46: 3883-99 (2003)

More data for this
Ligand-Target Pair
Dopamine receptors; D3 & D4


(Homo sapiens (Human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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30n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine D3 receptor expressed in CHO cells


Bioorg Med Chem 15: 5811-8 (2007)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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34n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine receptor D2 isoform long expressed in HEK293 cells assessed as change in quinpirole-induced intracellular calci...


Bioorg Med Chem 15: 5811-8 (2007)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155686
PNG
(2-{(E)-4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES COc1ccccc1N1CCN(C\C=C\CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H25N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-11H,12-17H2,1H3/b7-6+
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36n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-5-CT from binding to rat 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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75.4n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human Dopamine D5 receptor expressed in HEK293


Bioorg Med Chem 15: 5811-8 (2007)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155688
PNG
(2-{(Z)-4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES COc1ccccc1N1CCN(C\C=C/CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H25N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-11H,12-17H2,1H3/b7-6-
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77n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Dopamine D5 receptor


(Homo sapiens (Human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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137n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Antagonist activity at human Dopamine D5 receptor in HEK293 cells assessed as change in SKF 38393-induced intracellular calcium response


Bioorg Med Chem 15: 5811-8 (2007)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50132066
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)c3cc4ccccc4cc3C2=O)CC1
Show InChI InChI=1S/C27H29N3O3/c1-33-25-11-5-4-10-24(25)29-16-14-28(15-17-29)12-6-7-13-30-26(31)22-18-20-8-2-3-9-21(20)19-23(22)27(30)32/h2-5,8-11,18-19H,6-7,12-17H2,1H3
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145n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Binding affinity for human dopamine receptor D2 by displacing [125I]-iodosulpiride expressed in CHO cells


J Med Chem 46: 3883-99 (2003)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 7 (5-HT7)


(Homo sapiens (human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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158n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Displacement of [3H]LSD from human recombinant 5HT7 receptor expressed in CHOK1 cells


J Med Chem 52: 2384-92 (2009)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50132020
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-28-20-10-5-4-9-19(20)24-15-13-23(14-16-24)11-6-12-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
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300n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Binding affinity for human dopamine receptor D2 by displacing [125I]-iodosulpiride expressed in CHO cells


J Med Chem 46: 3883-99 (2003)

More data for this
Ligand-Target Pair
Dopamine receptor D2L/neurotensin receptor NTS1


(Homo sapiens (Human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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319n/an/an/an/an/an/an/an/a



Cairo University

Curated by ChEMBL


Assay Description
Displacement of [3H]Spiperone from human Dopamine receptor D2 isoform long expressed in HEK293 cells


Bioorg Med Chem 15: 5811-8 (2007)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155688
PNG
(2-{(Z)-4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-but...)
Show SMILES COc1ccccc1N1CCN(C\C=C/CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H25N3O3/c1-29-21-11-5-4-10-20(21)25-16-14-24(15-17-25)12-6-7-13-26-22(27)18-8-2-3-9-19(18)23(26)28/h2-11H,12-17H2,1H3/b7-6-
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353n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-5-CT from binding to rat 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155689
PNG
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-b...)
Show SMILES COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C27H27N3O3/c1-33-25-13-7-6-12-24(25)29-16-14-28(15-17-29)18-20-8-2-3-9-21(20)19-30-26(31)22-10-4-5-11-23(22)27(30)32/h2-13H,14-19H2,1H3
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367n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-5-CT from binding to rat 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155689
PNG
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-b...)
Show SMILES COc1ccccc1N1CCN(Cc2ccccc2CN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C27H27N3O3/c1-33-25-13-7-6-12-24(25)29-16-14-28(15-17-29)18-20-8-2-3-9-21(20)19-30-26(31)22-10-4-5-11-23(22)27(30)32/h2-13H,14-19H2,1H3
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405n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-OH-DPAT from binding to rat 5-hydroxytryptamine 1A receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Dopamine receptors; D3 & D4


(Homo sapiens (Human))
BDBM50132020
PNG
(2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O3/c1-28-20-10-5-4-9-19(20)24-15-13-23(14-16-24)11-6-12-25-21(26)17-7-2-3-8-18(17)22(25)27/h2-5,7-10H,6,11-16H2,1H3
PDB

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560n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-Universität

Curated by ChEMBL


Assay Description
Binding affinity for human dopamine receptor D3 by displacing [125I]-iodosulpiride expressed in CHO cells


J Med Chem 46: 3883-99 (2003)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50289019
PNG
(2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H23N3O3/c1-27-19-9-5-4-8-18(19)23-13-10-22(11-14-23)12-15-24-20(25)16-6-2-3-7-17(16)21(24)26/h2-9H,10-15H2,1H3
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990n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity at 5-hydroxytryptamine 1A receptor in rat cerebral cortex membranes by [3H]-8-OH-DPAT displacement.


Bioorg Med Chem Lett 6: 689-694 (1996)

More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (human))
BDBM50216047
PNG
(2-(4-(4-phenyl-1-piperazinyl)butyl)-1-isoindolinon...)
Show SMILES COc1ccccc1N1CCN(CCCCN2Cc3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H29N3O2/c1-28-22-11-5-4-10-21(22)25-16-14-24(15-17-25)12-6-7-13-26-18-19-8-2-3-9-20(19)23(26)27/h2-5,8-11H,6-7,12-18H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Universidad Complutense de Madrid

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HEK293 cells


J Med Chem 52: 2384-92 (2009)

More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50328457
PNG
(CHEMBL1258494 | N-[4-[4-(2-Methoxyphenyl)piperazin...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19-10-11-20(2)21(18-19)24(28)25-12-6-7-13-26-14-16-27(17-15-26)22-8-4-5-9-23(22)29-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3,(H,25,28)
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1.50E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]Ketanserin from 5-HT2 receptor in pig cortex membranes


J Med Chem 53: 7219-28 (2010)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50155690
PNG
(2-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-cyclohe...)
Show SMILES COc1ccccc1N1CCN(CC1)[C@H]1CC[C@@H](CC1)N1C(=O)c2ccccc2C1=O
Show InChI InChI=1S/C25H29N3O3/c1-31-23-9-5-4-8-22(23)27-16-14-26(15-17-27)18-10-12-19(13-11-18)28-24(29)20-6-2-3-7-21(20)25(28)30/h2-9,18-19H,10-17H2,1H3/t18-,19-
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2.05E+3n/an/an/an/an/an/an/an/a



Polish Academy of Sciences

Curated by ChEMBL


Assay Description
In vitro ability to displace the radioligand [3H]-5-CT from binding to rat 5-hydroxytryptamine 7 receptor


Bioorg Med Chem Lett 14: 5863-6 (2004)

Checked by Author
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50328457
PNG
(CHEMBL1258494 | N-[4-[4-(2-Methoxyphenyl)piperazin...)
Show SMILES COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1
Show InChI InChI=1S/C24H33N3O2/c1-19-10-11-20(2)21(18-19)24(28)25-12-6-7-13-26-14-16-27(17-15-26)22-8-4-5-9-23(22)29-3/h4-5,8-11,18H,6-7,12-17H2,1-3H3,(H,25,28)
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2.10E+3n/an/an/an/an/an/an/an/a



Friedrich Alexander University

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes


J Med Chem 53: 7219-28 (2010)

More data for this
Ligand-Target Pair