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12 similar compounds to monomer 50432652

Compile data set for download or QSAR
Wt: 542.4
BDBM50007654
Wt: 434.3
BDBM50432635
Wt: 434.3
BDBM50432638
Wt: 434.3
BDBM50432639
Wt: 434.3
BDBM50432643
Wt: 448.3
BDBM50432644
Wt: 433.3
BDBM50432645
Wt: 420.3
BDBM50432646
Wt: 416.3
BDBM50432647
Wt: 376.2
BDBM50432649
Wt: 336.2
BDBM50432650
Wt: 426.3
BDBM50432659

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50007654,50432635,50432638,50432639,50432643,50432644,50432645,50432646,50432647,50432649,50432650,50432659   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50007654
PNG
(CHEMBL3233136)
Show SMILES C[C@@H](CS(=O)(=O)C(C)(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29Cl2NO6S/c1-15(14-35(32,33)25(2,3)4)28-22(16-8-10-18(26)11-9-16)23(17-6-5-7-19(27)12-17)34-20(24(28)31)13-21(29)30/h5-12,15,20,22-23H,13-14H2,1-4H3,(H,29,30)/t15-,20+,22+,23+/m0/s1
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n/an/a 1.10n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in serum f...


J Med Chem 57: 2472-88 (2014)


Article DOI: 10.1021/jm401767k
BindingDB Entry DOI: 10.7270/Q2C24XZZ
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 1.57E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of MDM2-induced proliferation of human SJSA1 cells assessed as EdU incorporation by High content screening assay in presence of 10% serum


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 2.94E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human SJSA1 cells assessed as upregulation of p21 transcript level after 7 hrs by qRT-PCR analysis in presence of 10% serum


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432638
PNG
(CHEMBL2347377)
Show SMILES OC(=O)C[C@@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21+/m0/s1
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n/an/a 1.53E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of MDM2-induced proliferation of human SJSA1 cells assessed as EdU incorporation by High content screening assay in presence of 10% serum


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432639
PNG
(CHEMBL2347376)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20-,21-/m1/s1
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n/an/a 1.67E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of MDM2-induced proliferation of human SJSA1 cells assessed as EdU incorporation by High content screening assay in presence of 10% serum


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of MDM2-induced proliferation of human SJSA1 cells assessed as EdU incorporation by High content screening assay in presence of 10% serum


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432638
PNG
(CHEMBL2347377)
Show SMILES OC(=O)C[C@@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21+/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432639
PNG
(CHEMBL2347376)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20-,21-/m1/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432643
PNG
(CHEMBL2347392)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432644
PNG
(CHEMBL2347391)
Show SMILES OC(=O)CC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO4/c24-17-8-6-15(7-9-17)21-22(16-2-1-3-18(25)12-16)30-19(10-11-20(27)28)23(29)26(21)13-14-4-5-14/h1-3,6-9,12,14,19,21-22H,4-5,10-11,13H2,(H,27,28)/t19-,21+,22-/m0/s1
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n/an/a 1.52E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432645
PNG
(CHEMBL2347390)
Show SMILES CNCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H26Cl2N2O2/c1-26-12-11-20-23(28)27(14-15-5-6-15)21(16-7-9-18(24)10-8-16)22(29-20)17-3-2-4-19(25)13-17/h2-4,7-10,13,15,20-22,26H,5-6,11-12,14H2,1H3/t20-,21+,22-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 4.50E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432646
PNG
(CHEMBL2347388)
Show SMILES OCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H23Cl2NO3/c23-17-8-6-15(7-9-17)20-21(16-2-1-3-18(24)12-16)28-19(10-11-26)22(27)25(20)13-14-4-5-14/h1-3,6-9,12,14,19-21,26H,4-5,10-11,13H2/t19-,20+,21-/m0/s1
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n/an/a 1.44E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432647
PNG
(CHEMBL2347387)
Show SMILES Clc1ccc(cc1)[C@@H]1[C@@H](O[C@@H](CC=C)C(=O)N1CC1CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO2/c1-2-4-20-23(27)26(14-15-7-8-15)21(16-9-11-18(24)12-10-16)22(28-20)17-5-3-6-19(25)13-17/h2-3,5-6,9-13,15,20-22H,1,4,7-8,14H2/t20-,21+,22-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432649
PNG
(CHEMBL2347385)
Show SMILES Clc1ccc(cc1)[C@@H]1[C@@H](OCC(=O)N1CC1CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H19Cl2NO2/c21-16-8-6-14(7-9-16)19-20(15-2-1-3-17(22)10-15)25-12-18(24)23(19)11-13-4-5-13/h1-3,6-10,13,19-20H,4-5,11-12H2/t19-,20+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432650
PNG
(CHEMBL2347384)
Show SMILES CN1[C@@H]([C@@H](OCC1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15Cl2NO2/c1-20-15(21)10-22-17(12-3-2-4-14(19)9-12)16(20)11-5-7-13(18)8-6-11/h2-9,16-17H,10H2,1H3/t16-,17+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432638
PNG
(CHEMBL2347377)
Show SMILES OC(=O)C[C@@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21+/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432639
PNG
(CHEMBL2347376)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20-,21-/m1/s1
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n/an/a 290n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432643
PNG
(CHEMBL2347392)
Show SMILES OC(=O)C[C@H]1O[C@@H]([C@@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432644
PNG
(CHEMBL2347391)
Show SMILES OC(=O)CC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO4/c24-17-8-6-15(7-9-17)21-22(16-2-1-3-18(25)12-16)30-19(10-11-20(27)28)23(29)26(21)13-14-4-5-14/h1-3,6-9,12,14,19,21-22H,4-5,10-11,13H2,(H,27,28)/t19-,21+,22-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432645
PNG
(CHEMBL2347390)
Show SMILES CNCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H26Cl2N2O2/c1-26-12-11-20-23(28)27(14-15-5-6-15)21(16-7-9-18(24)10-8-16)22(29-20)17-3-2-4-19(25)13-17/h2-4,7-10,13,15,20-22,26H,5-6,11-12,14H2,1H3/t20-,21+,22-/m0/s1
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n/an/a 9.90E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432635
PNG
(CHEMBL2347389)
Show SMILES OC(=O)C[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H21Cl2NO4/c23-16-8-6-14(7-9-16)20-21(15-2-1-3-17(24)10-15)29-18(11-19(26)27)22(28)25(20)12-13-4-5-13/h1-3,6-10,13,18,20-21H,4-5,11-12H2,(H,26,27)/t18-,20+,21-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432646
PNG
(CHEMBL2347388)
Show SMILES OCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C22H23Cl2NO3/c23-17-8-6-15(7-9-17)20-21(16-2-1-3-18(24)12-16)28-19(10-11-26)22(27)25(20)13-14-4-5-14/h1-3,6-9,12,14,19-21,26H,4-5,10-11,13H2/t19-,20+,21-/m0/s1
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n/an/a 880n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432647
PNG
(CHEMBL2347387)
Show SMILES Clc1ccc(cc1)[C@@H]1[C@@H](O[C@@H](CC=C)C(=O)N1CC1CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23Cl2NO2/c1-2-4-20-23(27)26(14-15-7-8-15)21(16-9-11-18(24)12-10-16)22(28-20)17-5-3-6-19(25)13-17/h2-3,5-6,9-13,15,20-22H,1,4,7-8,14H2/t20-,21+,22-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432649
PNG
(CHEMBL2347385)
Show SMILES Clc1ccc(cc1)[C@@H]1[C@@H](OCC(=O)N1CC1CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C20H19Cl2NO2/c21-16-8-6-14(7-9-16)19-20(15-2-1-3-17(22)10-15)25-12-18(24)23(19)11-13-4-5-13/h1-3,6-10,13,19-20H,4-5,11-12H2/t19-,20+/m1/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432650
PNG
(CHEMBL2347384)
Show SMILES CN1[C@@H]([C@@H](OCC1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15Cl2NO2/c1-20-15(21)10-22-17(12-3-2-4-14(19)9-12)16(20)11-5-7-13(18)8-6-11/h2-9,16-17H,10H2,1H3/t16-,17+/m1/s1
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n/an/a 1.17E+4n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50432659
PNG
(CHEMBL2347401)
Show SMILES CN1[C@@H]([C@@H](O[C@@H](Cc2ccccc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H21Cl2NO2/c1-27-22(17-7-11-19(25)12-8-17)23(18-9-13-20(26)14-10-18)29-21(24(27)28)15-16-5-3-2-4-6-16/h2-14,21-23H,15H2,1H3/t21-,22+,23-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of human recombinant GST-thrombin-MDM2 (1 to 188) expressed in Escherichia coli assessed as reduction of MDM2-p53 interaction incubated fo...


J Med Chem 56: 4053-70 (2013)


Article DOI: 10.1021/jm400293z
BindingDB Entry DOI: 10.7270/Q2HD7X1P
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))
BDBM50007654
PNG
(CHEMBL3233136)
Show SMILES C[C@@H](CS(=O)(=O)C(C)(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H29Cl2NO6S/c1-15(14-35(32,33)25(2,3)4)28-22(16-8-10-18(26)11-9-16)23(17-6-5-7-19(27)12-17)34-20(24(28)31)13-21(29)30/h5-12,15,20,22-23H,13-14H2,1-4H3,(H,29,30)/t15-,20+,22+,23+/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Binding affinity to GST-thrombin-tagged human MDM2 (1 to 188) expressed in Escherichia coli assessed as inhibition of interaction with p53 in buffer ...


J Med Chem 57: 2472-88 (2014)


Article DOI: 10.1021/jm401767k
BindingDB Entry DOI: 10.7270/Q2C24XZZ
More data for this
Ligand-Target Pair