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7 similar compounds to monomer 50431232

Compile data set for download or QSAR
Wt: 327.1
BDBM50009370
Wt: 403.2
BDBM50431229
Wt: 383.2
BDBM50431230
Wt: 369.2
BDBM50431231
Wt: 401.2
BDBM50431233
Wt: 357.1
BDBM50431234
Wt: 341.1
BDBM50431235

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50009370,50431229,50431230,50431231,50431233,50431234,50431235   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dipeptidyl peptidase 2 (DPP II)


(Homo sapiens (Human))
BDBM50009370
PNG
(CHEMBL3233847)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C16H18BN3O4/c21-15(20-9-3-6-14(20)17(23)24)10-19-16(22)12-7-8-18-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14,23-24H,3,6,9-10H2,(H,19,22)/t14-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP2 purified from human seminal plasma using Lys-Ala-p-nitroanilide as substrate by spectrophotometry


J Med Chem 57: 3053-74 (2014)


Article DOI: 10.1021/jm500031w
BindingDB Entry DOI: 10.7270/Q2P84DFW
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431235
PNG
(CHEMBL2332619)
Show SMILES C[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C17H20BN3O4/c1-11(17(23)21-10-4-7-15(21)18(24)25)20-16(22)13-8-9-19-14-6-3-2-5-12(13)14/h2-3,5-6,8-9,11,15,24-25H,4,7,10H2,1H3,(H,20,22)/t11-,15+/m1/s1
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n/an/a 6.40n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein (FAP)


(Mus musculus (Mouse))
BDBM50009370
PNG
(CHEMBL3233847)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C16H18BN3O4/c21-15(20-9-3-6-14(20)17(23)24)10-19-16(22)12-7-8-18-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14,23-24H,3,6,9-10H2,(H,19,22)/t14-/m0/s1
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n/an/a 3.70n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant mouse FAP purified from HEK293 cell supernatant using Ala-Pro-p-nitroanilide as substrate by spectrophotometry


J Med Chem 57: 3053-74 (2014)


Article DOI: 10.1021/jm500031w
BindingDB Entry DOI: 10.7270/Q2P84DFW
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50009370
PNG
(CHEMBL3233847)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C16H18BN3O4/c21-15(20-9-3-6-14(20)17(23)24)10-19-16(22)12-7-8-18-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14,23-24H,3,6,9-10H2,(H,19,22)/t14-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometry


J Med Chem 57: 3053-74 (2014)


Article DOI: 10.1021/jm500031w
BindingDB Entry DOI: 10.7270/Q2P84DFW
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431229
PNG
(CHEMBL2333022)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)c1ccnc2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H22BN3O4/c27-21(17-12-13-24-18-10-5-4-9-16(17)18)25-20(15-7-2-1-3-8-15)22(28)26-14-6-11-19(26)23(29)30/h1-5,7-10,12-13,19-20,29-30H,6,11,14H2,(H,25,27)/t19-,20+/m0/s1
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n/an/a 57n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431230
PNG
(CHEMBL2332624)
Show SMILES CCCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C20H26BN3O4/c1-2-3-8-17(20(26)24-13-6-10-18(24)21(27)28)23-19(25)15-11-12-22-16-9-5-4-7-14(15)16/h4-5,7,9,11-12,17-18,27-28H,2-3,6,8,10,13H2,1H3,(H,23,25)/t17-,18+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431231
PNG
(CHEMBL2332623)
Show SMILES CCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H24BN3O4/c1-2-6-16(19(25)23-12-5-9-17(23)20(26)27)22-18(24)14-10-11-21-15-8-4-3-7-13(14)15/h3-4,7-8,10-11,16-17,26-27H,2,5-6,9,12H2,1H3,(H,22,24)/t16-,17+/m1/s1
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n/an/a 320n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431233
PNG
(CHEMBL2332621)
Show SMILES CSCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H24BN3O4S/c1-28-12-9-16(19(25)23-11-4-7-17(23)20(26)27)22-18(24)14-8-10-21-15-6-3-2-5-13(14)15/h2-3,5-6,8,10,16-17,26-27H,4,7,9,11-12H2,1H3,(H,22,24)/t16-,17+/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431234
PNG
(CHEMBL2332620)
Show SMILES OC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C17H20BN3O5/c22-10-14(17(24)21-9-3-6-15(21)18(25)26)20-16(23)12-7-8-19-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14-15,22,25-26H,3,6,9-10H2,(H,20,23)/t14-,15+/m1/s1
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n/an/a 440n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Prolyl endopeptidase


(Homo sapiens (Human))
BDBM50431235
PNG
(CHEMBL2332619)
Show SMILES C[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C17H20BN3O4/c1-11(17(23)21-10-4-7-15(21)18(24)25)20-16(22)13-8-9-19-14-6-3-2-5-12(13)14/h2-3,5-6,8-9,11,15,24-25H,4,7,10H2,1H3,(H,20,22)/t11-,15+/m1/s1
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n/an/a 1.00E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431229
PNG
(CHEMBL2333022)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)[C@H](NC(=O)c1ccnc2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H22BN3O4/c27-21(17-12-13-24-18-10-5-4-9-16(17)18)25-20(15-7-2-1-3-8-15)22(28)26-14-6-11-19(26)23(29)30/h1-5,7-10,12-13,19-20,29-30H,6,11,14H2,(H,25,27)/t19-,20+/m0/s1
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n/an/a 9.30E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431230
PNG
(CHEMBL2332624)
Show SMILES CCCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C20H26BN3O4/c1-2-3-8-17(20(26)24-13-6-10-18(24)21(27)28)23-19(25)15-11-12-22-16-9-5-4-7-14(15)16/h4-5,7,9,11-12,17-18,27-28H,2-3,6,8,10,13H2,1H3,(H,23,25)/t17-,18+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431231
PNG
(CHEMBL2332623)
Show SMILES CCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H24BN3O4/c1-2-6-16(19(25)23-12-5-9-17(23)20(26)27)22-18(24)14-10-11-21-15-8-4-3-7-13(14)15/h3-4,7-8,10-11,16-17,26-27H,2,5-6,9,12H2,1H3,(H,22,24)/t16-,17+/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431233
PNG
(CHEMBL2332621)
Show SMILES CSCC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C19H24BN3O4S/c1-28-12-9-16(19(25)23-11-4-7-17(23)20(26)27)22-18(24)14-8-10-21-15-6-3-2-5-13(14)15/h2-3,5-6,8,10,16-17,26-27H,4,7,9,11-12H2,1H3,(H,22,24)/t16-,17+/m1/s1
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n/an/a 350n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Fibroblast activation protein alpha


(Homo sapiens (Human))
BDBM50431234
PNG
(CHEMBL2332620)
Show SMILES OC[C@@H](NC(=O)c1ccnc2ccccc12)C(=O)N1CCC[C@H]1B(O)O
Show InChI InChI=1S/C17H20BN3O5/c22-10-14(17(24)21-9-3-6-15(21)18(25)26)20-16(23)12-7-8-19-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14-15,22,25-26H,3,6,9-10H2,(H,20,23)/t14-,15+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Tufts University Sackler School of Biomedical Sciences

Curated by ChEMBL


Assay Description
Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay


J Med Chem 56: 3467-77 (2013)


Article DOI: 10.1021/jm400351a
BindingDB Entry DOI: 10.7270/Q2C53N7W
More data for this
Ligand-Target Pair
Dipeptidyl peptidase 4


(Homo sapiens (Human))
BDBM50009370
PNG
(CHEMBL3233847)
Show SMILES OB(O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
Show InChI InChI=1S/C16H18BN3O4/c21-15(20-9-3-6-14(20)17(23)24)10-19-16(22)12-7-8-18-13-5-2-1-4-11(12)13/h1-2,4-5,7-8,14,23-24H,3,6,9-10H2,(H,19,22)/t14-/m0/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of DPP4 purified from human seminal plasma using Gly-Pro-p-nitroanilide as substrate by spectrophotometry


J Med Chem 57: 3053-74 (2014)


Article DOI: 10.1021/jm500031w
BindingDB Entry DOI: 10.7270/Q2P84DFW
More data for this
Ligand-Target Pair