BindingDB logo
myBDB logout

7 similar compounds to monomer 81982

Compile data set for download or QSAR
Wt: 240.3
BDBM50010744
Wt: 269.3
BDBM50010770
Wt: 254.3
BDBM50010775
Wt: 267.3
BDBM50010760
Wt: 253.3
BDBM50010790
Wt: 267.3
BDBM50010794
Wt: 253.3
BDBM50043966

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50010744,50010770,50010775,50010760,50010790,50010794,50043966   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010770
PNG
(CHEMBL79165 | N,N'-Bis-(4-amino-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(N)ccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H19N5/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,16-17H2,1-2H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 7.15E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 44n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010744
PNG
(CHEMBL78585 | N-(2-Amino-phenyl)-N'-o-tolyl-guanid...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1N
Show InChI InChI=1S/C14H16N4/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,15H2,1H3,(H3,16,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 463n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50043966
PNG
(CHEMBL412674 | N-Methyl-N,N'-di-o-tolyl-guanidine)
Show SMILES CN(C(N)=Nc1ccccc1C)c1ccccc1C
Show InChI InChI=1S/C16H19N3/c1-12-8-4-6-10-14(12)18-16(17)19(3)15-11-7-5-9-13(15)2/h4-11H,1-3H3,(H2,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 6.28E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane


J Med Chem 37: 260-7 (1994)


Article DOI: 10.1021/jm00028a009
BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010790
PNG
(CHEMBL78637 | N-(2,6-Dimethyl-phenyl)-N'-o-tolyl-g...)
Show SMILES Cc1ccccc1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C16H19N3/c1-11-7-4-5-10-14(11)18-16(17)19-15-12(2)8-6-9-13(15)3/h4-10H,1-3H3,(H3,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 42n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 14n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010794
PNG
(CHEMBL312318 | N,N'-Bis-(2,6-dimethyl-phenyl)-guan...)
Show SMILES Cc1cccc(C)c1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C17H21N3/c1-11-7-5-8-12(2)15(11)19-17(18)20-16-13(3)9-6-10-14(16)4/h5-10H,1-4H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 66n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to sigma receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010775
PNG
(CHEMBL543596 | N-(4-Amino-2-methyl-phenyl)-N'-o-to...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H18N4/c1-10-5-3-4-6-13(10)18-15(17)19-14-8-7-12(16)9-11(14)2/h3-9H,16H2,1-2H3,(H3,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010794
PNG
(CHEMBL312318 | N,N'-Bis-(2,6-dimethyl-phenyl)-guan...)
Show SMILES Cc1cccc(C)c1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C17H21N3/c1-11-7-5-8-12(2)15(11)19-17(18)20-16-13(3)9-6-10-14(16)4/h5-10H,1-4H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 90n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010790
PNG
(CHEMBL78637 | N-(2,6-Dimethyl-phenyl)-N'-o-tolyl-g...)
Show SMILES Cc1ccccc1NC(N)=Nc1c(C)cccc1C
Show InChI InChI=1S/C16H19N3/c1-11-7-4-5-10-14(11)18-16(17)19-15-12(2)8-6-9-13(15)3/h4-10H,1-3H3,(H3,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 70n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010770
PNG
(CHEMBL79165 | N,N'-Bis-(4-amino-2-methyl-phenyl)-g...)
Show SMILES Cc1cc(N)ccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H19N5/c1-9-7-11(16)3-5-13(9)19-15(18)20-14-6-4-12(17)8-10(14)2/h3-8H,16-17H2,1-2H3,(H3,18,19,20)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010744
PNG
(CHEMBL78585 | N-(2-Amino-phenyl)-N'-o-tolyl-guanid...)
Show SMILES Cc1ccccc1N=C(N)Nc1ccccc1N
Show InChI InChI=1S/C14H16N4/c1-10-6-2-4-8-12(10)17-14(16)18-13-9-5-3-7-11(13)15/h2-9H,15H2,1H3,(H3,16,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 440n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]- (+)-3-PPP binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))
BDBM50010775
PNG
(CHEMBL543596 | N-(4-Amino-2-methyl-phenyl)-N'-o-to...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccc(N)cc1C
Show InChI InChI=1S/C15H18N4/c1-10-5-3-4-6-13(10)18-15(17)19-14-8-7-12(16)9-11(14)2/h3-9H,16H2,1-2H3,(H3,17,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



University of Oregon

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against [3H]DTG binding to Sigma opioid receptor in guinea pig brain membrane homogenates


J Med Chem 33: 2421-9 (1990)


Article DOI: 10.1021/jm00171a016
BindingDB Entry DOI: 10.7270/Q25Q4WQ3
More data for this
Ligand-Target Pair