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4 similar compounds to monomer 50011736

Compile data set for download or QSAR
Wt: 275.3
BDBM50011739
Wt: 233.6
BDBM50011743
Purchase
Wt: 268.0
BDBM50011735
Wt: 233.6
BDBM50011744

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50011739,50011743,50011735,50011744   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011735
PNG
(CHEMBL3262908)
Show SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H7Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,15H,1H3
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n/an/a 460n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric an...


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011739
PNG
(CHEMBL3262912)
Show SMILES CNc1oc(nc1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C17H13N3O/c1-19-17-15(11-18)20-16(21-17)14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-10,19H,1H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric an...


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011743
PNG
(CHEMBL1547372)
Show SMILES CNc1oc(nc1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C11H8ClN3O/c1-14-11-9(6-13)15-10(16-11)7-2-4-8(12)5-3-7/h2-5,14H,1H3
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Article
PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric an...


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
15-Lipoxygenase-2 (15-LOX-2)


(Homo sapiens (Human))
BDBM50011735
PNG
(CHEMBL3262908)
Show SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H7Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,15H,1H3
PDB

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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged human epithelial 15-lipoxygenase-2 using arachidonic acid as substrate by UV-vis spectrometric analysis


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50011735
PNG
(CHEMBL3262908)
Show SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H7Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,15H,1H3
PDB
MMDB

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n/an/a>5.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of human 5-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011735
PNG
(CHEMBL3262908)
Show SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C11H7Cl2N3O/c1-15-11-8(5-14)16-10(17-11)6-3-2-4-7(12)9(6)13/h2-4,15H,1H3
PDB

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Article
PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His6-tagged human platelet 12-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric analysis


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Homo sapiens (Human))
BDBM50011744
PNG
(CHEMBL3262916)
Show SMILES CNc1oc(nc1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C11H8ClN3O/c1-14-11-9(6-13)15-10(16-11)7-3-2-4-8(12)5-7/h2-5,14H,1H3
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PubMed
n/an/a 6.30E+3n/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His6-tagged human reticulocyte 12/15-lipoxygenase using arachidonic acid as substrate by UV-vis spectrometric an...


J Med Chem 57: 4035-48 (2014)


Article DOI: 10.1021/jm401915r
BindingDB Entry DOI: 10.7270/Q26T0P58
More data for this
Ligand-Target Pair