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3 similar compounds to monomer 50038460

Compile data set for download or QSAR
Wt: 283.3
BDBM50012392
Wt: 253.3
BDBM50012428
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Wt: 297.3
BDBM50038457

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50012392,50012428,50038457   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50012392
PNG
(2-(4-Methoxy-phenyl)-5-phenyl-thiazol-4-ol | CHEMB...)
Show SMILES COc1ccc(cc1)-c1nc(O)c(s1)-c1ccccc1
Show InChI InChI=1S/C16H13NO2S/c1-19-13-9-7-12(8-10-13)16-17-15(18)14(20-16)11-5-3-2-4-6-11/h2-10,18H,1H3
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n/an/a 2.40E+3n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
The compound was tested for the inhibition of 5-lipoxygenase (5-lo) in human whole blood (HWBL)


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012392
PNG
(2-(4-Methoxy-phenyl)-5-phenyl-thiazol-4-ol | CHEMB...)
Show SMILES COc1ccc(cc1)-c1nc(O)c(s1)-c1ccccc1
Show InChI InChI=1S/C16H13NO2S/c1-19-13-9-7-12(8-10-13)16-17-15(18)14(20-16)11-5-3-2-4-6-11/h2-10,18H,1H3
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Article
PubMed
n/an/a 370n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012428
PNG
(2,5-Diphenyl-thiazol-4-ol | CHEMBL308001)
Show SMILES Oc1nc(sc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H11NOS/c17-14-13(11-7-3-1-4-8-11)18-15(16-14)12-9-5-2-6-10-12/h1-10,17H
PDB
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Purchase

CHEMBL
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Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50038457
PNG
(CHEMBL3353723)
Show SMILES COc1ccc(cc1)-c1sc(nc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C17H15NO2S/c1-11-3-5-13(6-4-11)17-18-16(19)15(21-17)12-7-9-14(20-2)10-8-12/h3-10,19H,1-2H3
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PubMed
n/an/a 170n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL S100 extract using arachidonic acid as substrate incubated for 15 mins prior to substrate addition measured after 10...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Homo sapiens (Human))
BDBM50038457
PNG
(CHEMBL3353723)
Show SMILES COc1ccc(cc1)-c1sc(nc1O)-c1ccc(C)cc1
Show InChI InChI=1S/C17H15NO2S/c1-11-3-5-13(6-4-11)17-18-16(19)15(21-17)12-7-9-14(20-2)10-8-12/h3-10,19H,1-2H3
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Article
PubMed
n/an/a 430n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in human PMNL using arachidonic acid as substrate assessed as product formation incubated for 15 mins prior to substrate addition ...


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012428
PNG
(2,5-Diphenyl-thiazol-4-ol | CHEMBL308001)
Show SMILES Oc1nc(sc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H11NOS/c17-14-13(11-7-3-1-4-8-11)18-15(16-14)12-9-5-2-6-10-12/h1-10,17H
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 530n/an/an/an/an/an/a



Goethe-University Frankfurt

Curated by ChEMBL


Assay Description
Inhibition of 5-LO in rat RBL1 cells


Eur J Med Chem 89: 503-23 (2014)


Article DOI: 10.1016/j.ejmech.2014.10.054
BindingDB Entry DOI: 10.7270/Q2959K5T
More data for this
Ligand-Target Pair
Arachidonate 5-lipoxygenase


(Rattus norvegicus)
BDBM50012392
PNG
(2-(4-Methoxy-phenyl)-5-phenyl-thiazol-4-ol | CHEMB...)
Show SMILES COc1ccc(cc1)-c1nc(O)c(s1)-c1ccccc1
Show InChI InChI=1S/C16H13NO2S/c1-19-13-9-7-12(8-10-13)16-17-15(18)14(20-16)11-5-3-2-4-6-11/h2-10,18H,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 450n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-lo) in intact rat polymorphonuclear leukocyte RPMNL


J Med Chem 34: 2158-65 (1991)


Article DOI: 10.1021/jm00111a035
BindingDB Entry DOI: 10.7270/Q2NS0SWM
More data for this
Ligand-Target Pair